Prostatitis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description Infiltration of inflammatory cells into the parenchyma of PROSTATE. The subtypes are classified by their varied laboratory analysis, clinical presentation and response to treatment. (Experimental Factor Ontology, EFO_0003830)
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Genes

302 genes co-occuring with the disease Prostatitis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
KLK3 kallikrein-related peptidase 3 3.616
IL6 interleukin 6 2.48
AR androgen receptor 2.46
IL1B interleukin 1, beta 2.421
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 2.406
CXCL8 chemokine (C-X-C motif) ligand 8 2.396
TNF tumor necrosis factor 2.387
KLK2 kallikrein-related peptidase 2 2.301
NKX3-1 NK3 homeobox 1 2.227
NGF nerve growth factor (beta polypeptide) 2.137
AMACR alpha-methylacyl-CoA racemase 2.134
IL10 interleukin 10 2.134
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.113
CD4 CD4 molecule 2.099
IFNG interferon, gamma 2.096
TMPRSS2 transmembrane protease, serine 2 2.093
CRP C-reactive protein, pentraxin-related 2.085
CCL2 chemokine (C-C motif) ligand 2 2.067
MSMB microseminoprotein, beta- 2.041
IL17A interleukin 17A 2.011
TGFB1 transforming growth factor, beta 1 1.975
TGM4 transglutaminase 4 1.973
TAC1 tachykinin, precursor 1 1.952
PDE5A phosphodiesterase 5A, cGMP-specific 1.951
IL2 interleukin 2 1.945
TLR4 toll-like receptor 4 1.917
CD8A CD8a molecule 1.898
GSTP1 glutathione S-transferase pi 1 1.897
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.872
TRPV1 transient receptor potential cation channel, subfamily V, member 1 1.868
ALB albumin 1.862
IL1A interleukin 1, alpha 1.85
PTEN phosphatase and tensin homolog 1.824
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.808
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.794
CCL3 chemokine (C-C motif) ligand 3 1.794
IL4 interleukin 4 1.778
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.759
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.758
BCL2 B-cell CLL/lymphoma 2 1.741
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.74
SEMG1 semenogelin I 1.739
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.73
PXDNL peroxidasin-like 1.728
PXDN peroxidasin 1.726
SP9 Sp9 transcription factor 1.716
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.709
PSCA prostate stem cell antigen 1.699
TP53 tumor protein p53 1.697
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.694
ESR2 estrogen receptor 2 (ER beta) 1.664
IL18 interleukin 18 1.652
ESR1 estrogen receptor 1 1.651
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 1.647
SP6 Sp6 transcription factor 1.629
DLX1 distal-less homeobox 1 1.626
FOXP3 forkhead box P3 1.614
PTPRC protein tyrosine phosphatase, receptor type, C 1.614
INS insulin 1.609
SLC39A1 solute carrier family 39 (zinc transporter), member 1 1.601
GDF15 growth differentiation factor 15 1.596
ADRA1A adrenoceptor alpha 1A 1.595
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.594
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.588
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.587
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.584
HOXC6 homeobox C6 1.581
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.58
CXCL10 chemokine (C-X-C motif) ligand 10 1.58
IGF1 insulin-like growth factor 1 (somatomedin C) 1.576
HOXB13 homeobox B13 1.568
ACTB actin, beta 1.559
EGF epidermal growth factor 1.551
MMP9 matrix metallopeptidase 9 1.551
AZGP1 alpha-2-glycoprotein 1, zinc-binding 1.551
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.546
CXCL12 chemokine (C-X-C motif) ligand 12 1.54
SHBG sex hormone-binding globulin 1.537
LTF lactotransferrin 1.532
MAPK3 mitogen-activated protein kinase 3 1.531
CD68 CD68 molecule 1.53
PRL prolactin 1.526
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.524
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 1.521
GPX3 glutathione peroxidase 3 1.518
A2M alpha-2-macroglobulin 1.517
FN1 fibronectin 1 1.517
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.51
KIAA1143 KIAA1143 1.501
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.491
IL13 interleukin 13 1.472
KRT8 keratin 8, type II 1.465
BDNF brain-derived neurotrophic factor 1.462
BAX BCL2-associated X protein 1.46
TLR2 toll-like receptor 2 1.458
MSR1 macrophage scavenger receptor 1 1.448
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 1.448
CXCR4 chemokine (C-X-C motif) receptor 4 1.439
HPN hepsin 1.438
GPX5 glutathione peroxidase 5 1.433
GPX2 glutathione peroxidase 2 1.426
CD44 CD44 molecule (Indian blood group) 1.426
ICAM1 intercellular adhesion molecule 1 1.425
GPX6 glutathione peroxidase 6 1.422
GPX7 glutathione peroxidase 7 1.417
CCL5 chemokine (C-C motif) ligand 5 1.416
CXCL5 chemokine (C-X-C motif) ligand 5 1.415
GPX8 glutathione peroxidase 8 (putative) 1.414
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 1.407
FGF2 fibroblast growth factor 2 (basic) 1.407
BRCA2 breast cancer 2, early onset 1.404
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.403
OR51E2 olfactory receptor, family 51, subfamily E, member 2 1.398
CXCR1 chemokine (C-X-C motif) receptor 1 1.394
NLRP3 NLR family, pyrin domain containing 3 1.393
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.387
CCND1 cyclin D1 1.387
KRT5 keratin 5, type II 1.382
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.382
EGFR epidermal growth factor receptor 1.382
FOS FBJ murine osteosarcoma viral oncogene homolog 1.376
SPOP speckle-type POZ protein 1.375
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.366
KLK11 kallikrein-related peptidase 11 1.364
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.359
UPK3A uroplakin 3A 1.359
TRPA1 transient receptor potential cation channel, subfamily A, member 1 1.342
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 1.335
TLR3 toll-like receptor 3 1.329
CXCR3 chemokine (C-X-C motif) receptor 3 1.325
SPDEF SAM pointed domain containing ETS transcription factor 1.324
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.323
JUN jun proto-oncogene 1.312
ADRA1D adrenoceptor alpha 1D 1.31
CHKA choline kinase alpha 1.308
PCNA proliferating cell nuclear antigen 1.308
NLRP1 NLR family, pyrin domain containing 1 1.305
MYD88 myeloid differentiation primary response 88 1.301
NFE2L2 nuclear factor, erythroid 2-like 2 1.295
MUC1 mucin 1, cell surface associated 1.294
AIRE autoimmune regulator 1.292
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.292
EPCAM epithelial cell adhesion molecule 1.285
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 1.285
UMOD uromodulin 1.28
BRCA1 breast cancer 1, early onset 1.28
VWA5B2 von Willebrand factor A domain containing 5B2 1.277
TACR1 tachykinin receptor 1 1.273
DEFB134 defensin, beta 134 1.273
MPO myeloperoxidase 1.272
HMOX1 heme oxygenase 1 1.271
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 1.27
CXCR2 chemokine (C-X-C motif) receptor 2 1.268
MMP2 matrix metallopeptidase 2 1.267
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.267
FGF10 fibroblast growth factor 10 1.261
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 1.26
IL15 interleukin 15 1.256
CCR2 chemokine (C-C motif) receptor 2 1.254
SPINK1 serine peptidase inhibitor, Kazal type 1 1.254
ERG v-ets avian erythroblastosis virus E26 oncogene homolog 1.251
BIRC5 baculoviral IAP repeat containing 5 1.247
CD274 CD274 molecule 1.243
AMBP alpha-1-microglobulin/bikunin precursor 1.234
KNG1 kininogen 1 1.23
TEX101 testis expressed 101 1.226
IGFBP3 insulin-like growth factor binding protein 3 1.225
ETV1 ets variant 1 1.22
ACE angiotensin I converting enzyme 1.22
NOS3 nitric oxide synthase 3 (endothelial cell) 1.219
FGF7 fibroblast growth factor 7 1.219
IL5 interleukin 5 1.211
FOXA1 forkhead box A1 1.207
PERM1 PPARGC1 and ESRR induced regulator, muscle 1 1.207
CD86 CD86 molecule 1.206
CD80 CD80 molecule 1.205
KITLG KIT ligand 1.202
SNAI1 snail family zinc finger 1 1.19
PCDH8 protocadherin 8 1.188
ELANE elastase, neutrophil expressed 1.185
CCL4 chemokine (C-C motif) ligand 4 1.185
IL7 interleukin 7 1.183
TDRD1 tudor domain containing 1 1.181
PPIG peptidylprolyl isomerase G (cyclophilin G) 1.179
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 1.177
GOLM1 golgi membrane protein 1 1.176
CTRL chymotrypsin-like 1.175
LEP leptin 1.174
PAGE4 P antigen family, member 4 (prostate associated) 1.166
B2M beta-2-microglobulin 1.165
ANXA3 annexin A3 1.165
CHGA chromogranin A 1.165
BCL2L1 BCL2-like 1 1.163
FGF9 fibroblast growth factor 9 1.163
ERBB2 erb-b2 receptor tyrosine kinase 2 1.156
RHOA ras homolog family member A 1.152
SIRT1 sirtuin 1 1.15
POMC proopiomelanocortin 1.15
CD63 CD63 molecule 1.149
FGF8 fibroblast growth factor 8 (androgen-induced) 1.147
EN2 engrailed homeobox 2 1.146
SLPI secretory leukocyte peptidase inhibitor 1.146
CYCS cytochrome c, somatic 1.145
UPK1A uroplakin 1A 1.143
C3 complement component 3 1.14
FGF4 fibroblast growth factor 4 1.137
FGF3 fibroblast growth factor 3 1.137
FGF17 fibroblast growth factor 17 1.135
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 1.134
SPP1 secreted phosphoprotein 1 1.134
FGF18 fibroblast growth factor 18 1.132
ACRV1 acrosomal vesicle protein 1 1.132
FGF22 fibroblast growth factor 22 1.131
FGF16 fibroblast growth factor 16 1.129
FGF6 fibroblast growth factor 6 1.129
FGF20 fibroblast growth factor 20 1.127
PECAM1 platelet/endothelial cell adhesion molecule 1 1.127
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.123
CD163 CD163 molecule 1.123
FGF5 fibroblast growth factor 5 1.121
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 1.12
GRPR gastrin-releasing peptide receptor 1.117
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.116
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.116
KRT7 keratin 7, type II 1.114
AIF1 allograft inflammatory factor 1 1.11
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.106
GRP gastrin-releasing peptide 1.102
CCL20 chemokine (C-C motif) ligand 20 1.099
PRTN3 proteinase 3 1.098
KRT18 keratin 18, type I 1.098
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.098
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.098
ALOX5 arachidonate 5-lipoxygenase 1.093
JAK2 Janus kinase 2 1.091
KLKB1 kallikrein B, plasma (Fletcher factor) 1 1.089
CCL11 chemokine (C-C motif) ligand 11 1.088
FASN fatty acid synthase 1.087
PPARG peroxisome proliferator-activated receptor gamma 1.08
HSPA4 heat shock 70kDa protein 4 1.079
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1.077
TMEM204 transmembrane protein 204 1.073
ERVW-1 endogenous retrovirus group W, member 1 1.073
STAT1 signal transducer and activator of transcription 1, 91kDa 1.071
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.07
AMH anti-Mullerian hormone 1.067
CD9 CD9 molecule 1.066
PDILT protein disulfide isomerase-like, testis expressed 1.066
MGAM maltase-glucoamylase 1.065
ERV3-1 endogenous retrovirus group 3, member 1 1.064
ERVFRD-1 endogenous retrovirus group FRD, member 1 1.064
IDO1 indoleamine 2,3-dioxygenase 1 1.06
HDAC9 histone deacetylase 9 1.059
OXT oxytocin/neurophysin I prepropeptide 1.059
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.056
KEAP1 kelch-like ECH-associated protein 1 1.056
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 1.055
KLK4 kallikrein-related peptidase 4 1.053
VIM vimentin 1.053
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.05
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.049
CRISP3 cysteine-rich secretory protein 3 1.048
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 1.047
PRM2 protamine 2 1.047
VCAM1 vascular cell adhesion molecule 1 1.046
PARP1 poly (ADP-ribose) polymerase 1 1.045
SI sucrase-isomaltase (alpha-glucosidase) 1.044
KRT14 keratin 14, type I 1.044
AFP alpha-fetoprotein 1.044
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.042
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa 1.038
TLR6 toll-like receptor 6 1.036
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.035
ITGA6 integrin, alpha 6 1.035
TRPM8 transient receptor potential cation channel, subfamily M, member 8 1.034
ITK IL2-inducible T-cell kinase 1.03
CXCL9 chemokine (C-X-C motif) ligand 9 1.025
STEAP4 STEAP family member 4 1.024
SYP synaptophysin 1.024
BCR breakpoint cluster region 1.023
ELAC2 elaC ribonuclease Z 2 1.022
CSF3 colony stimulating factor 3 (granulocyte) 1.021
NOS2 nitric oxide synthase 2, inducible 1.021
NUMA1 nuclear mitotic apparatus protein 1 1.016
IFNA1 interferon, alpha 1 1.014
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 1.013
CCK cholecystokinin 1.012
CA1 carbonic anhydrase I 1.01
CAMP cathelicidin antimicrobial peptide 1.01
SMAD4 SMAD family member 4 1.01
GIMAP6 GTPase, IMAP family member 6 1.009
KLK1 kallikrein 1 1.009
PLG plasminogen 1.008
CD276 CD276 molecule 1.007
CPA3 carboxypeptidase A3 (mast cell) 1.006
ACO1 aconitase 1, soluble 1.006
ANXA5 annexin A5 1.004
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 1.003
CLU clusterin 1.003
ANK1 ankyrin 1, erythrocytic 1.003
SLC45A3 solute carrier family 45, member 3 1.003
ACO2 aconitase 2, mitochondrial 1.0