| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pyridoxine (hydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pyridoxine (hydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.172147 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.165412 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.162976 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.161774 |
| VIM | vimentin | 0.148473 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.111062 |
| IGF2 | insulin-like growth factor 2 | 0.0886036 |
| PYGL | phosphorylase, glycogen, liver | 0.0873264 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0772574 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0726257 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0710325 |
| FLNA | filamin A, alpha | 0.0664886 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0640412 |
| TPM3 | tropomyosin 3 | 0.0630499 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0609877 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0586018 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.057922 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.054712 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0535504 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0526484 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0522576 |
| GRAMD1B | GRAM domain containing 1B | 0.0509144 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0506386 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0502148 |
| DOCK5 | dedicator of cytokinesis 5 | 0.049836 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0493959 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0493641 |
| FMNL2 | formin-like 2 | 0.0486445 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0484737 |
| FGB | fibrinogen beta chain | 0.0476993 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0470893 |
| UBC | ubiquitin C | 0.0465653 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0459443 |
| ATXN1 | ataxin 1 | 0.0440269 |
| CALR | calreticulin | 0.0438667 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0434613 |
| GLIS3 | GLIS family zinc finger 3 | 0.0434428 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0429882 |
| HDGF | hepatoma-derived growth factor | 0.0422768 |
| MCL1 | myeloid cell leukemia 1 | 0.0416113 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0408164 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0406839 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0403765 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0397107 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0395236 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0394527 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0391584 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0386795 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0384752 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0383838 |
| ENO1 | enolase 1, (alpha) | 0.0383631 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0379586 |
| SVIL | supervillin | 0.0375683 |
| PDE8A | phosphodiesterase 8A | 0.0370244 |
| PKM | pyruvate kinase, muscle | 0.0358326 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0356346 |
| MSN | moesin | 0.0356105 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0353985 |
| PFN1 | profilin 1 | 0.0352829 |
| SFTPA2 | surfactant protein A2 | 0.034832 |
| PCBP2 | poly(rC) binding protein 2 | 0.0347931 |
| NEBL | nebulette | 0.0346574 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0324671 |
| KIAA0319 | KIAA0319 | 0.0320926 |
| LAMB1 | laminin, beta 1 | 0.0317759 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0315565 |
| AHR | aryl hydrocarbon receptor | 0.0314517 |
| EXOC6B | exocyst complex component 6B | 0.0313228 |
| ANXA1 | annexin A1 | 0.0309491 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0309357 |
| CLU | clusterin | 0.0305191 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.030405 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0297338 |
| S100A6 | S100 calcium binding protein A6 | 0.0296372 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0295953 |
| FLNB | filamin B, beta | 0.0295645 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0293301 |
| BRD2 | bromodomain containing 2 | 0.0290065 |
| FAM107B | family with sequence similarity 107, member B | 0.0287918 |
| RPL3 | ribosomal protein L3 | 0.0287457 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0287019 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0285538 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0285009 |
| MYOF | myoferlin | 0.028251 |
| PDE10A | phosphodiesterase 10A | 0.0282317 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0274518 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0273845 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0273798 |
| CMIP | c-Maf inducing protein | 0.0272247 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0264929 |
| S100A10 | S100 calcium binding protein A10 | 0.0264528 |
| ADM | adrenomedullin | 0.0264164 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0263713 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0262544 |
| JUN | jun proto-oncogene | 0.0260259 |
| TLN1 | talin 1 | 0.0255824 |
| SLMAP | sarcolemma associated protein | 0.0249974 |
| EXOC4 | exocyst complex component 4 | 0.0248394 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0247465 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.024691 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.244536 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0965419 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0785381 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0746082 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0675058 |
| WDR43 | WD repeat domain 43 | -0.066416 |
| RBM39 | RNA binding motif protein 39 | -0.0621516 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0598142 |
| TMSB10 | thymosin beta 10 | -0.0547257 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0509676 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0489842 |
| RPL23 | ribosomal protein L23 | -0.0482942 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0482008 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0461521 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0457006 |
| EGR1 | early growth response 1 | -0.0451361 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0436838 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0409204 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0383009 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0378193 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0376201 |
| NHSL1 | NHS-like 1 | -0.0374498 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0363147 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0362619 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0358954 |
| PARD3 | par-3 family cell polarity regulator | -0.0357773 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0357271 |
| NUP98 | nucleoporin 98kDa | -0.0356267 |
| ECT2 | epithelial cell transforming 2 | -0.0354565 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0351729 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0346748 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0344014 |
| RPLP1 | ribosomal protein, large, P1 | -0.03437 |
| ZFR | zinc finger RNA binding protein | -0.0342124 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0339865 |
| NOP58 | NOP58 ribonucleoprotein | -0.0338927 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.0338867 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0335642 |
| RPS21 | ribosomal protein S21 | -0.0330035 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0327176 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0326997 |
| EWSR1 | EWS RNA-binding protein 1 | -0.0325712 |
| RHEB | Ras homolog enriched in brain | -0.0319868 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.031923 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0319167 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0317026 |
| NRG1 | neuregulin 1 | -0.0313654 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0308551 |
| FOXO3 | forkhead box O3 | -0.0306879 |
| RAB10 | RAB10, member RAS oncogene family | -0.0306672 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0304196 |
| RPL19 | ribosomal protein L19 | -0.0301289 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0300787 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0299843 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0297419 |
| PTK2 | protein tyrosine kinase 2 | -0.0295284 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0292111 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0291676 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.028638 |
| RBM25 | RNA binding motif protein 25 | -0.0286238 |
| ZNF644 | zinc finger protein 644 | -0.0283943 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0283579 |
| TNPO1 | transportin 1 | -0.0283292 |
| TMEM87A | transmembrane protein 87A | -0.0282374 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0279977 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0275114 |
| MT2A | metallothionein 2A | -0.0273875 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0273695 |
| AK1 | adenylate kinase 1 | -0.0273046 |
| AHCTF1 | AT hook containing transcription factor 1 | -0.0264956 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0262852 |
| USP3 | ubiquitin specific peptidase 3 | -0.0262126 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0252356 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0250864 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0250772 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0248349 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0246698 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0244496 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0243101 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0239342 |
| PHF3 | PHD finger protein 3 | -0.0238355 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0237703 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0237309 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0237019 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0236147 |
| RPL4 | ribosomal protein L4 | -0.0235961 |
| GNAS | GNAS complex locus | -0.0235898 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0235873 |
| CTBP2 | C-terminal binding protein 2 | -0.0233548 |
| PFDN2 | prefoldin subunit 2 | -0.0231426 |
| RPL35A | ribosomal protein L35a | -0.0230519 |
| RPS23 | ribosomal protein S23 | -0.0228997 |
| ZNF804A | zinc finger protein 804A | -0.0228769 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0228031 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0227229 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0225467 |
| RBM33 | RNA binding motif protein 33 | -0.022466 |
| DENND4A | DENN/MADD domain containing 4A | -0.0224355 |
| RPS24 | ribosomal protein S24 | -0.0221346 |
| OLA1 | Obg-like ATPase 1 | -0.0220966 |
