| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pyridoxine (hydrochloride) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pyridoxine (hydrochloride)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.165983 |
| RIGI | RNA sensor RIG-I | 0.165586 |
| KYNU | kynureninase | 0.161723 |
| TXNRD1 | thioredoxin reductase 1 | 0.132953 |
| LAMA4 | laminin, alpha 4 | 0.132126 |
| ASPH | aspartate beta-hydroxylase | 0.113541 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.100847 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0902852 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0838168 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.0770461 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0742328 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.070418 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0701496 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0676674 |
| EGFR | epidermal growth factor receptor | 0.0670023 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0667681 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0648597 |
| PRKCA | protein kinase C, alpha | 0.0641827 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0640302 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0635162 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0616178 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0608815 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0592393 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.058237 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0581188 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0579902 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0578994 |
| IGF2 | insulin-like growth factor 2 | 0.0577985 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0569101 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0563587 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0549212 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0546614 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.05372 |
| MYOF | myoferlin | 0.0535271 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0523298 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0522613 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0513292 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0506567 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0487227 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0468334 |
| NF1 | neurofibromin 1 | 0.0464147 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0461964 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0460218 |
| PCBP2 | poly(rC) binding protein 2 | 0.0458294 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0453158 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0451108 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0450535 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.044136 |
| SBF2 | SET binding factor 2 | 0.0434323 |
| UBE3A | ubiquitin protein ligase E3A | 0.0432337 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.043068 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0422882 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0421653 |
| PTK2 | protein tyrosine kinase 2 | 0.0420507 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0420391 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0412458 |
| SEPTIN9 | septin 9 | 0.0401791 |
| CP | ceruloplasmin (ferroxidase) | 0.0396037 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0385696 |
| RPS3 | ribosomal protein S3 | 0.0380997 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0379409 |
| SMAD3 | SMAD family member 3 | 0.0378898 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0374309 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0374218 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0373166 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0372813 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0372442 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0372276 |
| DSPP | dentin sialophosphoprotein | 0.0371736 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0367486 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0367319 |
| ATP13A3 | ATPase type 13A3 | 0.0362183 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.036137 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0356229 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0354652 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0350096 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0348229 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0342596 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0342098 |
| RAD51B | RAD51 paralog B | 0.0340718 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0340294 |
| FRY | furry homolog (Drosophila) | 0.0340243 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0339173 |
| ABHD17C | abhydrolase domain containing 17C | 0.0337144 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0336434 |
| JUN | jun proto-oncogene | 0.0333281 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0332045 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0331253 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0329122 |
| RPS12 | ribosomal protein S12 | 0.0327945 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.0325255 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.032494 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0324438 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0323638 |
| AFG3L2 | AFG3-like AAA ATPase 2 | 0.0322191 |
| MCL1 | myeloid cell leukemia 1 | 0.0321414 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0320936 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0320596 |
| RBM39 | RNA binding motif protein 39 | 0.0318782 |
| MYO1E | myosin IE | 0.0318096 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | -0.130575 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.118808 |
| ATOSA | atos homolog A | -0.0748746 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0739761 |
| RBM47 | RNA binding motif protein 47 | -0.0702772 |
| SVIL | supervillin | -0.0688324 |
| VCL | vinculin | -0.0679291 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0665584 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0664668 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0662082 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0639944 |
| FOXO3 | forkhead box O3 | -0.0619335 |
| TMCC3 | transmembrane and coiled-coil domain family 3 | -0.0602125 |
| FOXO1 | forkhead box O1 | -0.0589619 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0587026 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0581183 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0570972 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.05668 |
| ZNF217 | zinc finger protein 217 | -0.0562418 |
| POTEF | POTE ankyrin domain family, member F | -0.0543042 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0540397 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0539894 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0520486 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0513754 |
| ANXA2 | annexin A2 | -0.0507561 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0488113 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0483147 |
| ANXA1 | annexin A1 | -0.0482959 |
| PRELID2 | PRELI domain containing 2 | -0.0469166 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0469006 |
| AK1 | adenylate kinase 1 | -0.0467421 |
| VCAN | versican | -0.046697 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0464544 |
| MYO6 | myosin VI | -0.0457465 |
| CLDN4 | claudin 4 | -0.0454612 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0450679 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0448125 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0444868 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0427701 |
| FNIP1 | folliculin interacting protein 1 | -0.0418387 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0416056 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0411133 |
| PALLD | palladin, cytoskeletal associated protein | -0.0410836 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0409586 |
| TMEM165 | transmembrane protein 165 | -0.0408974 |
| USP3 | ubiquitin specific peptidase 3 | -0.0406359 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0402118 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0399776 |
| GLUL | glutamate-ammonia ligase | -0.039768 |
| PSEN1 | presenilin 1 | -0.0396914 |
| TJP2 | tight junction protein 2 | -0.0383962 |
| CMIP | c-Maf inducing protein | -0.0382727 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0379221 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.03788 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0377515 |
| CDK13 | cyclin-dependent kinase 13 | -0.037735 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.0377136 |
| DENND2C | DENN/MADD domain containing 2C | -0.0376067 |
| PRSS23 | protease, serine, 23 | -0.0372889 |
| TMEM87A | transmembrane protein 87A | -0.0370906 |
| KCNH8 | potassium channel, voltage gated eag related subfamily H, member 8 | -0.0370519 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0369245 |
| OXR1 | oxidation resistance 1 | -0.0368796 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0364136 |
| CDKL5 | cyclin-dependent kinase-like 5 | -0.036186 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0361671 |
| CPEB3 | cytoplasmic polyadenylation element binding protein 3 | -0.035205 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0351803 |
| IER3 | immediate early response 3 | -0.0348744 |
| MED13 | mediator complex subunit 13 | -0.0348579 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0345619 |
| PRDM1 | PR domain containing 1, with ZNF domain | -0.0339925 |
| YME1L1 | YME1-like 1 ATPase | -0.033969 |
| LDHA | lactate dehydrogenase A | -0.0339534 |
| GLIS3 | GLIS family zinc finger 3 | -0.0337587 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0333936 |
| ERBIN | erbb2 interacting protein | -0.0332374 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0331485 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0329358 |
| THRB | thyroid hormone receptor, beta | -0.0329033 |
| RIOK3 | RIO kinase 3 | -0.0328129 |
| RESF1 | retroelement silencing factor 1 | -0.0327072 |
| ABI1 | abl-interactor 1 | -0.032691 |
| IRF6 | interferon regulatory factor 6 | -0.0322581 |
| SGMS2 | sphingomyelin synthase 2 | -0.0322352 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0321544 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0320532 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0320512 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0320461 |
| S100A11 | S100 calcium binding protein A11 | -0.0319102 |
| AFDN | afadin, adherens junction formation factor | -0.0312955 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | -0.0310996 |
| F11R | F11 receptor | -0.0308175 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -0.0308054 |
| OCLN | occludin | -0.0307765 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0306738 |
| PCDH7 | protocadherin 7 | -0.0304862 |
| TTC9 | tetratricopeptide repeat domain 9 | -0.0304826 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0303845 |
| RPS21 | ribosomal protein S21 | -0.0301571 |
