| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pyridoxine perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pyridoxine_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0973375 |
| KYNU | kynureninase | 0.0888435 |
| ASPH | aspartate beta-hydroxylase | 0.0845426 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0824961 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0816674 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0744502 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0673382 |
| RBM39 | RNA binding motif protein 39 | 0.0643721 |
| DST | dystonin | 0.063402 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0616063 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0612801 |
| EFNA5 | ephrin-A5 | 0.0577857 |
| PDE10A | phosphodiesterase 10A | 0.0567166 |
| COL5A2 | collagen, type V, alpha 2 | 0.0565521 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0554706 |
| CANX | calnexin | 0.0549127 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0546413 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0533876 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0518687 |
| ENO1 | enolase 1, (alpha) | 0.050248 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0502232 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0494081 |
| CDH13 | cadherin 13 | 0.0491259 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0488611 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0487558 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0486231 |
| GLG1 | golgi glycoprotein 1 | 0.0479847 |
| NABP1 | nucleic acid binding protein 1 | 0.047614 |
| OGA | O-GlcNAcase | 0.046851 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0467279 |
| MYO6 | myosin VI | 0.0462754 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0458192 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0447448 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.044587 |
| TENM3 | teneurin transmembrane protein 3 | 0.0441164 |
| PTMA | prothymosin, alpha | 0.0440624 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0439521 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0434414 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0433754 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.043325 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0425274 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0424509 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0412556 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.040392 |
| RPL4 | ribosomal protein L4 | 0.040213 |
| IER3 | immediate early response 3 | 0.0401143 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0400401 |
| ANO6 | anoctamin 6 | 0.0397751 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0396422 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0395925 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0395733 |
| PCBP3 | poly(rC) binding protein 3 | 0.0382913 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0382833 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0382704 |
| SMAD3 | SMAD family member 3 | 0.0381721 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0378592 |
| YTHDC1 | YTH domain containing 1 | 0.0377753 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0371677 |
| ABLIM1 | actin binding LIM protein 1 | 0.0371072 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0366193 |
| FAM107B | family with sequence similarity 107, member B | 0.0358944 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0357203 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0356545 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0356339 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0355492 |
| RPL26 | ribosomal protein L26 | 0.0353969 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0353129 |
| VCL | vinculin | 0.0352211 |
| SPAG9 | sperm associated antigen 9 | 0.0347398 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0346102 |
| MYO10 | myosin X | 0.0345754 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.0345399 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0340372 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0340306 |
| FOXO1 | forkhead box O1 | 0.0336967 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0336755 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0335975 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0334986 |
| RPS8 | ribosomal protein S8 | 0.0333729 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0327526 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0324859 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.032382 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.032116 |
| MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | 0.0320216 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.0312884 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0311204 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0310762 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0307993 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0307735 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0306369 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | 0.0304356 |
| JUN | jun proto-oncogene | 0.0303563 |
| LAMB1 | laminin, beta 1 | 0.0302802 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0301024 |
| LRP12 | low density lipoprotein receptor-related protein 12 | 0.0299178 |
| INHBA | inhibin, beta A | 0.0297267 |
| EGFR | epidermal growth factor receptor | 0.0292809 |
| TLK1 | tousled-like kinase 1 | 0.0290066 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0288806 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0288405 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.231334 |
| LAMC2 | laminin, gamma 2 | -0.175456 |
| ATOSA | atos homolog A | -0.152952 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.126181 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.121165 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.114919 |
| MYO1E | myosin IE | -0.111466 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0969477 |
| S100A9 | S100 calcium binding protein A9 | -0.0911938 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0900467 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0895809 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0856014 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0788195 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0765711 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0728327 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0714923 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0692972 |
| MCL1 | myeloid cell leukemia 1 | -0.0687662 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0672463 |
| LAMB3 | laminin, beta 3 | -0.0670074 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0657293 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0645952 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0605789 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0597483 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0595217 |
| TXNRD1 | thioredoxin reductase 1 | -0.0581818 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0577598 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0571749 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0571116 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0558503 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0553824 |
| SBF2 | SET binding factor 2 | -0.0541534 |
| NDRG1 | N-myc downstream regulated 1 | -0.0536267 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0533557 |
| SVIL | supervillin | -0.0518506 |
| RAI14 | retinoic acid induced 14 | -0.0509096 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0508167 |
| MUC16 | mucin 16, cell surface associated | -0.0505245 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0488631 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0483763 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0482238 |
| GPC6 | glypican 6 | -0.047332 |
| STC1 | stanniocalcin 1 | -0.0470639 |
| TMPRSS4 | transmembrane protease, serine 4 | -0.046267 |
| MXD1 | MAX dimerization protein 1 | -0.0461337 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0461324 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0457645 |
| HLA-B | major histocompatibility complex, class I, B | -0.0457494 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.045141 |
| RREB1 | ras responsive element binding protein 1 | -0.0443433 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0431822 |
| TMSB10 | thymosin beta 10 | -0.0430212 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0427521 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0423778 |
| CSTB | cystatin B (stefin B) | -0.04145 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0412268 |
| RBM47 | RNA binding motif protein 47 | -0.0411657 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0410705 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0407878 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0407669 |
| PRDM1 | PR domain containing 1, with ZNF domain | -0.0406164 |
| CDCP1 | CUB domain containing protein 1 | -0.040074 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0389677 |
| PRKCA | protein kinase C, alpha | -0.0388136 |
| TXNIP | thioredoxin interacting protein | -0.0377537 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0375946 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0371288 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0371265 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0369565 |
| CMIP | c-Maf inducing protein | -0.0361379 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0359729 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0356122 |
| RRBP1 | ribosome binding protein 1 | -0.0354738 |
| S100A10 | S100 calcium binding protein A10 | -0.0353368 |
| B2M | beta-2-microglobulin | -0.0352649 |
| OSMR | oncostatin M receptor | -0.0345116 |
| RUNX1 | runt-related transcription factor 1 | -0.0343669 |
| FOXP1 | forkhead box P1 | -0.0343345 |
| FNIP1 | folliculin interacting protein 1 | -0.0342362 |
| MT2A | metallothionein 2A | -0.0339485 |
| DIAPH1 | diaphanous-related formin 1 | -0.0332034 |
| KRT17 | keratin 17, type I | -0.0330434 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0328015 |
| SDC4 | syndecan 4 | -0.0326247 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0319715 |
| POTEF | POTE ankyrin domain family, member F | -0.0316038 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0311332 |
| ACTG1 | actin gamma 1 | -0.0310663 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0309981 |
| KLF6 | Kruppel-like factor 6 | -0.0307554 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0307497 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0307045 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0306644 |
| CDK13 | cyclin-dependent kinase 13 | -0.0306353 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0300809 |
| USP53 | ubiquitin specific peptidase 53 | -0.0299528 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | -0.029939 |
| WASF2 | WAS protein family, member 2 | -0.029521 |
| HLA-A | major histocompatibility complex, class I, A | -0.029467 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0294344 |
