| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pyridoxine (hydrochloride) perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pyridoxine (hydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ASPH | aspartate beta-hydroxylase | 0.256835 |
| CD44 | CD44 molecule (Indian blood group) | 0.1207 |
| TXNRD1 | thioredoxin reductase 1 | 0.116789 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.113171 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0872003 |
| GLIS3 | GLIS family zinc finger 3 | 0.0717801 |
| KYNU | kynureninase | 0.0664231 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0614533 |
| MX1 | MX dynamin-like GTPase 1 | 0.0593339 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0485525 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0465388 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0454777 |
| FAT1 | FAT atypical cadherin 1 | 0.0448825 |
| SMAD3 | SMAD family member 3 | 0.0430114 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0429981 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0424036 |
| RNF213 | ring finger protein 213 | 0.0411523 |
| FLNA | filamin A, alpha | 0.0410753 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0405062 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.039453 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.039381 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0391278 |
| DST | dystonin | 0.0385584 |
| TSHZ2 | teashirt zinc finger homeobox 2 | 0.0377531 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0376769 |
| IFI44L | interferon-induced protein 44-like | 0.0369017 |
| NRP2 | neuropilin 2 | 0.0365927 |
| EFNA5 | ephrin-A5 | 0.0353542 |
| MKI67 | marker of proliferation Ki-67 | 0.0351527 |
| FLNB | filamin B, beta | 0.0319024 |
| RRM2 | ribonucleotide reductase M2 | 0.0313507 |
| HDAC9 | histone deacetylase 9 | 0.0307814 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0305729 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0296682 |
| TLE4 | transducin-like enhancer of split 4 | 0.0291014 |
| RIGI | RNA sensor RIG-I | 0.0288639 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0284351 |
| INTS6 | integrator complex subunit 6 | 0.0281145 |
| OSMR | oncostatin M receptor | 0.0280659 |
| SP100 | SP100 nuclear antigen | 0.0277932 |
| NFIB | nuclear factor I/B | 0.0277128 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0273486 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0270279 |
| FHL2 | four and a half LIM domains 2 | 0.0268454 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0262942 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0257393 |
| RDH10 | retinol dehydrogenase 10 (all-trans) | 0.0256771 |
| TGFA | transforming growth factor, alpha | 0.0255723 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0251048 |
| PLEKHA6 | pleckstrin homology domain containing, family A member 6 | 0.0249837 |
| MSN | moesin | 0.0244624 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0241935 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0240776 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0240141 |
| MCL1 | myeloid cell leukemia 1 | 0.0239568 |
| SVIL | supervillin | 0.0238911 |
| TGM2 | transglutaminase 2 | 0.023714 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0236149 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0233629 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.022954 |
| SLFN5 | schlafen family member 5 | 0.0226372 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0223136 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | 0.0221129 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.021979 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0217675 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0212328 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0211059 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0209283 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | 0.020915 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0207281 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.020719 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0205794 |
| GLIPR1 | GLI pathogenesis-related 1 | 0.0205666 |
| COL4A1 | collagen, type IV, alpha 1 | 0.020434 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0203758 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0202547 |
| FUS | FUS RNA binding protein | 0.0202334 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0199447 |
| NRP1 | neuropilin 1 | 0.019801 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0196287 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0196207 |
| ANXA1 | annexin A1 | 0.0196169 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0195062 |
| ENAH | enabled homolog (Drosophila) | 0.0194977 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0193159 |
| WWOX | WW domain containing oxidoreductase | 0.0191782 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.018788 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.0184341 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | 0.0183934 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0183776 |
| VMP1 | vacuole membrane protein 1 | 0.0182551 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0181591 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0179697 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0178925 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0177713 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0177108 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0176574 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0175622 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0175086 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0173857 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FRMD4A | FERM domain containing 4A | -0.197088 |
| VIM | vimentin | -0.149991 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.114107 |
| TMSB10 | thymosin beta 10 | -0.10287 |
| RRBP1 | ribosome binding protein 1 | -0.0828901 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0811816 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0792262 |
| GPC6 | glypican 6 | -0.0757976 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0732886 |
| CP | ceruloplasmin (ferroxidase) | -0.0709096 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0698524 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0680141 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0636765 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0629783 |
| GOLGA4 | golgin A4 | -0.0612122 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0572932 |
| PRRC2C | proline-rich coiled-coil 2C | -0.056447 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0560943 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0554433 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0536737 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0535291 |
| MTDH | metadherin | -0.0528195 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0524935 |
| CTSD | cathepsin D | -0.0514696 |
| NDRG1 | N-myc downstream regulated 1 | -0.0502545 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0496315 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0493393 |
| GNAS | GNAS complex locus | -0.0492646 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0492135 |
| PLIN2 | perilipin 2 | -0.0491849 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0484 |
| TMEM165 | transmembrane protein 165 | -0.0480562 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0476876 |
| COG5 | component of oligomeric golgi complex 5 | -0.0476022 |
| RTN4 | reticulon 4 | -0.0473307 |
| TRAM1 | translocation associated membrane protein 1 | -0.047167 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0469908 |
| S100A6 | S100 calcium binding protein A6 | -0.0468577 |
| CADM1 | cell adhesion molecule 1 | -0.0467026 |
| ATP13A3 | ATPase type 13A3 | -0.045114 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0448205 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0444511 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0443459 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0442996 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0442803 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0438167 |
| SCFD2 | sec1 family domain containing 2 | -0.0436358 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.043236 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0427847 |
| TPM1 | tropomyosin 1 (alpha) | -0.0425669 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0403014 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0397437 |
| MYADM | myeloid-associated differentiation marker | -0.039136 |
| CBX3 | chromobox homolog 3 | -0.0390914 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0390634 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0390612 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0388895 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0382004 |
| HM13 | histocompatibility (minor) 13 | -0.037736 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0372399 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0370017 |
| CALU | calumenin | -0.0360375 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0359316 |
| RND3 | Rho family GTPase 3 | -0.0357149 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0356435 |
| GGNBP2 | gametogenetin binding protein 2 | -0.0355284 |
| HMGA1 | high mobility group AT-hook 1 | -0.0354563 |
| TPM4 | tropomyosin 4 | -0.0353337 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0350428 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0347239 |
| NUCB2 | nucleobindin 2 | -0.0346596 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0344405 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0343814 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0343404 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0342656 |
| SRP72 | signal recognition particle 72kDa | -0.0333843 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | -0.0326351 |
| CEP95 | centrosomal protein 95kDa | -0.0325701 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0324911 |
| PFN1 | profilin 1 | -0.032486 |
| ANXA4 | annexin A4 | -0.0319585 |
| SQLE | squalene epoxidase | -0.0319242 |
| VPS53 | vacuolar protein sorting 53 homolog (S. cerevisiae) | -0.0317744 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.031597 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.0314535 |
| UBXN4 | UBX domain protein 4 | -0.0311899 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.031048 |
| TKT | transketolase | -0.0308778 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0308463 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | -0.030828 |
| SPAG9 | sperm associated antigen 9 | -0.0307392 |
| SEPTIN7 | septin 7 | -0.0306648 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0306173 |
| HLA-E | major histocompatibility complex, class I, E | -0.0305834 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0303783 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0303626 |
| HLA-B | major histocompatibility complex, class I, B | -0.0302604 |
| NOP58 | NOP58 ribonucleoprotein | -0.0301143 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0300966 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0299447 |
