| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pyridoxine perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pyridoxine_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.282521 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.159633 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0986459 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0845907 |
| RPS2 | ribosomal protein S2 | 0.0749061 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0664968 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0613831 |
| TPI1 | triosephosphate isomerase 1 | 0.0602319 |
| MMP12 | matrix metallopeptidase 12 | 0.0589834 |
| TPM3 | tropomyosin 3 | 0.0487607 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0473544 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.047153 |
| ENO1 | enolase 1, (alpha) | 0.0409532 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.040421 |
| RPS8 | ribosomal protein S8 | 0.040383 |
| TXNRD1 | thioredoxin reductase 1 | 0.0400895 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0390069 |
| PGK1 | phosphoglycerate kinase 1 | 0.0375821 |
| RPS12 | ribosomal protein S12 | 0.0374161 |
| RPS3 | ribosomal protein S3 | 0.037385 |
| KIF5B | kinesin family member 5B | 0.0366264 |
| LDHA | lactate dehydrogenase A | 0.0364309 |
| RRM2 | ribonucleotide reductase M2 | 0.0361958 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0361929 |
| EPHA6 | EPH receptor A6 | 0.0336716 |
| MGAT4C | MGAT4 family, member C | 0.0326647 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0324695 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0311246 |
| TENM3 | teneurin transmembrane protein 3 | 0.0310431 |
| ANXA1 | annexin A1 | 0.030952 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0306372 |
| PCDH9 | protocadherin 9 | 0.0302923 |
| SET | SET nuclear proto-oncogene | 0.0301648 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0300225 |
| AHNAK | AHNAK nucleoprotein | 0.0298948 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0296743 |
| CLTC | clathrin, heavy chain (Hc) | 0.0289438 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.028638 |
| SPAG9 | sperm associated antigen 9 | 0.0283627 |
| FNIP1 | folliculin interacting protein 1 | 0.0270695 |
| CEP350 | centrosomal protein 350kDa | 0.0261811 |
| CEP192 | centrosomal protein 192kDa | 0.0260976 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0260928 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0260714 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0253256 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0251922 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0251244 |
| DST | dystonin | 0.0251196 |
| CPOX | coproporphyrinogen oxidase | 0.024016 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0237289 |
| IL6ST | interleukin 6 signal transducer | 0.0236056 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0235325 |
| PLK2 | polo-like kinase 2 | 0.0235157 |
| VMP1 | vacuole membrane protein 1 | 0.0234542 |
| ZNF292 | zinc finger protein 292 | 0.0233661 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0230461 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0228171 |
| DTNA | dystrobrevin, alpha | 0.0225324 |
| XPO1 | exportin 1 | 0.0224064 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.022288 |
| WWOX | WW domain containing oxidoreductase | 0.0221235 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0217608 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0214543 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0213902 |
| NEK7 | NIMA-related kinase 7 | 0.0213317 |
| ASPH | aspartate beta-hydroxylase | 0.0210865 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0210227 |
| RPS13 | ribosomal protein S13 | 0.0209578 |
| DSPP | dentin sialophosphoprotein | 0.0207159 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 0.0205549 |
| RACK1 | receptor for activated C kinase 1 | 0.0204736 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0204031 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0200655 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.0199876 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0198243 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0197653 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0196616 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0195714 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0194244 |
| YBX1 | Y box binding protein 1 | 0.0193564 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0193559 |
| CLDND1 | claudin domain containing 1 | 0.0192238 |
| PCM1 | pericentriolar material 1 | 0.0192159 |
| PRELID2 | PRELI domain containing 2 | 0.0189668 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0189517 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0186933 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0185595 |
| RPL4 | ribosomal protein L4 | 0.0184534 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.018414 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0181268 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0180994 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.018083 |
| EXOC6B | exocyst complex component 6B | 0.0180197 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0180052 |
| SON | SON DNA binding protein | 0.0178876 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0177525 |
| RPS7 | ribosomal protein S7 | 0.0177309 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0176527 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0176015 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0174731 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.141712 |
| NLGN1 | neuroligin 1 | -0.124598 |
| VIM | vimentin | -0.119733 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0889535 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0847058 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.056279 |
| PCBP2 | poly(rC) binding protein 2 | -0.0522355 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0462745 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.046187 |
| RASAL2 | RAS protein activator like 2 | -0.0458626 |
| CMIP | c-Maf inducing protein | -0.0423867 |
| NHSL1 | NHS-like 1 | -0.0398521 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0364168 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0348061 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0347787 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0341556 |
| ZNF804A | zinc finger protein 804A | -0.0327138 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0313472 |
| CUX1 | cut-like homeobox 1 | -0.0303222 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0287774 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0282201 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0273991 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0269641 |
| PTMS | parathymosin | -0.0264782 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0260951 |
| PTMA | prothymosin, alpha | -0.0260859 |
| RPL36A | ribosomal protein L36a | -0.0257751 |
| NABP1 | nucleic acid binding protein 1 | -0.0254223 |
| HMGA2 | high mobility group AT-hook 2 | -0.0250741 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0246833 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0244132 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0242809 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0233783 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0233332 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0228775 |
| S100A6 | S100 calcium binding protein A6 | -0.0228423 |
| RBM25 | RNA binding motif protein 25 | -0.0226053 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0222414 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0221179 |
| EHBP1 | EH domain binding protein 1 | -0.0220553 |
| NAV3 | neuron navigator 3 | -0.0220489 |
| RPS16 | ribosomal protein S16 | -0.0216481 |
| RPS14 | ribosomal protein S14 | -0.0214681 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0206605 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | -0.0205298 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0204028 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | -0.0201119 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0200124 |
| TEAD4 | TEA domain family member 4 | -0.0197243 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0194378 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.019228 |
| THADA | thyroid adenoma associated | -0.019155 |
| RPL37 | ribosomal protein L37 | -0.0191386 |
| TRAF3 | TNF receptor-associated factor 3 | -0.0189812 |
| CALR | calreticulin | -0.0187798 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | -0.0186689 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0179131 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0177685 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.017749 |
| CDK12 | cyclin-dependent kinase 12 | -0.0176002 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0175501 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0172986 |
| COL5A2 | collagen, type V, alpha 2 | -0.0170733 |
| KIF18B | kinesin family member 18B | -0.0167857 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0166284 |
| LRRC23 | leucine rich repeat containing 23 | -0.0164916 |
| CCN2 | cellular communication network factor 2 | -0.0164799 |
| RPLP1 | ribosomal protein, large, P1 | -0.01643 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.016163 |
| PRR11 | proline rich 11 | -0.0161546 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0161371 |
| WDR43 | WD repeat domain 43 | -0.0160985 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0160947 |
| GATAD2A | GATA zinc finger domain containing 2A | -0.0160013 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0158887 |
| HMGB1 | high mobility group box 1 | -0.0158472 |
| MYPN | myopalladin | -0.015821 |
| FUS | FUS RNA binding protein | -0.0157315 |
| RPS29 | ribosomal protein S29 | -0.0153027 |
| PDCD6 | programmed cell death 6 | -0.0151971 |
| FBXO17 | F-box protein 17 | -0.0151099 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0150484 |
| RPS6 | ribosomal protein S6 | -0.0150441 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.015014 |
| RPS19 | ribosomal protein S19 | -0.0149059 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0147017 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0146977 |
| CENPF | centromere protein F, 350/400kDa | -0.0146811 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0145988 |
| RPL28 | ribosomal protein L28 | -0.0144301 |
| RPL36 | ribosomal protein L36 | -0.0144293 |
| PABPN1 | poly(A) binding protein, nuclear 1 | -0.0144253 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0143481 |
| TGM2 | transglutaminase 2 | -0.0142579 |
| PARN | poly(A)-specific ribonuclease | -0.0141598 |
| VASP | vasodilator-stimulated phosphoprotein | -0.0141159 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0140983 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0140305 |
| RPL34 | ribosomal protein L34 | -0.0139978 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0139107 |
