| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pyridoxine (hydrochloride) perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pyridoxine (hydrochloride)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.284691 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.162141 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.156627 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.106934 |
| FLNA | filamin A, alpha | 0.0739497 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0650544 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0610197 |
| MT2A | metallothionein 2A | 0.0591301 |
| ERBIN | erbb2 interacting protein | 0.053188 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0515068 |
| RPS6 | ribosomal protein S6 | 0.05146 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0501718 |
| TXNRD1 | thioredoxin reductase 1 | 0.0484899 |
| ENO1 | enolase 1, (alpha) | 0.0472085 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0426255 |
| MSN | moesin | 0.0425871 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0399142 |
| CD44 | CD44 molecule (Indian blood group) | 0.0398135 |
| INTS6 | integrator complex subunit 6 | 0.0364495 |
| ADM | adrenomedullin | 0.035809 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0356541 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0352531 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0350818 |
| ASPH | aspartate beta-hydroxylase | 0.0339042 |
| MT1X | metallothionein 1X | 0.0337262 |
| SP100 | SP100 nuclear antigen | 0.033317 |
| MKI67 | marker of proliferation Ki-67 | 0.0328262 |
| CALR | calreticulin | 0.032727 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0322633 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0317437 |
| PLK2 | polo-like kinase 2 | 0.031674 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0311686 |
| VCL | vinculin | 0.0311638 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0311266 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0309986 |
| CALD1 | caldesmon 1 | 0.0308688 |
| DST | dystonin | 0.030249 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0293743 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0293003 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0285367 |
| ACTG1 | actin gamma 1 | 0.0281882 |
| TPM3 | tropomyosin 3 | 0.027009 |
| THBS1 | thrombospondin 1 | 0.0269639 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0268321 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0268095 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.026662 |
| LMO7 | LIM domain 7 | 0.0265134 |
| MCL1 | myeloid cell leukemia 1 | 0.0263809 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.026348 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0258815 |
| VIM | vimentin | 0.0255249 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0251992 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | 0.0244989 |
| VMP1 | vacuole membrane protein 1 | 0.0242465 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0242021 |
| LIMA1 | LIM domain and actin binding 1 | 0.0241356 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0238825 |
| MAP1B | microtubule-associated protein 1B | 0.0237672 |
| SET | SET nuclear proto-oncogene | 0.0233827 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0230114 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0229588 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0221075 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0220005 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0219385 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.021837 |
| VGLL3 | vestigial-like family member 3 | 0.0216614 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0215877 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0214214 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0213565 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0212074 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0209994 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0206597 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.0204728 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0204227 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0200682 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0200387 |
| BRD2 | bromodomain containing 2 | 0.0200311 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0197224 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0196776 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0195736 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0193642 |
| CLIC4 | chloride intracellular channel 4 | 0.0191741 |
| SON | SON DNA binding protein | 0.019172 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0191307 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0189471 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0186103 |
| ACTN1 | actinin, alpha 1 | 0.0184228 |
| RPS17 | ribosomal protein S17 | 0.0183548 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0183027 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0181732 |
| TLN1 | talin 1 | 0.0180935 |
| MTAP | methylthioadenosine phosphorylase | 0.0180352 |
| CDCP1 | CUB domain containing protein 1 | 0.0180038 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0174814 |
| BPTF | bromodomain PHD finger transcription factor | 0.0174466 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.017289 |
| WWOX | WW domain containing oxidoreductase | 0.0171919 |
| STIP1 | stress-induced phosphoprotein 1 | 0.0171911 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0171468 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0170756 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NALF1 | NALCN channel auxiliary factor 1 | -0.226307 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.202549 |
| FN1 | fibronectin 1 | -0.174901 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.160917 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.124021 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.116486 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.116393 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0851834 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0841317 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0815835 |
| SLC12A8 | solute carrier family 12, member 8 | -0.0807329 |
| ATP13A3 | ATPase type 13A3 | -0.0725016 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0715656 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0663921 |
| HLA-B | major histocompatibility complex, class I, B | -0.0659905 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0649957 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0567091 |
| PLCB4 | phospholipase C, beta 4 | -0.0549803 |
| NDRG1 | N-myc downstream regulated 1 | -0.0537374 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0522793 |
| CCBE1 | collagen and calcium binding EGF domains 1 | -0.0512369 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.049817 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0484215 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0464631 |
| MMP12 | matrix metallopeptidase 12 | -0.045399 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0449548 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.044632 |
| DTNA | dystrobrevin, alpha | -0.0428289 |
| ZNF432 | zinc finger protein 432 | -0.0428124 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0426201 |
| DEK | DEK proto-oncogene | -0.0425312 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0411545 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0408633 |
| LDHA | lactate dehydrogenase A | -0.0405973 |
| GLIS3 | GLIS family zinc finger 3 | -0.0394942 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.0386246 |
| SULF1 | sulfatase 1 | -0.0385912 |
| NUP58 | nucleoporin 58 | -0.0379973 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0366356 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0365814 |
| ANXA2 | annexin A2 | -0.0354864 |
| COL5A1 | collagen, type V, alpha 1 | -0.0353385 |
| FNIP1 | folliculin interacting protein 1 | -0.0346324 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.0343607 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.034333 |
| YEATS2 | YEATS domain containing 2 | -0.0336941 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0336257 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0328364 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0326457 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0316692 |
| HLA-C | major histocompatibility complex, class I, C | -0.0314336 |
| COL5A2 | collagen, type V, alpha 2 | -0.0310204 |
| POSTN | periostin, osteoblast specific factor | -0.0300879 |
| CTSD | cathepsin D | -0.0299866 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0295385 |
| RBM39 | RNA binding motif protein 39 | -0.0293328 |
| TUBB | tubulin, beta class I | -0.0286053 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0279617 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.027633 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0273583 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.0273458 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0272866 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0272514 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0269692 |
| SBF2 | SET binding factor 2 | -0.0261715 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0261111 |
| PGK1 | phosphoglycerate kinase 1 | -0.0260864 |
| ZFR | zinc finger RNA binding protein | -0.0254123 |
| PLIN2 | perilipin 2 | -0.0254055 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0253784 |
| TNS3 | tensin 3 | -0.0253514 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0251466 |
| CADM1 | cell adhesion molecule 1 | -0.0248487 |
| ANKRD33B | ankyrin repeat domain 33B | -0.024845 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0247924 |
| CAST | calpastatin | -0.0244884 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0244259 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0244059 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0243218 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0241917 |
| FAR1 | fatty acyl CoA reductase 1 | -0.0239066 |
| TMEM165 | transmembrane protein 165 | -0.0238966 |
| RPL35A | ribosomal protein L35a | -0.0236844 |
| BBX | bobby sox homolog (Drosophila) | -0.0236473 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.023591 |
| DIPK2A | divergent protein kinase domain 2A | -0.0235754 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0235163 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0235112 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0233957 |
| RAI14 | retinoic acid induced 14 | -0.0233383 |
| AFAP1 | actin filament associated protein 1 | -0.0232904 |
| TMEM178B | transmembrane protein 178B | -0.023286 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0232674 |
| TPD52 | tumor protein D52 | -0.0231963 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0231761 |
| OSMR | oncostatin M receptor | -0.0231524 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0230949 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0229666 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0229312 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0226421 |
