Pterygium Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A fleshy mass of thickened conjunctiva that grows over part of the cornea usually from the inner side of the eyeball and causes a disturbance of vision. (BRENDA Tissue and Enzyme Source Ontology, BTO_0005180)
External Link https://www.disgenet.org/browser/0/1/0/C0033999
Similar Terms
Downloads & Tools

Genes

199 genes associated with the disease Pterygium in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACTB actin, beta
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANG angiogenin, ribonuclease, RNase A family, 5
ANGPTL4 angiopoietin-like 4
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ATRX alpha thalassemia/mental retardation syndrome X-linked
BCL2 B-cell CLL/lymphoma 2
BCL2L2 BCL2-like 2
BICD2 bicaudal D homolog 2 (Drosophila)
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCN2 cellular communication network factor 2
CD34 CD34 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CGA glycoprotein hormones, alpha polypeptide
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CKAP4 cytoskeleton-associated protein 4
CLDN4 claudin 4
CLU clusterin
CNTF ciliary neurotrophic factor
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COX2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNA3 catenin (cadherin-associated protein), alpha 3
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DKC1 dyskeratosis congenita 1, dyskerin
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DOK7 docking protein 7
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ELN elastin
EPHB2 EPH receptor B2
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
FBLN5 fibulin 5
FBN1 fibrillin 1
FGF2 fibroblast growth factor 2 (basic)
FGFR3 fibroblast growth factor receptor 3
FKBP10 FK506 binding protein 10, 65 kDa
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G6PD glucose-6-phosphate dehydrogenase
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GHRH growth hormone releasing hormone
GHRHR growth hormone releasing hormone receptor
GPC6 glypican 6
GRAP2 GRB2-related adaptor protein 2
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
GSTT1 glutathione S-transferase theta 1
HBEGF heparin-binding EGF-like growth factor
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
ICAM2 intercellular adhesion molecule 2
ICAM3 intercellular adhesion molecule 3
IFNA2 interferon, alpha 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
IL6 interleukin 6
IPO13 importin 13
IRF6 interferon regulatory factor 6
ITGA6 integrin, alpha 6
ITGB4 integrin, beta 4
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDR kinase insert domain receptor
KRT12 keratin 12, type I
KRT17 keratin 17, type I
KRT4 keratin 4, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LDLR low density lipoprotein receptor
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LRP1 low density lipoprotein receptor-related protein 1
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MATN3 matrilin 3
MBTPS1 membrane-bound transcription factor peptidase, site 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEPE matrix extracellular phosphoglycoprotein
MLH1 mutL homolog 1
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MPRIP myosin phosphatase Rho interacting protein
MSH2 mutS homolog 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUSK muscle, skeletal, receptor tyrosine kinase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOD1 myogenic differentiation 1
NFE2L2 nuclear factor, erythroid 2-like 2
NHP2 NHP2 ribonucleoprotein
NOP10 NOP10 ribonucleoprotein
NUP88 nucleoporin 88kDa
OGG1 8-oxoguanine DNA glycosylase
PCNA proliferating cell nuclear antigen
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDPN podoplanin
PECAM1 platelet/endothelial cell adhesion molecule 1
PHGDH phosphoglycerate dehydrogenase
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLAU plasminogen activator, urokinase
PLD1 phospholipase D1, phosphatidylcholine-specific
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLXNA2 plexin A2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POSTN periostin, osteoblast specific factor
POU5F1 POU class 5 homeobox 1
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PRDX1 peroxiredoxin 1
PRDX2 peroxiredoxin 2
PSAT1 phosphoserine aminotransferase 1
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAPSN receptor-associated protein of the synapse
RIPK4 receptor-interacting serine-threonine kinase 4
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPE65 retinal pigment epithelium-specific protein 65kDa
RYR1 ryanodine receptor 1 (skeletal)
S100A1 S100 calcium binding protein A1
S100A11 S100 calcium binding protein A11
S100A6 S100 calcium binding protein A6
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100B S100 calcium binding protein B
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SMAD7 SMAD family member 7
SMN1 survival of motor neuron 1, telomeric
SMN2 survival of motor neuron 2, centromeric
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRR3 small proline-rich protein 3
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3
TAZ tafazzin
TCF4 transcription factor 4
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TIMP2 TIMP metallopeptidase inhibitor 2
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TP53 tumor protein p53
TP63 tumor protein p63
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV3 transient receptor potential cation channel, subfamily V, member 3
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TWIST1 twist family bHLH transcription factor 1
UVRAG UV radiation resistance associated
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VIM vimentin
WWOX WW domain containing oxidoreductase
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZEB1 zinc finger E-box binding homeobox 1
ZEB2 zinc finger E-box binding homeobox 2