Pyridoxine (hydrochloride)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pyridoxine (hydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Pyridoxine (hydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DSPP dentin sialophosphoprotein 0.185439
FN1 fibronectin 1 0.183931
SAMD4A sterile alpha motif domain containing 4A 0.145262
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.132931
C3 complement component 3 0.111007
SVIL supervillin 0.109043
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.106835
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0942766
EHBP1 EH domain binding protein 1 0.090717
DST dystonin 0.0859492
FAT1 FAT atypical cadherin 1 0.0706211
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0689667
GPC6 glypican 6 0.0681176
VCL vinculin 0.063144
FRMD5 FERM domain containing 5 0.0605699
PEG3 paternally expressed 3 0.0541226
MYH9 myosin, heavy chain 9, non-muscle 0.0496954
LMCD1 LIM and cysteine-rich domains 1 0.0491888
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0486898
MAML2 mastermind-like 2 (Drosophila) 0.0461661
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.044267
NKD1 naked cuticle homolog 1 (Drosophila) 0.0440051
FAM107B family with sequence similarity 107, member B 0.0436808
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0421093
FLNA filamin A, alpha 0.0401595
SLC38A2 solute carrier family 38, member 2 0.0367519
DOCK4 dedicator of cytokinesis 4 0.0365895
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0355408
ASPH aspartate beta-hydroxylase 0.0355102
RNF213 ring finger protein 213 0.0350213
ATXN1 ataxin 1 0.0344568
PTCHD4 patched domain containing 4 0.033291
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0331959
INTS6 integrator complex subunit 6 0.0328044
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0325567
LIMS1 LIM and senescent cell antigen-like domains 1 0.0323363
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0321278
LCOR ligand dependent nuclear receptor corepressor 0.0309642
RIGI RNA sensor RIG-I 0.0303188
BCL2L1 BCL2-like 1 0.0303048
FHL2 four and a half LIM domains 2 0.0302496
UBASH3B ubiquitin associated and SH3 domain containing B 0.0296664
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0295603
ABTB3 ankyrin repeat and BTB domain containing 3 0.0283906
CCN2 cellular communication network factor 2 0.0280633
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0279893
ITGA6 integrin, alpha 6 0.0276085
PDLIM5 PDZ and LIM domain 5 0.0274962
RAD51B RAD51 paralog B 0.0273996
VMP1 vacuole membrane protein 1 0.0271739
MCL1 myeloid cell leukemia 1 0.0270041
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0264969
SRRM2 serine/arginine repetitive matrix 2 0.0261302
ANO6 anoctamin 6 0.0261095
OSBPL10 oxysterol binding protein-like 10 0.0260563
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0259944
DNAH17 dynein, axonemal, heavy chain 17 0.0258121
THBS1 thrombospondin 1 0.0256015
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.025487
MACF1 microtubule-actin crosslinking factor 1 0.0249365
KRT23 keratin 23, type I 0.0248231
ALPK2 alpha-kinase 2 0.0248221
GRB10 growth factor receptor-bound protein 10 0.0247463
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0244262
SORBS1 sorbin and SH3 domain containing 1 0.0243872
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0243789
ZBTB38 zinc finger and BTB domain containing 38 0.0242725
FLNB filamin B, beta 0.024211
UBC ubiquitin C 0.0241466
SP100 SP100 nuclear antigen 0.0240627
AHNAK AHNAK nucleoprotein 0.0239578
JUN jun proto-oncogene 0.0236616
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0229358
FOXP1 forkhead box P1 0.0228452
TBC1D5 TBC1 domain family, member 5 0.0225522
EXT1 exostosin glycosyltransferase 1 0.0224036
MYO1E myosin IE 0.0223843
APLP2 amyloid beta (A4) precursor-like protein 2 0.0223811
CTSB cathepsin B 0.0222111
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0219959
RASA2 RAS p21 protein activator 2 0.0219851
TPM1 tropomyosin 1 (alpha) 0.0218483
MBNL2 muscleblind-like splicing regulator 2 0.0218041
LMO7 LIM domain 7 0.021562
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0212418
LPP LIM domain containing preferred translocation partner in lipoma 0.0210231
KALRN kalirin, RhoGEF kinase 0.0208401
BCAR3 breast cancer anti-estrogen resistance 3 0.0207458
EXOC6B exocyst complex component 6B 0.0205307
GLIPR1 GLI pathogenesis-related 1 0.0204011
UTRN utrophin 0.0203946
MYO5B myosin VB 0.020385
RUNX1 runt-related transcription factor 1 0.0201643
TLE4 transducin-like enhancer of split 4 0.0201077
FERMT2 fermitin family member 2 0.0199671
FMNL2 formin-like 2 0.0199649
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0197346
TNS3 tensin 3 0.0196634
JAG1 jagged 1 0.0196346
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0194189

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.155537
FNDC3B fibronectin type III domain containing 3B -0.154147
TPT1 tumor protein, translationally-controlled 1 -0.146211
RPS6 ribosomal protein S6 -0.113654
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0922726
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0863545
MT2A metallothionein 2A -0.0856955
GPC3 glypican 3 -0.0850549
APOA2 apolipoprotein A-II -0.0826037
RPLP1 ribosomal protein, large, P1 -0.0823099
RPL37A ribosomal protein L37a -0.0740246
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0735686
RPS24 ribosomal protein S24 -0.071544
RPL35A ribosomal protein L35a -0.0704647
RPL11 ribosomal protein L11 -0.0698692
ZMYND8 zinc finger, MYND-type containing 8 -0.0697089
FTL ferritin, light polypeptide -0.0670473
AHSG alpha-2-HS-glycoprotein -0.0668288
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0657313
RPS8 ribosomal protein S8 -0.0654238
RPS12 ribosomal protein S12 -0.0650666
RPL34 ribosomal protein L34 -0.0641708
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0631548
RPLP0 ribosomal protein, large, P0 -0.0607476
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0601954
EML4 echinoderm microtubule associated protein like 4 -0.0598344
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0574692
RPS19 ribosomal protein S19 -0.0572116
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0566297
NAP1L1 nucleosome assembly protein 1-like 1 -0.0555233
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0548219
RPL31 ribosomal protein L31 -0.053972
TMSB10 thymosin beta 10 -0.0535295
GNAS GNAS complex locus -0.0534081
ERRFI1 ERBB receptor feedback inhibitor 1 -0.05317
RBM39 RNA binding motif protein 39 -0.0531678
WDR45B WD repeat domain 45B -0.0497741
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0487425
AFDN afadin, adherens junction formation factor -0.0477099
NDRG1 N-myc downstream regulated 1 -0.047208
RPL23 ribosomal protein L23 -0.0470579
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0465568
HMGA1 high mobility group AT-hook 1 -0.0465299
RPL37 ribosomal protein L37 -0.0464714
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0460882
APOE apolipoprotein E -0.0458994
RPL9 ribosomal protein L9 -0.0452931
FBF1 Fas (TNFRSF6) binding factor 1 -0.0440944
SDC4 syndecan 4 -0.0437298
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0426573
RACK1 receptor for activated C kinase 1 -0.0424973
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0422878
AMBP alpha-1-microglobulin/bikunin precursor -0.0420081
IGF2 insulin-like growth factor 2 -0.0409131
RPS21 ribosomal protein S21 -0.0408815
RAB1A RAB1A, member RAS oncogene family -0.040848
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0408301
GDF15 growth differentiation factor 15 -0.0407759
DDIT4 DNA-damage-inducible transcript 4 -0.0406074
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0396252
RPS27A ribosomal protein S27a -0.0396005
IGFBP1 insulin-like growth factor binding protein 1 -0.0394841
SLC38A1 solute carrier family 38, member 1 -0.0394183
RPS3 ribosomal protein S3 -0.0394086
BIRC6 baculoviral IAP repeat containing 6 -0.0391307
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0390687
RPS29 ribosomal protein S29 -0.0386397
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0383776
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0383173
RPL12 ribosomal protein L12 -0.0367785
RRBP1 ribosome binding protein 1 -0.0367682
ELL2 elongation factor, RNA polymerase II, 2 -0.0365039
KDM3A lysine (K)-specific demethylase 3A -0.036253
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0362276
RPS23 ribosomal protein S23 -0.0360023
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0356819
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0356479
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0355358
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0352696
MSI2 musashi RNA-binding protein 2 -0.0347776
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0345639
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0344732
PERP PERP, TP53 apoptosis effector -0.0344483
INSIG2 insulin induced gene 2 -0.0342479
LDHA lactate dehydrogenase A -0.0335064
SESTD1 SEC14 and spectrin domains 1 -0.0332824
CP ceruloplasmin (ferroxidase) -0.033088
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0328558
GOLGA4 golgin A4 -0.0322464
RPL28 ribosomal protein L28 -0.0321577
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0320227
TRIM26 tripartite motif containing 26 -0.0317081
RPL26 ribosomal protein L26 -0.0312381
ZFAND3 zinc finger, AN1-type domain 3 -0.0309909
BHLHE40 basic helix-loop-helix family, member e40 -0.0308514
RPL10A ribosomal protein L10a -0.0305026
RPS25 ribosomal protein S25 -0.0302548
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0297935
RBM25 RNA binding motif protein 25 -0.0295448
IER3 immediate early response 3 -0.029428