Pyridoxine_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pyridoxine perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pyridoxine_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.133402
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.107246
NDRG1 N-myc downstream regulated 1 0.105409
AHNAK AHNAK nucleoprotein 0.104223
IGFBP3 insulin-like growth factor binding protein 3 0.0945646
ERRFI1 ERBB receptor feedback inhibitor 1 0.0778458
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0634875
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0629338
ELL2 elongation factor, RNA polymerase II, 2 0.062281
LAMB3 laminin, beta 3 0.0619937
CANX calnexin 0.0615105
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0608678
DSPP dentin sialophosphoprotein 0.0522486
GRB10 growth factor receptor-bound protein 10 0.0515945
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0515045
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0504964
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0504485
FAM13A family with sequence similarity 13, member A 0.0501205
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0500533
TSC22D2 TSC22 domain family, member 2 0.04988
APLP2 amyloid beta (A4) precursor-like protein 2 0.0465764
FNDC3B fibronectin type III domain containing 3B 0.0459643
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0458559
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0440305
TRIO trio Rho guanine nucleotide exchange factor 0.0419594
ACTG1 actin gamma 1 0.0403824
EZR ezrin 0.0403352
MYH9 myosin, heavy chain 9, non-muscle 0.0396442
ARRDC3 arrestin domain containing 3 0.0378104
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0368451
LAMC2 laminin, gamma 2 0.0367673
SAMD4A sterile alpha motif domain containing 4A 0.0365111
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0364521
SQSTM1 sequestosome 1 0.0338915
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0333947
TXNIP thioredoxin interacting protein 0.0327645
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0326768
DSCAM Down syndrome cell adhesion molecule 0.0319409
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0309808
BHLHE40 basic helix-loop-helix family, member e40 0.0309533
MYO6 myosin VI 0.030615
TPM3 tropomyosin 3 0.0305371
FLNB filamin B, beta 0.0304321
MYO5B myosin VB 0.0298403
SPAG9 sperm associated antigen 9 0.0297896
NPEPPS aminopeptidase puromycin sensitive 0.0296954
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0293903
IRF6 interferon regulatory factor 6 0.0293325
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0284084
RPL4 ribosomal protein L4 0.0281446
SDC4 syndecan 4 0.027387
RPS2 ribosomal protein S2 0.0273212
ENO1 enolase 1, (alpha) 0.0267532
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0266714
UPP1 uridine phosphorylase 1 0.025908
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0257209
NAV2 neuron navigator 2 0.0251525
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0248154
FNBP1L formin binding protein 1-like 0.0248044
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0247348
DTNA dystrobrevin, alpha 0.0244478
BZW1 basic leucine zipper and W2 domains 1 0.024119
ANXA2 annexin A2 0.0239847
FN1 fibronectin 1 0.0237957
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0236862
CDCP1 CUB domain containing protein 1 0.0231963
RIOK3 RIO kinase 3 0.0230486
KDM3A lysine (K)-specific demethylase 3A 0.0227001
HSPA8 heat shock 70kDa protein 8 0.0224865
DUSP10 dual specificity phosphatase 10 0.022124
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0218428
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0216335
UBA6 ubiquitin-like modifier activating enzyme 6 0.0216055
MYO10 myosin X 0.0215639
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0212106
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0210378
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0208806
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0208468
PPARD peroxisome proliferator-activated receptor delta 0.0206473
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0206351
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0205344
IQGAP1 IQ motif containing GTPase activating protein 1 0.0204758
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0203828
TOP1 topoisomerase (DNA) I 0.0201401
HELZ helicase with zinc finger 0.0201121
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.0200856
TMSB4X thymosin beta 4, X-linked 0.0199687
ANXA5 annexin A5 0.0197269
APP amyloid beta (A4) precursor protein 0.0195994
RAD21 RAD21 homolog (S. pombe) 0.0194594
RPS12 ribosomal protein S12 0.0193466
CTSS cathepsin S 0.0191083
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0188907
CDC73 cell division cycle 73 0.0186953
PDIA6 protein disulfide isomerase family A, member 6 0.0186633
AFDN afadin, adherens junction formation factor 0.0186071
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0185531
OGA O-GlcNAcase 0.0184831
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0184747
ANO6 anoctamin 6 0.0184612

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.183583
FTL ferritin, light polypeptide -0.0988647
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0721837
PTMA prothymosin, alpha -0.0691509
IFI27 interferon, alpha-inducible protein 27 -0.0666213
POTEF POTE ankyrin domain family, member F -0.0663923
TPT1 tumor protein, translationally-controlled 1 -0.0642141
S100A6 S100 calcium binding protein A6 -0.0618103
HMGA1 high mobility group AT-hook 1 -0.0497405
RPL35A ribosomal protein L35a -0.0455393
KRT7 keratin 7, type II -0.0425219
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0407419
ISG15 ISG15 ubiquitin-like modifier -0.0403151
ALCAM activated leukocyte cell adhesion molecule -0.0356758
LY6E lymphocyte antigen 6 complex, locus E -0.0341256
HLA-B major histocompatibility complex, class I, B -0.0317073
RPS19 ribosomal protein S19 -0.0313765
RPLP1 ribosomal protein, large, P1 -0.0303852
RPS24 ribosomal protein S24 -0.0288211
IFI6 interferon, alpha-inducible protein 6 -0.0285101
RBM25 RNA binding motif protein 25 -0.0284013
CCND1 cyclin D1 -0.0279402
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0275305
IFI16 interferon, gamma-inducible protein 16 -0.0268549
UQCRB ubiquinol-cytochrome c reductase binding protein -0.026746
RPL9 ribosomal protein L9 -0.0266981
ZBTB20 zinc finger and BTB domain containing 20 -0.0263909
GNAS GNAS complex locus -0.0261474
RPL34 ribosomal protein L34 -0.0256161
KRT18 keratin 18, type I -0.0240297
HSPB1 heat shock 27kDa protein 1 -0.0236321
MDK midkine (neurite growth-promoting factor 2) -0.0235562
ACBD3 acyl-CoA binding domain containing 3 -0.0232554
IFITM3 interferon induced transmembrane protein 3 -0.0229667
TMEM263 transmembrane protein 263 -0.0228495
RAB7A RAB7A, member RAS oncogene family -0.0227449
EXT1 exostosin glycosyltransferase 1 -0.0227364
MGST1 microsomal glutathione S-transferase 1 -0.0225444
S100A9 S100 calcium binding protein A9 -0.0223041
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0218844
RRBP1 ribosome binding protein 1 -0.0212616
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.020703
F3 coagulation factor III (thromboplastin, tissue factor) -0.0206059
LMNA lamin A/C -0.0205487
RPS21 ribosomal protein S21 -0.0204973
RPLP0 ribosomal protein, large, P0 -0.0204186
SOX4 SRY (sex determining region Y)-box 4 -0.0203979
RPS23 ribosomal protein S23 -0.020278
MX2 MX dynamin-like GTPase 2 -0.0201363
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0200355
TM4SF1 transmembrane 4 L six family member 1 -0.0194422
TPI1 triosephosphate isomerase 1 -0.019186
CTSD cathepsin D -0.0189264
ARHGAP20 Rho GTPase activating protein 20 -0.018889
KRT8 keratin 8, type II -0.0187712
S100A10 S100 calcium binding protein A10 -0.0185681
KRT19 keratin 19, type I -0.0184312
ERBIN erbb2 interacting protein -0.0181237
CSTB cystatin B (stefin B) -0.0181157
ATP5F1B ATP synthase F1 subunit beta -0.0180573
RPLP2 ribosomal protein, large, P2 -0.0179369
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0178782
AREG amphiregulin -0.0174646
ETV6 ets variant 6 -0.0174299
RPL36AL ribosomal protein L36a-like -0.0170725
H3-3B H3.3 histone B -0.0170442
IFIH1 interferon induced with helicase C domain 1 -0.0165524
MYL12B myosin, light chain 12B, regulatory -0.0165122
RPS14 ribosomal protein S14 -0.0164582
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0164433
SH3RF1 SH3 domain containing ring finger 1 -0.0164375
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0163673
ANKRD17 ankyrin repeat domain 17 -0.0161265
RPL23 ribosomal protein L23 -0.0160538
RPL36A ribosomal protein L36a -0.0160146
TUBA1B tubulin, alpha 1b -0.0158667
IFITM1 interferon induced transmembrane protein 1 -0.0158567
ADNP activity-dependent neuroprotector homeobox -0.0156017
RPL11 ribosomal protein L11 -0.0155552
MGLL monoglyceride lipase -0.0155332
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0153882
FBXO34 F-box protein 34 -0.0153655
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.015322
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0153189
BLZF1 basic leucine zipper nuclear factor 1 -0.0151877
FBXO32 F-box protein 32 -0.0149946
RPL37 ribosomal protein L37 -0.0149379
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.014905
TJP1 tight junction protein 1 -0.0147714
GRAMD2B GRAM domain containing 2B -0.0144786
COX7C cytochrome c oxidase subunit VIIc -0.0144461
PFN1 profilin 1 -0.0144456
RPL8 ribosomal protein L8 -0.0144251
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0143578
DSTN destrin (actin depolymerizing factor) -0.0142983
ATP5F1E ATP synthase F1 subunit epsilon -0.0141414
LOC102724023 ES1 protein homolog, mitochondrial -0.0140574
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0137192
CD63 CD63 molecule -0.013709
CBX3 chromobox homolog 3 -0.0135834