Protein digestion and absorption Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Protein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancreatic and small intestinal enzymes. The result of this proteolytic activity is a mixture of amino acids and small peptides. Amino acids (AAs) are transported into the enterocyte (intestinal epithelial cell) by a variety of AA transporters that are specific for cationic (basic) AA, neutral AA, and anionic (acidic) AA. Small peptides are absorbed into enterocytes by the PEPT1 transporter. Inside enterocytes peptides are hydrolyzed, and the resulting amino acids are released together with those absorbed by AA transporters into blood via multiple, basolateral, AA transporters. Hydrolysis-resistant peptides, however, are transported out of the cells by a basolateral peptide transporter that has not been identified molecularly. (Kyoto Encyclopedia of Genes and Genomes, hsa04974)
External Link https://www.kegg.jp/entry/hsa04974
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102 proteins participating in the Protein digestion and absorption pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ACE2 angiotensin I converting enzyme 2
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP1B4 ATPase, Na+/K+ transporting, beta 4 polypeptide
CELA2A chymotrypsin-like elastase family, member 2A
CELA2B chymotrypsin-like elastase family, member 2B
CELA3A chymotrypsin-like elastase family, member 3A
CELA3B chymotrypsin-like elastase family, member 3B
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL11A2 collagen, type XI, alpha 2
COL12A1 collagen, type XII, alpha 1
COL13A1 collagen, type XIII, alpha 1
COL14A1 collagen, type XIV, alpha 1
COL15A1 collagen, type XV, alpha 1
COL16A1 collagen, type XVI, alpha 1
COL17A1 collagen, type XVII, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COL19A1 collagen, type XIX, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL20A1 collagen, type XX, alpha 1
COL21A1 collagen, type XXI, alpha 1
COL22A1 collagen, type XXII, alpha 1
COL23A1 collagen, type XXIII, alpha 1
COL24A1 collagen, type XXIV, alpha 1
COL25A1 collagen, type XXV, alpha 1
COL26A1 collagen, type XXVI, alpha 1
COL27A1 collagen, type XXVII, alpha 1
COL28A1 collagen, type XXVIII, alpha 1
COL2A1 collagen, type II, alpha 1
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL4A4 collagen, type IV, alpha 4
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
COL5A3 collagen, type V, alpha 3
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
COL6A5 collagen, type VI, alpha 5
COL6A6 collagen, type VI, alpha 6
COL7A1 collagen, type VII, alpha 1
COL8A1 collagen, type VIII, alpha 1
COL8A2 collagen, type VIII, alpha 2
COL9A1 collagen, type IX, alpha 1
COL9A2 collagen, type IX, alpha 2
COL9A3 collagen, type IX, alpha 3
CPA1 carboxypeptidase A1 (pancreatic)
CPA2 carboxypeptidase A2 (pancreatic)
CPA4 carboxypeptidase A4
CPB1 carboxypeptidase B1 (tissue)
CPB2 carboxypeptidase B2 (plasma)
CTRB1 chymotrypsinogen B1
CTRB2 chymotrypsinogen B2
CTRL chymotrypsin-like
DPP4 dipeptidyl-peptidase 4
ERLN endoregulin
FXYD2 FXYD domain containing ion transport regulator 2
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13
KCNK5 potassium channel, two pore domain subfamily K, member 5
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
MEP1A meprin A, alpha (PABA peptide hydrolase)
MEP1B meprin A, beta
MMP12 matrix metallopeptidase 12
PGA3 pepsinogen 3, group I (pepsinogen A)
PGA4 pepsinogen 4, group I (pepsinogen A)
PGA5 pepsinogen 5, group I (pepsinogen A)
PRCP prolylcarboxypeptidase (angiotensinase C)
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PRSS58 protease, serine, 58
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2
SLC36A3 solute carrier family 36, member 3
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4
SLC38A2 solute carrier family 38, member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound