Pyridoxine (hydrochloride)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pyridoxine (hydrochloride) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pyridoxine (hydrochloride)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EZR ezrin 0.0986149
FAT1 FAT atypical cadherin 1 0.0821985
DSPP dentin sialophosphoprotein 0.0769236
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0751421
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0686032
MKI67 marker of proliferation Ki-67 0.0625839
CANX calnexin 0.0558085
SRRM2 serine/arginine repetitive matrix 2 0.055454
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0544777
MACC1 metastasis associated in colon cancer 1 0.0538161
NKD1 naked cuticle homolog 1 (Drosophila) 0.0530315
EHBP1 EH domain binding protein 1 0.0502202
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0499591
NEBL nebulette 0.0485388
PCLO piccolo presynaptic cytomatrix protein 0.0483496
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0469163
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0441006
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0437351
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0432148
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0420286
CSNK1A1 casein kinase 1, alpha 1 0.0413125
CEMIP cell migration inducing protein, hyaluronan binding 0.0411983
KDM7A lysine (K)-specific demethylase 7A 0.0410872
UBC ubiquitin C 0.0399946
KDM3A lysine (K)-specific demethylase 3A 0.0398493
HSPA8 heat shock 70kDa protein 8 0.0394503
CKAP5 cytoskeleton associated protein 5 0.0378464
FMN1 formin 1 0.037421
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0368271
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0351395
AFDN afadin, adherens junction formation factor 0.0339171
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0337737
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0322838
AHNAK AHNAK nucleoprotein 0.0316499
RNF43 ring finger protein 43 0.0316259
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0313629
GCC2 GRIP and coiled-coil domain containing 2 0.0309837
EPS8 epidermal growth factor receptor pathway substrate 8 0.0307364
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0302097
MYH9 myosin, heavy chain 9, non-muscle 0.0298631
ITGA6 integrin, alpha 6 0.029676
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0295218
EHF ets homologous factor 0.0293902
MTAP methylthioadenosine phosphorylase 0.0292413
PRELID2 PRELI domain containing 2 0.0292345
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0291024
H1-0 H1.0 linker histone 0.0288283
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.028549
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0284075
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0280179
EPCAM epithelial cell adhesion molecule 0.0279975
ARHGAP5 Rho GTPase activating protein 5 0.0276922
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0273421
STAU1 staufen double-stranded RNA binding protein 1 0.0272996
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0272728
CTNND1 catenin (cadherin-associated protein), delta 1 0.0269951
ETV6 ets variant 6 0.0269571
TXNRD1 thioredoxin reductase 1 0.0268609
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0266613
SERINC5 serine incorporator 5 0.0265694
BPTF bromodomain PHD finger transcription factor 0.0265038
ADAM19 ADAM metallopeptidase domain 19 0.0263002
MACF1 microtubule-actin crosslinking factor 1 0.0262184
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0261772
ARHGAP42 Rho GTPase activating protein 42 0.0256806
IQGAP1 IQ motif containing GTPase activating protein 1 0.0256728
MUC13 mucin 13, cell surface associated 0.0256529
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0256163
MX2 MX dynamin-like GTPase 2 0.025315
FHIT fragile histidine triad 0.0253088
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0252469
LPP LIM domain containing preferred translocation partner in lipoma 0.0252268
TBC1D5 TBC1 domain family, member 5 0.0252138
MYO1E myosin IE 0.0251554
PARD3B par-3 family cell polarity regulator beta 0.0249657
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0246676
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0245678
NCKAP1 NCK-associated protein 1 0.0241433
ZNRF3 zinc and ring finger 3 0.0241339
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0240554
EEF2 eukaryotic translation elongation factor 2 0.023999
XRN1 5'-3' exoribonuclease 1 0.0239946
SMYD3 SET and MYND domain containing 3 0.0237789
CAPRIN1 cell cycle associated protein 1 0.0236278
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0235644
FNBP4 formin binding protein 4 0.0233446
NAV2 neuron navigator 2 0.0229841
CD2AP CD2-associated protein 0.0227415
TGFA transforming growth factor, alpha 0.0227167
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0226841
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0226588
STC2 stanniocalcin 2 0.0225044
GOLGB1 golgin B1 0.0224426
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0220787
NCOA7 nuclear receptor coactivator 7 0.0219528
SLTM SAFB-like, transcription modulator 0.0219236
MYO10 myosin X 0.0218415
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0217104
ICE1 interactor of little elongation complex ELL subunit 1 0.0215262
ATAD2 ATPase family, AAA domain containing 2 0.021408

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.240807
FTL ferritin, light polypeptide -0.237911
RPL35A ribosomal protein L35a -0.121754
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.116215
FTH1 ferritin, heavy polypeptide 1 -0.106147
RPS21 ribosomal protein S21 -0.103419
PTMA prothymosin, alpha -0.0945147
RPLP1 ribosomal protein, large, P1 -0.090787
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.088787
KRT8 keratin 8, type II -0.0796796
GNAS GNAS complex locus -0.0763187
PERP PERP, TP53 apoptosis effector -0.0742317
B2M beta-2-microglobulin -0.0713168
RPL23 ribosomal protein L23 -0.0659302
RPLP2 ribosomal protein, large, P2 -0.065892
RPS13 ribosomal protein S13 -0.0651998
RPL18 ribosomal protein L18 -0.0632506
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.063038
RPS19 ribosomal protein S19 -0.0617758
RPL12 ribosomal protein L12 -0.0596428
ACTG1 actin gamma 1 -0.0585505
RPL28 ribosomal protein L28 -0.0584705
HMGA1 high mobility group AT-hook 1 -0.0572955
CST3 cystatin C -0.0550716
ATP5F1E ATP synthase F1 subunit epsilon -0.0538124
RPS6 ribosomal protein S6 -0.0528244
HLA-A major histocompatibility complex, class I, A -0.0519945
RPS5 ribosomal protein S5 -0.0495203
POTEF POTE ankyrin domain family, member F -0.0485093
RPL8 ribosomal protein L8 -0.0467868
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0459222
EGR1 early growth response 1 -0.045868
DLG1 discs, large homolog 1 (Drosophila) -0.0457092
LOC112694756 uncharaterized LOC112694756 -0.0450321
RPS8 ribosomal protein S8 -0.0441594
RPS14 ribosomal protein S14 -0.042032
RPS11 ribosomal protein S11 -0.042022
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0419601
GSTP1 glutathione S-transferase pi 1 -0.0406553
IFITM1 interferon induced transmembrane protein 1 -0.0397943
S100A6 S100 calcium binding protein A6 -0.0391368
RPL32 ribosomal protein L32 -0.0388008
GMDS GDP-mannose 4,6-dehydratase -0.0383235
RAB7A RAB7A, member RAS oncogene family -0.0379851
RPLP0 ribosomal protein, large, P0 -0.0377198
MAML2 mastermind-like 2 (Drosophila) -0.0372208
RPS24 ribosomal protein S24 -0.0369647
RPL31 ribosomal protein L31 -0.0356016
RPL19 ribosomal protein L19 -0.0355377
RPL34 ribosomal protein L34 -0.035213
RPS23 ribosomal protein S23 -0.034911
RPL36 ribosomal protein L36 -0.0346272
EIF1 eukaryotic translation initiation factor 1 -0.0346128
CCND1 cyclin D1 -0.0343661
CBX3 chromobox homolog 3 -0.0337071
RPL35 ribosomal protein L35 -0.0334768
RPS15 ribosomal protein S15 -0.033371
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0333094
WWC1 WW and C2 domain containing 1 -0.0331301
TIMP2 TIMP metallopeptidase inhibitor 2 -0.033005
SETD5 SET domain containing 5 -0.0328664
GOLGA4 golgin A4 -0.0325715
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0323973
KRT18 keratin 18, type I -0.0320619
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0317077
RPL37 ribosomal protein L37 -0.0315116
S100A2 S100 calcium binding protein A2 -0.0314194
PFN1 profilin 1 -0.0310869
RPL15 ribosomal protein L15 -0.0305368
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.030383
PKM pyruvate kinase, muscle -0.0301067
RPL26 ribosomal protein L26 -0.0301063
RPL9 ribosomal protein L9 -0.0300403
CTSD cathepsin D -0.0300031
IFITM3 interferon induced transmembrane protein 3 -0.0298487
TMEM47 transmembrane protein 47 -0.0295584
RPL27A ribosomal protein L27a -0.0293998
LDHA lactate dehydrogenase A -0.0293877
IFRD1 interferon-related developmental regulator 1 -0.0289925
ADNP activity-dependent neuroprotector homeobox -0.0288859
RPL37A ribosomal protein L37a -0.0286471
LOC102724023 ES1 protein homolog, mitochondrial -0.0285947
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0285336
MIDN midnolin -0.0284318
TPT1 tumor protein, translationally-controlled 1 -0.0284263
ROMO1 reactive oxygen species modulator 1 -0.0281812
RPS3 ribosomal protein S3 -0.0278227
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0274158
S100A9 S100 calcium binding protein A9 -0.0270616
RPL30 ribosomal protein L30 -0.0270201
HMGB1 high mobility group box 1 -0.0267132
CLDN7 claudin 7 -0.0264149
RPL36A ribosomal protein L36a -0.0261717
LMNA lamin A/C -0.0261128
S100A10 S100 calcium binding protein A10 -0.0260091
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0258588
RPS4X ribosomal protein S4, X-linked -0.0258521
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0256873
RPL11 ribosomal protein L11 -0.0251407
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0250258