| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pyridoxine (hydrochloride) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pyridoxine (hydrochloride)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.476095 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0797663 |
| CDH13 | cadherin 13 | 0.0697483 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0536778 |
| VEGFA | vascular endothelial growth factor A | 0.052809 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.046888 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0439854 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0424904 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0408285 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0389499 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0380808 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0375551 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0361056 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0353245 |
| HDAC9 | histone deacetylase 9 | 0.0336584 |
| FBN1 | fibrillin 1 | 0.0332589 |
| GLIS3 | GLIS family zinc finger 3 | 0.0329335 |
| DST | dystonin | 0.031373 |
| VCL | vinculin | 0.0305961 |
| INTS6 | integrator complex subunit 6 | 0.0282278 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0280467 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0275325 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0269908 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0263429 |
| HMGA2 | high mobility group AT-hook 2 | 0.0263257 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0257951 |
| PLEC | plectin | 0.0257709 |
| FLNA | filamin A, alpha | 0.0250544 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0248583 |
| TLE4 | transducin-like enhancer of split 4 | 0.024827 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0239997 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0239771 |
| EGFR | epidermal growth factor receptor | 0.0235629 |
| NEK10 | NIMA-related kinase 10 | 0.0219166 |
| MSN | moesin | 0.0218692 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0216379 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0214751 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0201933 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0198826 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0193136 |
| GOLGB1 | golgin B1 | 0.0192889 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0186462 |
| NABP1 | nucleic acid binding protein 1 | 0.0185879 |
| MYO10 | myosin X | 0.0185692 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0185188 |
| FERMT2 | fermitin family member 2 | 0.0178246 |
| JAG1 | jagged 1 | 0.0177455 |
| DSPP | dentin sialophosphoprotein | 0.0177217 |
| BRD2 | bromodomain containing 2 | 0.0172951 |
| ATXN1 | ataxin 1 | 0.0172508 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0169783 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0168077 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.016793 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0164104 |
| EPHB1 | EPH receptor B1 | 0.0162564 |
| ARHGAP24 | Rho GTPase activating protein 24 | 0.015933 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0158623 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0157871 |
| HYOU1 | hypoxia up-regulated 1 | 0.0154555 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0153559 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0153371 |
| VMP1 | vacuole membrane protein 1 | 0.0153366 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0152708 |
| CYTH3 | cytohesin 3 | 0.0149428 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0147799 |
| KLF12 | Kruppel-like factor 12 | 0.0147441 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0146773 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0146348 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0145916 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0143749 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0143241 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0142056 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0137012 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.013642 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0134182 |
| STC2 | stanniocalcin 2 | 0.0133319 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0132278 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.013222 |
| MRTFA | myocardin related transcription factor A | 0.0130974 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0130822 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0130246 |
| ITGA11 | integrin, alpha 11 | 0.0129886 |
| RAD51B | RAD51 paralog B | 0.0129868 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0129759 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0128303 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0128236 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0127847 |
| ZMYM4 | zinc finger, MYM-type 4 | 0.0127277 |
| EXOC6B | exocyst complex component 6B | 0.0127174 |
| ANXA1 | annexin A1 | 0.0126914 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | 0.0123796 |
| KCTD16 | potassium channel tetramerization domain containing 16 | 0.012261 |
| SETBP1 | SET binding protein 1 | 0.0122598 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.0122307 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0119127 |
| GATAD2A | GATA zinc finger domain containing 2A | 0.0118331 |
| NAV3 | neuron navigator 3 | 0.011823 |
| RCOR1 | REST corepressor 1 | 0.0117899 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | 0.0117844 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0117783 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.235068 |
| COL1A1 | collagen, type I, alpha 1 | -0.208484 |
| VIM | vimentin | -0.196473 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.177236 |
| FN1 | fibronectin 1 | -0.166938 |
| MT2A | metallothionein 2A | -0.157247 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.151128 |
| TMSB10 | thymosin beta 10 | -0.128706 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.100159 |
| NDRG1 | N-myc downstream regulated 1 | -0.0952368 |
| LOXL2 | lysyl oxidase-like 2 | -0.0897364 |
| RPL35A | ribosomal protein L35a | -0.0844839 |
| IER3 | immediate early response 3 | -0.0832141 |
| LDHA | lactate dehydrogenase A | -0.0810286 |
| COL1A2 | collagen, type I, alpha 2 | -0.078927 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0690588 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0685441 |
| STC1 | stanniocalcin 1 | -0.0680386 |
| RPS8 | ribosomal protein S8 | -0.0634853 |
| CD44 | CD44 molecule (Indian blood group) | -0.0617353 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.060797 |
| TPM4 | tropomyosin 4 | -0.0606911 |
| ENO1 | enolase 1, (alpha) | -0.0596626 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0583253 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0566303 |
| PTMA | prothymosin, alpha | -0.0557066 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0518829 |
| FTL | ferritin, light polypeptide | -0.0518449 |
| HLA-B | major histocompatibility complex, class I, B | -0.0509076 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0494637 |
| ATP13A3 | ATPase type 13A3 | -0.048354 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0479535 |
| S100A9 | S100 calcium binding protein A9 | -0.0474016 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0460753 |
| RRBP1 | ribosome binding protein 1 | -0.0444373 |
| B2M | beta-2-microglobulin | -0.0444073 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0442847 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0437829 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0433861 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0421943 |
| ANXA2 | annexin A2 | -0.0401913 |
| ACTG1 | actin gamma 1 | -0.0399586 |
| PGK1 | phosphoglycerate kinase 1 | -0.0391787 |
| RPL11 | ribosomal protein L11 | -0.0387105 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0386642 |
| INHBA | inhibin, beta A | -0.0378151 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0371568 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0364322 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0362654 |
| RPL23 | ribosomal protein L23 | -0.0355422 |
| RPL26 | ribosomal protein L26 | -0.0352605 |
| S100A6 | S100 calcium binding protein A6 | -0.0351134 |
| RPL34 | ribosomal protein L34 | -0.034501 |
| RPLP1 | ribosomal protein, large, P1 | -0.0336351 |
| TMSB4X | thymosin beta 4, X-linked | -0.0329204 |
| GNAS | GNAS complex locus | -0.0325254 |
| RAB2A | RAB2A, member RAS oncogene family | -0.032069 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0320382 |
| CANX | calnexin | -0.0319049 |
| RTN4 | reticulon 4 | -0.0318002 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0316613 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0314525 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0314163 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0309864 |
| CAVIN1 | caveolae associated protein 1 | -0.0306751 |
| OSMR | oncostatin M receptor | -0.0304314 |
| SEPTIN7 | septin 7 | -0.0303747 |
| RPL30 | ribosomal protein L30 | -0.0299884 |
| RACK1 | receptor for activated C kinase 1 | -0.0299776 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0298132 |
| RPS24 | ribosomal protein S24 | -0.029024 |
| RPL7 | ribosomal protein L7 | -0.0288516 |
| RPL12 | ribosomal protein L12 | -0.0288482 |
| IL6 | interleukin 6 | -0.028493 |
| PDE10A | phosphodiesterase 10A | -0.0284668 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0277602 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.027513 |
| RPS19 | ribosomal protein S19 | -0.0273624 |
| RPS21 | ribosomal protein S21 | -0.0269673 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0268051 |
| RPS20 | ribosomal protein S20 | -0.0268002 |
| COL3A1 | collagen, type III, alpha 1 | -0.0263743 |
| RPL28 | ribosomal protein L28 | -0.02635 |
| RPLP0 | ribosomal protein, large, P0 | -0.0261427 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0261183 |
| MT1X | metallothionein 1X | -0.025978 |
| RPS13 | ribosomal protein S13 | -0.0259461 |
| RPL8 | ribosomal protein L8 | -0.0257285 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.025588 |
| RPS6 | ribosomal protein S6 | -0.0255132 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0253854 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0253299 |
| RPL19 | ribosomal protein L19 | -0.0252214 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0248395 |
| CADM1 | cell adhesion molecule 1 | -0.0246815 |
| RPS5 | ribosomal protein S5 | -0.0244275 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0243769 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0243601 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0240511 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0239491 |
