Pyridoxine (hydrochloride)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pyridoxine (hydrochloride) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pyridoxine (hydrochloride)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ELL2 elongation factor, RNA polymerase II, 2 0.095986
FLNB filamin B, beta 0.0862497
NAV3 neuron navigator 3 0.0816892
SRRM2 serine/arginine repetitive matrix 2 0.0622928
ZNF438 zinc finger protein 438 0.0603889
ARHGAP22 Rho GTPase activating protein 22 0.05926
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.058174
AKAP12 A kinase (PRKA) anchor protein 12 0.0536473
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0496511
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0478544
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0460858
EEF2 eukaryotic translation elongation factor 2 0.0442677
IARS1 isoleucyl-tRNA synthetase 1 0.0428076
MCL1 myeloid cell leukemia 1 0.0418975
NAV2 neuron navigator 2 0.0409908
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0406969
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0402699
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0401854
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0388679
HDAC9 histone deacetylase 9 0.0374086
JMJD1C jumonji domain containing 1C 0.0371365
DST dystonin 0.0340959
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0323253
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0315913
TXNRD1 thioredoxin reductase 1 0.030221
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0301422
FLNA filamin A, alpha 0.0296442
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0290112
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0285578
TBC1D5 TBC1 domain family, member 5 0.0271131
MACF1 microtubule-actin crosslinking factor 1 0.0265259
FHL2 four and a half LIM domains 2 0.0259424
RIGI RNA sensor RIG-I 0.0258962
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.02585
ANTXR2 anthrax toxin receptor 2 0.0257562
TRIM44 tripartite motif containing 44 0.0254643
ATP13A3 ATPase type 13A3 0.0254093
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0251327
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0250306
TRIP12 thyroid hormone receptor interactor 12 0.024996
C2CD2 C2 calcium-dependent domain containing 2 0.024713
ASPH aspartate beta-hydroxylase 0.0242043
FHIT fragile histidine triad 0.024132
RASA2 RAS p21 protein activator 2 0.0238898
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.023807
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0235487
BNC2 basonuclin 2 0.023351
ANXA5 annexin A5 0.0232227
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0230379
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0223569
EMP1 epithelial membrane protein 1 0.0221659
MX1 MX dynamin-like GTPase 1 0.0219509
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0219093
MYH9 myosin, heavy chain 9, non-muscle 0.0216603
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0212525
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0209501
RAD51B RAD51 paralog B 0.0207323
ADTRP androgen-dependent TFPI-regulating protein 0.0204908
ZEB1 zinc finger E-box binding homeobox 1 0.0203341
SGMS2 sphingomyelin synthase 2 0.0202635
RPL3 ribosomal protein L3 0.019969
STRIP2 striatin interacting protein 2 0.0198884
SETX senataxin 0.0195899
EXOC4 exocyst complex component 4 0.0193758
DGKI diacylglycerol kinase, iota 0.0193116
MAST4 microtubule associated serine/threonine kinase family member 4 0.0192887
UPP1 uridine phosphorylase 1 0.0190366
EFNB2 ephrin-B2 0.019022
HSPA8 heat shock 70kDa protein 8 0.0189447
IFI16 interferon, gamma-inducible protein 16 0.0186383
NPC1 Niemann-Pick disease, type C1 0.0186323
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0183889
PLSCR1 phospholipid scramblase 1 0.018178
UBC ubiquitin C 0.0178933
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0178651
FER fer (fps/fes related) tyrosine kinase 0.0178253
WWOX WW domain containing oxidoreductase 0.0177286
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.017681
RGMB repulsive guidance molecule family member b 0.0176023
LRMDA leucine rich melanocyte differentiation associated 0.0173034
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0171118
DOCK4 dedicator of cytokinesis 4 0.0170261
CD68 CD68 molecule 0.0168764
SCMH1 sex comb on midleg homolog 1 (Drosophila) 0.016839
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0167312
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 0.0166485
CORO1C coronin, actin binding protein, 1C 0.0166364
CDK17 cyclin-dependent kinase 17 0.0164932
EFL1 elongation factor like GTPase 1 0.0163309
CAPRIN2 caprin family member 2 0.0163165
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0162666
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0161529
PCBP2 poly(rC) binding protein 2 0.0158739
ZBTB38 zinc finger and BTB domain containing 38 0.0158729
TM4SF19 transmembrane 4 L six family member 19 0.0158131
TRIM14 tripartite motif containing 14 0.0158125
WDFY3 WD repeat and FYVE domain containing 3 0.0157616
ADAR adenosine deaminase, RNA-specific 0.015735
NUP188 nucleoporin 188kDa 0.0156876
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0155893

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.163
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.131988
ACTG1 actin gamma 1 -0.122701
RPS6 ribosomal protein S6 -0.113022
RPLP1 ribosomal protein, large, P1 -0.0951819
RPL35A ribosomal protein L35a -0.0899492
RPL12 ribosomal protein L12 -0.0875715
TMSB10 thymosin beta 10 -0.0869761
RPL23 ribosomal protein L23 -0.0832034
RPL8 ribosomal protein L8 -0.0814195
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.081117
RPS19 ribosomal protein S19 -0.0792557
RPS8 ribosomal protein S8 -0.077597
RPLP2 ribosomal protein, large, P2 -0.0773956
TPT1 tumor protein, translationally-controlled 1 -0.0729837
RPS21 ribosomal protein S21 -0.0703049
RPL7A ribosomal protein L7a -0.0685425
RPS3 ribosomal protein S3 -0.0598048
PTMA prothymosin, alpha -0.0591042
RPLP0 ribosomal protein, large, P0 -0.0580131
RPL34 ribosomal protein L34 -0.0577295
RPL35 ribosomal protein L35 -0.0544943
RPL36 ribosomal protein L36 -0.0539334
RPL32 ribosomal protein L32 -0.0538532
RPL19 ribosomal protein L19 -0.0536128
RPL30 ribosomal protein L30 -0.0533773
RPS29 ribosomal protein S29 -0.0516757
RPL7 ribosomal protein L7 -0.0514787
RPL9 ribosomal protein L9 -0.0512196
RPL13A ribosomal protein L13a -0.0484536
RPL26 ribosomal protein L26 -0.0475488
LOC112694756 uncharaterized LOC112694756 -0.0473866
LAMB3 laminin, beta 3 -0.0471747
RPL37A ribosomal protein L37a -0.0469109
RPL11 ribosomal protein L11 -0.0460884
EIF1 eukaryotic translation initiation factor 1 -0.0457002
MTDH metadherin -0.0455315
RPS27A ribosomal protein S27a -0.0446934
RPS16 ribosomal protein S16 -0.0441414
RPS4X ribosomal protein S4, X-linked -0.043668
RPS12 ribosomal protein S12 -0.0428156
RPL18 ribosomal protein L18 -0.0427553
RPS24 ribosomal protein S24 -0.0426486
RPL31 ribosomal protein L31 -0.0403185
NAP1L1 nucleosome assembly protein 1-like 1 -0.0390816
TTR transthyretin -0.0378874
RPS13 ribosomal protein S13 -0.0377478
S100A2 S100 calcium binding protein A2 -0.0376198
RPS20 ribosomal protein S20 -0.0374868
RPL28 ribosomal protein L28 -0.0367602
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0363642
GNAS GNAS complex locus -0.0357694
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.035635
RPS5 ribosomal protein S5 -0.0355958
S100A9 S100 calcium binding protein A9 -0.0354006
FTL ferritin, light polypeptide -0.0342101
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0338204
RPS23 ribosomal protein S23 -0.0331744
RPL36A ribosomal protein L36a -0.0328833
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0325177
RAD21 RAD21 homolog (S. pombe) -0.032505
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0322534
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0322162
KDM3A lysine (K)-specific demethylase 3A -0.0316572
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0314087
RPS25 ribosomal protein S25 -0.031302
RPS11 ribosomal protein S11 -0.0310435
RPS14 ribosomal protein S14 -0.0307721
RPL27A ribosomal protein L27a -0.0307322
RPS27 ribosomal protein S27 -0.0306972
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0305712
RPL5 ribosomal protein L5 -0.0304692
RPS15 ribosomal protein S15 -0.0302211
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0301185
DLC1 DLC1 Rho GTPase activating protein -0.0294443
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0293514
RPL27 ribosomal protein L27 -0.0286168
RPL10A ribosomal protein L10a -0.0277752
RACK1 receptor for activated C kinase 1 -0.0277604
STAU1 staufen double-stranded RNA binding protein 1 -0.0275762
MYL12B myosin, light chain 12B, regulatory -0.0275747
RPS17 ribosomal protein S17 -0.0272452
RPS10 ribosomal protein S10 -0.0272016
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0269731
GARS1 glycyl-tRNA synthetase 1 -0.0265338
RPL38 ribosomal protein L38 -0.0261919
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0257836
CANX calnexin -0.0254839
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0253898
PFN1 profilin 1 -0.0251654
POTEF POTE ankyrin domain family, member F -0.0249284
RLF rearranged L-myc fusion -0.0248662
ANKRD17 ankyrin repeat domain 17 -0.0244177
PA2G4 proliferation-associated 2G4, 38kDa -0.0241006
HMGA1 high mobility group AT-hook 1 -0.0239296
CELF1 CUGBP, Elav-like family member 1 -0.0236948
NIPBL Nipped-B homolog (Drosophila) -0.0235978
RPL36AL ribosomal protein L36a-like -0.0235558
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0235429
EIF5B eukaryotic translation initiation factor 5B -0.0235041