| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pyridoxine (hydrochloride) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pyridoxine (hydrochloride)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.147719 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.13618 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.132786 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.121872 |
| MKI67 | marker of proliferation Ki-67 | 0.11104 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.110116 |
| NLGN1 | neuroligin 1 | 0.0955311 |
| DST | dystonin | 0.0922728 |
| CALR | calreticulin | 0.0838606 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0831142 |
| TPI1 | triosephosphate isomerase 1 | 0.0822337 |
| YAP1 | Yes-associated protein 1 | 0.0804197 |
| SMC4 | structural maintenance of chromosomes 4 | 0.079513 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0723759 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0642971 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0624163 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0608976 |
| RRM2 | ribonucleotide reductase M2 | 0.0604632 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0565415 |
| ANXA1 | annexin A1 | 0.0526601 |
| MTAP | methylthioadenosine phosphorylase | 0.0514949 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0514901 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0513499 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0507116 |
| YBX3 | Y box binding protein 3 | 0.0481415 |
| H1-0 | H1.0 linker histone | 0.047858 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.047547 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0461838 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0461001 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0455899 |
| UBC | ubiquitin C | 0.0455703 |
| CENPF | centromere protein F, 350/400kDa | 0.0432221 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0427329 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0425153 |
| EDARADD | EDAR-associated death domain | 0.0420845 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0405595 |
| INTS6 | integrator complex subunit 6 | 0.0400312 |
| FUS | FUS RNA binding protein | 0.0399385 |
| PEG10 | paternally expressed 10 | 0.0398222 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.039706 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0396825 |
| ERBIN | erbb2 interacting protein | 0.038458 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0384484 |
| SMC1A | structural maintenance of chromosomes 1A | 0.038037 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0371998 |
| HMGA2 | high mobility group AT-hook 2 | 0.0371555 |
| ADIPOR2 | adiponectin receptor 2 | 0.0371081 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0353728 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | 0.034901 |
| ENO1 | enolase 1, (alpha) | 0.034838 |
| CENPE | centromere protein E, 312kDa | 0.0343057 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0341702 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0340146 |
| STIP1 | stress-induced phosphoprotein 1 | 0.0336879 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.033683 |
| PCM1 | pericentriolar material 1 | 0.0336593 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0331923 |
| CANX | calnexin | 0.0330079 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0327688 |
| PLK2 | polo-like kinase 2 | 0.0320279 |
| TPX2 | TPX2, microtubule-associated | 0.0318805 |
| KIF4A | kinesin family member 4A | 0.0316247 |
| H2AZ1 | H2A.Z variant histone 1 | 0.0311352 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0311078 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0310986 |
| RBBP6 | retinoblastoma binding protein 6 | 0.0310898 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0308101 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0306633 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0300694 |
| RACGAP1 | Rac GTPase activating protein 1 | 0.0300532 |
| STAU1 | staufen double-stranded RNA binding protein 1 | 0.0299201 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0294725 |
| CKAP5 | cytoskeleton associated protein 5 | 0.029286 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0292464 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0287003 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0286019 |
| CBFB | core-binding factor, beta subunit | 0.028541 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0283339 |
| CCDC47 | coiled-coil domain containing 47 | 0.0281872 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0279065 |
| TPM3 | tropomyosin 3 | 0.0278192 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0277392 |
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 0.0277114 |
| HDAC9 | histone deacetylase 9 | 0.0276165 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | 0.0274061 |
| CCN2 | cellular communication network factor 2 | 0.027326 |
| INTS4 | integrator complex subunit 4 | 0.0270538 |
| PRIM2 | primase, DNA, polypeptide 2 (58kDa) | 0.0267975 |
| TAF7 | TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa | 0.0267213 |
| PCDH7 | protocadherin 7 | 0.0266316 |
| CEP112 | centrosomal protein 112kDa | 0.026606 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | 0.0264014 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0263968 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0263301 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0260518 |
| MAP1B | microtubule-associated protein 1B | 0.0259948 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0259114 |
| DEPDC1B | DEP domain containing 1B | 0.0259078 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | 0.0257113 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0253485 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.138622 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.101575 |
| TMSB10 | thymosin beta 10 | -0.0920243 |
| MMP12 | matrix metallopeptidase 12 | -0.089598 |
| RPL35A | ribosomal protein L35a | -0.0885968 |
| HMGA1 | high mobility group AT-hook 1 | -0.0829184 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0790229 |
| TMEM41B | transmembrane protein 41B | -0.0696653 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0693018 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0670976 |
| MGAT4C | MGAT4 family, member C | -0.0617913 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0589323 |
| RPS2 | ribosomal protein S2 | -0.0583305 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0560607 |
| RPLP1 | ribosomal protein, large, P1 | -0.0553176 |
| USP34 | ubiquitin specific peptidase 34 | -0.0528754 |
| YEATS2 | YEATS domain containing 2 | -0.0523121 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0509669 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0505436 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0502584 |
| CPOX | coproporphyrinogen oxidase | -0.0494163 |
| BCHE | butyrylcholinesterase | -0.0475206 |
| CLDN1 | claudin 1 | -0.045521 |
| RPS13 | ribosomal protein S13 | -0.0453386 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0452645 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0441032 |
| RPS19 | ribosomal protein S19 | -0.043103 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0431012 |
| RPL7 | ribosomal protein L7 | -0.0420274 |
| TENM3 | teneurin transmembrane protein 3 | -0.0409284 |
| KLHL24 | kelch-like family member 24 | -0.0408946 |
| RPL11 | ribosomal protein L11 | -0.0400529 |
| POTEF | POTE ankyrin domain family, member F | -0.0389003 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0386031 |
| RPL37 | ribosomal protein L37 | -0.0380657 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0375255 |
| AREG | amphiregulin | -0.0374214 |
| RPL26 | ribosomal protein L26 | -0.0374173 |
| RPS23 | ribosomal protein S23 | -0.0366909 |
| RPS29 | ribosomal protein S29 | -0.036432 |
| ZNF292 | zinc finger protein 292 | -0.0360726 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0355947 |
| LDHB | lactate dehydrogenase B | -0.0355189 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0353528 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0348133 |
| RPL37A | ribosomal protein L37a | -0.0339548 |
| RPL34 | ribosomal protein L34 | -0.033855 |
| RPL9 | ribosomal protein L9 | -0.0335532 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | -0.0330634 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0330125 |
| SMYD3 | SET and MYND domain containing 3 | -0.0329762 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | -0.032908 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0323711 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0320409 |
| TNPO1 | transportin 1 | -0.0318014 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | -0.0314161 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0312816 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0310576 |
| NKTR | natural killer cell triggering receptor | -0.0309417 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0307775 |
| RPS16 | ribosomal protein S16 | -0.0307453 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0306415 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0305809 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0305742 |
| EHBP1 | EH domain binding protein 1 | -0.0302483 |
| MED13L | mediator complex subunit 13-like | -0.0300656 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0299719 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0297841 |
| RPS24 | ribosomal protein S24 | -0.0295322 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0288041 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0284826 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0282336 |
| S100A6 | S100 calcium binding protein A6 | -0.0278766 |
| RPS21 | ribosomal protein S21 | -0.0277926 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0276 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0271808 |
| SEPTIN7 | septin 7 | -0.0271788 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0268694 |
| CDK19 | cyclin-dependent kinase 19 | -0.0266913 |
| RSF1 | remodeling and spacing factor 1 | -0.0265568 |
| SESN2 | sestrin 2 | -0.0264493 |
| GART | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase | -0.0263925 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0262627 |
| RASAL2 | RAS protein activator like 2 | -0.0262057 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0261859 |
| RPS27 | ribosomal protein S27 | -0.0261424 |
| RPS5 | ribosomal protein S5 | -0.0257378 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0256965 |
| TMEM123 | transmembrane protein 123 | -0.0256863 |
| PRKCI | protein kinase C, iota | -0.0256534 |
| NECTIN3 | nectin cell adhesion molecule 3 | -0.025513 |
| RPL31 | ribosomal protein L31 | -0.0253854 |
| SBF2 | SET binding factor 2 | -0.0252734 |
| RPS20 | ribosomal protein S20 | -0.0250289 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0246804 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0246711 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0246363 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0245448 |
| TGM2 | transglutaminase 2 | -0.0243206 |
| NEBL | nebulette | -0.0243088 |
