Pyridoxine_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pyridoxine perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pyridoxine_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.239248
THSD4 thrombospondin, type I, domain containing 4 0.152052
GRAMD1B GRAM domain containing 1B 0.122558
PDE4D phosphodiesterase 4D, cAMP-specific 0.108107
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0957651
SLTM SAFB-like, transcription modulator 0.0902621
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0868138
ASPH aspartate beta-hydroxylase 0.0728005
FNDC3B fibronectin type III domain containing 3B 0.0721817
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0717638
PTPRM protein tyrosine phosphatase, receptor type, M 0.0713562
CEMIP cell migration inducing protein, hyaluronan binding 0.0661736
ELL2 elongation factor, RNA polymerase II, 2 0.0647963
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0636311
ERRFI1 ERBB receptor feedback inhibitor 1 0.0632575
SMAD3 SMAD family member 3 0.0616533
PM20D1 peptidase M20 domain containing 1 0.0605342
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0586233
SAMD4A sterile alpha motif domain containing 4A 0.0584681
TBC1D22A TBC1 domain family, member 22A 0.05524
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0478586
GSK3B glycogen synthase kinase 3 beta 0.0475351
MCTP1 multiple C2 domains, transmembrane 1 0.0451566
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.044973
LMO7 LIM domain 7 0.044788
BCAR3 breast cancer anti-estrogen resistance 3 0.0446108
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0433584
LRP1B low density lipoprotein receptor-related protein 1B 0.0414084
VCL vinculin 0.041069
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0404778
PDLIM5 PDZ and LIM domain 5 0.0400911
NPAS2 neuronal PAS domain protein 2 0.0391173
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0391018
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0387702
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0386146
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0382048
LAMC2 laminin, gamma 2 0.0379759
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0379403
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0369484
SUMF1 sulfatase modifying factor 1 0.0361884
USP34 ubiquitin specific peptidase 34 0.0349187
CES1 carboxylesterase 1 0.034896
OSMR oncostatin M receptor 0.0343717
MACF1 microtubule-actin crosslinking factor 1 0.0341066
NAMPT nicotinamide phosphoribosyltransferase 0.032738
TSC22D2 TSC22 domain family, member 2 0.0324753
LAMA4 laminin, alpha 4 0.032467
ZNF638 zinc finger protein 638 0.0323516
VMP1 vacuole membrane protein 1 0.031857
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0316839
DSCAM Down syndrome cell adhesion molecule 0.0309875
SMYD3 SET and MYND domain containing 3 0.030778
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0304636
INTS6 integrator complex subunit 6 0.030302
CSNK1A1 casein kinase 1, alpha 1 0.0301438
CXCL8 chemokine (C-X-C motif) ligand 8 0.0300093
EFNA5 ephrin-A5 0.0298993
MYOF myoferlin 0.0297801
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0295854
IGF1R insulin-like growth factor 1 receptor 0.0292073
DOCK5 dedicator of cytokinesis 5 0.0289392
TOP1 topoisomerase (DNA) I 0.0288426
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0287322
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0287137
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0286281
SPAG9 sperm associated antigen 9 0.0286278
LGALS12 lectin, galactoside-binding, soluble, 12 0.0279726
MAP7 microtubule-associated protein 7 0.0279411
RAD51B RAD51 paralog B 0.0278582
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0276579
FAM13A family with sequence similarity 13, member A 0.0276507
MYO1E myosin IE 0.0276092
GPC6 glypican 6 0.0273762
VEGFC vascular endothelial growth factor C 0.0272852
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0271341
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0266542
AKAP13 A kinase (PRKA) anchor protein 13 0.0265431
RUNX1 runt-related transcription factor 1 0.0264856
JMJD1C jumonji domain containing 1C 0.0263854
CCSER1 coiled-coil serine-rich protein 1 0.0262438
FNDC3A fibronectin type III domain containing 3A 0.0261713
GRB10 growth factor receptor-bound protein 10 0.0261436
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0260665
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0260586
AKAP12 A kinase (PRKA) anchor protein 12 0.0259851
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0258883
TRIO trio Rho guanine nucleotide exchange factor 0.0255323
EXT1 exostosin glycosyltransferase 1 0.0254323
MCL1 myeloid cell leukemia 1 0.0251387
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0238495
RNF213 ring finger protein 213 0.0238172
ANKRD11 ankyrin repeat domain 11 0.0234414
GCLC glutamate-cysteine ligase, catalytic subunit 0.0234352
ARHGAP32 Rho GTPase activating protein 32 0.0233087
DOCK1 dedicator of cytokinesis 1 0.0232778
EPAS1 endothelial PAS domain protein 1 0.0228691
LPP LIM domain containing preferred translocation partner in lipoma 0.0226524
KYNU kynureninase 0.0225571
MYH9 myosin, heavy chain 9, non-muscle 0.0223895
RIMS2 regulating synaptic membrane exocytosis 2 0.022384

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.266189
TMSB10 thymosin beta 10 -0.120798
TPT1 tumor protein, translationally-controlled 1 -0.077761
PTMA prothymosin, alpha -0.068039
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0656554
FTL ferritin, light polypeptide -0.0591034
MT2A metallothionein 2A -0.0581491
SEC61G Sec61 gamma subunit -0.0513498
NDRG1 N-myc downstream regulated 1 -0.0507679
RPL35A ribosomal protein L35a -0.0502838
RPS3 ribosomal protein S3 -0.0481011
EIF1 eukaryotic translation initiation factor 1 -0.0476939
S100A10 S100 calcium binding protein A10 -0.0422661
EGR1 early growth response 1 -0.0402897
B2M beta-2-microglobulin -0.034817
RPLP1 ribosomal protein, large, P1 -0.0347145
CST3 cystatin C -0.0344317
RPS8 ribosomal protein S8 -0.0343198
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0338
RPL34 ribosomal protein L34 -0.0327193
S100P S100 calcium binding protein P -0.0309761
ACTG1 actin gamma 1 -0.0299162
RPS12 ribosomal protein S12 -0.0290863
RPL37A ribosomal protein L37a -0.0280975
RPS24 ribosomal protein S24 -0.0280558
RPS27A ribosomal protein S27a -0.0278466
AKR1C1 aldo-keto reductase family 1, member C1 -0.0273591
RPL31 ribosomal protein L31 -0.0273445
HLA-B major histocompatibility complex, class I, B -0.0262743
RPS25 ribosomal protein S25 -0.0252021
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.024604
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0244219
RPS23 ribosomal protein S23 -0.0241361
RPS6 ribosomal protein S6 -0.0240656
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0236787
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0234505
CAV1 caveolin 1, caveolae protein, 22kDa -0.0234309
RPL12 ribosomal protein L12 -0.0232442
RPL11 ribosomal protein L11 -0.0230777
RPL8 ribosomal protein L8 -0.02217
TRIM56 tripartite motif containing 56 -0.0217708
KRT18 keratin 18, type I -0.0216297
UBC ubiquitin C -0.0215627
S100A9 S100 calcium binding protein A9 -0.0213163
RPS19 ribosomal protein S19 -0.0212655
RPS27 ribosomal protein S27 -0.0210411
S100A6 S100 calcium binding protein A6 -0.0210056
RPLP0 ribosomal protein, large, P0 -0.0208102
WASF2 WAS protein family, member 2 -0.020718
HMGA1 high mobility group AT-hook 1 -0.0203831
LDHA lactate dehydrogenase A -0.0203705
IFI6 interferon, alpha-inducible protein 6 -0.0203189
PRRC2C proline-rich coiled-coil 2C -0.0202841
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0202757
RPS13 ribosomal protein S13 -0.0202371
RPS29 ribosomal protein S29 -0.0201356
HDLBP high density lipoprotein binding protein -0.0198842
S100A11 S100 calcium binding protein A11 -0.0197871
RPL19 ribosomal protein L19 -0.0197505
CCNI cyclin I -0.0197318
RACK1 receptor for activated C kinase 1 -0.0195209
PERP PERP, TP53 apoptosis effector -0.0186909
RPS14 ribosomal protein S14 -0.0186424
PKM pyruvate kinase, muscle -0.0184039
CIB1 calcium and integrin binding 1 (calmyrin) -0.0181406
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0180881
RPS21 ribosomal protein S21 -0.0177587
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0177423
ATF4 activating transcription factor 4 -0.0172868
SERF2 small EDRK-rich factor 2 -0.0170329
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.016962
CSTB cystatin B (stefin B) -0.0165751
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0164904
RPL36 ribosomal protein L36 -0.0163226
AGR2 anterior gradient 2 -0.0162932
RPL9 ribosomal protein L9 -0.0161168
LAMB3 laminin, beta 3 -0.0159325
RPL30 ribosomal protein L30 -0.0154694
MT1X metallothionein 1X -0.0151198
RPL32 ribosomal protein L32 -0.0150942
RPS16 ribosomal protein S16 -0.015065
RPL23 ribosomal protein L23 -0.0149981
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0149865
WDR45B WD repeat domain 45B -0.0146027
H1-0 H1.0 linker histone -0.0145605
RPLP2 ribosomal protein, large, P2 -0.0142141
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0141678
TMEM165 transmembrane protein 165 -0.0141578
RPS17 ribosomal protein S17 -0.0140584
KRT7 keratin 7, type II -0.0140188
NACA nascent polypeptide-associated complex alpha subunit -0.013915
SLC38A1 solute carrier family 38, member 1 -0.0138756
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.013726
GNAS GNAS complex locus -0.0136157
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) -0.0133727
RAB1A RAB1A, member RAS oncogene family -0.013356
PFN1 profilin 1 -0.013339
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0130106
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0130014
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0129478