Pyridoxine (hydrochloride)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pyridoxine (hydrochloride) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pyridoxine (hydrochloride)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
STAT1 signal transducer and activator of transcription 1, 91kDa 0.206912
COL5A2 collagen, type V, alpha 2 0.135557
RIGI RNA sensor RIG-I 0.117392
CADM2 cell adhesion molecule 2 0.109812
MKI67 marker of proliferation Ki-67 0.099422
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0929765
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0908774
EEF2 eukaryotic translation elongation factor 2 0.0897992
TENM3 teneurin transmembrane protein 3 0.0867363
ZNF608 zinc finger protein 608 0.0809625
PDE4D phosphodiesterase 4D, cAMP-specific 0.0800931
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0773427
CENPF centromere protein F, 350/400kDa 0.0747729
SLIT2 slit homolog 2 (Drosophila) 0.074052
VCL vinculin 0.0730938
SRRM2 serine/arginine repetitive matrix 2 0.071938
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0654845
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0603593
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0597935
SHROOM3 shroom family member 3 0.0587488
MLIP muscular LMNA-interacting protein 0.0584967
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0576747
TRIP12 thyroid hormone receptor interactor 12 0.0562666
CDH18 cadherin 18, type 2 0.0545856
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0529638
ENO1 enolase 1, (alpha) 0.0514708
SMC1A structural maintenance of chromosomes 1A 0.0511595
HSPA8 heat shock 70kDa protein 8 0.0488708
FBXL7 F-box and leucine-rich repeat protein 7 0.0475329
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0454909
RBBP6 retinoblastoma binding protein 6 0.0441482
SET SET nuclear proto-oncogene 0.0426765
SETX senataxin 0.0416227
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0413888
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0408448
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0400173
TXNRD1 thioredoxin reductase 1 0.0395341
SOX5 SRY (sex determining region Y)-box 5 0.0387473
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0384925
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0383168
EXOC4 exocyst complex component 4 0.0370352
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0357713
FLNA filamin A, alpha 0.0355428
SFPQ splicing factor proline/glutamine-rich 0.0350798
NALF1 NALCN channel auxiliary factor 1 0.0349078
HDAC8 histone deacetylase 8 0.0348295
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0347732
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0340828
VMP1 vacuole membrane protein 1 0.03406
TTC28 tetratricopeptide repeat domain 28 0.0338776
CAPRIN1 cell cycle associated protein 1 0.0337638
DNAH14 dynein, axonemal, heavy chain 14 0.0336126
WWOX WW domain containing oxidoreductase 0.033604
PMP22 peripheral myelin protein 22 0.0335875
MAP1B microtubule-associated protein 1B 0.0334491
RAD51B RAD51 paralog B 0.0333934
RABGAP1L RAB GTPase activating protein 1-like 0.033321
RNF213 ring finger protein 213 0.0331544
BPTF bromodomain PHD finger transcription factor 0.0326746
ATG10 autophagy related 10 0.0324308
TNRC18 trinucleotide repeat containing 18 0.0322638
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0319458
BNC2 basonuclin 2 0.0318753
TOP2B topoisomerase (DNA) II beta 180kDa 0.0318706
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0314658
MACF1 microtubule-actin crosslinking factor 1 0.0310186
ZBTB20 zinc finger and BTB domain containing 20 0.0310123
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0308783
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0304298
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0302356
GIGYF2 GRB10 interacting GYF protein 2 0.0301336
ADGRG6 adhesion G protein-coupled receptor G6 0.0299634
CCSER1 coiled-coil serine-rich protein 1 0.0298654
NRDC nardilysin convertase 0.029755
KIF1B kinesin family member 1B 0.0296564
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0293074
CKAP5 cytoskeleton associated protein 5 0.0292431
UBC ubiquitin C 0.0291004
WLS wntless Wnt ligand secretion mediator 0.028957
DST dystonin 0.0289556
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0289087
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0288255
CEP112 centrosomal protein 112kDa 0.0287581
MAML3 mastermind-like 3 (Drosophila) 0.0284435
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0283674
PCM1 pericentriolar material 1 0.0279
ZNFX1 zinc finger, NFX1-type containing 1 0.0277712
IFI6 interferon, alpha-inducible protein 6 0.0277649
CSNK1A1 casein kinase 1, alpha 1 0.0273006
ADAR adenosine deaminase, RNA-specific 0.0272784
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0267562
ANKRD36 ankyrin repeat domain 36 0.0263817
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0262566
MX1 MX dynamin-like GTPase 1 0.0261791
H1-3 H1.3 linker histone, cluster member 0.0260265
AOPEP aminopeptidase O (putative) 0.0259075
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0256904
SCLT1 sodium channel and clathrin linker 1 0.0255146
FUS FUS RNA binding protein 0.0252933
ENAH enabled homolog (Drosophila) 0.0252222

decreased expression

Symbol Name Standardized Value
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.111493
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0908006
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0895116
RPLP1 ribosomal protein, large, P1 -0.0844538
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0795363
ZFP36L1 ZFP36 ring finger protein-like 1 -0.076358
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0704284
RPL34 ribosomal protein L34 -0.0693156
PTMA prothymosin, alpha -0.065762
RPS19 ribosomal protein S19 -0.0624954
RPS21 ribosomal protein S21 -0.0607221
RPS8 ribosomal protein S8 -0.0597895
RAP1B RAP1B, member of RAS oncogene family -0.0567595
RPL35A ribosomal protein L35a -0.0550249
SLF1 SMC5-SMC6 complex localization factor 1 -0.0541508
RPS13 ribosomal protein S13 -0.0532091
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0502979
RPL23 ribosomal protein L23 -0.0500313
HMGA1 high mobility group AT-hook 1 -0.0498949
RPS5 ribosomal protein S5 -0.0492179
ATP9A ATPase, class II, type 9A -0.0480565
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0479987
RPS11 ribosomal protein S11 -0.0479298
RPS6 ribosomal protein S6 -0.0459147
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0456149
LDHA lactate dehydrogenase A -0.0450813
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0446143
RPLP0 ribosomal protein, large, P0 -0.0444644
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0442356
WDR45B WD repeat domain 45B -0.0442335
RPS24 ribosomal protein S24 -0.0442314
KDM3A lysine (K)-specific demethylase 3A -0.0435752
ATRN attractin -0.0432225
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.042956
VIM vimentin -0.0428041
TMSB10 thymosin beta 10 -0.0415969
EFNA5 ephrin-A5 -0.0414377
NUP58 nucleoporin 58 -0.0412423
RPL31 ribosomal protein L31 -0.0411102
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0408295
RPL32 ribosomal protein L32 -0.0408164
PIAS2 protein inhibitor of activated STAT, 2 -0.0407202
USP37 ubiquitin specific peptidase 37 -0.0405285
RAB1A RAB1A, member RAS oncogene family -0.0386608
RPS28 ribosomal protein S28 -0.0386108
RPS29 ribosomal protein S29 -0.0385449
TRIO trio Rho guanine nucleotide exchange factor -0.0384469
FOXO3 forkhead box O3 -0.0383468
RNF130 ring finger protein 130 -0.0379528
RPS23 ribosomal protein S23 -0.0379455
LPIN2 lipin 2 -0.0376846
RPS16 ribosomal protein S16 -0.0372238
NGLY1 N-glycanase 1 -0.0370965
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0370231
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0370211
RPL12 ribosomal protein L12 -0.0364882
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0364691
TNPO1 transportin 1 -0.0359845
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0354193
RPS4X ribosomal protein S4, X-linked -0.0354044
RPL28 ribosomal protein L28 -0.0353299
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0339276
RPS14 ribosomal protein S14 -0.0339275
KDM5B lysine (K)-specific demethylase 5B -0.0339243
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0338365
JARID2 jumonji, AT rich interactive domain 2 -0.0337547
RPS25 ribosomal protein S25 -0.0333303
SOX2 SRY (sex determining region Y)-box 2 -0.033041
HILPDA hypoxia inducible lipid droplet-associated -0.0324367
RPL7A ribosomal protein L7a -0.0318491
NPAS3 neuronal PAS domain protein 3 -0.031342
S100A9 S100 calcium binding protein A9 -0.0312622
RNF145 ring finger protein 145 -0.0312501
RPS3 ribosomal protein S3 -0.0312013
RPL11 ribosomal protein L11 -0.0306669
OLA1 Obg-like ATPase 1 -0.0304172
PGAP1 post-GPI attachment to proteins 1 -0.0301279
MYL12B myosin, light chain 12B, regulatory -0.0299505
UBE4B ubiquitination factor E4B -0.0295841
CDC73 cell division cycle 73 -0.0294503
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.029439
GNAS GNAS complex locus -0.0287604
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0286453
RPL7 ribosomal protein L7 -0.0286214
RPL26 ribosomal protein L26 -0.0285355
TTC19 tetratricopeptide repeat domain 19 -0.0283412
NAMPT nicotinamide phosphoribosyltransferase -0.028051
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.027911
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0278816
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0277912
SETD5 SET domain containing 5 -0.027446
MED13L mediator complex subunit 13-like -0.0274071
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0273641
SREBF2 sterol regulatory element binding transcription factor 2 -0.0272417
EEF1G eukaryotic translation elongation factor 1 gamma -0.0271027
TENT4A terminal nucleotidyltransferase 4A -0.0270897
TENM2 teneurin transmembrane protein 2 -0.0270473
XPO1 exportin 1 -0.0270002
UBE2K ubiquitin-conjugating enzyme E2K -0.0269066
ZNF638 zinc finger protein 638 -0.0268368