Pyridoxine (hydrochloride)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pyridoxine (hydrochloride) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pyridoxine (hydrochloride)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SYT1 synaptotagmin I 0.0931442
FMN1 formin 1 0.0840814
PTPRD protein tyrosine phosphatase, receptor type, D 0.0759215
VCL vinculin 0.0642669
LINGO2 leucine rich repeat and Ig domain containing 2 0.0639769
THBS1 thrombospondin 1 0.0589646
VMP1 vacuole membrane protein 1 0.0525315
TPST1 tyrosylprotein sulfotransferase 1 0.0476146
PLPP1 phospholipid phosphatase 1 0.0465637
DNM3 dynamin 3 0.0443091
MEIS2 Meis homeobox 2 0.0439899
RIGI RNA sensor RIG-I 0.0434767
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0415954
DST dystonin 0.0411953
PDE10A phosphodiesterase 10A 0.0395947
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0394083
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0394061
ADGRB3 adhesion G protein-coupled receptor B3 0.0391761
STK38L serine/threonine kinase 38 like 0.0386947
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0365774
AUTS2 autism susceptibility candidate 2 0.0362023
TLE4 transducin-like enhancer of split 4 0.0361121
PCDH7 protocadherin 7 0.0359778
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0354325
PDE4D phosphodiesterase 4D, cAMP-specific 0.0343904
RNF213 ring finger protein 213 0.0343791
BPTF bromodomain PHD finger transcription factor 0.0337885
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.033025
FNDC3A fibronectin type III domain containing 3A 0.0328914
SIK2 salt-inducible kinase 2 0.0328145
ZSWIM6 zinc finger, SWIM-type containing 6 0.0328104
PCDH15 protocadherin-related 15 0.0322775
GLCCI1 glucocorticoid induced 1 0.0314224
PTPRK protein tyrosine phosphatase, receptor type, K 0.0304048
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0303631
RALYL RALY RNA binding protein-like 0.030175
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0301579
MAPK10 mitogen-activated protein kinase 10 0.0284767
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0284373
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0282889
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0279843
NCAM2 neural cell adhesion molecule 2 0.0270831
CHD9 chromodomain helicase DNA binding protein 9 0.0269042
FAM107B family with sequence similarity 107, member B 0.0264929
FER fer (fps/fes related) tyrosine kinase 0.0260106
RAD51B RAD51 paralog B 0.0258212
UNC5C unc-5 homolog C (C. elegans) 0.0256916
FRMD6 FERM domain containing 6 0.0255189
KCNT2 potassium channel, sodium activated subfamily T, member 2 0.0254208
IGFBP3 insulin-like growth factor binding protein 3 0.0253251
NRP1 neuropilin 1 0.0252822
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0250102
NALF1 NALCN channel auxiliary factor 1 0.0250018
ARHGAP24 Rho GTPase activating protein 24 0.0249102
SLIT2 slit homolog 2 (Drosophila) 0.0247678
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0243591
MAP1B microtubule-associated protein 1B 0.0241743
EXOC4 exocyst complex component 4 0.0241669
ANTXR1 anthrax toxin receptor 1 0.0241336
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0236463
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0236103
PACS1 phosphofurin acidic cluster sorting protein 1 0.0234015
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0229585
SVIL supervillin 0.0229576
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0229074
SENP6 SUMO1/sentrin specific peptidase 6 0.0228541
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0226756
GAB2 GRB2-associated binding protein 2 0.0220078
CEMIP cell migration inducing protein, hyaluronan binding 0.0218363
DUSP10 dual specificity phosphatase 10 0.0218141
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0215914
EPHA7 EPH receptor A7 0.0212953
EEF2 eukaryotic translation elongation factor 2 0.0212316
TRPS1 trichorhinophalangeal syndrome I 0.0211772
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0206388
SRRM2 serine/arginine repetitive matrix 2 0.020611
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0200391
HAND2 heart and neural crest derivatives expressed 2 0.0199647
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0197821
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0193615
PTPRE protein tyrosine phosphatase, receptor type, E 0.0193037
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0192477
TNRC6C trinucleotide repeat containing 6C 0.0192438
FGF14 fibroblast growth factor 14 0.0191628
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0190308
ITPRID2 ITPR interacting domain containing 2 0.0187405
DIAPH2 diaphanous-related formin 2 0.0186778
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0181547
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0180966
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.0180029
HDX highly divergent homeobox 0.0179803
PHF14 PHD finger protein 14 0.0178479
PRKCA protein kinase C, alpha 0.0178042
LRRC7 leucine rich repeat containing 7 0.017791
METTL15 methyltransferase like 15 0.0177878
ZNF804A zinc finger protein 804A 0.0177515
RNF144A ring finger protein 144A 0.0173047
PTEN phosphatase and tensin homolog 0.0169601
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0169126
PLAGL1 pleiomorphic adenoma gene-like 1 0.0168421

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.432803
PTMA prothymosin, alpha -0.141024
NRG1 neuregulin 1 -0.114708
VIM vimentin -0.113218
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.100627
RPS6 ribosomal protein S6 -0.0912314
RPLP1 ribosomal protein, large, P1 -0.0849909
RPL23 ribosomal protein L23 -0.0849696
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0827918
RPL35A ribosomal protein L35a -0.0804933
AKAP12 A kinase (PRKA) anchor protein 12 -0.0756999
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0742655
ACTG1 actin gamma 1 -0.0714626
COL1A1 collagen, type I, alpha 1 -0.0707603
RPS24 ribosomal protein S24 -0.0694757
RPL34 ribosomal protein L34 -0.0659798
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0633191
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0583894
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0581588
TPT1 tumor protein, translationally-controlled 1 -0.0563167
EXT1 exostosin glycosyltransferase 1 -0.0558381
LPIN1 lipin 1 -0.0540004
HIP1 huntingtin interacting protein 1 -0.0523268
TMSB10 thymosin beta 10 -0.0522926
KPNB1 karyopherin (importin) beta 1 -0.0521346
COL3A1 collagen, type III, alpha 1 -0.051543
WDR45B WD repeat domain 45B -0.0510067
RPL19 ribosomal protein L19 -0.0509977
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0493828
GOLGA4 golgin A4 -0.0480365
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0478589
MSI2 musashi RNA-binding protein 2 -0.0457173
RPL26 ribosomal protein L26 -0.0449947
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0435208
MEF2A myocyte enhancer factor 2A -0.0432928
H3-3B H3.3 histone B -0.0422001
EIF1 eukaryotic translation initiation factor 1 -0.0413725
SEPTIN9 septin 9 -0.0411997
RPL37A ribosomal protein L37a -0.0411127
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0394898
HELZ helicase with zinc finger -0.0390097
PLAT plasminogen activator, tissue -0.0379258
RPL12 ribosomal protein L12 -0.0376987
RPS19 ribosomal protein S19 -0.0373552
B2M beta-2-microglobulin -0.0354558
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0350589
RPL38 ribosomal protein L38 -0.0347173
RPL36 ribosomal protein L36 -0.034169
FTL ferritin, light polypeptide -0.0340265
RPS3 ribosomal protein S3 -0.0339984
SPAG9 sperm associated antigen 9 -0.033764
EIF5B eukaryotic translation initiation factor 5B -0.0332389
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0330936
PKM pyruvate kinase, muscle -0.0328495
MAML2 mastermind-like 2 (Drosophila) -0.0328081
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.032649
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0320992
S100A9 S100 calcium binding protein A9 -0.0318146
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0318127
CCND1 cyclin D1 -0.0318008
RAB1A RAB1A, member RAS oncogene family -0.0315348
RPS21 ribosomal protein S21 -0.0312897
RPS27 ribosomal protein S27 -0.0309511
GNAS GNAS complex locus -0.0309427
RPS11 ribosomal protein S11 -0.0308171
RPLP0 ribosomal protein, large, P0 -0.03074
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0306925
BIRC6 baculoviral IAP repeat containing 6 -0.0305677
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0305221
RPS14 ribosomal protein S14 -0.0296254
NDRG1 N-myc downstream regulated 1 -0.0294152
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.029368
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0293678
DTNA dystrobrevin, alpha -0.0292803
RPS23 ribosomal protein S23 -0.0292364
TRIB2 tribbles pseudokinase 2 -0.0291471
PARD3 par-3 family cell polarity regulator -0.0282365
CRABP2 cellular retinoic acid binding protein 2 -0.0281438
DCAF7 DDB1 and CUL4 associated factor 7 -0.0279829
RPL31 ribosomal protein L31 -0.0279621
ACBD3 acyl-CoA binding domain containing 3 -0.0276055
DDIT4 DNA-damage-inducible transcript 4 -0.027414
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0272558
LMNA lamin A/C -0.0266243
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0265316
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0263749
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0263498
RPS12 ribosomal protein S12 -0.0261692
IGFBP4 insulin-like growth factor binding protein 4 -0.026022
PRRC2C proline-rich coiled-coil 2C -0.0259214
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0258824
COPA coatomer protein complex, subunit alpha -0.0258335
NRIP1 nuclear receptor interacting protein 1 -0.0255828
RPL32 ribosomal protein L32 -0.0253992
RBM25 RNA binding motif protein 25 -0.0252968
GCC2 GRIP and coiled-coil domain containing 2 -0.0252464
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0250043
LDHA lactate dehydrogenase A -0.0249875
NAP1L1 nucleosome assembly protein 1-like 1 -0.024972
RPS16 ribosomal protein S16 -0.0248749