Pyridoxine (hydrochloride)_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pyridoxine (hydrochloride) perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pyridoxine (hydrochloride)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0841349
CEMIP cell migration inducing protein, hyaluronan binding 0.0482173
VCL vinculin 0.0461878
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0399235
MYO1E myosin IE 0.0367014
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0332416
ONECUT3 one cut homeobox 3 0.0328848
H1-0 H1.0 linker histone 0.0323882
LAMA4 laminin, alpha 4 0.0235321
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0232711
CAB39 calcium binding protein 39 0.0203548
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0191464
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0190795
PKP2 plakophilin 2 0.0190309
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0179027
MYH9 myosin, heavy chain 9, non-muscle 0.0176327
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0175016
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0170772
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0170611
AXIN2 axin 2 0.0168305
HSPA8 heat shock 70kDa protein 8 0.0167961
SOX9 SRY (sex determining region Y)-box 9 0.0167638
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0164916
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0163634
CADPS Ca++-dependent secretion activator 0.0159166
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0145722
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0143925
PLEC plectin 0.0140246
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0138024
FLNA filamin A, alpha 0.013624
ECT2 epithelial cell transforming 2 0.0135297
H1-4 H1.4 linker histone, cluster member 0.0133403
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0131903
SVIL supervillin 0.0128873
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.0126174
FOXP1 forkhead box P1 0.0125421
ATP10B ATPase, class V, type 10B 0.0124963
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 0.0123007
ANTXR2 anthrax toxin receptor 2 0.0121841
SHB Src homology 2 domain containing adaptor protein B 0.0121518
KLF6 Kruppel-like factor 6 0.011966
CAPRIN1 cell cycle associated protein 1 0.0117399
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0117059
FHIT fragile histidine triad 0.0116151
RAD51B RAD51 paralog B 0.0115742
AKAP13 A kinase (PRKA) anchor protein 13 0.0114699
EGFR epidermal growth factor receptor 0.0114694
USP6NL USP6 N-terminal like 0.0114427
NKD1 naked cuticle homolog 1 (Drosophila) 0.0110974
RESF1 retroelement silencing factor 1 0.0110659
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0110068
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0107274
PDE4D phosphodiesterase 4D, cAMP-specific 0.010606
MTAP methylthioadenosine phosphorylase 0.0105876
MACF1 microtubule-actin crosslinking factor 1 0.0105655
RNF217 ring finger protein 217 0.0105039
EPHA4 EPH receptor A4 0.0104763
LURAP1L leucine rich adaptor protein 1-like 0.0103478
GMDS GDP-mannose 4,6-dehydratase 0.0103197
TNRC18 trinucleotide repeat containing 18 0.0102155
NCEH1 neutral cholesterol ester hydrolase 1 0.0100908
ARHGAP42 Rho GTPase activating protein 42 0.0100869
TPM1 tropomyosin 1 (alpha) 0.00998318
ZNF770 zinc finger protein 770 0.00994482
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.00988
DST dystonin 0.00968725
NCAPG2 non-SMC condensin II complex, subunit G2 0.00963166
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.00944383
SON SON DNA binding protein 0.00941954
EIF5 eukaryotic translation initiation factor 5 0.00941858
ZC3H12B zinc finger CCCH-type containing 12B 0.00928328
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.00922268
ANXA3 annexin A3 0.00920637
PSD3 pleckstrin and Sec7 domain containing 3 0.00912774
CD44 CD44 molecule (Indian blood group) 0.00911658
MACROD2 MACRO domain containing 2 0.00903957
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.00903675
MPRIP myosin phosphatase Rho interacting protein 0.00902232
ASPH aspartate beta-hydroxylase 0.00899503
PCDH9 protocadherin 9 0.00876957
RBBP6 retinoblastoma binding protein 6 0.00872562
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.00871257
HMGA2 high mobility group AT-hook 2 0.00861635
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 0.00848192
ZBTB38 zinc finger and BTB domain containing 38 0.00833997
SAMD5 sterile alpha motif domain containing 5 0.0083299
BBS9 Bardet-Biedl syndrome 9 0.00832694
PDE10A phosphodiesterase 10A 0.00824426
ABR active BCR-related 0.00823789
LTBP1 latent transforming growth factor beta binding protein 1 0.00815276
AEBP2 AE binding protein 2 0.00814128
AKAP12 A kinase (PRKA) anchor protein 12 0.0080545
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.00798334
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.00779177
STK38L serine/threonine kinase 38 like 0.00779016
SIM2 single-minded family bHLH transcription factor 2 0.00775371
LAMC2 laminin, gamma 2 0.00771176
TUFT1 tuftelin 1 0.00769576
VMP1 vacuole membrane protein 1 0.00766473
SPIDR scaffolding protein involved in DNA repair 0.00763718

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.206023
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.205525
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.179616
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.177118
TMSB10 thymosin beta 10 -0.175613
TPT1 tumor protein, translationally-controlled 1 -0.11539
RPL35A ribosomal protein L35a -0.112043
MUC6 mucin 6, oligomeric mucus/gel-forming -0.106325
LDHA lactate dehydrogenase A -0.0996464
RPLP1 ribosomal protein, large, P1 -0.0891982
RPS8 ribosomal protein S8 -0.0859941
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0817754
RPS6 ribosomal protein S6 -0.0760248
NDRG1 N-myc downstream regulated 1 -0.073904
FTL ferritin, light polypeptide -0.0714089
ANXA2 annexin A2 -0.0683631
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0674773
RPL34 ribosomal protein L34 -0.066029
GOLGA4 golgin A4 -0.0659833
RPS19 ribosomal protein S19 -0.0644361
S100A6 S100 calcium binding protein A6 -0.0618773
EIF1 eukaryotic translation initiation factor 1 -0.0611233
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0611214
ENO1 enolase 1, (alpha) -0.0602255
RPL37A ribosomal protein L37a -0.0584207
S100P S100 calcium binding protein P -0.0573166
PGK1 phosphoglycerate kinase 1 -0.0569955
RPL23 ribosomal protein L23 -0.0564017
PKM pyruvate kinase, muscle -0.0560211
RPL9 ribosomal protein L9 -0.0552932
RPS23 ribosomal protein S23 -0.0545527
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0535195
RPS24 ribosomal protein S24 -0.0534887
FTH1 ferritin, heavy polypeptide 1 -0.051683
RPL31 ribosomal protein L31 -0.0514666
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0509653
RPS27A ribosomal protein S27a -0.0506227
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0505861
TXNIP thioredoxin interacting protein -0.050519
RPS29 ribosomal protein S29 -0.0496748
RPL26 ribosomal protein L26 -0.0492096
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.048932
AHNAK AHNAK nucleoprotein -0.0488909
LOC112694756 uncharaterized LOC112694756 -0.0483569
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0479078
EEF2 eukaryotic translation elongation factor 2 -0.046876
TTC3 tetratricopeptide repeat domain 3 -0.0467807
RPL7 ribosomal protein L7 -0.0463947
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0457661
RPL11 ribosomal protein L11 -0.0457557
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0453284
RPS3 ribosomal protein S3 -0.0441189
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0439451
RPL36 ribosomal protein L36 -0.0438571
RPLP2 ribosomal protein, large, P2 -0.0438092
RPS13 ribosomal protein S13 -0.0436153
AGR2 anterior gradient 2 -0.0427975
FAM13A family with sequence similarity 13, member A -0.0427317
PDIA3 protein disulfide isomerase family A, member 3 -0.0423988
RPL12 ribosomal protein L12 -0.0413772
RPL19 ribosomal protein L19 -0.0411206
ESYT2 extended synaptotagmin-like protein 2 -0.0409564
MBNL2 muscleblind-like splicing regulator 2 -0.0408744
UBC ubiquitin C -0.0407293
B2M beta-2-microglobulin -0.0404665
RPS25 ribosomal protein S25 -0.0400192
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0395597
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0393289
WDR45B WD repeat domain 45B -0.039324
NCOR1 nuclear receptor corepressor 1 -0.0385692
HMGA1 high mobility group AT-hook 1 -0.0378349
RPLP0 ribosomal protein, large, P0 -0.0370971
RAB1A RAB1A, member RAS oncogene family -0.0366024
BIRC6 baculoviral IAP repeat containing 6 -0.0365221
ATP5F1B ATP synthase F1 subunit beta -0.0363964
POTEF POTE ankyrin domain family, member F -0.036318
RPL5 ribosomal protein L5 -0.0361826
BTBD9 BTB (POZ) domain containing 9 -0.0356223
RPS27 ribosomal protein S27 -0.0354603
EZR ezrin -0.0353546
RPL27A ribosomal protein L27a -0.0348378
RPS14 ribosomal protein S14 -0.0346384
ACTG1 actin gamma 1 -0.0343375
PCBP2 poly(rC) binding protein 2 -0.0343366
ZFAND3 zinc finger, AN1-type domain 3 -0.0341506
RPS16 ribosomal protein S16 -0.0341204
RPS11 ribosomal protein S11 -0.0337871
SEC31A SEC31 homolog A (S. cerevisiae) -0.0335535
RPL7A ribosomal protein L7a -0.0332973
PERP PERP, TP53 apoptosis effector -0.0332969
RPL37 ribosomal protein L37 -0.0332462
CALR calreticulin -0.0328764
PTEN phosphatase and tensin homolog -0.0328716
RPL28 ribosomal protein L28 -0.0326087
TFF3 trefoil factor 3 (intestinal) -0.0325408
RPL8 ribosomal protein L8 -0.0321932
IARS1 isoleucyl-tRNA synthetase 1 -0.0321898
RPS20 ribosomal protein S20 -0.0320602
GCC2 GRIP and coiled-coil domain containing 2 -0.0311187
PIGR polymeric immunoglobulin receptor -0.0310465