Pyridoxine (hydrochloride)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pyridoxine (hydrochloride) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pyridoxine (hydrochloride)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PRKG1 protein kinase, cGMP-dependent, type I 0.162605
CADM2 cell adhesion molecule 2 0.107313
HMGA2 high mobility group AT-hook 2 0.0859915
TSHZ2 teashirt zinc finger homeobox 2 0.0840195
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0687386
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0594133
PDE4D phosphodiesterase 4D, cAMP-specific 0.0477883
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0447007
LPP LIM domain containing preferred translocation partner in lipoma 0.0429074
THSD4 thrombospondin, type I, domain containing 4 0.0346095
GMDS GDP-mannose 4,6-dehydratase 0.0323078
PCM1 pericentriolar material 1 0.0308763
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0291968
PRELID2 PRELI domain containing 2 0.028761
MYOF myoferlin 0.0275225
FRMD6 FERM domain containing 6 0.0270759
TRIO trio Rho guanine nucleotide exchange factor 0.0248243
FLNA filamin A, alpha 0.0244223
FMNL2 formin-like 2 0.0229483
NBEA neurobeachin 0.022624
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0213112
CHD3 chromodomain helicase DNA binding protein 3 0.0211438
ANO6 anoctamin 6 0.0209463
ATP11A ATPase, class VI, type 11A 0.0209
IGF2R insulin-like growth factor 2 receptor 0.0208001
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0203913
PDE10A phosphodiesterase 10A 0.0199463
HDAC8 histone deacetylase 8 0.0199022
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0195256
PEG10 paternally expressed 10 0.0195117
WWOX WW domain containing oxidoreductase 0.0192872
MTUS1 microtubule associated tumor suppressor 1 0.0189168
SRRM2 serine/arginine repetitive matrix 2 0.0188619
EGFR epidermal growth factor receptor 0.0184355
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0183382
FAM13A family with sequence similarity 13, member A 0.0181795
TSC22D1 TSC22 domain family, member 1 0.0179326
CREM cAMP responsive element modulator 0.01787
LCOR ligand dependent nuclear receptor corepressor 0.017204
PARD3B par-3 family cell polarity regulator beta 0.0169096
ZMIZ1 zinc finger, MIZ-type containing 1 0.0162961
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0162724
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0161276
TM9SF4 transmembrane 9 superfamily protein member 4 0.0158809
EEF2 eukaryotic translation elongation factor 2 0.0156262
EXOC4 exocyst complex component 4 0.01526
LYPD6 LY6/PLAUR domain containing 6 0.0150359
SUGCT succinyl-CoA:glutarate-CoA transferase 0.0149865
PRKN parkin RBR E3 ubiquitin protein ligase 0.0149589
AFF4 AF4/FMR2 family, member 4 0.0148608
MBD5 methyl-CpG binding domain protein 5 0.0144784
SUMF1 sulfatase modifying factor 1 0.0143538
CTIF CBP80/20-dependent translation initiation factor 0.0142434
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.014037
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0140316
SH3RF1 SH3 domain containing ring finger 1 0.0139926
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0139737
ZFHX3 zinc finger homeobox 3 0.0139052
SOBP sine oculis binding protein homolog (Drosophila) 0.0139035
LINGO2 leucine rich repeat and Ig domain containing 2 0.0138935
ZBTB40 zinc finger and BTB domain containing 40 0.0138346
ARB2A ARB2 cotranscriptional regulator A 0.0136586
FLNB filamin B, beta 0.0136205
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0134739
VEGFA vascular endothelial growth factor A 0.0132927
THBS1 thrombospondin 1 0.0132232
HOOK2 hook microtubule-tethering protein 2 0.0131978
C1D C1D nuclear receptor corepressor 0.0131715
RSU1 Ras suppressor protein 1 0.0129679
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0129076
GTF2IRD1 GTF2I repeat domain containing 1 0.0128421
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 0.0127396
EFL1 elongation factor like GTPase 1 0.0126703
USO1 USO1 vesicle transport factor 0.0126445
SCMH1 sex comb on midleg homolog 1 (Drosophila) 0.0125985
KIF26B kinesin family member 26B 0.0125925
ZNF516 zinc finger protein 516 0.0125222
KIAA1549 KIAA1549 0.0124571
TRRAP transformation/transcription domain-associated protein 0.0124318
OSBPL10 oxysterol binding protein-like 10 0.0123786
MAML3 mastermind-like 3 (Drosophila) 0.0122999
MGMT O-6-methylguanine-DNA methyltransferase 0.0122849
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0122124
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.012138
KANK1 KN motif and ankyrin repeat domains 1 0.0121146
TRAPPC9 trafficking protein particle complex 9 0.0120504
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0120143
PRLR prolactin receptor 0.0119293
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0117753
RAI1 retinoic acid induced 1 0.0117377
ADM adrenomedullin 0.0117164
TUT7 terminal uridylyl transferase 7 0.0116935
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0116611
TBC1D22A TBC1 domain family, member 22A 0.0115697
PHF14 PHD finger protein 14 0.0115469
SHROOM3 shroom family member 3 0.0115421
MACF1 microtubule-actin crosslinking factor 1 0.0114694
EVC2 Ellis van Creveld syndrome 2 0.0113422
ATP9A ATPase, class II, type 9A 0.0113382
MEIS2 Meis homeobox 2 0.0113317

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.172493
MEST mesoderm specific transcript -0.170079
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.150308
MT2A metallothionein 2A -0.115689
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.105452
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0830779
RPLP1 ribosomal protein, large, P1 -0.0828422
MGP matrix Gla protein -0.0808009
VIM vimentin -0.0790207
RPS8 ribosomal protein S8 -0.0789294
RPS24 ribosomal protein S24 -0.0736167
RPS2 ribosomal protein S2 -0.0731487
RPS23 ribosomal protein S23 -0.0727225
RPS6 ribosomal protein S6 -0.0711598
RPL35A ribosomal protein L35a -0.0701595
RPL34 ribosomal protein L34 -0.0675156
CENPF centromere protein F, 350/400kDa -0.0618525
HMGB2 high mobility group box 2 -0.0604743
ZEB1 zinc finger E-box binding homeobox 1 -0.058267
MED13L mediator complex subunit 13-like -0.0548927
RPL31 ribosomal protein L31 -0.053645
TPT1 tumor protein, translationally-controlled 1 -0.0535101
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0533248
NAMPT nicotinamide phosphoribosyltransferase -0.0505362
RPLP0 ribosomal protein, large, P0 -0.0495925
RPL37A ribosomal protein L37a -0.0494974
RPL26 ribosomal protein L26 -0.0492942
RPL12 ribosomal protein L12 -0.0488525
RPL36 ribosomal protein L36 -0.0484701
TMSB10 thymosin beta 10 -0.0481729
RPL7 ribosomal protein L7 -0.0480479
RPL37 ribosomal protein L37 -0.0480437
RPS19 ribosomal protein S19 -0.0472564
ZNF292 zinc finger protein 292 -0.0470795
RAD21 RAD21 homolog (S. pombe) -0.0468969
MATR3 matrin 3 -0.0467943
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0467805
IER3 immediate early response 3 -0.0467157
RPL19 ribosomal protein L19 -0.0457059
RPLP2 ribosomal protein, large, P2 -0.0454169
LDHA lactate dehydrogenase A -0.0447795
RPL11 ribosomal protein L11 -0.0438426
RPS3 ribosomal protein S3 -0.0431375
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0427874
RPS25 ribosomal protein S25 -0.0424295
TMSB4X thymosin beta 4, X-linked -0.0421451
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0408581
RACK1 receptor for activated C kinase 1 -0.0401851
FTL ferritin, light polypeptide -0.0399715
SEPTIN7 septin 7 -0.0399685
RPS29 ribosomal protein S29 -0.0395197
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.039001
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0389229
RPS12 ribosomal protein S12 -0.0387377
RPS14 ribosomal protein S14 -0.038729
RPL23 ribosomal protein L23 -0.0375065
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0374257
B2M beta-2-microglobulin -0.0373923
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0364182
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0363532
LOC112694756 uncharaterized LOC112694756 -0.0363435
DEK DEK proto-oncogene -0.0355875
CAMTA1 calmodulin binding transcription activator 1 -0.0352621
HMGA1 high mobility group AT-hook 1 -0.0349669
RHEB Ras homolog enriched in brain -0.034592
RPL32 ribosomal protein L32 -0.033944
PRRC2C proline-rich coiled-coil 2C -0.0334424
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0333337
MKI67 marker of proliferation Ki-67 -0.0332397
RPS13 ribosomal protein S13 -0.0329868
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0328055
RPS16 ribosomal protein S16 -0.0326509
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0323336
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0318417
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0317352
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0314658
SQSTM1 sequestosome 1 -0.0312624
RPL38 ribosomal protein L38 -0.0308546
RPL8 ribosomal protein L8 -0.0306927
SBF2 SET binding factor 2 -0.0304164
USP3 ubiquitin specific peptidase 3 -0.0303379
NAP1L1 nucleosome assembly protein 1-like 1 -0.0301058
RPL28 ribosomal protein L28 -0.0299938
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0299849
RPS27A ribosomal protein S27a -0.0297766
PDIA3 protein disulfide isomerase family A, member 3 -0.0297516
PDIA6 protein disulfide isomerase family A, member 6 -0.0296545
DLG1 discs, large homolog 1 (Drosophila) -0.0289848
GSE1 Gse1 coiled-coil protein -0.0284735
HMGB1 high mobility group box 1 -0.0283301
CALR calreticulin -0.0283235
VDAC1 voltage-dependent anion channel 1 -0.0279154
RNF145 ring finger protein 145 -0.0274809
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0274504
RPS27 ribosomal protein S27 -0.0271478
PHIP pleckstrin homology domain interacting protein -0.0269635
TPX2 TPX2, microtubule-associated -0.0268326
DDIT4 DNA-damage-inducible transcript 4 -0.0267623
S100A9 S100 calcium binding protein A9 -0.0267413
EIF1 eukaryotic translation initiation factor 1 -0.0266116