| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pyridoxine (hydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pyridoxine (hydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | 0.251799 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.193239 |
| DST | dystonin | 0.126711 |
| COL5A2 | collagen, type V, alpha 2 | 0.116941 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.108484 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0996504 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.092766 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0864275 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0842413 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0777172 |
| ASPH | aspartate beta-hydroxylase | 0.0769882 |
| PDE10A | phosphodiesterase 10A | 0.0760138 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0729958 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0719149 |
| KYNU | kynureninase | 0.0695585 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0652841 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0585933 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.055955 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0527421 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0497667 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0496585 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0494356 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0493779 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0491438 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0486521 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | 0.0461314 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0440236 |
| GRAMD1B | GRAM domain containing 1B | 0.0430787 |
| LSAMP | limbic system-associated membrane protein | 0.0428788 |
| TXNRD1 | thioredoxin reductase 1 | 0.041614 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0414618 |
| PCBP2 | poly(rC) binding protein 2 | 0.0414388 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0408706 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0404653 |
| PDE7B | phosphodiesterase 7B | 0.0401262 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0387742 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0369388 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0362894 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0356969 |
| VCL | vinculin | 0.0342053 |
| EZR | ezrin | 0.0337805 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.0328066 |
| FLNA | filamin A, alpha | 0.0327326 |
| UBC | ubiquitin C | 0.0317262 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0316178 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0312539 |
| MKI67 | marker of proliferation Ki-67 | 0.031187 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0311375 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0310692 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0310207 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0308944 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.030782 |
| CENPF | centromere protein F, 350/400kDa | 0.0303626 |
| PRKD3 | protein kinase D3 | 0.0298404 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0295792 |
| GREM2 | gremlin 2, DAN family BMP antagonist | 0.0290299 |
| MYOF | myoferlin | 0.0288841 |
| EPHA4 | EPH receptor A4 | 0.0282343 |
| MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | 0.0281874 |
| CD109 | CD109 molecule | 0.0279451 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0279095 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0277536 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0275012 |
| NRCAM | neuronal cell adhesion molecule | 0.0274231 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0265988 |
| PRELID2 | PRELI domain containing 2 | 0.026134 |
| ARHGEF7 | Rho guanine nucleotide exchange factor (GEF) 7 | 0.0259378 |
| POTEF | POTE ankyrin domain family, member F | 0.0253511 |
| KIAA0825 | KIAA0825 | 0.025343 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0247003 |
| CLU | clusterin | 0.0245332 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0244602 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0241762 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0241563 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0241361 |
| CDK6 | cyclin-dependent kinase 6 | 0.0239854 |
| ITPK1 | inositol-tetrakisphosphate 1-kinase | 0.0236632 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0232841 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0230838 |
| INTS6 | integrator complex subunit 6 | 0.0227119 |
| ATXN1 | ataxin 1 | 0.0225078 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 0.0224396 |
| CEP72 | centrosomal protein 72kDa | 0.0222692 |
| MSN | moesin | 0.022169 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0219261 |
| ALPK2 | alpha-kinase 2 | 0.0217847 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0214135 |
| PLK2 | polo-like kinase 2 | 0.0213486 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 0.0211281 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.021127 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0210121 |
| TPM3 | tropomyosin 3 | 0.0208528 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0205426 |
| RPL3 | ribosomal protein L3 | 0.0205339 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | 0.0201575 |
| MCL1 | myeloid cell leukemia 1 | 0.0200296 |
| CTSC | cathepsin C | 0.0199634 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0198684 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0196096 |
| RPS12 | ribosomal protein S12 | 0.0191946 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.211556 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.16605 |
| EFNA5 | ephrin-A5 | -0.126239 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.120632 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.114953 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.10291 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0985404 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0834922 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.069996 |
| SMYD3 | SET and MYND domain containing 3 | -0.0669949 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0621081 |
| STC1 | stanniocalcin 1 | -0.059438 |
| VIM | vimentin | -0.0550415 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0532619 |
| PTMA | prothymosin, alpha | -0.0515906 |
| PCBP3 | poly(rC) binding protein 3 | -0.0511508 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.051003 |
| RPLP1 | ribosomal protein, large, P1 | -0.0508905 |
| HLA-B | major histocompatibility complex, class I, B | -0.0479012 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0474069 |
| NCKAP5 | NCK-associated protein 5 | -0.0473367 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0471915 |
| CDH13 | cadherin 13 | -0.0469672 |
| BMERB1 | bMERB domain containing 1 | -0.0463162 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0457202 |
| RPS24 | ribosomal protein S24 | -0.0447432 |
| S100A6 | S100 calcium binding protein A6 | -0.0433137 |
| CANX | calnexin | -0.0420252 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0408057 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0406495 |
| RPL35A | ribosomal protein L35a | -0.0403737 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0396443 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0388409 |
| TMSB10 | thymosin beta 10 | -0.0387829 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0384154 |
| CTSL | cathepsin L | -0.0378364 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0376196 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0372479 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.036121 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0348897 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0348212 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.034571 |
| SLC16A6 | solute carrier family 16, member 6 | -0.0336202 |
| RPL26 | ribosomal protein L26 | -0.0336075 |
| AUTS2 | autism susceptibility candidate 2 | -0.0328571 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0322654 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0320993 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0314237 |
| RTN4 | reticulon 4 | -0.0311753 |
| PGK1 | phosphoglycerate kinase 1 | -0.0311495 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0311044 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.030597 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0304902 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0300204 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0296838 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0292486 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0290243 |
| OSMR | oncostatin M receptor | -0.0276024 |
| DENND1A | DENN/MADD domain containing 1A | -0.027487 |
| HLA-A | major histocompatibility complex, class I, A | -0.0265711 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0263352 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0262065 |
| NF1 | neurofibromin 1 | -0.0262 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0261727 |
| B2M | beta-2-microglobulin | -0.025937 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0257314 |
| SEPTIN10 | septin 10 | -0.0255231 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0254799 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0253241 |
| NBEAL1 | neurobeachin-like 1 | -0.0251814 |
| STEAP1B | STEAP family member 1B | -0.0247019 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0246676 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0246537 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0245831 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.024509 |
| PYGL | phosphorylase, glycogen, liver | -0.0243952 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0239546 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0239422 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.023801 |
| LDHA | lactate dehydrogenase A | -0.0237587 |
| TMEM165 | transmembrane protein 165 | -0.0237436 |
| RPL34 | ribosomal protein L34 | -0.023537 |
| RPL31 | ribosomal protein L31 | -0.0234958 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.0234173 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0231357 |
| TENM3 | teneurin transmembrane protein 3 | -0.0231206 |
| CD44 | CD44 molecule (Indian blood group) | -0.0229547 |
| RANBP17 | RAN binding protein 17 | -0.0228821 |
| RAI14 | retinoic acid induced 14 | -0.0228708 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0228546 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0227566 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0223175 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0222163 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.022046 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | -0.0219258 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0217269 |
| CLMP | CXADR-like membrane protein | -0.0216657 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0216283 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0215435 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0215243 |
