| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pyridoxine perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pyridoxine_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0578853 |
| FN1 | fibronectin 1 | 0.0497464 |
| MT2A | metallothionein 2A | 0.0442235 |
| ATP13A3 | ATPase type 13A3 | 0.0423483 |
| SMAD3 | SMAD family member 3 | 0.0375032 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0333331 |
| LOXL2 | lysyl oxidase-like 2 | 0.0326042 |
| AHNAK | AHNAK nucleoprotein | 0.032174 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0312986 |
| ARRDC3 | arrestin domain containing 3 | 0.0310528 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0308675 |
| SPAG9 | sperm associated antigen 9 | 0.0287858 |
| NDRG1 | N-myc downstream regulated 1 | 0.0280363 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0278618 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0269735 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0254662 |
| ZNF292 | zinc finger protein 292 | 0.0243166 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0239928 |
| CADM1 | cell adhesion molecule 1 | 0.0231627 |
| RPS2 | ribosomal protein S2 | 0.0223927 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0220692 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0211257 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0203539 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0193331 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0183063 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0179671 |
| OGA | O-GlcNAcase | 0.0179314 |
| CANX | calnexin | 0.0178756 |
| POSTN | periostin, osteoblast specific factor | 0.0175981 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0175066 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0168534 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0167891 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0166451 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0166235 |
| USP3 | ubiquitin specific peptidase 3 | 0.0159915 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0158276 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0157966 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0156282 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0154098 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0153825 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0151104 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0151023 |
| RLF | rearranged L-myc fusion | 0.0150471 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0149059 |
| TPM3 | tropomyosin 3 | 0.0148229 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0146868 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0145219 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0143037 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0138306 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0135876 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0134711 |
| XPO1 | exportin 1 | 0.0133778 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0133762 |
| RPS3 | ribosomal protein S3 | 0.0132227 |
| RNF145 | ring finger protein 145 | 0.0131428 |
| RNF24 | ring finger protein 24 | 0.0131289 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0131035 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0125718 |
| FMNL2 | formin-like 2 | 0.0122846 |
| MLF1 | myeloid leukemia factor 1 | 0.0122388 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0121605 |
| GRID1 | glutamate receptor, ionotropic, delta 1 | 0.0121585 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0121211 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.012009 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0119283 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.0119161 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0119046 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0117869 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0117532 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0115681 |
| MT1X | metallothionein 1X | 0.0112609 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.011244 |
| RPS12 | ribosomal protein S12 | 0.0111764 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0111217 |
| RARB | retinoic acid receptor, beta | 0.0110864 |
| B2M | beta-2-microglobulin | 0.0110846 |
| MTSS1 | metastasis suppressor 1 | 0.0109784 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0108563 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0106738 |
| ENO1 | enolase 1, (alpha) | 0.0106653 |
| FAM107B | family with sequence similarity 107, member B | 0.0106575 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0106024 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.010535 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0105285 |
| ANXA5 | annexin A5 | 0.0103626 |
| RBM39 | RNA binding motif protein 39 | 0.0103535 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0101471 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.0101304 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0101125 |
| FBXO42 | F-box protein 42 | 0.00999326 |
| ECE1 | endothelin converting enzyme 1 | 0.00997972 |
| EMP1 | epithelial membrane protein 1 | 0.00997808 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.00997021 |
| COL3A1 | collagen, type III, alpha 1 | 0.00995996 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.00993571 |
| TAC4 | tachykinin 4 (hemokinin) | 0.00987632 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.00982392 |
| INSIG2 | insulin induced gene 2 | 0.00981105 |
| KIF5B | kinesin family member 5B | 0.00974187 |
| RASA2 | RAS p21 protein activator 2 | 0.00970923 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL1A1 | collagen, type I, alpha 1 | -0.132378 |
| VIM | vimentin | -0.12845 |
| CDH13 | cadherin 13 | -0.103581 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0998199 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0814529 |
| TMSB10 | thymosin beta 10 | -0.0735159 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.070753 |
| CALD1 | caldesmon 1 | -0.0685586 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0679786 |
| COL1A2 | collagen, type I, alpha 2 | -0.0676647 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0668713 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0647132 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0580628 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0559634 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0466115 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0448009 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0434678 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0428561 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0420898 |
| GLIS3 | GLIS family zinc finger 3 | -0.0405766 |
| VCAN | versican | -0.037441 |
| MAP1B | microtubule-associated protein 1B | -0.0372212 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0368997 |
| VCL | vinculin | -0.0363934 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0352233 |
| TPM4 | tropomyosin 4 | -0.0334226 |
| CNTN5 | contactin 5 | -0.0328204 |
| POTEF | POTE ankyrin domain family, member F | -0.0319556 |
| NEK10 | NIMA-related kinase 10 | -0.0309989 |
| ACTG1 | actin gamma 1 | -0.0307113 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0306762 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0304432 |
| ASPH | aspartate beta-hydroxylase | -0.0299536 |
| FOXP1 | forkhead box P1 | -0.0288013 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0276104 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0275065 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0266894 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0263033 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0261841 |
| FBN1 | fibrillin 1 | -0.0249403 |
| FTL | ferritin, light polypeptide | -0.0248574 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0241381 |
| NAV1 | neuron navigator 1 | -0.0241076 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0239019 |
| EGR1 | early growth response 1 | -0.0238506 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0236859 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0236853 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0234504 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0231307 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0231168 |
| COL5A1 | collagen, type V, alpha 1 | -0.0228284 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0224233 |
| CLMP | CXADR-like membrane protein | -0.0223216 |
| ATXN1 | ataxin 1 | -0.0218404 |
| TPM1 | tropomyosin 1 (alpha) | -0.0217791 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0216834 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0215441 |
| TENM3 | teneurin transmembrane protein 3 | -0.0214481 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0212616 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0209623 |
| CUX1 | cut-like homeobox 1 | -0.0209194 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0208817 |
| PALLD | palladin, cytoskeletal associated protein | -0.0204194 |
| ZNF644 | zinc finger protein 644 | -0.0202796 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0201235 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0199356 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0197876 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0196247 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0195127 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0193594 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0192414 |
| PRSS23 | protease, serine, 23 | -0.0188683 |
| S100A6 | S100 calcium binding protein A6 | -0.0187614 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0186406 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0185029 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.018482 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0183708 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0183367 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0183079 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0180809 |
| INHBA | inhibin, beta A | -0.0177617 |
| RASAL2 | RAS protein activator like 2 | -0.017592 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0175421 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0175418 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0175393 |
| GOLGB1 | golgin B1 | -0.0174532 |
| NREP | neuronal regeneration related protein | -0.0173761 |
| LMO4 | LIM domain only 4 | -0.0172968 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0172453 |
| HLA-B | major histocompatibility complex, class I, B | -0.0172313 |
| OSMR | oncostatin M receptor | -0.0169666 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0169265 |
| DGKI | diacylglycerol kinase, iota | -0.0168725 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0167801 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0167801 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0166876 |
| DST | dystonin | -0.0166649 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0163601 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0162859 |
| IL6ST | interleukin 6 signal transducer | -0.0162567 |
