Pyridoxine_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pyridoxine perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pyridoxine_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.132184
EPSTI1 epithelial stromal interaction 1 (breast) 0.0781814
LYZ lysozyme 0.0755989
STS steroid sulfatase (microsomal), isozyme S 0.0735142
GMDS GDP-mannose 4,6-dehydratase 0.0669092
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0631882
AKAP13 A kinase (PRKA) anchor protein 13 0.0613659
MACC1 metastasis associated in colon cancer 1 0.0580522
MX1 MX dynamin-like GTPase 1 0.0578262
ERBIN erbb2 interacting protein 0.0566382
LCN2 lipocalin 2 0.055679
TMC5 transmembrane channel-like 5 0.054726
ANXA2 annexin A2 0.0509133
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0506503
ARHGAP26 Rho GTPase activating protein 26 0.0490689
ITGA6 integrin, alpha 6 0.048933
EXT1 exostosin glycosyltransferase 1 0.0482886
NPSR1 neuropeptide S receptor 1 0.0471681
MAML2 mastermind-like 2 (Drosophila) 0.0467162
IGFBP3 insulin-like growth factor binding protein 3 0.0455348
B2M beta-2-microglobulin 0.0454576
MX2 MX dynamin-like GTPase 2 0.0440181
AREG amphiregulin 0.0427333
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0401059
TSHZ2 teashirt zinc finger homeobox 2 0.0400309
TJP1 tight junction protein 1 0.0391854
BAIAP2L1 BAI1-associated protein 2-like 1 0.038618
SP100 SP100 nuclear antigen 0.0383355
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0382814
RIGI RNA sensor RIG-I 0.0382183
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0381194
EGR1 early growth response 1 0.0368194
MCU mitochondrial calcium uniporter 0.0357686
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.0356982
DIAPH1 diaphanous-related formin 1 0.0343973
PLSCR2 phospholipid scramblase 2 0.034299
SPATA13 spermatogenesis associated 13 0.033126
IFI6 interferon, alpha-inducible protein 6 0.0329624
RAB7A RAB7A, member RAS oncogene family 0.0327543
TM4SF19 transmembrane 4 L six family member 19 0.0318537
MAP7 microtubule-associated protein 7 0.0318245
PERP PERP, TP53 apoptosis effector 0.0310494
MCL1 myeloid cell leukemia 1 0.0307426
EPS8 epidermal growth factor receptor pathway substrate 8 0.0307337
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.029883
ZHX2 zinc fingers and homeoboxes 2 0.0285177
LAMA4 laminin, alpha 4 0.0284317
EGLN3 egl-9 family hypoxia-inducible factor 3 0.027771
RNF213 ring finger protein 213 0.0276461
C6ORF132 chromosome 6 open reading frame 132 0.0270729
GCLC glutamate-cysteine ligase, catalytic subunit 0.0264662
CEMIP cell migration inducing protein, hyaluronan binding 0.0260714
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0258581
ASPH aspartate beta-hydroxylase 0.0255297
TSC22D1 TSC22 domain family, member 1 0.0254625
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.025419
VMP1 vacuole membrane protein 1 0.0252155
ZSWIM6 zinc finger, SWIM-type containing 6 0.0250024
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0245427
NCEH1 neutral cholesterol ester hydrolase 1 0.0242156
GK glycerol kinase 0.0241801
PLSCR1 phospholipid scramblase 1 0.0240285
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0238605
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0236262
IFI27 interferon, alpha-inducible protein 27 0.0234207
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0232028
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0228624
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 0.02252
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.0224852
UBAP2 ubiquitin associated protein 2 0.0221917
FNDC3B fibronectin type III domain containing 3B 0.0218689
SEPTIN9 septin 9 0.0217162
MYO1E myosin IE 0.0216457
BCL2L1 BCL2-like 1 0.0214733
CDHR2 cadherin-related family member 2 0.0212283
CYSTM1 cysteine-rich transmembrane module containing 1 0.0211403
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.021079
JMJD1C jumonji domain containing 1C 0.020991
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0209191
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0208603
MCTP1 multiple C2 domains, transmembrane 1 0.0208122
EPHB2 EPH receptor B2 0.020784
FTH1 ferritin, heavy polypeptide 1 0.0205023
ALCAM activated leukocyte cell adhesion molecule 0.0204649
LPP LIM domain containing preferred translocation partner in lipoma 0.0203004
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.0202505
PTMA prothymosin, alpha 0.0201004
SIK3 SIK family kinase 3 0.02003
MYO5B myosin VB 0.0199456
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0198146
EZR ezrin 0.0197137
INTS6 integrator complex subunit 6 0.0195948
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0195289
LOC102724023 ES1 protein homolog, mitochondrial 0.0194902
N4BP2L2 NEDD4 binding protein 2-like 2 0.0192986
PRKCA protein kinase C, alpha 0.0192535
CXCL8 chemokine (C-X-C motif) ligand 8 0.0191199
CATSPERB catsper channel auxiliary subunit beta 0.0190626
MYH14 myosin, heavy chain 14, non-muscle 0.018941
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0189091

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.165737
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.089733
RUNX1 runt-related transcription factor 1 -0.0613069
NDRG1 N-myc downstream regulated 1 -0.0602095
RNF43 ring finger protein 43 -0.0525804
NRIP1 nuclear receptor interacting protein 1 -0.0509241
BTBD9 BTB (POZ) domain containing 9 -0.0501561
MBNL2 muscleblind-like splicing regulator 2 -0.045556
DSCAM Down syndrome cell adhesion molecule -0.0435877
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0430038
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0424312
PDIA3 protein disulfide isomerase family A, member 3 -0.0421919
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0415339
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0397407
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0391863
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.035952
H1-0 H1.0 linker histone -0.035773
SREBF2 sterol regulatory element binding transcription factor 2 -0.0357469
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0341552
TXNIP thioredoxin interacting protein -0.0336813
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0330312
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0322349
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0317578
RNF149 ring finger protein 149 -0.0305013
CANX calnexin -0.0299498
RHOBTB3 Rho-related BTB domain containing 3 -0.0298506
SEC24D SEC24 family member D -0.0294742
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0291506
ZMYM2 zinc finger, MYM-type 2 -0.0289924
RBM39 RNA binding motif protein 39 -0.028671
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0286377
CALR calreticulin -0.0278032
RRBP1 ribosome binding protein 1 -0.0277089
TPT1 tumor protein, translationally-controlled 1 -0.0272054
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0271738
AKAP9 A kinase (PRKA) anchor protein 9 -0.0269883
HDLBP high density lipoprotein binding protein -0.026449
OGA O-GlcNAcase -0.0261369
USP3 ubiquitin specific peptidase 3 -0.0259594
SBF2 SET binding factor 2 -0.0258752
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0255896
EHF ets homologous factor -0.0251654
TSC22D2 TSC22 domain family, member 2 -0.0251001
IFNGR1 interferon gamma receptor 1 -0.0249509
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.02476
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0242657
COG6 component of oligomeric golgi complex 6 -0.0242506
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0241471
HDAC8 histone deacetylase 8 -0.0238068
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0227877
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.022699
PRELID2 PRELI domain containing 2 -0.0224815
PTBP3 polypyrimidine tract binding protein 3 -0.0223467
TMEM263 transmembrane protein 263 -0.0223183
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.021814
WSB1 WD repeat and SOCS box containing 1 -0.021569
PDIA4 protein disulfide isomerase family A, member 4 -0.0215108
PTEN phosphatase and tensin homolog -0.0213628
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0213242
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0210439
KDM3A lysine (K)-specific demethylase 3A -0.0206705
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0200904
HELZ helicase with zinc finger -0.0200827
GOLGA2 golgin A2 -0.0200746
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0198537
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0197217
GOLGA4 golgin A4 -0.0197036
MCTP2 multiple C2 domains, transmembrane 2 -0.0194308
SUCO SUN domain containing ossification factor -0.0193555
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0192986
ZNRF3 zinc and ring finger 3 -0.0192837
TMPRSS4 transmembrane protease, serine 4 -0.0190483
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 -0.0189931
ACBD3 acyl-CoA binding domain containing 3 -0.018833
BHLHE40 basic helix-loop-helix family, member e40 -0.0187863
UBR1 ubiquitin protein ligase E3 component n-recognin 1 -0.0185596
ARGLU1 arginine and glutamate rich 1 -0.0185209
METTL15 methyltransferase like 15 -0.0182431
PHC3 polyhomeotic homolog 3 (Drosophila) -0.0182033
ZNF638 zinc finger protein 638 -0.0180416
EIF1 eukaryotic translation initiation factor 1 -0.0180312
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0179497
CLTC clathrin, heavy chain (Hc) -0.0179039
AGR2 anterior gradient 2 -0.0178407
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0177914
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0176649
UGDH UDP-glucose 6-dehydrogenase -0.0172902
TM9SF2 transmembrane 9 superfamily member 2 -0.0172775
DIAPH3 diaphanous-related formin 3 -0.017237
RAB1A RAB1A, member RAS oncogene family -0.0172113
NUCB2 nucleobindin 2 -0.0171959
SSR1 signal sequence receptor, alpha -0.0171659
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.017075
RPL26 ribosomal protein L26 -0.0169743
NKTR natural killer cell triggering receptor -0.0167939
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0167485
TC2N tandem C2 domains, nuclear -0.0167359
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0166881
FNDC3A fibronectin type III domain containing 3A -0.0166856
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0166797