Pyridoxine (hydrochloride)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pyridoxine (hydrochloride) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pyridoxine (hydrochloride)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.311769
ERRFI1 ERBB receptor feedback inhibitor 1 0.132441
GRAMD1B GRAM domain containing 1B 0.12904
THSD4 thrombospondin, type I, domain containing 4 0.103674
PDE10A phosphodiesterase 10A 0.0934082
PDE4D phosphodiesterase 4D, cAMP-specific 0.0851043
RAD51B RAD51 paralog B 0.0762972
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0726366
RIMS2 regulating synaptic membrane exocytosis 2 0.0611712
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0594229
EEF2 eukaryotic translation elongation factor 2 0.0561613
IGF1R insulin-like growth factor 1 receptor 0.0545873
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0500818
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0483552
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0481062
TPM3 tropomyosin 3 0.0475415
OSMR oncostatin M receptor 0.0465981
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0453816
TM4SF1 transmembrane 4 L six family member 1 0.0443047
FMNL2 formin-like 2 0.0427591
EXOC4 exocyst complex component 4 0.0418426
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0390256
AFF3 AF4/FMR2 family, member 3 0.0389513
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0359203
TXNRD1 thioredoxin reductase 1 0.0356361
HSPA8 heat shock 70kDa protein 8 0.0353905
ATP11A ATPase, class VI, type 11A 0.0351454
CDCP1 CUB domain containing protein 1 0.0350118
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0347316
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0345586
KDM2A lysine (K)-specific demethylase 2A 0.034356
MMP12 matrix metallopeptidase 12 0.0338208
WWOX WW domain containing oxidoreductase 0.033789
EPAS1 endothelial PAS domain protein 1 0.0333323
MACF1 microtubule-actin crosslinking factor 1 0.0328855
SSH2 slingshot protein phosphatase 2 0.0322908
LATS2 large tumor suppressor kinase 2 0.0322072
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0319202
DSPP dentin sialophosphoprotein 0.0316376
HMGA2 high mobility group AT-hook 2 0.0307367
MYH9 myosin, heavy chain 9, non-muscle 0.0306297
IL6ST interleukin 6 signal transducer 0.0303632
SRRM2 serine/arginine repetitive matrix 2 0.0302966
PGK1 phosphoglycerate kinase 1 0.0294275
AHNAK AHNAK nucleoprotein 0.0291524
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0289239
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0283889
ANO6 anoctamin 6 0.0283517
TRIP12 thyroid hormone receptor interactor 12 0.0277204
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0276632
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0276249
ADAR adenosine deaminase, RNA-specific 0.0275653
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0273632
FLNA filamin A, alpha 0.027277
CDK17 cyclin-dependent kinase 17 0.0272367
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0270831
ZFAND3 zinc finger, AN1-type domain 3 0.027011
DENND5B DENN/MADD domain containing 5B 0.0267319
SPIDR scaffolding protein involved in DNA repair 0.0262197
BASP1 brain abundant, membrane attached signal protein 1 0.0261617
UBC ubiquitin C 0.0260069
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0259422
PRKCE protein kinase C, epsilon 0.0258055
EGFR epidermal growth factor receptor 0.0257439
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0250981
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.024658
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0245411
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.024132
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0237496
DNAH14 dynein, axonemal, heavy chain 14 0.0234816
TPM4 tropomyosin 4 0.0233318
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0232899
DOCK1 dedicator of cytokinesis 1 0.0231045
PDE4B phosphodiesterase 4B, cAMP-specific 0.0231009
RNF213 ring finger protein 213 0.0230824
PYGL phosphorylase, glycogen, liver 0.0230821
NCKAP1 NCK-associated protein 1 0.0224859
PLEC plectin 0.0224047
PHF21A PHD finger protein 21A 0.0223979
EIF4B eukaryotic translation initiation factor 4B 0.0223949
APP amyloid beta (A4) precursor protein 0.0223657
ANKRD36 ankyrin repeat domain 36 0.0222737
AFG2A AFG2 AAA ATPase homolog A 0.0222479
XPO1 exportin 1 0.0221311
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0221294
LOXL2 lysyl oxidase-like 2 0.0220269
CEP250 centrosomal protein 250kDa 0.0219751
BIRC2 baculoviral IAP repeat containing 2 0.0216204
FNDC3B fibronectin type III domain containing 3B 0.0214585
TLN1 talin 1 0.021318
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0213071
ENO1 enolase 1, (alpha) 0.0212272
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0211643
MKI67 marker of proliferation Ki-67 0.0211514
NT5E 5'-nucleotidase, ecto (CD73) 0.0211274
NCOA7 nuclear receptor coactivator 7 0.0209451
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0208117
MYOF myoferlin 0.0207657
RICTOR RPTOR independent companion of MTOR, complex 2 0.0206033
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0203761

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.126225
TMSB10 thymosin beta 10 -0.124688
VIM vimentin -0.0804929
EGR1 early growth response 1 -0.0786664
PTMA prothymosin, alpha -0.0697852
RPS21 ribosomal protein S21 -0.0659123
RPL35A ribosomal protein L35a -0.0545996
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0537112
RPS3 ribosomal protein S3 -0.0467894
RPL23 ribosomal protein L23 -0.0459602
RPL12 ribosomal protein L12 -0.0454043
RPLP1 ribosomal protein, large, P1 -0.0443566
RPS19 ribosomal protein S19 -0.0433178
RPL37 ribosomal protein L37 -0.0430552
PFN1 profilin 1 -0.0424213
RPS8 ribosomal protein S8 -0.0419799
RPLP0 ribosomal protein, large, P0 -0.0401566
MYL12B myosin, light chain 12B, regulatory -0.0367615
MT2A metallothionein 2A -0.0361046
RBM25 RNA binding motif protein 25 -0.0345743
RPL26 ribosomal protein L26 -0.0338503
WNT2B wingless-type MMTV integration site family, member 2B -0.0329815
RPL34 ribosomal protein L34 -0.0318231
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0314407
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0313099
RPS6 ribosomal protein S6 -0.0308808
HMGA1 high mobility group AT-hook 1 -0.03068
RPL37A ribosomal protein L37a -0.0305591
YBX3 Y box binding protein 3 -0.0304147
RPL19 ribosomal protein L19 -0.0290901
RPS24 ribosomal protein S24 -0.0290656
ANKRD12 ankyrin repeat domain 12 -0.0288082
RPS12 ribosomal protein S12 -0.0286996
TPI1 triosephosphate isomerase 1 -0.0286261
RPS29 ribosomal protein S29 -0.0285896
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0273744
RPS15 ribosomal protein S15 -0.0270183
FTL ferritin, light polypeptide -0.0269972
GOLGA4 golgin A4 -0.0267992
RPL32 ribosomal protein L32 -0.0266202
KRT18 keratin 18, type I -0.0266119
RPL11 ribosomal protein L11 -0.0265881
POTEF POTE ankyrin domain family, member F -0.0264815
WSB1 WD repeat and SOCS box containing 1 -0.0262745
RPL9 ribosomal protein L9 -0.02604
ATP5F1E ATP synthase F1 subunit epsilon -0.0257846
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0250664
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.025002
EIF1 eukaryotic translation initiation factor 1 -0.0249374
INTS6 integrator complex subunit 6 -0.0248298
RPL36 ribosomal protein L36 -0.0243155
RPL5 ribosomal protein L5 -0.0234924
TPT1 tumor protein, translationally-controlled 1 -0.0233485
RACK1 receptor for activated C kinase 1 -0.0232144
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0223633
RPLP2 ribosomal protein, large, P2 -0.0221812
RPS13 ribosomal protein S13 -0.0221588
RAB7A RAB7A, member RAS oncogene family -0.0213097
GARS1 glycyl-tRNA synthetase 1 -0.0211889
RPL31 ribosomal protein L31 -0.0211661
HLA-B major histocompatibility complex, class I, B -0.0210274
RPL8 ribosomal protein L8 -0.0208485
KTN1 kinectin 1 (kinesin receptor) -0.0208077
NAP1L1 nucleosome assembly protein 1-like 1 -0.0206265
RPL27 ribosomal protein L27 -0.0205011
DEK DEK proto-oncogene -0.0204951
SRSF11 serine/arginine-rich splicing factor 11 -0.0203642
RPS10 ribosomal protein S10 -0.0202882
RPS27 ribosomal protein S27 -0.0197788
RPS23 ribosomal protein S23 -0.0197225
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0196022
SMC4 structural maintenance of chromosomes 4 -0.0195985
RPS17 ribosomal protein S17 -0.0194271
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0193779
GSTP1 glutathione S-transferase pi 1 -0.0193129
RPS14 ribosomal protein S14 -0.0188429
RPL36A ribosomal protein L36a -0.0185846
PCLO piccolo presynaptic cytomatrix protein -0.0180542
RPL35 ribosomal protein L35 -0.0180422
RPL27A ribosomal protein L27a -0.0179526
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0178872
TPM2 tropomyosin 2 (beta) -0.0177802
WASF2 WAS protein family, member 2 -0.0177498
RPL18 ribosomal protein L18 -0.0177424
PABPN1 poly(A) binding protein, nuclear 1 -0.0174809
MORF4L2 mortality factor 4 like 2 -0.0173361
TUBA1C tubulin, alpha 1c -0.0170391
MIDN midnolin -0.0170142
BSG basigin (Ok blood group) -0.0169242
MT1X metallothionein 1X -0.0168668
ATP5F1B ATP synthase F1 subunit beta -0.0166558
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0166359
RPS25 ribosomal protein S25 -0.0166063
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0163632
RPS4X ribosomal protein S4, X-linked -0.0160937
LOC102724023 ES1 protein homolog, mitochondrial -0.0160463
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0160071
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0158448
RPL28 ribosomal protein L28 -0.015623
HOMER1 homer scaffolding protein 1 -0.0154761