Pyridoxine (hydrochloride)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pyridoxine (hydrochloride) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pyridoxine (hydrochloride)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.109997
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0750952
TXNRD1 thioredoxin reductase 1 0.064524
EEF2 eukaryotic translation elongation factor 2 0.0529729
MYH9 myosin, heavy chain 9, non-muscle 0.0472063
FLNA filamin A, alpha 0.0439299
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0345842
MED13L mediator complex subunit 13-like 0.0341452
TPM3 tropomyosin 3 0.0320158
HSPA8 heat shock 70kDa protein 8 0.0312454
ZFAND3 zinc finger, AN1-type domain 3 0.0304605
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0285406
SRRM2 serine/arginine repetitive matrix 2 0.0282871
OGA O-GlcNAcase 0.027687
TENM3 teneurin transmembrane protein 3 0.0275852
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0273063
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0269461
NUP58 nucleoporin 58 0.0264406
EIF4B eukaryotic translation initiation factor 4B 0.0262944
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0261957
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0256426
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0255832
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0253288
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0241774
CAPRIN1 cell cycle associated protein 1 0.0240324
EXOC6B exocyst complex component 6B 0.02337
ATAD2 ATPase family, AAA domain containing 2 0.0233278
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.02321
GPHN gephyrin 0.0225448
PLEC plectin 0.0223718
TRIP12 thyroid hormone receptor interactor 12 0.0223215
TOP2B topoisomerase (DNA) II beta 180kDa 0.0215876
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0215337
H1-4 H1.4 linker histone, cluster member 0.0215202
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0214433
EIF5 eukaryotic translation initiation factor 5 0.0213589
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0211504
KIF1B kinesin family member 1B 0.0211178
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0210506
MATR3 matrin 3 0.0206082
KIF5B kinesin family member 5B 0.0204771
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0201575
PDIA3 protein disulfide isomerase family A, member 3 0.0201569
ARL15 ADP-ribosylation factor-like 15 0.0199491
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0199319
UBA2 ubiquitin-like modifier activating enzyme 2 0.019498
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0194757
PARD3B par-3 family cell polarity regulator beta 0.019435
TNRC6A trinucleotide repeat containing 6A 0.019409
NCKAP1 NCK-associated protein 1 0.0193556
TM9SF2 transmembrane 9 superfamily member 2 0.0192965
GARS1 glycyl-tRNA synthetase 1 0.019265
PCM1 pericentriolar material 1 0.0191372
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0190906
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0189747
SAMD12 sterile alpha motif domain containing 12 0.0187809
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0187221
RPL3 ribosomal protein L3 0.0185754
KLC1 kinesin light chain 1 0.0182408
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0182166
CALR calreticulin 0.0181937
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0180684
RBM39 RNA binding motif protein 39 0.018056
PDE4D phosphodiesterase 4D, cAMP-specific 0.0179447
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0177435
XPO1 exportin 1 0.0176891
CARD16 caspase recruitment domain family, member 16 0.0176838
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.017679
PKP4 plakophilin 4 0.0176378
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0176184
RAD23B RAD23 homolog B (S. cerevisiae) 0.0175894
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0171929
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0171885
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0171757
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0171351
NAMPT nicotinamide phosphoribosyltransferase 0.0171046
USP6NL USP6 N-terminal like 0.0169354
SFPQ splicing factor proline/glutamine-rich 0.0168839
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0168715
PELI1 pellino E3 ubiquitin protein ligase 1 0.0168229
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0167326
IQGAP1 IQ motif containing GTPase activating protein 1 0.0165771
KMT2C lysine (K)-specific methyltransferase 2C 0.0165252
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0164794
RAB6A RAB6A, member RAS oncogene family 0.0164682
TRIM44 tripartite motif containing 44 0.0164308
SHROOM3 shroom family member 3 0.0163936
TBC1D5 TBC1 domain family, member 5 0.0162772
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0162512
CEP192 centrosomal protein 192kDa 0.0162182
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0162057
CAMKMT calmodulin-lysine N-methyltransferase 0.0161282
NUP153 nucleoporin 153kDa 0.0159064
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0158858
MYO6 myosin VI 0.0158836
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 0.0157704
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0156735
SLK STE20-like kinase 0.0156128
SCARB2 scavenger receptor class B, member 2 0.0156017
TMED2 transmembrane emp24 domain trafficking protein 2 0.0155871

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.301834
TMSB10 thymosin beta 10 -0.193455
NDRG1 N-myc downstream regulated 1 -0.187257
TPT1 tumor protein, translationally-controlled 1 -0.158103
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.145634
ERRFI1 ERBB receptor feedback inhibitor 1 -0.121517
EGR1 early growth response 1 -0.0995511
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0990077
RPS8 ribosomal protein S8 -0.0949598
RPL35A ribosomal protein L35a -0.0837553
RPS6 ribosomal protein S6 -0.0741455
TBC1D22A TBC1 domain family, member 22A -0.07388
SERINC5 serine incorporator 5 -0.0709764
MT2A metallothionein 2A -0.0672076
INTS6 integrator complex subunit 6 -0.0668803
PATJ PATJ crumbs cell polarity complex component -0.0641358
MCL1 myeloid cell leukemia 1 -0.0595305
RPLP0 ribosomal protein, large, P0 -0.0572151
RPL34 ribosomal protein L34 -0.0560118
PKM pyruvate kinase, muscle -0.054183
RPLP1 ribosomal protein, large, P1 -0.0525455
ACTG1 actin gamma 1 -0.0525073
CTBP2 C-terminal binding protein 2 -0.0511201
HMGA1 high mobility group AT-hook 1 -0.0504853
POTEF POTE ankyrin domain family, member F -0.050377
S100A9 S100 calcium binding protein A9 -0.0500183
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0485715
RPS24 ribosomal protein S24 -0.0485268
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0482192
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.047959
LDHA lactate dehydrogenase A -0.0473934
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.047382
KRT19 keratin 19, type I -0.046327
RPL23 ribosomal protein L23 -0.0456092
RPLP2 ribosomal protein, large, P2 -0.0454855
LRRC23 leucine rich repeat containing 23 -0.0432991
RPS13 ribosomal protein S13 -0.0426005
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0424812
RAD51B RAD51 paralog B -0.0418685
RPS21 ribosomal protein S21 -0.0417033
SLC38A2 solute carrier family 38, member 2 -0.0413634
RACK1 receptor for activated C kinase 1 -0.0413062
RPL37A ribosomal protein L37a -0.0410175
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0406562
RPS19 ribosomal protein S19 -0.0405552
RPS25 ribosomal protein S25 -0.0391066
SCARB1 scavenger receptor class B, member 1 -0.0388916
CEMIP2 cell migration inducing hyaluronidase 2 -0.0388467
KRT18 keratin 18, type I -0.0388074
RPL32 ribosomal protein L32 -0.038618
S100A6 S100 calcium binding protein A6 -0.0385279
TPM4 tropomyosin 4 -0.037849
HMGB1 high mobility group box 1 -0.0375174
TUBA1B tubulin, alpha 1b -0.0374881
ANKRD12 ankyrin repeat domain 12 -0.0369273
HLA-A major histocompatibility complex, class I, A -0.0368108
RPL31 ribosomal protein L31 -0.0367143
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0362738
RPL26 ribosomal protein L26 -0.0358343
RPS3 ribosomal protein S3 -0.0357282
RPL7A ribosomal protein L7a -0.0348031
VCL vinculin -0.0342306
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0337953
IFITM3 interferon induced transmembrane protein 3 -0.0337917
RPL18 ribosomal protein L18 -0.0332441
RPL11 ribosomal protein L11 -0.0331511
KDM4C lysine (K)-specific demethylase 4C -0.0330115
S100A10 S100 calcium binding protein A10 -0.0327397
RPL37 ribosomal protein L37 -0.0323195
JUN jun proto-oncogene -0.0321685
HDLBP high density lipoprotein binding protein -0.0320063
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0319758
RPL7 ribosomal protein L7 -0.0318406
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0312061
SLC38A1 solute carrier family 38, member 1 -0.03099
RPS29 ribosomal protein S29 -0.0309799
HMGA2 high mobility group AT-hook 2 -0.0307279
LMNA lamin A/C -0.0306778
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0303183
SPDYA speedy/RINGO cell cycle regulator family member A -0.0303151
RPS14 ribosomal protein S14 -0.0302037
MYO1E myosin IE -0.0301529
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0300368
PERP PERP, TP53 apoptosis effector -0.0299866
RPS16 ribosomal protein S16 -0.0297342
RSF1 remodeling and spacing factor 1 -0.0296239
RPL9 ribosomal protein L9 -0.0296151
RPL27A ribosomal protein L27a -0.0293855
RPS11 ribosomal protein S11 -0.0293762
GNAS GNAS complex locus -0.0292376
TUBB tubulin, beta class I -0.0290114
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0289472
SDC4 syndecan 4 -0.028926
KLF6 Kruppel-like factor 6 -0.028871
TGFB1 transforming growth factor, beta 1 -0.0288512
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0287656
RPS15 ribosomal protein S15 -0.0286316
RPS27A ribosomal protein S27a -0.028468
TUBB4B tubulin, beta 4B class IVb -0.0284293
VEGFA vascular endothelial growth factor A -0.0282302