| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pyridoxine (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pyridoxine (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.263682 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.249362 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.140517 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.102551 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0910555 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0868343 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0810176 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0795048 |
| PDE10A | phosphodiesterase 10A | 0.0716029 |
| STC1 | stanniocalcin 1 | 0.0691083 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0677546 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0602772 |
| EPAS1 | endothelial PAS domain protein 1 | 0.057968 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0564947 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0542634 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0533604 |
| MCL1 | myeloid cell leukemia 1 | 0.0532732 |
| ASPH | aspartate beta-hydroxylase | 0.0511223 |
| VIM | vimentin | 0.049991 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0495567 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0491146 |
| CD44 | CD44 molecule (Indian blood group) | 0.0488502 |
| FLNA | filamin A, alpha | 0.0438436 |
| RPS6 | ribosomal protein S6 | 0.0414193 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0413899 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0400675 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0389015 |
| UBC | ubiquitin C | 0.0377675 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0371629 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0363289 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.035391 |
| MSN | moesin | 0.0339432 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0332922 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0328733 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0327969 |
| FLNB | filamin B, beta | 0.032714 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0318547 |
| ADM | adrenomedullin | 0.0314835 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0307547 |
| DSPP | dentin sialophosphoprotein | 0.0306924 |
| EZR | ezrin | 0.0301923 |
| MT1X | metallothionein 1X | 0.029944 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0288741 |
| LAMB1 | laminin, beta 1 | 0.0284938 |
| FAT1 | FAT atypical cadherin 1 | 0.0273677 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0268524 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0265967 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.02657 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0258953 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0257199 |
| CCNL1 | cyclin L1 | 0.0252991 |
| GRAMD1B | GRAM domain containing 1B | 0.0251344 |
| AXL | AXL receptor tyrosine kinase | 0.0250066 |
| RPS12 | ribosomal protein S12 | 0.0246826 |
| HMGA2 | high mobility group AT-hook 2 | 0.0244585 |
| MKI67 | marker of proliferation Ki-67 | 0.023877 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0238426 |
| HSPA8 | heat shock 70kDa protein 8 | 0.023748 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0234448 |
| RPL3 | ribosomal protein L3 | 0.0228004 |
| WWOX | WW domain containing oxidoreductase | 0.0225761 |
| C1D | C1D nuclear receptor corepressor | 0.0222173 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.021983 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.021614 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0211132 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0211017 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0210751 |
| SET | SET nuclear proto-oncogene | 0.0208971 |
| CENPF | centromere protein F, 350/400kDa | 0.0206594 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0205123 |
| EREG | epiregulin | 0.0199681 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0198992 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0198815 |
| ITGA6 | integrin, alpha 6 | 0.0194841 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0192871 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0192549 |
| JUN | jun proto-oncogene | 0.0190643 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0190604 |
| CCDC88A | coiled-coil domain containing 88A | 0.0189126 |
| ANXA1 | annexin A1 | 0.0186899 |
| FOSL1 | FOS-like antigen 1 | 0.0183954 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0182681 |
| DHX40 | DEAH (Asp-Glu-Ala-His) box polypeptide 40 | 0.0180755 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0177434 |
| TGM2 | transglutaminase 2 | 0.0175006 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0174148 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0173886 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0167799 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0166478 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0166196 |
| TXNRD1 | thioredoxin reductase 1 | 0.0166011 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0163907 |
| BRD2 | bromodomain containing 2 | 0.0163044 |
| WWC1 | WW and C2 domain containing 1 | 0.01607 |
| AHR | aryl hydrocarbon receptor | 0.0160319 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | 0.0160209 |
| KANK1 | KN motif and ankyrin repeat domains 1 | 0.0159897 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.015891 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0158458 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.015408 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.146126 |
| TMSB10 | thymosin beta 10 | -0.103508 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0680818 |
| AHNAK | AHNAK nucleoprotein | -0.0676204 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0667066 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0660854 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0641813 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0612415 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0578241 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0563665 |
| ANXA2 | annexin A2 | -0.0536935 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0512603 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0490461 |
| VCL | vinculin | -0.0475828 |
| NAV2 | neuron navigator 2 | -0.0473538 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0471081 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0470909 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0469504 |
| ACTG1 | actin gamma 1 | -0.0463686 |
| RPLP1 | ribosomal protein, large, P1 | -0.0463253 |
| SBF2 | SET binding factor 2 | -0.0462952 |
| RPS24 | ribosomal protein S24 | -0.0457845 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0457337 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0456126 |
| USP34 | ubiquitin specific peptidase 34 | -0.0450423 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0446855 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0440769 |
| TNS3 | tensin 3 | -0.0437564 |
| ANXA4 | annexin A4 | -0.0429516 |
| PALLD | palladin, cytoskeletal associated protein | -0.0411923 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0400635 |
| GOLGA4 | golgin A4 | -0.0398497 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0397772 |
| LDHA | lactate dehydrogenase A | -0.0396829 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0396407 |
| RIGI | RNA sensor RIG-I | -0.0394956 |
| EFNA5 | ephrin-A5 | -0.0393865 |
| ATG7 | autophagy related 7 | -0.0393731 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0390118 |
| HDLBP | high density lipoprotein binding protein | -0.0387796 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0383532 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0373715 |
| TKT | transketolase | -0.0373305 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0372989 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0367608 |
| RPS16 | ribosomal protein S16 | -0.0365264 |
| DENND1A | DENN/MADD domain containing 1A | -0.0360957 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0359269 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0352401 |
| FNIP1 | folliculin interacting protein 1 | -0.0342828 |
| PTK2 | protein tyrosine kinase 2 | -0.0336413 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0335856 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0335393 |
| NF1 | neurofibromin 1 | -0.0329865 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0328574 |
| MORF4L2 | mortality factor 4 like 2 | -0.0328537 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0323318 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.032107 |
| DENND4A | DENN/MADD domain containing 4A | -0.0321027 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0320714 |
| PGK1 | phosphoglycerate kinase 1 | -0.0320479 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0318201 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0316942 |
| ZNF609 | zinc finger protein 609 | -0.0316131 |
| TAOK1 | TAO kinase 1 | -0.031566 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.0315564 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.031364 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0312895 |
| AUTS2 | autism susceptibility candidate 2 | -0.0310785 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0310588 |
| RPL35A | ribosomal protein L35a | -0.0305458 |
| CEP95 | centrosomal protein 95kDa | -0.0303828 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0303338 |
| KRT81 | keratin 81, type II | -0.0302883 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0296061 |
| TPM1 | tropomyosin 1 (alpha) | -0.029595 |
| RNF213 | ring finger protein 213 | -0.029423 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.0293573 |
| PARD3 | par-3 family cell polarity regulator | -0.0292771 |
| LAMB3 | laminin, beta 3 | -0.0291355 |
| MSI2 | musashi RNA-binding protein 2 | -0.0290558 |
| RAB10 | RAB10, member RAS oncogene family | -0.0289257 |
| S100A10 | S100 calcium binding protein A10 | -0.0288397 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0287069 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0286729 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0285686 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0285129 |
| CLINT1 | clathrin interactor 1 | -0.0284736 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0282786 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.028211 |
| CLTC | clathrin, heavy chain (Hc) | -0.0280179 |
| ETNK1 | ethanolamine kinase 1 | -0.0279796 |
| URI1 | URI1, prefoldin-like chaperone | -0.0279047 |
| TMEM165 | transmembrane protein 165 | -0.0276297 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0274064 |
| APP | amyloid beta (A4) precursor protein | -0.0273493 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.0267379 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0267177 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0267086 |
| HMGA1 | high mobility group AT-hook 1 | -0.0265596 |
