Proteoglycans in cancer Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR:00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors. (Kyoto Encyclopedia of Genes and Genomes, hsa05205)
External Link https://www.kegg.jp/entry/hsa05205
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197 proteins participating in the Proteoglycans in cancer pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ACTG1 actin gamma 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ANK1 ankyrin 1, erythrocytic
ANK2 ankyrin 2, neuronal
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
BRAF B-Raf proto-oncogene, serine/threonine kinase
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CASP3 caspase 3, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CAV3 caveolin 3
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CD63 CD63 molecule
CDC42 cell division cycle 42
CDPF1 cysteine-rich, DPF motif domain containing 1
CLSTN1 calsyntenin 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSL cathepsin L
CTTN cortactin
DCN decorin
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DROSHA drosha, ribonuclease type III
EGFR epidermal growth factor receptor
EIF4B eukaryotic translation initiation factor 4B
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
EZR ezrin
FASLG Fas ligand (TNF superfamily, member 6)
FASN fatty acid synthase
FGF13 fibroblast growth factor 13
FGFR1 fibroblast growth factor receptor 1
FLNA filamin A, alpha
FN1 fibronectin 1
FRS2 fibroblast growth factor receptor substrate 2
FZD1 frizzled class receptor 1
FZD10 frizzled class receptor 10
FZD2 frizzled class receptor 2
FZD4 frizzled class receptor 4
FZD5 frizzled class receptor 5
FZD6 frizzled class receptor 6
FZD7 frizzled class receptor 7
FZD8 frizzled class receptor 8
FZD9 frizzled class receptor 9
GPC1 glypican 1
GPC3 glypican 3
GRB2 growth factor receptor-bound protein 2
HBEGF heparin-binding EGF-like growth factor
HCLS1 hematopoietic cell-specific Lyn substrate 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HOXD10 homeobox D10
HPSE heparanase
HPSE2 heparanase 2 (inactive)
HRAS Harvey rat sarcoma viral oncogene homolog
HSPB2 heat shock 27kDa protein 2
HSPG2 heparan sulfate proteoglycan 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IHH indian hedgehog
IL12B interleukin 12B
IQGAP1 IQ motif containing GTPase activating protein 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB5 integrin, beta 5
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8
KDR kinase insert domain receptor
LNCEGFL7OS lncRNA EGFL7 opposite strand
LUM lumican
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK11 mitogen-activated protein kinase 11
MAPK12 mitogen-activated protein kinase 12
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MRAS muscle RAS oncogene homolog
MSN moesin
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NANOG Nanog homeobox
NANOGP8 Nanog homeobox pseudogene 8
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NUDT16L1 nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDPK1 3-phosphoinositide dependent protein kinase 1
PIGU phosphatidylinositol glycan anchor biosynthesis, class U
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PKN1 protein kinase N1
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLCE1 phospholipase C, epsilon 1
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
POTEF POTE ankyrin domain family, member F
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PPP1R12C protein phosphatase 1, regulatory subunit 12C
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCG protein kinase C, gamma
PTCH1 patched 1
PTK2 protein tyrosine kinase 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PXDN peroxidasin
RDX radixin
RHOA ras homolog family member A
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE3 ribonuclease, RNase A family, 3
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPS6 ribosomal protein S6
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RRAS related RAS viral (r-ras) oncogene homolog
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SDC1 syndecan 1
SDC2 syndecan 2
SDC4 syndecan 4
SHH sonic hedgehog
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLTM SAFB-like, transcription modulator
SMAD2 SMAD family member 2
SMOX spermine oxidase
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
THBS1 thrombospondin 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP3 TIMP metallopeptidase inhibitor 3
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TP53 tumor protein p53
TWIST1 twist family bHLH transcription factor 1
TWIST2 twist family bHLH transcription factor 2
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
VTN vitronectin
WNT1 wingless-type MMTV integration site family, member 1
WNT10A wingless-type MMTV integration site family, member 10A
WNT10B wingless-type MMTV integration site family, member 10B
WNT11 wingless-type MMTV integration site family, member 11
WNT16 wingless-type MMTV integration site family, member 16
WNT2 wingless-type MMTV integration site family member 2
WNT2B wingless-type MMTV integration site family, member 2B
WNT3 wingless-type MMTV integration site family, member 3
WNT3A wingless-type MMTV integration site family, member 3A
WNT4 wingless-type MMTV integration site family, member 4
WNT5A wingless-type MMTV integration site family, member 5A
WNT5B wingless-type MMTV integration site family, member 5B
WNT6 wingless-type MMTV integration site family, member 6
WNT7A wingless-type MMTV integration site family, member 7A
WNT7B wingless-type MMTV integration site family, member 7B
WNT8A wingless-type MMTV integration site family, member 8A
WNT8B wingless-type MMTV integration site family, member 8B
WNT9A wingless-type MMTV integration site family, member 9A
WNT9B wingless-type MMTV integration site family, member 9B