| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/3052762 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Prucalopride relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYO3A | myosin IIIA | 1.54 |
| ZSCAN32 | zinc finger and SCAN domain containing 32 | 0.67 |
| NAA38 | N(alpha)-acetyltransferase 38, NatC auxiliary subunit | 0.53 |
| S100A2 | S100 calcium binding protein A2 | 0.48 |
| RPLP1 | ribosomal protein, large, P1 | 0.47 |
| UBE2G2 | ubiquitin-conjugating enzyme E2G 2 | 0.47 |
| ZMYM6 | zinc finger, MYM-type 6 | 0.46 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | 0.43 |
| KLHL20 | kelch-like family member 20 | 0.42 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | 0.42 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.42 |
| HSBP1 | heat shock factor binding protein 1 | 0.39 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | 0.39 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 0.39 |
| ACTN4 | actinin, alpha 4 | 0.39 |
| PPP1R26 | protein phosphatase 1, regulatory subunit 26 | 0.38 |
| BORA | bora, aurora kinase A activator | 0.37 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 0.36 |
| MDP1 | magnesium-dependent phosphatase 1 | 0.36 |
| ZNF22 | zinc finger protein 22 | 0.35 |
| YAE1 | YAE1 maturation factor of ABCE1 | 0.33 |
| BRK1 | BRICK1, SCAR/WAVE actin-nucleating complex subunit | 0.33 |
| DOCK11 | dedicator of cytokinesis 11 | 0.33 |
| TIMM10 | translocase of inner mitochondrial membrane 10 homolog (yeast) | 0.33 |
| COX5A | cytochrome c oxidase subunit Va | 0.33 |
| TSSC4 | tumor suppressing subtransferable candidate 4 | 0.33 |
| HAPLN3 | hyaluronan and proteoglycan link protein 3 | 0.33 |
| BID | BH3 interacting domain death agonist | 0.32 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.32 |
| PTMA | prothymosin, alpha | 0.31 |
| RPE | ribulose-5-phosphate-3-epimerase | 0.31 |
| XTBD1 | XRN2 binding domain containing 1 | 0.31 |
| PFDN5 | prefoldin subunit 5 | 0.3 |
| RUFY3 | RUN and FYVE domain containing 3 | 0.3 |
| TMEM160 | transmembrane protein 160 | 0.3 |
| NFYB | nuclear transcription factor Y, beta | 0.3 |
| ZNF226 | zinc finger protein 226 | 0.3 |
| TAF1L | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like | 0.3 |
| SH3RF2 | SH3 domain containing ring finger 2 | 0.29 |
| BAG4 | BCL2-associated athanogene 4 | 0.29 |
| TLCD4 | TLC domain containing 4 | 0.29 |
| PAIP2 | poly(A) binding protein interacting protein 2 | 0.29 |
| SSNA1 | Sjogren syndrome nuclear autoantigen 1 | 0.29 |
| TRIAP1 | TP53 regulated inhibitor of apoptosis 1 | 0.29 |
| B2M | beta-2-microglobulin | 0.29 |
| POLR2J | polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa | 0.28 |
| SLC2A4RG | SLC2A4 regulator | 0.28 |
| POMP | proteasome maturation protein | 0.28 |
| MXRA7 | matrix-remodelling associated 7 | 0.28 |
| ANAPC16 | anaphase promoting complex subunit 16 | 0.28 |
| BLOC1S2 | biogenesis of lysosomal organelles complex-1, subunit 2 | 0.28 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | 0.27 |
| POLQ | polymerase (DNA directed), theta | 0.27 |
| H3C1 | H3 clustered histone 1 | 0.27 |
| ZGRF1 | zinc finger, GRF-type containing 1 | 0.27 |
| CIAO2B | cytosolic iron-sulfur assembly component 2B | 0.27 |
| DCTPP1 | dCTP pyrophosphatase 1 | 0.26 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | 0.26 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | 0.26 |
| ATG4A | autophagy related 4A, cysteine peptidase | 0.26 |
| AKT1S1 | AKT1 substrate 1 (proline-rich) | 0.25 |
| GID8 | GID complex subunit 8 | 0.25 |
| C12ORF57 | chromosome 12 open reading frame 57 | 0.25 |
| ATF6B | activating transcription factor 6 beta | 0.25 |
| SMTN | smoothelin | 0.25 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.25 |
| RNF17 | ring finger protein 17 | 0.25 |
| SGTB | small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta | 0.25 |
| ARL13B | ADP-ribosylation factor-like 13B | 0.25 |
| MTPN | myotrophin | 0.25 |
| DISP2 | dispatched homolog 2 (Drosophila) | 0.25 |
| BORCS7 | BLOC-1 related complex subunit 7 | 0.24 |
| B4GALT3 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 | 0.24 |
| PTPN18 | protein tyrosine phosphatase, non-receptor type 18 (brain-derived) | 0.24 |
| BCAS2 | breast carcinoma amplified sequence 2 | 0.24 |
| GATA6 | GATA binding protein 6 | 0.24 |
| DPY30 | dpy-30 homolog (C. elegans) | 0.24 |
| KLHL15 | kelch-like family member 15 | 0.24 |
| PKNOX1 | PBX/knotted 1 homeobox 1 | 0.24 |
| HINT1 | histidine triad nucleotide binding protein 1 | 0.24 |
| ZNF35 | zinc finger protein 35 | 0.24 |
| NOS1 | nitric oxide synthase 1 (neuronal) | 0.23 |
| UBXN2B | UBX domain protein 2B | 0.23 |
| EPOP | elongin BC and polycomb repressive complex 2 associated protein | 0.23 |
| MRPL12 | mitochondrial ribosomal protein L12 | 0.23 |
| ATP5F1D | ATP synthase F1 subunit delta | 0.23 |
| SECISBP2 | SECIS binding protein 2 | 0.23 |
| ZRSR2 | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 | 0.23 |
| PLAUR | plasminogen activator, urokinase receptor | 0.23 |
| KLF10 | Kruppel-like factor 10 | 0.23 |
| CSTF2 | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa | 0.23 |
| MYNN | myoneurin | 0.23 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | 0.23 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | 0.23 |
| ORC3 | origin recognition complex, subunit 3 | 0.23 |
| GTSF1 | gametocyte specific factor 1 | 0.23 |
| ACVR2A | activin A receptor, type IIA | 0.23 |
| CCDC57 | coiled-coil domain containing 57 | 0.23 |
| APEX2 | APEX nuclease (apurinic/apyrimidinic endonuclease) 2 | 0.22 |
| AAMDC | adipogenesis associated, Mth938 domain containing | 0.22 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZFP62 | ZFP62 zinc finger protein | -0.59 |
| C2ORF16 | chromosome 2 open reading frame 16 | -0.58 |
| EYS | eyes shut homolog (Drosophila) | -0.47 |
| FAM189B | family with sequence similarity 189, member B | -0.43 |
| ZFPM1 | zinc finger protein, FOG family member 1 | -0.4 |
| SFXN5 | sideroflexin 5 | -0.4 |
| MCRIP2 | MAPK regulated corepressor interacting protein 2 | -0.38 |
| COL6A3 | collagen, type VI, alpha 3 | -0.32 |
| MT-ND4 | NADH dehydrogenase, subunit 4 (complex I) | -0.31 |
| ZDHHC8 | zinc finger, DHHC-type containing 8 | -0.31 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.29 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | -0.29 |
| BLOC1S5 | biogenesis of lysosomal organelles complex-1, subunit 5, muted | -0.29 |
| TMEM97 | transmembrane protein 97 | -0.28 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.28 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | -0.28 |
| CHRD | chordin | -0.28 |
| SLC35B3 | solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 | -0.28 |
| SELENOK | selenoprotein K | -0.28 |
| THBS2 | thrombospondin 2 | -0.28 |
| IGSF8 | immunoglobulin superfamily, member 8 | -0.28 |
| DDT | D-dopachrome tautomerase | -0.27 |
| NPTXR | neuronal pentraxin receptor | -0.27 |
| CCDC167 | coiled-coil domain containing 167 | -0.27 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | -0.27 |
| SDHAF4 | succinate dehydrogenase complex assembly factor 4 | -0.27 |
| ABHD2 | abhydrolase domain containing 2 | -0.26 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.26 |
| FTL | ferritin, light polypeptide | -0.25 |
| UNC5B | unc-5 homolog B (C. elegans) | -0.25 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.25 |
| HRH1 | histamine receptor H1 | -0.24 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.24 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.24 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | -0.24 |
| GRAMD4 | GRAM domain containing 4 | -0.24 |
| FDXACB1 | ferredoxin-fold anticodon binding domain containing 1 | -0.24 |
| ALG10B | ALG10B, alpha-1,2-glucosyltransferase | -0.24 |
| FAM219B | family with sequence similarity 219, member B | -0.24 |
| NPDC1 | neural proliferation, differentiation and control, 1 | -0.23 |
| DPP4 | dipeptidyl-peptidase 4 | -0.23 |
| ABHD4 | abhydrolase domain containing 4 | -0.22 |
| HSPA8 | heat shock 70kDa protein 8 | -0.22 |
| STX1A | syntaxin 1A (brain) | -0.22 |
| ITGB2 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | -0.22 |
| C6ORF141 | chromosome 6 open reading frame 141 | -0.21 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | -0.21 |
| SYNPO | synaptopodin | -0.21 |
| TAB3 | TGF-beta activated kinase 1/MAP3K7 binding protein 3 | -0.21 |
| SLC25A14 | solute carrier family 25 (mitochondrial carrier, brain), member 14 | -0.21 |
| YIF1A | Yip1 interacting factor homolog A (S. cerevisiae) | -0.21 |
| RNF170 | ring finger protein 170 | -0.21 |
| MT-ND5 | NADH dehydrogenase, subunit 5 (complex I) | -0.21 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -0.21 |
| ABHD3 | abhydrolase domain containing 3 | -0.21 |
| SEC11C | SEC11 homolog C (S. cerevisiae) | -0.21 |
| DGAT1 | diacylglycerol O-acyltransferase 1 | -0.21 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.21 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | -0.21 |
| RAB8B | RAB8B, member RAS oncogene family | -0.21 |
| DST | dystonin | -0.2 |
| SLFN5 | schlafen family member 5 | -0.2 |
| KDELR3 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 | -0.2 |
| NLGN2 | neuroligin 2 | -0.2 |
| FBXL8 | F-box and leucine-rich repeat protein 8 | -0.2 |
| PXMP4 | peroxisomal membrane protein 4, 24kDa | -0.2 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.2 |
| CXXC5 | CXXC finger protein 5 | -0.2 |
| CBR1 | carbonyl reductase 1 | -0.2 |
| LRP10 | low density lipoprotein receptor-related protein 10 | -0.19 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | -0.19 |
| MYADM | myeloid-associated differentiation marker | -0.19 |
| KIAA1109 | KIAA1109 | -0.19 |
| SLC17A5 | solute carrier family 17 (acidic sugar transporter), member 5 | -0.19 |
| LENG9 | leukocyte receptor cluster (LRC) member 9 | -0.19 |
| FAT2 | FAT atypical cadherin 2 | -0.19 |
| EVL | Enah/Vasp-like | -0.19 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.19 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.19 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.19 |
| ZNF525 | zinc finger protein 525 | -0.19 |
| TSPYL2 | TSPY-like 2 | -0.18 |
| NCOA1 | nuclear receptor coactivator 1 | -0.18 |
| NRP1 | neuropilin 1 | -0.18 |
| ADPRHL1 | ADP-ribosylhydrolase like 1 | -0.18 |
| CYBRD1 | cytochrome b reductase 1 | -0.18 |
| ENO1 | enolase 1, (alpha) | -0.18 |
| PLEKHN1 | pleckstrin homology domain containing, family N member 1 | -0.18 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.18 |
| CERCAM | cerebral endothelial cell adhesion molecule | -0.18 |
| PIGL | phosphatidylinositol glycan anchor biosynthesis, class L | -0.18 |
| CHN1 | chimerin 1 | -0.18 |
| TMEM120A | transmembrane protein 120A | -0.18 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | -0.18 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | -0.17 |
| CRLF1 | cytokine receptor-like factor 1 | -0.17 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | -0.17 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | -0.17 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | -0.17 |
| DNPH1 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | -0.17 |
