Pseudohypoaldosteronism Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
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Genes

180 genes co-occuring with the disease Pseudohypoaldosteronism in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
WNK4 WNK lysine deficient protein kinase 4 4.0
SCNN1G sodium channel, non voltage gated 1 gamma subunit 3.79
WNK1 WNK lysine deficient protein kinase 1 3.754
KLHL3 kelch-like family member 3 3.478
STK39 serine threonine kinase 39 3.446
SCNN1B sodium channel, non voltage gated 1 beta subunit 3.389
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 3.317
SCNN1A sodium channel, non voltage gated 1 alpha subunit 3.25
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 3.217
CUL3 cullin 3 3.095
NR3C2 nuclear receptor subfamily 3, group C, member 2 3.074
WNK3 WNK lysine deficient protein kinase 3 3.07
OXSR1 oxidative stress responsive 1 3.035
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 2.923
STK24 serine/threonine kinase 24 2.866
REN renin 2.812
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.568
WNK2 WNK lysine deficient protein kinase 2 2.529
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 2.488
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 2.485
SGK1 serum/glucocorticoid regulated kinase 1 2.468
ASIC2 acid sensing (proton gated) ion channel 2 2.449
CLCNKB chloride channel, voltage-sensitive Kb 2.425
KLHL2 kelch-like family member 2 2.389
PRSS8 protease, serine, 8 2.289
KLHL31 kelch-like family member 31 2.276
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 2.224
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 2.188
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.151
CLDN8 claudin 8 2.146
AQP2 aquaporin 2 (collecting duct) 2.145
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.141
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.109
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 2.093
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 2.084
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 2.043
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 2.023
TRPV5 transient receptor potential cation channel, subfamily V, member 5 1.996
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 1.965
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 1.948
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 1.933
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4 1.911
ASIC1 acid sensing (proton gated) ion channel 1 1.9
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 1.886
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.88
RHOBTB1 Rho-related BTB domain containing 1 1.852
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 1.834
CLDN4 claudin 4 1.801
POMC proopiomelanocortin 1.8
CLCNKA chloride channel, voltage-sensitive Ka 1.788
DNAH8 dynein, axonemal, heavy chain 8 1.783
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 1.775
CLDN16 claudin 16 1.772
TRPM6 transient receptor potential cation channel, subfamily M, member 6 1.761
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 1.73
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 1.72
CASR calcium-sensing receptor 1.715
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 1.715
TSC22D3 TSC22 domain family, member 3 1.709
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 1.705
TMPRSS3 transmembrane protease, serine 3 1.643
RBX1 ring-box 1, E3 ubiquitin protein ligase 1.64
CLDN19 claudin 19 1.602
FURIN furin (paired basic amino acid cleaving enzyme) 1.601
ITSN1 intersectin 1 (SH3 domain protein) 1.599
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 1.591
CAB39 calcium binding protein 39 1.584
AVPR2 arginine vasopressin receptor 2 1.581
CLCN5 chloride channel, voltage-sensitive 5 1.576
LHX8 LIM homeobox 8 1.547
AVP arginine vasopressin 1.544
FXYD2 FXYD domain containing ion transport regulator 2 1.524
TMPRSS4 transmembrane protease, serine 4 1.522
KLHL40 kelch-like family member 40 1.516
MAP3K15 mitogen-activated protein kinase kinase kinase 15 1.511
ITSN2 intersectin 2 1.496
INS insulin 1.488
ACE angiotensin I converting enzyme 1.475
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 1.474
KLHL9 kelch-like family member 9 1.473
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 1.471
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 1.461
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 1.454
CA2 carbonic anhydrase II 1.445
ADD1 adducin 1 (alpha) 1.435
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 1.428
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 1.406
CAND1 cullin-associated and neddylation-dissociated 1 1.4
CLDN14 claudin 14 1.398
KLHL1 kelch-like family member 1 1.397
SLC26A9 solute carrier family 26 (anion exchanger), member 9 1.394
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) 1.393
CLDN2 claudin 2 1.366
FOXI1 forkhead box I1 1.349
CLDN7 claudin 7 1.33
OCRL oculocerebrorenal syndrome of Lowe 1.323
KLHL20 kelch-like family member 20 1.316
SLC26A6 solute carrier family 26 (anion exchanger), member 6 1.307
RHOA ras homolog family member A 1.306
PDE3A phosphodiesterase 3A, cGMP-inhibited 1.305
UMOD uromodulin 1.305
PLEKHA7 pleckstrin homology domain containing, family A member 7 1.305
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.305
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.297
TRPV4 transient receptor potential cation channel, subfamily V, member 4 1.292
SLC26A1 solute carrier family 26 (anion exchanger), member 1 1.291
CLDN10 claudin 10 1.289
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.287
WDR72 WD repeat domain 72 1.282
OSR1 odd-skipped related transciption factor 1 1.278
UBE2S ubiquitin-conjugating enzyme E2S 1.276
CLCN2 chloride channel, voltage-sensitive 2 1.267
KLHL7 kelch-like family member 7 1.257
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 1.256
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 1.253
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.252
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 1.243
UBE2K ubiquitin-conjugating enzyme E2K 1.241
BPIFA1 BPI fold containing family A, member 1 1.239
ST14 suppression of tumorigenicity 14 (colon carcinoma) 1.238
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 1.228
NPPA natriuretic peptide A 1.213
TRPV6 transient receptor potential cation channel, subfamily V, member 6 1.208
ADRB2 adrenoceptor beta 2, surface 1.207
KCNK5 potassium channel, two pore domain subfamily K, member 5 1.204
AGTR1 angiotensin II receptor, type 1 1.203
NR0B1 nuclear receptor subfamily 0, group B, member 1 1.198
SLC12A8 solute carrier family 12, member 8 1.196
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 1.189
CUL1 cullin 1 1.186
CLDN3 claudin 3 1.176
TRPC3 transient receptor potential cation channel, subfamily C, member 3 1.167
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.159
OSGEP O-sialoglycoprotein endopeptidase 1.154
FCHO1 FCH domain only 1 1.151
KCTD13 potassium channel tetramerization domain containing 13 1.142
TRPC6 transient receptor potential cation channel, subfamily C, member 6 1.139
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 1.139
KLHL12 kelch-like family member 12 1.134
SLC26A3 solute carrier family 26 (anion exchanger), member 3 1.134
KLHL34 kelch-like family member 34 1.133
KLHDC8A kelch domain containing 8A 1.132
HPN hepsin 1.128
OR2A2 olfactory receptor, family 2, subfamily A, member 2 1.125
ASIC5 acid sensing (proton gated) ion channel family member 5 1.116
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 1.116
USP2 ubiquitin specific peptidase 2 1.116
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 1.109
C1ORF21 chromosome 1 open reading frame 21 1.106
CA12 carbonic anhydrase XII 1.105
PTH parathyroid hormone 1.104
PKD2L1 polycystic kidney disease 2-like 1 1.102
ARHGAP42 Rho GTPase activating protein 42 1.098
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 1.098
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 1.096
ECHDC2 enoyl CoA hydratase domain containing 2 1.09
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 1.089
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 1.083
EPN3 epsin 3 1.075
CTRB2 chymotrypsinogen B2 1.065
FCHO2 FCH domain only 2 1.064
EPN2 epsin 2 1.06
CTRB1 chymotrypsinogen B1 1.059
PDZRN3 PDZ domain containing ring finger 3 1.058
ADD3 adducin 3 (gamma) 1.045
CLDN1 claudin 1 1.043
CUL7 cullin 7 1.041
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 1.036
KLHL32 kelch-like family member 32 1.035
SLC41A1 solute carrier family 41 (magnesium transporter), member 1 1.032
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 1.031
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 1.028
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 1.022
KLHL24 kelch-like family member 24 1.013
SYTL5 synaptotagmin-like 5 1.01
ZFP36L1 ZFP36 ring finger protein-like 1 1.008
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 1.007
ATP6V1G3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 1.006
ULK3 unc-51 like kinase 3 1.005
PAX8 paired box 8 1.004