| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pyridoxine perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pyridoxine_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.18893 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.13427 |
| TSC22D1 | TSC22 domain family, member 1 | 0.110167 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.109374 |
| DST | dystonin | 0.109259 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.106163 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0900144 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0851736 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0812629 |
| TXNIP | thioredoxin interacting protein | 0.0742855 |
| AHNAK | AHNAK nucleoprotein | 0.0740824 |
| EREG | epiregulin | 0.0731259 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | 0.0722867 |
| CD44 | CD44 molecule (Indian blood group) | 0.0708311 |
| PRELID2 | PRELI domain containing 2 | 0.0705254 |
| MYOF | myoferlin | 0.0653921 |
| TP63 | tumor protein p63 | 0.0613421 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0606141 |
| CADM2 | cell adhesion molecule 2 | 0.0601918 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0597623 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0587692 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0563248 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0537083 |
| SQSTM1 | sequestosome 1 | 0.0520669 |
| EHBP1 | EH domain binding protein 1 | 0.0504214 |
| EPHA4 | EPH receptor A4 | 0.0487206 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0482635 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.047471 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0463694 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0457718 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0436322 |
| ENO1 | enolase 1, (alpha) | 0.0433727 |
| LRRC49 | leucine rich repeat containing 49 | 0.0429457 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0429088 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0424353 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0424209 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0412764 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0398124 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0381676 |
| HDAC9 | histone deacetylase 9 | 0.0366244 |
| RUNX1 | runt-related transcription factor 1 | 0.0363337 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0360835 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0360598 |
| RAP2B | RAP2B, member of RAS oncogene family | 0.0353371 |
| EGFR | epidermal growth factor receptor | 0.034373 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0341849 |
| EFNA5 | ephrin-A5 | 0.0341416 |
| DOCK11 | dedicator of cytokinesis 11 | 0.0332415 |
| FNIP1 | folliculin interacting protein 1 | 0.0331971 |
| PLIN2 | perilipin 2 | 0.0330599 |
| PDE10A | phosphodiesterase 10A | 0.0330069 |
| TNS3 | tensin 3 | 0.0316033 |
| SLK | STE20-like kinase | 0.0315099 |
| JAK1 | Janus kinase 1 | 0.0314978 |
| FMNL2 | formin-like 2 | 0.0312624 |
| TMSB4X | thymosin beta 4, X-linked | 0.0307366 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | 0.0302673 |
| VCL | vinculin | 0.0297789 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0297706 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0297263 |
| CDK19 | cyclin-dependent kinase 19 | 0.0296799 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | 0.0296797 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0288422 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0287336 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0281505 |
| MYO9A | myosin IXA | 0.028003 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0276978 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.0269342 |
| SCGB1D1 | secretoglobin, family 1D, member 1 | 0.0267854 |
| VPS35 | vacuolar protein sorting 35 homolog (S. cerevisiae) | 0.026775 |
| DNER | delta/notch-like EGF repeat containing | 0.0265481 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0256968 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0256471 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0255079 |
| HLA-B | major histocompatibility complex, class I, B | 0.0255067 |
| B2M | beta-2-microglobulin | 0.0253313 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.02526 |
| AEBP2 | AE binding protein 2 | 0.025154 |
| WFDC10B | WAP four-disulfide core domain 10B | 0.025096 |
| MT1E | metallothionein 1E | 0.0248885 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0246371 |
| VIM | vimentin | 0.0243714 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0242801 |
| DENND1A | DENN/MADD domain containing 1A | 0.0240329 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0239257 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | 0.0234268 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.023273 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.023208 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.023191 |
| RPS12 | ribosomal protein S12 | 0.0231794 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0231759 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0230366 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0229344 |
| SDC4 | syndecan 4 | 0.0227879 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0227269 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0226109 |
| ZBTB1 | zinc finger and BTB domain containing 1 | 0.0223499 |
| ZNF91 | zinc finger protein 91 | 0.0222871 |
| UBC | ubiquitin C | 0.0220689 |
| NEK10 | NIMA-related kinase 10 | 0.0218238 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.108342 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0714003 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0685255 |
| CENPF | centromere protein F, 350/400kDa | -0.0653844 |
| TXNRD1 | thioredoxin reductase 1 | -0.0645283 |
| RAI1 | retinoic acid induced 1 | -0.0565377 |
| MKI67 | marker of proliferation Ki-67 | -0.0558134 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0515342 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0508176 |
| CEP170 | centrosomal protein 170kDa | -0.0482686 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0474724 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0473512 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0470971 |
| RTN4 | reticulon 4 | -0.0469037 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0454306 |
| EZR | ezrin | -0.0450131 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.044132 |
| DIAPH3 | diaphanous-related formin 3 | -0.0421839 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0401047 |
| COL5A2 | collagen, type V, alpha 2 | -0.039882 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0392612 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0388215 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0386424 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0384531 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0377277 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0372686 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0370669 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0363116 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0362001 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0360613 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0359147 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.034044 |
| ECT2 | epithelial cell transforming 2 | -0.033865 |
| TMEM41B | transmembrane protein 41B | -0.0331333 |
| TPX2 | TPX2, microtubule-associated | -0.0330448 |
| TMSB10 | thymosin beta 10 | -0.032568 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0322255 |
| YBX1 | Y box binding protein 1 | -0.0319699 |
| RRM2 | ribonucleotide reductase M2 | -0.0317295 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0306705 |
| POTEF | POTE ankyrin domain family, member F | -0.0301385 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0300058 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | -0.0299575 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0299307 |
| R3HDM1 | R3H domain containing 1 | -0.029633 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0294946 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0292885 |
| FLNB | filamin B, beta | -0.0290898 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0286586 |
| RBM25 | RNA binding motif protein 25 | -0.0284622 |
| CKAP2 | cytoskeleton associated protein 2 | -0.028396 |
| ANLN | anillin, actin binding protein | -0.0282 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0277456 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0276893 |
| KIF14 | kinesin family member 14 | -0.0275434 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0273404 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0272629 |
| RPS8 | ribosomal protein S8 | -0.0271642 |
| WDR43 | WD repeat domain 43 | -0.0269909 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0269815 |
| RPL26 | ribosomal protein L26 | -0.0269633 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.0268286 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0267997 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0261768 |
| CENPE | centromere protein E, 312kDa | -0.0261537 |
| ETNK1 | ethanolamine kinase 1 | -0.0260297 |
| ACTG1 | actin gamma 1 | -0.0259077 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0259018 |
| PCBP2 | poly(rC) binding protein 2 | -0.0256797 |
| MYO10 | myosin X | -0.025539 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0254704 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0254499 |
| FERMT1 | fermitin family member 1 | -0.025081 |
| RPL35A | ribosomal protein L35a | -0.0250774 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.025021 |
| SEPTIN7 | septin 7 | -0.0248906 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0248724 |
| NUP58 | nucleoporin 58 | -0.0245082 |
| CUL1 | cullin 1 | -0.0244983 |
| DEK | DEK proto-oncogene | -0.0244825 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0241448 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0241007 |
| EP300 | E1A binding protein p300 | -0.0239077 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0238779 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0238154 |
| NOP58 | NOP58 ribonucleoprotein | -0.0236422 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0235507 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0233305 |
| RBM27 | RNA binding motif protein 27 | -0.0231601 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0230092 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0225653 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0223872 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0223811 |
| RPS19 | ribosomal protein S19 | -0.0223749 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0223616 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0223138 |
| RPS14 | ribosomal protein S14 | -0.022249 |
| PRDX1 | peroxiredoxin 1 | -0.0221271 |
| RASA2 | RAS p21 protein activator 2 | -0.0220581 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0219725 |
