Pyridoxine (hydrochloride)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pyridoxine (hydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

123 genes differentially expressed following the Pyridoxine (hydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.235161
ASPH aspartate beta-hydroxylase 0.206305
MT2A metallothionein 2A 0.201087
FAT1 FAT atypical cadherin 1 0.198332
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.194058
COL6A3 collagen, type VI, alpha 3 0.168755
PDE10A phosphodiesterase 10A 0.165948
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.128795
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.124135
IGFBP3 insulin-like growth factor binding protein 3 0.119453
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.11117
ANKRD11 ankyrin repeat domain 11 0.103446
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0995948
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0986854
PSD3 pleckstrin and Sec7 domain containing 3 0.0957174
FN1 fibronectin 1 0.0933381
VMP1 vacuole membrane protein 1 0.0810507
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.080513
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0763595
PDLIM5 PDZ and LIM domain 5 0.0707082
MAML3 mastermind-like 3 (Drosophila) 0.0700503
COL6A2 collagen, type VI, alpha 2 0.0597879
ANKRD17 ankyrin repeat domain 17 0.0592602
ZBTB20 zinc finger and BTB domain containing 20 0.0587208
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0573591
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0548362
MATR3 matrin 3 0.0533276
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0530979
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0492401
EGFR epidermal growth factor receptor 0.0490229
MYO1E myosin IE 0.0469688
ERRFI1 ERBB receptor feedback inhibitor 1 0.043828
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0423533
FNIP1 folliculin interacting protein 1 0.03885
PTMA prothymosin, alpha 0.0347193
PTBP3 polypyrimidine tract binding protein 3 0.0337073
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0318066
FBXO11 F-box protein 11 0.0288816
SMYD3 SET and MYND domain containing 3 0.0242884
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.022542
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.022497
ANKRD12 ankyrin repeat domain 12 0.0183628
NBEAL1 neurobeachin-like 1 0.0178113
KYNU kynureninase 0.0177621
CSNK1A1 casein kinase 1, alpha 1 0.0173257
NAV1 neuron navigator 1 0.0133473
EFNA5 ephrin-A5 0.0131928
PRKN parkin RBR E3 ubiquitin protein ligase 0.0115328
AKAP12 A kinase (PRKA) anchor protein 12 0.010208
TMSB10 thymosin beta 10 0.00832196
PRELID2 PRELI domain containing 2 0.00450272
DIAPH2 diaphanous-related formin 2 0.00448277
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.00231347
MYOF myoferlin 0.00135594

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.24914
VIM vimentin -0.248848
ZNF292 zinc finger protein 292 -0.139283
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.113982
CCNI cyclin I -0.11262
NAP1L1 nucleosome assembly protein 1-like 1 -0.101274
PKM pyruvate kinase, muscle -0.099975
GOLGA4 golgin A4 -0.0965697
CADM2 cell adhesion molecule 2 -0.0952519
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0925538
RPL11 ribosomal protein L11 -0.0889865
MAP1B microtubule-associated protein 1B -0.0883598
JMJD1C jumonji domain containing 1C -0.0828557
AHNAK AHNAK nucleoprotein -0.0823962
SYT1 synaptotagmin I -0.0802053
EXT1 exostosin glycosyltransferase 1 -0.0791624
B2M beta-2-microglobulin -0.0774875
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0767619
STC1 stanniocalcin 1 -0.0759076
INTS6 integrator complex subunit 6 -0.0754155
DSCAM Down syndrome cell adhesion molecule -0.0720052
RPS8 ribosomal protein S8 -0.0700812
NKD1 naked cuticle homolog 1 (Drosophila) -0.0688468
MAML2 mastermind-like 2 (Drosophila) -0.0685961
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0672923
PRKCA protein kinase C, alpha -0.0646735
PRRC2C proline-rich coiled-coil 2C -0.0617853
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0602493
NF1 neurofibromin 1 -0.0586042
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0559295
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0528944
MBD5 methyl-CpG binding domain protein 5 -0.0525781
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.048909
PGK1 phosphoglycerate kinase 1 -0.048592
TPT1 tumor protein, translationally-controlled 1 -0.0478474
IGF2 insulin-like growth factor 2 -0.0468911
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0467138
ZNF608 zinc finger protein 608 -0.0461214
MACF1 microtubule-actin crosslinking factor 1 -0.0438836
HDLBP high density lipoprotein binding protein -0.0438711
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0427861
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0395717
CD44 CD44 molecule (Indian blood group) -0.0378603
PTK2 protein tyrosine kinase 2 -0.0372434
CDH13 cadherin 13 -0.0336635
RNF24 ring finger protein 24 -0.0316605
TXNRD1 thioredoxin reductase 1 -0.028683
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0283639
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0270382
PEG10 paternally expressed 10 -0.0261579
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0256116
OSMR oncostatin M receptor -0.0238882
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0211867
HMGA2 high mobility group AT-hook 2 -0.0204497
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0190485
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0163637
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0150397
RAD51B RAD51 paralog B -0.0132297
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 -0.012645
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0104025
LDHA lactate dehydrogenase A -0.00986551
CD36 CD36 molecule (thrombospondin receptor) -0.00895533
NDRG1 N-myc downstream regulated 1 -0.00809435
RPS6 ribosomal protein S6 -0.007639
LOC112694756 uncharaterized LOC112694756 -0.00339366
MAP4 microtubule-associated protein 4 -0.00269135
FNDC3B fibronectin type III domain containing 3B -8.0494E-4
TRIO trio Rho guanine nucleotide exchange factor -2.27766E-4
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -2.17787E-4