Pyridoxine (hydrochloride)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pyridoxine (hydrochloride) perturbation in SW48 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Pyridoxine (hydrochloride)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.158462
EEF2 eukaryotic translation elongation factor 2 0.119208
EGFR epidermal growth factor receptor 0.109482
EMP1 epithelial membrane protein 1 0.0895193
AHNAK AHNAK nucleoprotein 0.0893982
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0867683
HSPA8 heat shock 70kDa protein 8 0.0820391
HMGA2 high mobility group AT-hook 2 0.0809936
DSPP dentin sialophosphoprotein 0.0739386
ATXN1 ataxin 1 0.0713986
ANXA1 annexin A1 0.0680449
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0664917
AREG amphiregulin 0.0663252
EZR ezrin 0.0650718
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0634257
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0613859
ACTG1 actin gamma 1 0.0611702
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0610562
FAT1 FAT atypical cadherin 1 0.0583239
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0566872
VMP1 vacuole membrane protein 1 0.0520744
SRRM2 serine/arginine repetitive matrix 2 0.0520453
FLNA filamin A, alpha 0.0519968
HILPDA hypoxia inducible lipid droplet-associated 0.0509868
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.050927
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0506323
CTSB cathepsin B 0.0504621
NCEH1 neutral cholesterol ester hydrolase 1 0.0502428
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0488064
BIRC3 baculoviral IAP repeat containing 3 0.0488003
ANXA2 annexin A2 0.0487224
RPL3 ribosomal protein L3 0.0472273
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0471637
AXIN2 axin 2 0.0459978
SEPTIN9 septin 9 0.0458669
UBC ubiquitin C 0.0454272
ENO1 enolase 1, (alpha) 0.04492
LOC102724023 ES1 protein homolog, mitochondrial 0.0447263
LAMA4 laminin, alpha 4 0.0446181
CPOX coproporphyrinogen oxidase 0.0443876
LAMC2 laminin, gamma 2 0.0432374
TMSB10 thymosin beta 10 0.0425989
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0421323
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0418526
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0417285
SGMS2 sphingomyelin synthase 2 0.0415333
OXR1 oxidation resistance 1 0.0403503
RPS6 ribosomal protein S6 0.0402512
HOMER1 homer scaffolding protein 1 0.0394725
RAD51B RAD51 paralog B 0.0392463
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0390886
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0385637
ARHGAP42 Rho GTPase activating protein 42 0.0380633
CD9 CD9 molecule 0.0379614
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0362014
SLTM SAFB-like, transcription modulator 0.0357352
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0354129
EFNB2 ephrin-B2 0.0353964
PDE4B phosphodiesterase 4B, cAMP-specific 0.0348311
ITGA6 integrin, alpha 6 0.0343877
MACF1 microtubule-actin crosslinking factor 1 0.0343391
FBXL17 F-box and leucine-rich repeat protein 17 0.0338291
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0337959
FHL2 four and a half LIM domains 2 0.0337696
RPL32 ribosomal protein L32 0.033746
CD36 CD36 molecule (thrombospondin receptor) 0.033372
MACROD2 MACRO domain containing 2 0.0330815
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0330109
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0329095
ZBTB20 zinc finger and BTB domain containing 20 0.032904
KITLG KIT ligand 0.0317532
JUN jun proto-oncogene 0.0310649
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0310424
MKI67 marker of proliferation Ki-67 0.0305943
EPHA2 EPH receptor A2 0.0303729
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0299178
OSBPL10 oxysterol binding protein-like 10 0.0296925
SPRED2 sprouty-related, EVH1 domain containing 2 0.0295729
SMAD3 SMAD family member 3 0.0291123
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0289698
USP9X ubiquitin specific peptidase 9, X-linked 0.0289315
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0289258
DPY19L1 dpy-19-like 1 (C. elegans) 0.0285588
PARD3B par-3 family cell polarity regulator beta 0.0284812
TXNIP thioredoxin interacting protein 0.0279847
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0276329
ABR active BCR-related 0.0274334
RABGAP1L RAB GTPase activating protein 1-like 0.0273141
RPLP2 ribosomal protein, large, P2 0.0267236
ITPKC inositol-trisphosphate 3-kinase C 0.0264609
RPS27A ribosomal protein S27a 0.0264284
MBNL1 muscleblind-like splicing regulator 1 0.0264278
YAP1 Yes-associated protein 1 0.0263184
SFTPA2 surfactant protein A2 0.0262691
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0262349
RPS8 ribosomal protein S8 0.0256474
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0256325
WWOX WW domain containing oxidoreductase 0.0255897
ARL15 ADP-ribosylation factor-like 15 0.0252914
BBS9 Bardet-Biedl syndrome 9 0.0252824

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.246207
FRAS1 Fraser extracellular matrix complex subunit 1 -0.12338
GOLGA4 golgin A4 -0.0961948
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.092214
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0916644
COG5 component of oligomeric golgi complex 5 -0.0907371
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0829143
NBAS neuroblastoma amplified sequence -0.0636179
SCFD1 sec1 family domain containing 1 -0.0601889
RPS24 ribosomal protein S24 -0.0574642
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0563967
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0561394
LMO7 LIM domain 7 -0.0543672
TOP1 topoisomerase (DNA) I -0.0543079
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0531683
TXNRD1 thioredoxin reductase 1 -0.0520249
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0507904
KLF5 Kruppel-like factor 5 (intestinal) -0.0481563
OSBPL3 oxysterol binding protein-like 3 -0.048005
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0470122
PDIA5 protein disulfide isomerase family A, member 5 -0.0452548
ZBTB7C zinc finger and BTB domain containing 7C -0.0449362
CDK13 cyclin-dependent kinase 13 -0.0444622
FERMT1 fermitin family member 1 -0.0440879
IARS1 isoleucyl-tRNA synthetase 1 -0.0430723
RBM25 RNA binding motif protein 25 -0.042753
ZMYM2 zinc finger, MYM-type 2 -0.0412919
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0403855
FNDC3B fibronectin type III domain containing 3B -0.0389881
SEC24D SEC24 family member D -0.0371917
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0365078
NDRG1 N-myc downstream regulated 1 -0.036486
SEC31A SEC31 homolog A (S. cerevisiae) -0.0360502
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0358582
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0354114
BBX bobby sox homolog (Drosophila) -0.0353224
GARS1 glycyl-tRNA synthetase 1 -0.0347485
NCOR2 nuclear receptor corepressor 2 -0.0336908
FYN FYN proto-oncogene, Src family tyrosine kinase -0.0332804
PTK2 protein tyrosine kinase 2 -0.0328879
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0316265
NFXL1 nuclear transcription factor, X-box binding-like 1 -0.0310345
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.030801
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0306583
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0302397
RPL35A ribosomal protein L35a -0.0302263
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0300541
BIRC6 baculoviral IAP repeat containing 6 -0.0296304
GRB10 growth factor receptor-bound protein 10 -0.0295729
RCOR1 REST corepressor 1 -0.0295534
TJP1 tight junction protein 1 -0.028976
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0288427
ESYT2 extended synaptotagmin-like protein 2 -0.0287082
PRRC2B proline-rich coiled-coil 2B -0.0286762
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) -0.0284105
LCORL ligand dependent nuclear receptor corepressor-like -0.0282494
RAB10 RAB10, member RAS oncogene family -0.0281858
KDM4B lysine (K)-specific demethylase 4B -0.0278014
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0275136
WARS1 tryptophanyl-tRNA synthetase 1 -0.0269685
BRWD1 bromodomain and WD repeat domain containing 1 -0.0268596
FNDC3A fibronectin type III domain containing 3A -0.0268555
TET3 tet methylcytosine dioxygenase 3 -0.0267897
GPC5 glypican 5 -0.0267643
STK39 serine threonine kinase 39 -0.026759
STRN3 striatin, calmodulin binding protein 3 -0.0266908
DENND1A DENN/MADD domain containing 1A -0.0265534
AVL9 AVL9 homolog (S. cerevisiase) -0.0263672
CALU calumenin -0.0263018
COG6 component of oligomeric golgi complex 6 -0.0261127
ANKRD10 ankyrin repeat domain 10 -0.0256961
MON2 MON2 homolog (S. cerevisiae) -0.0256784
MAP4 microtubule-associated protein 4 -0.025587
HM13 histocompatibility (minor) 13 -0.0253951
TBC1D22A TBC1 domain family, member 22A -0.0253398
RAB7A RAB7A, member RAS oncogene family -0.0252849
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0252393
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0251991
RAP1B RAP1B, member of RAS oncogene family -0.0251778
RPS21 ribosomal protein S21 -0.0249333
ARHGAP32 Rho GTPase activating protein 32 -0.0248516
XYLT1 xylosyltransferase I -0.0246605
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.024554
UBE3C ubiquitin protein ligase E3C -0.0243603
TMEM39A transmembrane protein 39A -0.0242903
LAMB3 laminin, beta 3 -0.0242095
SEC63 SEC63 homolog (S. cerevisiae) -0.0240882
NCOR1 nuclear receptor corepressor 1 -0.0240613
RBM39 RNA binding motif protein 39 -0.0240242
SERINC5 serine incorporator 5 -0.0239059
RREB1 ras responsive element binding protein 1 -0.023874
ZC3H11A zinc finger CCCH-type containing 11A -0.0238634
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0238278
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.0237194
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.02362
PTBP2 polypyrimidine tract binding protein 2 -0.023599
PCNX1 pecanex 1 -0.0235027
TAS2R14 taste receptor, type 2, member 14 -0.023478
RFX7 regulatory factor X, 7 -0.0233697
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.023303