| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pyridoxine (hydrochloride) perturbation in PANC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pyridoxine (hydrochloride)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VCL | vinculin | 0.320542 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.155886 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.137438 |
| ASPH | aspartate beta-hydroxylase | 0.101017 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0996582 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0796117 |
| CD44 | CD44 molecule (Indian blood group) | 0.0766943 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0766437 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0761313 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0753285 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0723141 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0714768 |
| VMP1 | vacuole membrane protein 1 | 0.0678427 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0667797 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0645268 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0626184 |
| MKI67 | marker of proliferation Ki-67 | 0.0626102 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0602835 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.05975 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0590966 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0580762 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0578899 |
| PLEKHG2 | pleckstrin homology domain containing, family G (with RhoGef domain) member 2 | 0.0575349 |
| UBC | ubiquitin C | 0.0573426 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0547977 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0546809 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0502089 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0489032 |
| JMJD1C | jumonji domain containing 1C | 0.0479215 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0475655 |
| RPS12 | ribosomal protein S12 | 0.0469001 |
| ITGAV | integrin, alpha V | 0.0467967 |
| EFNA5 | ephrin-A5 | 0.0467628 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0463921 |
| MCL1 | myeloid cell leukemia 1 | 0.045676 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0456515 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0454836 |
| PTK2 | protein tyrosine kinase 2 | 0.0452077 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0451745 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0451606 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0450994 |
| SMYD3 | SET and MYND domain containing 3 | 0.0441762 |
| ZNF780B | zinc finger protein 780B | 0.0437912 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0437892 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0424383 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0413658 |
| FLNA | filamin A, alpha | 0.0405825 |
| DNMBP | dynamin binding protein | 0.0404727 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0396155 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0394902 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0374482 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0369318 |
| HMGA2 | high mobility group AT-hook 2 | 0.0364202 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0363923 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0361485 |
| INTS6 | integrator complex subunit 6 | 0.0356435 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0352489 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0351857 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0344146 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0343007 |
| PDE10A | phosphodiesterase 10A | 0.03419 |
| MYO1E | myosin IE | 0.0341492 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0338189 |
| PAF1 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 0.0335943 |
| IL6ST | interleukin 6 signal transducer | 0.0333612 |
| MSN | moesin | 0.0330359 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0327913 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0327586 |
| DST | dystonin | 0.032528 |
| ZFP36 | ZFP36 ring finger protein | 0.0324703 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0323805 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0323281 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.032305 |
| EXOC6B | exocyst complex component 6B | 0.0321543 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0320268 |
| CTTN | cortactin | 0.0317108 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0316317 |
| MYO10 | myosin X | 0.0314656 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0305988 |
| SATB2 | SATB homeobox 2 | 0.0301365 |
| USP47 | ubiquitin specific peptidase 47 | 0.0300424 |
| ACTN4 | actinin, alpha 4 | 0.029898 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0294643 |
| ERBIN | erbb2 interacting protein | 0.0290733 |
| EGR1 | early growth response 1 | 0.0289656 |
| ITGB5 | integrin, beta 5 | 0.0288897 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0288804 |
| ZNF644 | zinc finger protein 644 | 0.0287961 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0286845 |
| DOCK5 | dedicator of cytokinesis 5 | 0.028473 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0281881 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0279792 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0279496 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0277994 |
| LUZP1 | leucine zipper protein 1 | 0.027793 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0276513 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.027466 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0274647 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0272984 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0272198 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS16 | ribosomal protein S16 | -0.110513 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0989114 |
| RPL35A | ribosomal protein L35a | -0.079384 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0699803 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0694314 |
| AHNAK | AHNAK nucleoprotein | -0.0688266 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0658484 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.054095 |
| MYOF | myoferlin | -0.0505453 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0494715 |
| LDHA | lactate dehydrogenase A | -0.0465566 |
| RPLP1 | ribosomal protein, large, P1 | -0.0459265 |
| CTSD | cathepsin D | -0.0400043 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0378698 |
| PGK1 | phosphoglycerate kinase 1 | -0.0368163 |
| HMGA1 | high mobility group AT-hook 1 | -0.035522 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0354698 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0352386 |
| SEPTIN7 | septin 7 | -0.0345382 |
| FBL | fibrillarin | -0.0314612 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0310139 |
| S100A6 | S100 calcium binding protein A6 | -0.0307823 |
| TMSB10 | thymosin beta 10 | -0.0305485 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0303698 |
| RPS24 | ribosomal protein S24 | -0.0290768 |
| PTMA | prothymosin, alpha | -0.028909 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0288521 |
| TNS3 | tensin 3 | -0.0286207 |
| MORF4L2 | mortality factor 4 like 2 | -0.0276369 |
| TMEM123 | transmembrane protein 123 | -0.0275431 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0251946 |
| WDR45B | WD repeat domain 45B | -0.0248999 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0246044 |
| TAPBP | TAP binding protein (tapasin) | -0.0242973 |
| EGFR | epidermal growth factor receptor | -0.0239206 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0236964 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.023632 |
| SMAD3 | SMAD family member 3 | -0.0233974 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0233554 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0223307 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0217883 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0217178 |
| ANXA2 | annexin A2 | -0.0215792 |
| GNAS | GNAS complex locus | -0.0213539 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0213243 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0207972 |
| SEPTIN9 | septin 9 | -0.0206745 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0205776 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0205393 |
| HM13 | histocompatibility (minor) 13 | -0.0204991 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0198658 |
| CMIP | c-Maf inducing protein | -0.0198227 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0196763 |
| FOXO3 | forkhead box O3 | -0.0196741 |
| MTCL1 | microtubule crosslinking factor 1 | -0.019672 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0191812 |
| JPT2 | Jupiter microtubule associated homolog 2 | -0.0191248 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | -0.0190031 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0186275 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0183922 |
| RPS19 | ribosomal protein S19 | -0.0181458 |
| RNF220 | ring finger protein 220 | -0.0180413 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0179825 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0179013 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0178152 |
| TMEM165 | transmembrane protein 165 | -0.0177333 |
| PERP | PERP, TP53 apoptosis effector | -0.0177245 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0177102 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0176354 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.01748 |
| RPS5 | ribosomal protein S5 | -0.0172983 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0172774 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0169184 |
| SUCO | SUN domain containing ossification factor | -0.0167096 |
| CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | -0.015766 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0157431 |
| SEC23IP | SEC23 interacting protein | -0.0156475 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0155273 |
| CRABP2 | cellular retinoic acid binding protein 2 | -0.015491 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0154095 |
| RPS13 | ribosomal protein S13 | -0.0153218 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0152759 |
| RAB1B | RAB1B, member RAS oncogene family | -0.0150851 |
| SEC63 | SEC63 homolog (S. cerevisiae) | -0.014997 |
| RPL11 | ribosomal protein L11 | -0.0146664 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0146607 |
| ERLEC1 | endoplasmic reticulum lectin 1 | -0.0144894 |
| CDK19 | cyclin-dependent kinase 19 | -0.0144251 |
| DEK | DEK proto-oncogene | -0.0143606 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.0143354 |
| TUT4 | terminal uridylyl transferase 4 | -0.0143335 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0143091 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0142974 |
| CD47 | CD47 molecule | -0.0141634 |
| RPL4 | ribosomal protein L4 | -0.0141138 |
| RPL28 | ribosomal protein L28 | -0.0141118 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0140562 |
| SEPTIN2 | septin 2 | -0.014028 |
| MFGE8 | milk fat globule-EGF factor 8 protein | -0.0140023 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0139541 |
