| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | An ortho- and peri-fused polycyclic arene consisting of four fused benzene rings, resulting in a flat aromatic system. (Chemical Entities of Biological Interest Ontology, CHEBI_39106) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/31423 |
| Similar Terms | |
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200 proteins with high or low expression in Pyrene relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | 3.15 |
| SBSN | suprabasin | 1.49 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 1.4 |
| TMEM64 | transmembrane protein 64 | 0.92 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | 0.82 |
| GPR161 | G protein-coupled receptor 161 | 0.71 |
| LAMA2 | laminin, alpha 2 | 0.6 |
| SLC38A1 | solute carrier family 38, member 1 | 0.57 |
| HIPK1 | homeodomain interacting protein kinase 1 | 0.57 |
| DOLK | dolichol kinase | 0.52 |
| ALDH1L2 | aldehyde dehydrogenase 1 family, member L2 | 0.51 |
| MYH2 | myosin, heavy chain 2, skeletal muscle, adult | 0.47 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | 0.45 |
| HAUS7 | HAUS augmin-like complex, subunit 7 | 0.44 |
| BRF2 | BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit | 0.43 |
| MIEN1 | migration and invasion enhancer 1 | 0.43 |
| SLC41A3 | solute carrier family 41, member 3 | 0.41 |
| HTD2 | hydroxyacyl-thioester dehydratase type 2 | 0.41 |
| PLEKHG6 | pleckstrin homology domain containing, family G (with RhoGef domain) member 6 | 0.4 |
| FAM122A | family with sequence similarity 122A | 0.37 |
| PDGFC | platelet derived growth factor C | 0.37 |
| TEAD2 | TEA domain family member 2 | 0.37 |
| ENDOG | endonuclease G | 0.37 |
| CST6 | cystatin E/M | 0.37 |
| MSH5 | mutS homolog 5 | 0.36 |
| TMEM208 | transmembrane protein 208 | 0.36 |
| TTLL5 | tubulin tyrosine ligase-like family member 5 | 0.35 |
| ZMAT3 | zinc finger, matrin-type 3 | 0.34 |
| MAGEF1 | melanoma antigen family F1 | 0.33 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.33 |
| OIP5 | Opa interacting protein 5 | 0.32 |
| ADCY6 | adenylate cyclase 6 | 0.32 |
| LYST | lysosomal trafficking regulator | 0.32 |
| TELO2 | telomere maintenance 2 | 0.32 |
| TWISTNB | TWIST neighbor | 0.32 |
| ZNF777 | zinc finger protein 777 | 0.31 |
| CEP68 | centrosomal protein 68kDa | 0.31 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.31 |
| CNOT7 | CCR4-NOT transcription complex, subunit 7 | 0.31 |
| PPP4R4 | protein phosphatase 4, regulatory subunit 4 | 0.3 |
| ATF1 | activating transcription factor 1 | 0.3 |
| GPHRA | golgi pH regulator A | 0.3 |
| PIP | prolactin-induced protein | 0.3 |
| ENDOV | endonuclease V | 0.3 |
| MALSU1 | mitochondrial assembly of ribosomal large subunit 1 | 0.29 |
| ELL3 | elongation factor RNA polymerase II-like 3 | 0.29 |
| AXIN2 | axin 2 | 0.28 |
| KCTD6 | potassium channel tetramerization domain containing 6 | 0.28 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.28 |
| YBX3 | Y box binding protein 3 | 0.27 |
| NEIL1 | nei endonuclease VIII-like 1 (E. coli) | 0.27 |
| PIGH | phosphatidylinositol glycan anchor biosynthesis, class H | 0.27 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.27 |
| TMEM68 | transmembrane protein 68 | 0.27 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.27 |
| CLCN5 | chloride channel, voltage-sensitive 5 | 0.27 |
| STK36 | serine/threonine kinase 36 | 0.27 |
| ATPSCKMT | ATP synthase c subunit lysine N-methyltransferase | 0.27 |
| ODC1 | ornithine decarboxylase 1 | 0.27 |
| HAX1 | HCLS1 associated protein X-1 | 0.27 |
| H3-3A | H3.3 histone A | 0.27 |
| TMEM135 | transmembrane protein 135 | 0.27 |
| RBM18 | RNA binding motif protein 18 | 0.26 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | 0.26 |
| COMMD6 | COMM domain containing 6 | 0.26 |
| CYTH3 | cytohesin 3 | 0.26 |
| VASN | vasorin | 0.26 |
| STN1 | STN1 subunit of CST complex | 0.26 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.25 |
| CKM | creatine kinase, muscle | 0.25 |
| PIGU | phosphatidylinositol glycan anchor biosynthesis, class U | 0.25 |
| VPS16 | vacuolar protein sorting 16 homolog (S. cerevisiae) | 0.25 |
| ZNF57 | zinc finger protein 57 | 0.25 |
| ACTL8 | actin-like 8 | 0.25 |
| CCDC138 | coiled-coil domain containing 138 | 0.25 |
| GLMP | glycosylated lysosomal membrane protein | 0.25 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.25 |
| PRDM16 | PR domain containing 16 | 0.25 |
| TBRG1 | transforming growth factor beta regulator 1 | 0.25 |
| UBE2W | ubiquitin-conjugating enzyme E2W (putative) | 0.25 |
| UQCRH | ubiquinol-cytochrome c reductase hinge protein | 0.24 |
| MCPH1 | microcephalin 1 | 0.24 |
| UPP1 | uridine phosphorylase 1 | 0.24 |
| TMEM230 | transmembrane protein 230 | 0.24 |
| MEGF8 | multiple EGF-like-domains 8 | 0.24 |
| SLC35C1 | solute carrier family 35 (GDP-fucose transporter), member C1 | 0.24 |
| RNFT2 | ring finger protein, transmembrane 2 | 0.24 |
| TRIM23 | tripartite motif containing 23 | 0.24 |
| SLC25A23 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 | 0.24 |
| L3MBTL2 | l(3)mbt-like 2 (Drosophila) | 0.23 |
| PDXP | pyridoxal (pyridoxine, vitamin B6) phosphatase | 0.23 |
| AOC1 | amine oxidase, copper containing 1 | 0.23 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.23 |
| GALNT11 | polypeptide N-acetylgalactosaminyltransferase 11 | 0.23 |
| PLCB4 | phospholipase C, beta 4 | 0.23 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.23 |
| ENPP5 | ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) | 0.23 |
| CCM2 | cerebral cavernous malformation 2 | 0.23 |
| ADCY9 | adenylate cyclase 9 | 0.22 |
| ABHD5 | abhydrolase domain containing 5 | 0.22 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TUB | tubby bipartite transcription factor | -2.27 |
| EPHA4 | EPH receptor A4 | -1.96 |
| PRAME | preferentially expressed antigen in melanoma | -1.94 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -1.42 |
| PISD | phosphatidylserine decarboxylase | -1.03 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.91 |
| SRD5A3 | steroid 5 alpha-reductase 3 | -0.89 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.76 |
| SLC6A17 | solute carrier family 6 (neutral amino acid transporter), member 17 | -0.75 |
| SPEG | SPEG complex locus | -0.74 |
| FBXW2 | F-box and WD repeat domain containing 2 | -0.73 |
| ZBED2 | zinc finger, BED-type containing 2 | -0.69 |
| ADSS1 | adenylosuccinate synthase 1 | -0.68 |
| FARP2 | FERM, RhoGEF and pleckstrin domain protein 2 | -0.66 |
| WDR60 | WD repeat domain 60 | -0.63 |
| LRRC28 | leucine rich repeat containing 28 | -0.59 |
| CYB5R2 | cytochrome b5 reductase 2 | -0.55 |
| SH3YL1 | SH3 and SYLF domain containing 1 | -0.55 |
| EIF1AX | eukaryotic translation initiation factor 1A, X-linked | -0.54 |
| PARP16 | poly (ADP-ribose) polymerase family, member 16 | -0.51 |
| ARHGAP42 | Rho GTPase activating protein 42 | -0.5 |
| SLC16A10 | solute carrier family 16 (aromatic amino acid transporter), member 10 | -0.5 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | -0.49 |
| GID8 | GID complex subunit 8 | -0.48 |
| TP73 | tumor protein p73 | -0.47 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | -0.47 |
| TM7SF3 | transmembrane 7 superfamily member 3 | -0.47 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.46 |
| BAIAP2 | BAI1-associated protein 2 | -0.46 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | -0.46 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | -0.45 |
| PARD6A | par-6 family cell polarity regulator alpha | -0.45 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.44 |
| ZNF286B | zinc finger protein 286B | -0.43 |
| CDC26 | cell division cycle 26 | -0.43 |
| IL10RB | interleukin 10 receptor, beta | -0.43 |
| HSH2D | hematopoietic SH2 domain containing | -0.43 |
| CENPP | centromere protein P | -0.42 |
| TJAP1 | tight junction associated protein 1 (peripheral) | -0.41 |
| CRAT | carnitine O-acetyltransferase | -0.4 |
| TECPR1 | tectonin beta-propeller repeat containing 1 | -0.4 |
| PROS1 | protein S (alpha) | -0.4 |
| TCP11L1 | t-complex 11, testis-specific-like 1 | -0.39 |
| FTL | ferritin, light polypeptide | -0.39 |
| YPEL5 | yippee-like 5 (Drosophila) | -0.39 |
| ORMDL1 | ORMDL sphingolipid biosynthesis regulator 1 | -0.38 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | -0.38 |
| CRPPA | CDP-L-ribitol pyrophosphorylase A | -0.38 |
| CACNB3 | calcium channel, voltage-dependent, beta 3 subunit | -0.38 |
| NBEAL1 | neurobeachin-like 1 | -0.37 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.36 |
| USP53 | ubiquitin specific peptidase 53 | -0.36 |
| ABRACL | ABRA C-terminal like | -0.36 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | -0.35 |
| AKT1S1 | AKT1 substrate 1 (proline-rich) | -0.35 |
| KLHL25 | kelch-like family member 25 | -0.35 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.34 |
| NCOA1 | nuclear receptor coactivator 1 | -0.34 |
| KSR2 | kinase suppressor of ras 2 | -0.34 |
| MTRF1 | mitochondrial translational release factor 1 | -0.34 |
| TASP1 | taspase, threonine aspartase, 1 | -0.34 |
| RUSC2 | RUN and SH3 domain containing 2 | -0.34 |
| FAM53C | family with sequence similarity 53, member C | -0.34 |
| MED31 | mediator complex subunit 31 | -0.34 |
| ATG4D | autophagy related 4D, cysteine peptidase | -0.34 |
| GAB1 | GRB2-associated binding protein 1 | -0.33 |
| NARS2 | asparaginyl-tRNA synthetase 2, mitochondrial (putative) | -0.33 |
| NLGN2 | neuroligin 2 | -0.33 |
| TMUB2 | transmembrane and ubiquitin-like domain containing 2 | -0.33 |
| NUCB2 | nucleobindin 2 | -0.32 |
| INAVA | innate immunity activator | -0.32 |
| GRHL2 | grainyhead-like 2 (Drosophila) | -0.32 |
| TSC22D1 | TSC22 domain family, member 1 | -0.32 |
| MAPKBP1 | mitogen-activated protein kinase binding protein 1 | -0.32 |
| EPS8L1 | EPS8-like 1 | -0.32 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | -0.31 |
| LRFN1 | leucine rich repeat and fibronectin type III domain containing 1 | -0.31 |
| TTC14 | tetratricopeptide repeat domain 14 | -0.31 |
| STMN1 | stathmin 1 | -0.31 |
| PTMS | parathymosin | -0.31 |
| FAM219B | family with sequence similarity 219, member B | -0.31 |
| RARA | retinoic acid receptor, alpha | -0.31 |
| RBPJL | recombination signal binding protein for immunoglobulin kappa J region-like | -0.31 |
| KSR1 | kinase suppressor of ras 1 | -0.31 |
| FSD1L | fibronectin type III and SPRY domain containing 1-like | -0.3 |
| HSPA8 | heat shock 70kDa protein 8 | -0.3 |
| FITM2 | fat storage-inducing transmembrane protein 2 | -0.3 |
| GPRASP2 | G protein-coupled receptor associated sorting protein 2 | -0.3 |
| ZNF165 | zinc finger protein 165 | -0.3 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.3 |
| SP100 | SP100 nuclear antigen | -0.3 |
| CENPH | centromere protein H | -0.3 |
| FBXO41 | F-box protein 41 | -0.3 |
| ERVK3-1 | endogenous retrovirus group K3, member 1 | -0.29 |
| CRBN | cereblon | -0.29 |
| FAM241B | family with sequence similarity 241 member B | -0.29 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | -0.29 |
| ALKBH5 | AlkB family member 5, RNA demethylase | -0.29 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -0.29 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.29 |
