| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pyridoxine perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pyridoxine_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.321953 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.159335 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.133712 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.107682 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0884903 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0783127 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0704702 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0646465 |
| ENO1 | enolase 1, (alpha) | 0.0644849 |
| DSPP | dentin sialophosphoprotein | 0.0610084 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0603227 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0539111 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0523322 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0490315 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0454613 |
| SVIL | supervillin | 0.044981 |
| NDRG1 | N-myc downstream regulated 1 | 0.0435671 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0426721 |
| TF | transferrin | 0.0386349 |
| GOLGA4 | golgin A4 | 0.0383985 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0382558 |
| VEGFA | vascular endothelial growth factor A | 0.037928 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0373611 |
| ZNF292 | zinc finger protein 292 | 0.0370851 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.036322 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0361031 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0354343 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0350519 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0346642 |
| AFDN | afadin, adherens junction formation factor | 0.0342242 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0341993 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0333276 |
| FAM13A | family with sequence similarity 13, member A | 0.0315375 |
| INSIG2 | insulin induced gene 2 | 0.0308222 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0307156 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0303956 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.029707 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0295286 |
| C3 | complement component 3 | 0.0286059 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0280099 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0276696 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.027557 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0274476 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0273599 |
| ARFGEF3 | ARFGEF family member 3 | 0.0273552 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0269909 |
| FBXO42 | F-box protein 42 | 0.026665 |
| CRY1 | cryptochrome circadian clock 1 | 0.0263303 |
| JMJD1C | jumonji domain containing 1C | 0.0263027 |
| RPS6 | ribosomal protein S6 | 0.0262751 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0259993 |
| PCBP2 | poly(rC) binding protein 2 | 0.0257175 |
| QKI | QKI, KH domain containing, RNA binding | 0.025696 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0255583 |
| RBM39 | RNA binding motif protein 39 | 0.0254622 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0254305 |
| WDR45B | WD repeat domain 45B | 0.0253857 |
| WWC2 | WW and C2 domain containing 2 | 0.0245949 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0244496 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.0244451 |
| SPAG9 | sperm associated antigen 9 | 0.0241991 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.024055 |
| CANX | calnexin | 0.0240291 |
| NGLY1 | N-glycanase 1 | 0.0237688 |
| HELZ | helicase with zinc finger | 0.0232825 |
| ANKRD12 | ankyrin repeat domain 12 | 0.023106 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0228627 |
| NUP58 | nucleoporin 58 | 0.0227595 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0226484 |
| LDHA | lactate dehydrogenase A | 0.0226435 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0225688 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0222842 |
| RYBP | RING1 and YY1 binding protein | 0.0221425 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0220389 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0219479 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0219214 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0218259 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0217229 |
| TNS1 | tensin 1 | 0.0215136 |
| ZNF638 | zinc finger protein 638 | 0.0214264 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0214101 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.021247 |
| GSE1 | Gse1 coiled-coil protein | 0.0211727 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0209343 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0207194 |
| PDE8A | phosphodiesterase 8A | 0.0206246 |
| SEC24A | SEC24 family member A | 0.0205041 |
| KIF1B | kinesin family member 1B | 0.0204208 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0203282 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0202471 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0200427 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0199616 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0197187 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0194969 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0193015 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0193014 |
| TXNRD1 | thioredoxin reductase 1 | 0.0192313 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0191164 |
| PER2 | period circadian clock 2 | 0.0191052 |
| CPE | carboxypeptidase E | 0.0186863 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.427152 |
| TMSB10 | thymosin beta 10 | -0.0683999 |
| VCL | vinculin | -0.0607105 |
| GPC6 | glypican 6 | -0.0601111 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.057118 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.054632 |
| ITGAV | integrin, alpha V | -0.0522532 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0519918 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0517241 |
| EHBP1 | EH domain binding protein 1 | -0.0510648 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0491705 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0487064 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0452993 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0452732 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0452431 |
| APOA2 | apolipoprotein A-II | -0.044582 |
| PTCHD4 | patched domain containing 4 | -0.0423842 |
| APOB | apolipoprotein B | -0.0388444 |
| HMGA1 | high mobility group AT-hook 1 | -0.0371433 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0367294 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0362971 |
| FRMD5 | FERM domain containing 5 | -0.0358502 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0352878 |
| BCL2L1 | BCL2-like 1 | -0.0341216 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0338229 |
| EGR1 | early growth response 1 | -0.0332918 |
| RPS24 | ribosomal protein S24 | -0.0324498 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0313048 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0296971 |
| GPC3 | glypican 3 | -0.0279614 |
| RNF213 | ring finger protein 213 | -0.0278269 |
| RIGI | RNA sensor RIG-I | -0.0276599 |
| RPS21 | ribosomal protein S21 | -0.0265288 |
| MRTFA | myocardin related transcription factor A | -0.0255593 |
| ACTN4 | actinin, alpha 4 | -0.024234 |
| DST | dystonin | -0.0239541 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0231723 |
| TRIM26 | tripartite motif containing 26 | -0.0225727 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0224698 |
| RPL35A | ribosomal protein L35a | -0.0224378 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0223612 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0222928 |
| ACTG1 | actin gamma 1 | -0.0216791 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0214897 |
| ARHGEF18 | Rho/Rac guanine nucleotide exchange factor (GEF) 18 | -0.0214321 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0211512 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0211407 |
| MX2 | MX dynamin-like GTPase 2 | -0.0194131 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0193731 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.019141 |
| TPM1 | tropomyosin 1 (alpha) | -0.0190278 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0188954 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0188621 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0187782 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0186913 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0186861 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0185878 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0185346 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0184172 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.018313 |
| HMGA2 | high mobility group AT-hook 2 | -0.0176293 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0175916 |
| RPL23 | ribosomal protein L23 | -0.0175536 |
| ZFHX3 | zinc finger homeobox 3 | -0.0175528 |
| FERMT1 | fermitin family member 1 | -0.0174506 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0171871 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.017181 |
| RPL34 | ribosomal protein L34 | -0.0169708 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.016865 |
| SP100 | SP100 nuclear antigen | -0.0165961 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.016531 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0162722 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0159216 |
| MYO1E | myosin IE | -0.0157552 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0154263 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0152635 |
| OSMR | oncostatin M receptor | -0.0152326 |
| RPL26 | ribosomal protein L26 | -0.0152151 |
| ARL5A | ADP-ribosylation factor-like 5A | -0.015133 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0151003 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0149869 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0149291 |
| NHSL1 | NHS-like 1 | -0.0147878 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0145892 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.014575 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0145576 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.0145194 |
| RSU1 | Ras suppressor protein 1 | -0.0144657 |
| ATXN1 | ataxin 1 | -0.0139792 |
| KRT8 | keratin 8, type II | -0.0138624 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0138572 |
| PLSCR1 | phospholipid scramblase 1 | -0.0138099 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0137793 |
| RBBP6 | retinoblastoma binding protein 6 | -0.0137629 |
| ARHGAP9 | Rho GTPase activating protein 9 | -0.0136405 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0135831 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0135596 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0133153 |
| MIDN | midnolin | -0.0132109 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -0.013138 |
