| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/448991 |
| Similar Terms | |
| Downloads & Tools |
195 proteins with high or low expression in Purvalanol relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 2.67 |
| ZNF91 | zinc finger protein 91 | 1.79 |
| OMA1 | OMA1 zinc metallopeptidase | 1.07 |
| WDR24 | WD repeat domain 24 | 0.77 |
| ADK | adenosine kinase | 0.71 |
| CAMTA2 | calmodulin binding transcription activator 2 | 0.68 |
| DNAH1 | dynein, axonemal, heavy chain 1 | 0.66 |
| HFE | hemochromatosis | 0.64 |
| ZNF57 | zinc finger protein 57 | 0.54 |
| USP43 | ubiquitin specific peptidase 43 | 0.48 |
| AFF3 | AF4/FMR2 family, member 3 | 0.47 |
| PSEN2 | presenilin 2 | 0.45 |
| ATF6B | activating transcription factor 6 beta | 0.45 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.45 |
| ZFP64 | ZFP64 zinc finger protein | 0.44 |
| ANKS6 | ankyrin repeat and sterile alpha motif domain containing 6 | 0.43 |
| SCLT1 | sodium channel and clathrin linker 1 | 0.43 |
| GEMIN2 | gem (nuclear organelle) associated protein 2 | 0.42 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | 0.42 |
| AGFG2 | ArfGAP with FG repeats 2 | 0.41 |
| PKHD1L1 | polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 | 0.41 |
| MIB2 | mindbomb E3 ubiquitin protein ligase 2 | 0.41 |
| CASP9 | caspase 9, apoptosis-related cysteine peptidase | 0.4 |
| MSLN | mesothelin | 0.4 |
| ZSCAN29 | zinc finger and SCAN domain containing 29 | 0.39 |
| GUSB | glucuronidase, beta | 0.39 |
| C15ORF61 | chromosome 15 open reading frame 61 | 0.39 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | 0.39 |
| CCNQ | cyclin Q | 0.38 |
| ZNF544 | zinc finger protein 544 | 0.38 |
| SYDE1 | synapse defective 1, Rho GTPase, homolog 1 (C. elegans) | 0.37 |
| GVINP1 | GTPase, very large interferon inducible pseudogene 1 | 0.37 |
| ATG4C | autophagy related 4C, cysteine peptidase | 0.37 |
| PKD2 | polycystic kidney disease 2 (autosomal dominant) | 0.36 |
| MOCOS | molybdenum cofactor sulfurase | 0.36 |
| ZFHX3 | zinc finger homeobox 3 | 0.35 |
| KLHL8 | kelch-like family member 8 | 0.35 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.34 |
| METTL9 | methyltransferase like 9 | 0.33 |
| TIMM10 | translocase of inner mitochondrial membrane 10 homolog (yeast) | 0.32 |
| MISO1 | mitochondrial inner membrane subdomain organizer 1 | 0.32 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.32 |
| ZC3H14 | zinc finger CCCH-type containing 14 | 0.32 |
| CCDC77 | coiled-coil domain containing 77 | 0.32 |
| PROSER1 | proline and serine rich 1 | 0.31 |
| RASSF3 | Ras association (RalGDS/AF-6) domain family member 3 | 0.31 |
| SPATA33 | spermatogenesis associated 33 | 0.31 |
| TPGS2 | tubulin polyglutamylase complex subunit 2 | 0.3 |
| TMEM184A | transmembrane protein 184A | 0.3 |
| CEP68 | centrosomal protein 68kDa | 0.3 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.3 |
| CCNG1 | cyclin G1 | 0.29 |
| ZNF337 | zinc finger protein 337 | 0.29 |
| RFXANK | regulatory factor X-associated ankyrin-containing protein | 0.29 |
| SLC6A17 | solute carrier family 6 (neutral amino acid transporter), member 17 | 0.29 |
| FAM20C | family with sequence similarity 20, member C | 0.29 |
| ARHGEF39 | Rho guanine nucleotide exchange factor (GEF) 39 | 0.29 |
| RALGAPB | Ral GTPase activating protein, beta subunit (non-catalytic) | 0.29 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | 0.28 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.28 |
| CDK14 | cyclin-dependent kinase 14 | 0.28 |
| TMEM200A | transmembrane protein 200A | 0.28 |
| ZNF669 | zinc finger protein 669 | 0.28 |
| FGF2 | fibroblast growth factor 2 (basic) | 0.28 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.28 |
| ERVK3-1 | endogenous retrovirus group K3, member 1 | 0.27 |
| BLOC1S3 | biogenesis of lysosomal organelles complex-1, subunit 3 | 0.27 |
| CCT6B | chaperonin containing TCP1, subunit 6B (zeta 2) | 0.27 |
| RAB27B | RAB27B, member RAS oncogene family | 0.27 |
| MBP | myelin basic protein | 0.26 |
| MIDN | midnolin | 0.26 |
| ZBED5 | zinc finger, BED-type containing 5 | 0.26 |
| MCUR1 | mitochondrial calcium uniporter regulator 1 | 0.26 |
| PPHLN1 | periphilin 1 | 0.26 |
| ARHGAP44 | Rho GTPase activating protein 44 | 0.26 |
| C5ORF34 | chromosome 5 open reading frame 34 | 0.26 |
| DOK1 | docking protein 1, 62kDa (downstream of tyrosine kinase 1) | 0.25 |
| CRLF1 | cytokine receptor-like factor 1 | 0.25 |
| BLOC1S2 | biogenesis of lysosomal organelles complex-1, subunit 2 | 0.25 |
| SPAG17 | sperm associated antigen 17 | 0.25 |
| CARD8 | caspase recruitment domain family, member 8 | 0.25 |
| APLF | aprataxin and PNKP like factor | 0.25 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | 0.25 |
| IRF3 | interferon regulatory factor 3 | 0.24 |
| MITD1 | MIT, microtubule interacting and transport, domain containing 1 | 0.24 |
| FBXW4 | F-box and WD repeat domain containing 4 | 0.24 |
| FAM135A | family with sequence similarity 135, member A | 0.24 |
| TRPM4 | transient receptor potential cation channel, subfamily M, member 4 | 0.24 |
| ABCA13 | ATP-binding cassette, sub-family A (ABC1), member 13 | 0.24 |
| MED10 | mediator complex subunit 10 | 0.24 |
| UBL7 | ubiquitin-like 7 | 0.24 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.24 |
| RBP1 | retinol binding protein 1, cellular | 0.23 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.23 |
| GHDC | GH3 domain containing | 0.23 |
| FAM126B | family with sequence similarity 126, member B | 0.23 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.23 |
| NXT1 | nuclear transport factor 2-like export factor 1 | 0.23 |
| Symbol | Name | Standardized Value |
|---|---|---|
| INVS | inversin | -0.83 |
| ANKRD22 | ankyrin repeat domain 22 | -0.74 |
| DUOX1 | dual oxidase 1 | -0.73 |
| SYNE4 | spectrin repeat containing, nuclear envelope family member 4 | -0.56 |
| RAET1G | retinoic acid early transcript 1G | -0.5 |
| LARGE2 | LARGE xylosyl- and glucuronyltransferase 2 | -0.48 |
| SATB2 | SATB homeobox 2 | -0.48 |
| GMCL2 | germ cell-less 2, spermatogenesis associated | -0.48 |
| ACTBL2 | actin, beta-like 2 | -0.45 |
| RUSC2 | RUN and SH3 domain containing 2 | -0.41 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | -0.41 |
| TP73 | tumor protein p73 | -0.41 |
| CLASP1 | cytoplasmic linker associated protein 1 | -0.4 |
| NSUN3 | NOP2/Sun domain family, member 3 | -0.39 |
| MYL9 | myosin, light chain 9, regulatory | -0.39 |
| SLC35A4 | solute carrier family 35, member A4 | -0.39 |
| HOXB4 | homeobox B4 | -0.39 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | -0.39 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.37 |
| NAPEPLD | N-acyl phosphatidylethanolamine phospholipase D | -0.36 |
| STARD3NL | STARD3 N-terminal like | -0.35 |
| PLPP6 | phospholipid phosphatase 6 | -0.35 |
| C8ORF76 | chromosome 8 open reading frame 76 | -0.34 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.32 |
| FIG4 | FIG4 phosphoinositide 5-phosphatase | -0.31 |
| LMBRD1 | LMBR1 domain containing 1 | -0.31 |
| WIPI2 | WD repeat domain, phosphoinositide interacting 2 | -0.3 |
| ZNF518B | zinc finger protein 518B | -0.3 |
| ABCF1 | ATP-binding cassette, sub-family F (GCN20), member 1 | -0.3 |
| MFSD6 | major facilitator superfamily domain containing 6 | -0.29 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.29 |
| DPY19L2 | dpy-19-like 2 (C. elegans) | -0.29 |
| PAQR7 | progestin and adipoQ receptor family member VII | -0.29 |
| TDRKH | tudor and KH domain containing | -0.28 |
| TNNC2 | troponin C type 2 (fast) | -0.28 |
| EIF2B4 | eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa | -0.27 |
| TRIM15 | tripartite motif containing 15 | -0.26 |
| HAPLN3 | hyaluronan and proteoglycan link protein 3 | -0.26 |
| HSP90AA4P | heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene | -0.26 |
| SKIL | SKI-like proto-oncogene | -0.26 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.26 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.26 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | -0.25 |
| KLK7 | kallikrein-related peptidase 7 | -0.25 |
| ALG11 | ALG11, alpha-1,2-mannosyltransferase | -0.25 |
| CCDC138 | coiled-coil domain containing 138 | -0.25 |
| SGMS2 | sphingomyelin synthase 2 | -0.25 |
| CD320 | CD320 molecule | -0.24 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.24 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.24 |
| CD63 | CD63 molecule | -0.24 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.24 |
| LGALSL | lectin, galactoside-binding-like | -0.24 |
| CDC42SE2 | CDC42 small effector 2 | -0.23 |
| EPHA4 | EPH receptor A4 | -0.23 |
| SLC22A18 | solute carrier family 22, member 18 | -0.23 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.23 |
| FSIP2 | fibrous sheath interacting protein 2 | -0.23 |
| MED19 | mediator complex subunit 19 | -0.23 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.23 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.23 |
| ADGRG1 | adhesion G protein-coupled receptor G1 | -0.22 |
| MFGE8 | milk fat globule-EGF factor 8 protein | -0.22 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.22 |
| IP6K2 | inositol hexakisphosphate kinase 2 | -0.22 |
| MCF2L | MCF.2 cell line derived transforming sequence-like | -0.22 |
| GBA2 | glucosidase, beta (bile acid) 2 | -0.21 |
| CINP | cyclin-dependent kinase 2 interacting protein | -0.21 |
| SHLD2 | shieldin complex subunit 2 | -0.21 |
| DTNB | dystrobrevin, beta | -0.21 |
| SDCBP | syndecan binding protein (syntenin) | -0.21 |
| IQCE | IQ motif containing E | -0.21 |
| BTN2A1 | butyrophilin, subfamily 2, member A1 | -0.2 |
| FOXC1 | forkhead box C1 | -0.2 |
| BRF2 | BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit | -0.2 |
| ATXN1 | ataxin 1 | -0.19 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.19 |
| RNF141 | ring finger protein 141 | -0.19 |
| KCTD2 | potassium channel tetramerization domain containing 2 | -0.19 |
| RABEP1 | rabaptin, RAB GTPase binding effector protein 1 | -0.19 |
| PRXL2A | peroxiredoxin like 2A | -0.19 |
| ANO10 | anoctamin 10 | -0.18 |
| KLHDC3 | kelch domain containing 3 | -0.18 |
| USP19 | ubiquitin specific peptidase 19 | -0.18 |
| FAM102B | family with sequence similarity 102, member B | -0.18 |
| SLC25A52 | solute carrier family 25, member 52 | -0.18 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.18 |
| B4GALT1 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | -0.18 |
| CDC37 | cell division cycle 37 | -0.18 |
| CTDNEP1 | CTD nuclear envelope phosphatase 1 | -0.18 |
| NDUFB3 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa | -0.18 |
| C1ORF43 | chromosome 1 open reading frame 43 | -0.17 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.17 |
| CYP2U1 | cytochrome P450, family 2, subfamily U, polypeptide 1 | -0.17 |
| GALT | galactose-1-phosphate uridylyltransferase | -0.17 |
| CAPN5 | calpain 5 | -0.17 |
| ATG2A | autophagy related 2A | -0.17 |
