Purpura Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
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Genes

399 genes co-occuring with the disease Purpura in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 3.194
PRTN3 proteinase 3 3.006
F2 coagulation factor II (thrombin) 2.903
F3 coagulation factor III (thromboplastin, tissue factor) 2.899
CRP C-reactive protein, pentraxin-related 2.826
MPO myeloperoxidase 2.784
VWF von Willebrand factor 2.775
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 2.623
THPO thrombopoietin 2.573
MPL MPL proto-oncogene, thrombopoietin receptor 2.531
ALB albumin 2.511
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.439
TRIM21 tripartite motif containing 21 2.426
C3 complement component 3 2.419
THBD thrombomodulin 2.408
HP haptoglobin 2.401
CD4 CD4 molecule 2.398
POU2F3 POU class 2 homeobox 3 2.392
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.382
TNF tumor necrosis factor 2.348
SSB Sjogren syndrome antigen B (autoantigen La) 2.332
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2.319
IL6 interleukin 6 2.308
PF4 platelet factor 4 2.305
GP1BA glycoprotein Ib (platelet), alpha polypeptide 2.257
CD8A CD8a molecule 2.235
IFNA1 interferon, alpha 1 2.181
F8 coagulation factor VIII, procoagulant component 2.137
IFNG interferon, gamma 2.123
PROCR protein C receptor, endothelial 2.108
IL1B interleukin 1, beta 2.107
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 2.105
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 2.065
IFNA2 interferon, alpha 2 2.019
ACE angiotensin I converting enzyme 2.015
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.006
APOH apolipoprotein H (beta-2-glycoprotein I) 2.005
PLAT plasminogen activator, tissue 1.998
IL10 interleukin 10 1.99
B2M beta-2-microglobulin 1.988
CD19 CD19 molecule 1.984
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.98
IL1A interleukin 1, alpha 1.976
IFNA17 interferon, alpha 17 1.962
CSF3 colony stimulating factor 3 (granulocyte) 1.962
HPSE2 heparanase 2 (inactive) 1.955
ACE2 angiotensin I converting enzyme 2 1.953
IFNA10 interferon, alpha 10 1.945
IFNA6 interferon, alpha 6 1.944
IFNA16 interferon, alpha 16 1.943
IFNA14 interferon, alpha 14 1.942
IFNA8 interferon, alpha 8 1.942
IFNA21 interferon, alpha 21 1.942
IFNA7 interferon, alpha 7 1.942
IFNA5 interferon, alpha 5 1.94
IFNA4 interferon, alpha 4 1.94
IL4 interleukin 4 1.939
IFNA13 interferon, alpha 13 1.939
IL5 interleukin 5 1.928
CXCL8 chemokine (C-X-C motif) ligand 8 1.927
IL2 interleukin 2 1.922
CKB creatine kinase, brain 1.916
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.913
CKM creatine kinase, muscle 1.913
CKMT1B creatine kinase, mitochondrial 1B 1.912
CD5 CD5 molecule 1.912
CFH complement factor H 1.91
IL17A interleukin 17A 1.907
PF4V1 platelet factor 4 variant 1 1.897
PLG plasminogen 1.893
C4B complement component 4B (Chido blood group) 1.886
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.875
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 1.873
C4A complement component 4A (Rodgers blood group) 1.871
MYOM2 myomesin 2 1.865
POMC proopiomelanocortin 1.854
CD34 CD34 molecule 1.849
MASP2 mannan-binding lectin serine peptidase 2 1.836
GP1BB glycoprotein Ib (platelet), beta polypeptide 1.829
FCAR Fc fragment of IgA receptor 1.826
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.803
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.803
CD46 CD46 molecule, complement regulatory protein 1.798
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.796
PROC protein C (inactivator of coagulation factors Va and VIIIa) 1.779
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.775
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 1.775
CD109 CD109 molecule 1.765
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.76
TTR transthyretin 1.757
PROS1 protein S (alpha) 1.754
BTK Bruton agammaglobulinemia tyrosine kinase 1.751
MME membrane metallo-endopeptidase 1.749
ADA2 adenosine deaminase 2 1.746
F10 coagulation factor X 1.745
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.738
MEFV Mediterranean fever 1.735
NPPB natriuretic peptide B 1.732
NCAM1 neural cell adhesion molecule 1 1.73
GP6 glycoprotein VI (platelet) 1.727
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 1.718
F9 coagulation factor IX 1.707
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 1.706
CD7 CD7 molecule 1.706
GP9 glycoprotein IX (platelet) 1.706
FCGRT Fc fragment of IgG, receptor, transporter, alpha 1.697
FIP1L1 factor interacting with PAPOLA and CPSF1 1.692
STX2 syntaxin 2 1.686
ETHE1 ethylmalonic encephalopathy 1 1.685
REN renin 1.682
RHD Rh blood group, D antigen 1.667
ICAM1 intercellular adhesion molecule 1 1.666
ELANE elastase, neutrophil expressed 1.665
CFP complement factor properdin 1.66
CD38 CD38 molecule 1.659
IL18 interleukin 18 1.655
RO60 Ro60, Y RNA binding protein 1.655
EPO erythropoietin 1.653
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 1.65
IL13 interleukin 13 1.646
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 1.645
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C 1.64
CPB2 carboxypeptidase B2 (plasma) 1.636
SYK spleen tyrosine kinase 1.632
CD40LG CD40 ligand 1.631
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 1.626
CR2 complement component (3d/Epstein Barr virus) receptor 2 1.621
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.619
CNOT11 CCR4-NOT transcription complex, subunit 11 1.614
IFNB1 interferon, beta 1, fibroblast 1.612
TGFB1 transforming growth factor, beta 1 1.612
FN1 fibronectin 1 1.608
SELE selectin E 1.604
CD52 CD52 molecule 1.601
C5 complement component 5 1.601
JAK2 Janus kinase 2 1.591
LOC102723407 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 1.589
INS insulin 1.584
CD68 CD68 molecule 1.58
CFI complement factor I 1.577
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 1.571
F2R coagulation factor II (thrombin) receptor 1.567
MBL2 mannose-binding lectin (protein C) 2, soluble 1.563
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 1.556
CCL2 chemokine (C-C motif) ligand 2 1.556
C1S complement component 1, s subcomponent 1.552
SDC1 syndecan 1 1.549
CD40 CD40 molecule, TNF receptor superfamily member 5 1.544
CFHR1 complement factor H-related 1 1.541
KNG1 kininogen 1 1.54
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 1.538
CD27 CD27 molecule 1.536
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.532
DGKE diacylglycerol kinase, epsilon 64kDa 1.52
FOXP3 forkhead box P3 1.513
HLA-B major histocompatibility complex, class I, B 1.512
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.51
VCAM1 vascular cell adhesion molecule 1 1.507
SLC26A5 solute carrier family 26 (anion exchanger), member 5 1.502
CD59 CD59 molecule, complement regulatory protein 1.502
CD1B CD1b molecule 1.501
CD1A CD1a molecule 1.5
CXCL10 chemokine (C-X-C motif) ligand 10 1.499
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.497
CD2 CD2 molecule 1.496
PTH parathyroid hormone 1.496
PECAM1 platelet/endothelial cell adhesion molecule 1 1.495
CD1E CD1e molecule 1.493
TLR7 toll-like receptor 7 1.493
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 1.492
CD79A CD79a molecule, immunoglobulin-associated alpha 1.492
BCR breakpoint cluster region 1.488
TLR4 toll-like receptor 4 1.487
CFB complement factor B 1.48
CD1D CD1d molecule 1.475
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.473
CD22 CD22 molecule 1.473
CD81 CD81 molecule 1.471
RNASE3 ribonuclease, RNase A family, 3 1.465
LTF lactotransferrin 1.462
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.46
TPO thyroid peroxidase 1.459
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 1.458
TLR9 toll-like receptor 9 1.455
ASPG asparaginase 1.455
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 1.45
MYH9 myosin, heavy chain 9, non-muscle 1.448
STX1A syntaxin 1A (brain) 1.443
PRF1 perforin 1 (pore forming protein) 1.442
HLA-A major histocompatibility complex, class I, A 1.436
IL3 interleukin 3 1.434
PLA2R1 phospholipase A2 receptor 1, 180kDa 1.43
CD1C CD1c molecule 1.421
IL22 interleukin 22 1.412
PTPRC protein tyrosine phosphatase, receptor type, C 1.411
COL17A1 collagen, type XVII, alpha 1 1.41
IL7 interleukin 7 1.407
ANPEP alanyl (membrane) aminopeptidase 1.407
CTSG cathepsin G 1.405
ERVW-1 endogenous retrovirus group W, member 1 1.405
CD33 CD33 molecule 1.404
CXCL13 chemokine (C-X-C motif) ligand 13 1.402
CD36 CD36 molecule (thrombospondin receptor) 1.401
IL11 interleukin 11 1.398
MYD88 myeloid differentiation primary response 88 1.395
F11 coagulation factor XI 1.394
BCL2 B-cell CLL/lymphoma 2 1.386
WAS Wiskott-Aldrich syndrome 1.38
TMPRSS2 transmembrane protease, serine 2 1.379
MVK mevalonate kinase 1.375
MB myoglobin 1.374
TLR2 toll-like receptor 2 1.373
JAK1 Janus kinase 1 1.365
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 1.353
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 1.352
SCARB2 scavenger receptor class B, member 2 1.352
C1R complement component 1, r subcomponent 1.346
PXDNL peroxidasin-like 1.345
PXDN peroxidasin 1.344
SCARB1 scavenger receptor class B, member 1 1.344
VTN vitronectin 1.339
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 1.337
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.335
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.335
CCL3 chemokine (C-C motif) ligand 3 1.334
IL33 interleukin 33 1.332
TLR3 toll-like receptor 3 1.329
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.327
ERV3-1 endogenous retrovirus group 3, member 1 1.324
ERVFRD-1 endogenous retrovirus group FRD, member 1 1.323
BPI bactericidal/permeability-increasing protein 1.321
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.32
CLEC1B C-type lectin domain family 1, member B 1.319
F5 coagulation factor V (proaccelerin, labile factor) 1.315
MX1 MX dynamin-like GTPase 1 1.313
CD163 CD163 molecule 1.309
CCL5 chemokine (C-C motif) ligand 5 1.308
CFHR3 complement factor H-related 3 1.306
GFM1 G elongation factor, mitochondrial 1 1.302
NLRP3 NLR family, pyrin domain containing 3 1.302
TP53 tumor protein p53 1.301
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 1.301
SAA1 serum amyloid A1 1.301
DSG1 desmoglein 1 1.299
DST dystonin 1.295
CD80 CD80 molecule 1.295
EXOC1 exocyst complex component 1 1.293
TG thyroglobulin 1.292
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.287
SPN sialophorin 1.286
LYST lysosomal trafficking regulator 1.284
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.284
STX11 syntaxin 11 1.283
UNC13D unc-13 homolog D (C. elegans) 1.283
CD28 CD28 molecule 1.28
CFHR5 complement factor H-related 5 1.278
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 1.271
CD86 CD86 molecule 1.268
FLT3 fms-related tyrosine kinase 3 1.268
EGF epidermal growth factor 1.265
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.263
IFIH1 interferon induced with helicase C domain 1 1.26
IL3RA interleukin 3 receptor, alpha (low affinity) 1.258
CD274 CD274 molecule 1.257
CXCL9 chemokine (C-X-C motif) ligand 9 1.253
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 1.247
ADA adenosine deaminase 1.243
SAA2 serum amyloid A2 1.24
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 1.235
NBEAL2 neurobeachin-like 2 1.235
STXBP2 syntaxin binding protein 2 1.231
SAA2-SAA4 SAA2-SAA4 readthrough 1.229
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.228
IL31 interleukin 31 1.225
BCL6 B-cell CLL/lymphoma 6 1.22
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 1.219
BSG basigin (Ok blood group) 1.212
PDCD1 programmed cell death 1 1.208
MAG myelin associated glycoprotein 1.208
CCL17 chemokine (C-C motif) ligand 17 1.203
SAA4 serum amyloid A4, constitutive 1.201
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 1.199
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.197
P2RY12 purinergic receptor P2Y, G-protein coupled, 12 1.193
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 1.189
SELPLG selectin P ligand 1.187
NAAA N-acylethanolamine acid amidase 1.187
C5AR1 complement component 5a receptor 1 1.186
STAT1 signal transducer and activator of transcription 1, 91kDa 1.185
STAT5B signal transducer and activator of transcription 5B 1.184
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 1.182
FASLG Fas ligand (TNF superfamily, member 6) 1.182
ELN elastin 1.175
IL15 interleukin 15 1.174
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 1.172
TPMT thiopurine S-methyltransferase 1.171
DUSP1 dual specificity phosphatase 1 1.169
A2M alpha-2-macroglobulin 1.168
TNNI3 troponin I type 3 (cardiac) 1.168
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 1.163
TFRC transferrin receptor 1.163
STAT4 signal transducer and activator of transcription 4 1.162
MMP9 matrix metallopeptidase 9 1.16
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 1.158
GNLY granulysin 1.157
CST3 cystatin C 1.155
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 1.151
CXCR5 chemokine (C-X-C motif) receptor 5 1.15
ADAM17 ADAM metallopeptidase domain 17 1.15
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 1.15
FURIN furin (paired basic amino acid cleaving enzyme) 1.149
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.148
GATA1 GATA binding protein 1 (globin transcription factor 1) 1.147
EGFR epidermal growth factor receptor 1.143
JCHAIN joining chain of multimeric IgA and IgM 1.141
C1GALT1C1 C1GALT1-specific chaperone 1 1.139
FLG filaggrin 1.133
CXCL12 chemokine (C-X-C motif) ligand 12 1.128
RUNX1 runt-related transcription factor 1 1.125
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 1.125
TAL1 T-cell acute lymphocytic leukemia 1 1.123
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 1.121
CCL11 chemokine (C-C motif) ligand 11 1.119
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.118
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.118
ICOS inducible T-cell co-stimulator 1.116
AFF2 AF4/FMR2 family, member 2 1.114
KITLG KIT ligand 1.114
APOL1 apolipoprotein L, 1 1.112
CCL4 chemokine (C-C motif) ligand 4 1.108
FAS Fas cell surface death receptor 1.108
DSG3 desmoglein 3 1.106
FLG2 filaggrin family member 2 1.105
CXCR4 chemokine (C-X-C motif) receptor 4 1.105
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.103
PLAU plasminogen activator, urokinase 1.102
SELL selectin L 1.102
MEST mesoderm specific transcript 1.102
IL9 interleukin 9 1.1
UROD uroporphyrinogen decarboxylase 1.099
IL2RA interleukin 2 receptor, alpha 1.096
C1QBP complement component 1, q subcomponent binding protein 1.096
CCL26 chemokine (C-C motif) ligand 26 1.091
BLK BLK proto-oncogene, Src family tyrosine kinase 1.088
SLAMF1 signaling lymphocytic activation molecule family member 1 1.087
ANGPT2 angiopoietin 2 1.086
IL5RA interleukin 5 receptor, alpha 1.085
OGA O-GlcNAcase 1.083
IL4R interleukin 4 receptor 1.082
EPX eosinophil peroxidase 1.08
AP2M1 adaptor-related protein complex 2, mu 1 subunit 1.079
WDR11 WD repeat domain 11 1.078
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.077
FERMT3 fermitin family member 3 1.074
PIGR polymeric immunoglobulin receptor 1.07
ITK IL2-inducible T-cell kinase 1.068
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 1.068
IRAK4 interleukin-1 receptor-associated kinase 4 1.067
CD209 CD209 molecule 1.066
PAX5 paired box 5 1.065
MYH14 myosin, heavy chain 14, non-muscle 1.065
THSD7A thrombospondin, type I, domain containing 7A 1.064
APCS amyloid P component, serum 1.063
G6PD glucose-6-phosphate dehydrogenase 1.061
IFNAR1 interferon (alpha, beta and omega) receptor 1 1.054
IL1RN interleukin 1 receptor antagonist 1.054
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.053
PPIG peptidylprolyl isomerase G (cyclophilin G) 1.053
SENP8 SUMO/sentrin specific peptidase family member 8 1.053
STAG1 stromal antigen 1 1.05
DNTT DNA nucleotidylexotransferase 1.049
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.046
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.045
COMP cartilage oligomeric matrix protein 1.045
HAMP hepcidin antimicrobial peptide 1.044
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.037
CD79B CD79b molecule, immunoglobulin-associated beta 1.036
TSLP thymic stromal lymphopoietin 1.034
CD44 CD44 molecule (Indian blood group) 1.03
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.03
AP3B1 adaptor-related protein complex 3, beta 1 subunit 1.029
GP5 glycoprotein V (platelet) 1.028
TGM2 transglutaminase 2 1.028
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 1.027
GPA33 glycoprotein A33 (transmembrane) 1.025
STAT5A signal transducer and activator of transcription 5A 1.024
CSF3R colony stimulating factor 3 receptor (granulocyte) 1.023
ANKRD26 ankyrin repeat domain 26 1.022
COLEC11 collectin sub-family member 11 1.022
AVP arginine vasopressin 1.02
ERBB2 erb-b2 receptor tyrosine kinase 2 1.019
ACR acrosin 1.013
IL1R1 interleukin 1 receptor, type I 1.011
ICAM3 intercellular adhesion molecule 3 1.007
MOG myelin oligodendrocyte glycoprotein 1.006
TNNT2 troponin T type 2 (cardiac) 1.004
IRF5 interferon regulatory factor 5 1.004
CMA1 chymase 1, mast cell 1.004
JUN jun proto-oncogene 1.002