Pyridoxine_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pyridoxine perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pyridoxine_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.167195
CLU clusterin 0.137525
MEF2A myocyte enhancer factor 2A 0.105741
AHNAK AHNAK nucleoprotein 0.0953293
NDRG1 N-myc downstream regulated 1 0.0912213
SULF1 sulfatase 1 0.0860779
TRIO trio Rho guanine nucleotide exchange factor 0.0787596
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.075054
ITGA6 integrin, alpha 6 0.0725592
MSN moesin 0.0693968
FOXO1 forkhead box O1 0.0679111
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0673471
MYOF myoferlin 0.0604782
PGK1 phosphoglycerate kinase 1 0.056402
NAMPT nicotinamide phosphoribosyltransferase 0.0550562
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0548632
BCL2L1 BCL2-like 1 0.0530916
LMO7 LIM domain 7 0.0527128
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0520628
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0500104
EMP1 epithelial membrane protein 1 0.0483529
DPYD dihydropyrimidine dehydrogenase 0.0476006
MT1X metallothionein 1X 0.0463518
NEK7 NIMA-related kinase 7 0.0457565
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0439764
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0437641
KRT17 keratin 17, type I 0.0424817
RICTOR RPTOR independent companion of MTOR, complex 2 0.042185
ZEB1 zinc finger E-box binding homeobox 1 0.0419947
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0397029
KTN1 kinectin 1 (kinesin receptor) 0.0389587
ENO1 enolase 1, (alpha) 0.0387226
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0386583
EZR ezrin 0.0382698
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.038073
MYO10 myosin X 0.0379942
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0378032
H1-0 H1.0 linker histone 0.0373351
TPM3 tropomyosin 3 0.0372749
ITCH itchy E3 ubiquitin protein ligase 0.0371803
TAGLN2 transgelin 2 0.0371195
MTSS1 metastasis suppressor 1 0.036719
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0361276
GOLGA4 golgin A4 0.0359495
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0354016
CD44 CD44 molecule (Indian blood group) 0.0352493
ARHGAP29 Rho GTPase activating protein 29 0.0351652
RBM39 RNA binding motif protein 39 0.034535
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0344739
OSMR oncostatin M receptor 0.0334775
SBF2 SET binding factor 2 0.0333196
CUL4B cullin 4B 0.0332219
ANKRD33B ankyrin repeat domain 33B 0.0331409
TXNIP thioredoxin interacting protein 0.0330516
TIMP3 TIMP metallopeptidase inhibitor 3 0.0327597
LNPEP leucyl/cystinyl aminopeptidase 0.032506
RASAL2 RAS protein activator like 2 0.032248
LAMC2 laminin, gamma 2 0.0318073
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0312243
CD59 CD59 molecule, complement regulatory protein 0.0311355
CAPRIN2 caprin family member 2 0.0304814
CSDE1 cold shock domain containing E1, RNA-binding 0.0301779
SERINC3 serine incorporator 3 0.0299442
PLEC plectin 0.0296919
OGA O-GlcNAcase 0.0290157
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0289667
RIN2 Ras and Rab interactor 2 0.028829
PARP4 poly (ADP-ribose) polymerase family, member 4 0.02849
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0284291
PALLD palladin, cytoskeletal associated protein 0.0277548
YBX3 Y box binding protein 3 0.0277268
SLK STE20-like kinase 0.0277128
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0275701
SAMD9 sterile alpha motif domain containing 9 0.027566
FOXP1 forkhead box P1 0.0274741
EFHD2 EF-hand domain family, member D2 0.0274493
MYH9 myosin, heavy chain 9, non-muscle 0.026907
DOCK5 dedicator of cytokinesis 5 0.0267746
MBNL1 muscleblind-like splicing regulator 1 0.0265725
SLC45A4 solute carrier family 45, member 4 0.0264011
ESYT2 extended synaptotagmin-like protein 2 0.0262097
RABGAP1L RAB GTPase activating protein 1-like 0.0261167
APLP2 amyloid beta (A4) precursor-like protein 2 0.0259879
GRB10 growth factor receptor-bound protein 10 0.025855
TGM2 transglutaminase 2 0.0256583
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0252143
MECOM MDS1 and EVI1 complex locus 0.0249504
PRSS23 protease, serine, 23 0.0248331
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0248268
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0247918
PTK2 protein tyrosine kinase 2 0.0243764
LIMA1 LIM domain and actin binding 1 0.0239829
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0239373
DOK5 docking protein 5 0.0238044
SMAD3 SMAD family member 3 0.0237527
NRG1 neuregulin 1 0.0237402
MACF1 microtubule-actin crosslinking factor 1 0.0235343
WASF2 WAS protein family, member 2 0.0233111
ARHGAP21 Rho GTPase activating protein 21 0.0232198
ACTN4 actinin, alpha 4 0.0231501

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.129658
HLA-B major histocompatibility complex, class I, B -0.0807026
TPT1 tumor protein, translationally-controlled 1 -0.0781918
RPLP1 ribosomal protein, large, P1 -0.0612357
INTS6 integrator complex subunit 6 -0.0596041
RPS25 ribosomal protein S25 -0.0533943
RPL35A ribosomal protein L35a -0.0482774
RPL31 ribosomal protein L31 -0.0481529
RPL37A ribosomal protein L37a -0.0472787
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0469518
RPL34 ribosomal protein L34 -0.0451944
RPL36A ribosomal protein L36a -0.0449664
RPS24 ribosomal protein S24 -0.0442746
IGF2 insulin-like growth factor 2 -0.0423304
RPLP2 ribosomal protein, large, P2 -0.0385438
SPINK5 serine peptidase inhibitor, Kazal type 5 -0.0377947
SQSTM1 sequestosome 1 -0.037142
RPS27A ribosomal protein S27a -0.0342505
RPL9 ribosomal protein L9 -0.0336132
SP100 SP100 nuclear antigen -0.0328209
RPS29 ribosomal protein S29 -0.0322312
RPL37 ribosomal protein L37 -0.0318193
RPL26 ribosomal protein L26 -0.0303979
ZMYND8 zinc finger, MYND-type containing 8 -0.030085
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.028944
HMGA2 high mobility group AT-hook 2 -0.028619
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0283807
RPS8 ribosomal protein S8 -0.0282377
IER3 immediate early response 3 -0.0275102
HDAC9 histone deacetylase 9 -0.0269585
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0267963
RPL7A ribosomal protein L7a -0.0264647
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0258845
RPL27A ribosomal protein L27a -0.0258294
RPS23 ribosomal protein S23 -0.0256649
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0249826
IFI6 interferon, alpha-inducible protein 6 -0.024884
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0246694
B2M beta-2-microglobulin -0.0245772
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.024204
IFI27 interferon, alpha-inducible protein 27 -0.023908
FTL ferritin, light polypeptide -0.0238589
RPS20 ribosomal protein S20 -0.0236841
RAD51B RAD51 paralog B -0.0233585
RPS27 ribosomal protein S27 -0.022854
RPL12 ribosomal protein L12 -0.0227425
CTBP2 C-terminal binding protein 2 -0.0222192
RPL11 ribosomal protein L11 -0.0221905
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0220148
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0219895
RPS13 ribosomal protein S13 -0.0219057
TRA2A transformer 2 alpha homolog (Drosophila) -0.0217784
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0215301
STAU1 staufen double-stranded RNA binding protein 1 -0.0208486
CAVIN1 caveolae associated protein 1 -0.0207986
RPS11 ribosomal protein S11 -0.0207815
CUX1 cut-like homeobox 1 -0.020731
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0206728
S100A10 S100 calcium binding protein A10 -0.020343
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0203376
FAF1 Fas (TNFRSF6) associated factor 1 -0.0203161
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0199793
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0199225
DDIT3 DNA-damage-inducible transcript 3 -0.0198537
VDAC1 voltage-dependent anion channel 1 -0.0194177
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0193952
GNAS GNAS complex locus -0.0192862
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0192093
TUBB4B tubulin, beta 4B class IVb -0.0191234
VIM vimentin -0.0186746
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0181717
RPL5 ribosomal protein L5 -0.0181113
HM13 histocompatibility (minor) 13 -0.0178792
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.017786
NOP56 NOP56 ribonucleoprotein -0.017494
FAM107B family with sequence similarity 107, member B -0.0174116
BLCAP bladder cancer associated protein -0.01725
ADIRF adipogenesis regulatory factor -0.0172175
RPS10 ribosomal protein S10 -0.0171537
MAML2 mastermind-like 2 (Drosophila) -0.0170209
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.01684
RPS15 ribosomal protein S15 -0.0168149
ACTG1 actin gamma 1 -0.0167753
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0167592
RPL8 ribosomal protein L8 -0.0166112
RPL38 ribosomal protein L38 -0.0165477
RPL39 ribosomal protein L39 -0.0164023
NECTIN4 nectin cell adhesion molecule 4 -0.0160747
AHRR aryl-hydrocarbon receptor repressor -0.0159407
MBNL2 muscleblind-like splicing regulator 2 -0.0154794
S100A6 S100 calcium binding protein A6 -0.0152601
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0150659
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0148924
TBCA tubulin folding cofactor A -0.0148573
NPAS2 neuronal PAS domain protein 2 -0.0147975
SEPTIN7 septin 7 -0.0147888
ATP5F1E ATP synthase F1 subunit epsilon -0.0147619
TRAF3 TNF receptor-associated factor 3 -0.0147456
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0146772
LARP1B La ribonucleoprotein domain family, member 1B -0.0145435