Pyridoxine_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pyridoxine perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pyridoxine_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.0768058
COL8A1 collagen, type VIII, alpha 1 0.0751069
RPS12 ribosomal protein S12 0.0693304
RPS2 ribosomal protein S2 0.062468
DST dystonin 0.0561535
COL4A6 collagen, type IV, alpha 6 0.0433379
COL4A5 collagen, type IV, alpha 5 0.0421167
MT2A metallothionein 2A 0.039046
EFNA5 ephrin-A5 0.03802
RPL26 ribosomal protein L26 0.0357645
RPS3 ribosomal protein S3 0.0346989
RPL9 ribosomal protein L9 0.0333795
RPS17 ribosomal protein S17 0.0322763
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0319707
UNC5D unc-5 homolog D (C. elegans) 0.0305682
KYNU kynureninase 0.0299322
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0292681
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0292624
RPL35A ribosomal protein L35a 0.0279374
FMNL2 formin-like 2 0.0277744
RPL36 ribosomal protein L36 0.0257705
DISP1 dispatched homolog 1 (Drosophila) 0.0255293
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.0238384
NEK7 NIMA-related kinase 7 0.0235038
CTSC cathepsin C 0.0231161
TPM3 tropomyosin 3 0.0226854
DPY19L1 dpy-19-like 1 (C. elegans) 0.0226475
TXNIP thioredoxin interacting protein 0.0225509
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0219231
SMOC1 SPARC related modular calcium binding 1 0.0215732
RPL21 ribosomal protein L21 0.0212074
BCAR3 breast cancer anti-estrogen resistance 3 0.0211345
MBD5 methyl-CpG binding domain protein 5 0.0209169
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0201806
RPS8 ribosomal protein S8 0.0197472
SORBS2 sorbin and SH3 domain containing 2 0.0195557
RPL23 ribosomal protein L23 0.0193179
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0189541
PDE7B phosphodiesterase 7B 0.0184603
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0180081
ZNF292 zinc finger protein 292 0.017972
FNDC3B fibronectin type III domain containing 3B 0.0178102
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0175249
MYO10 myosin X 0.0172117
PSD3 pleckstrin and Sec7 domain containing 3 0.0171498
RPS23 ribosomal protein S23 0.0170176
TRIO trio Rho guanine nucleotide exchange factor 0.0169603
BMERB1 bMERB domain containing 1 0.0169398
PDE10A phosphodiesterase 10A 0.0168007
MFF mitochondrial fission factor 0.0166916
MAML3 mastermind-like 3 (Drosophila) 0.0166835
RPS13 ribosomal protein S13 0.0161456
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0161037
RPS6 ribosomal protein S6 0.0158555
SCARA5 scavenger receptor class A, member 5 0.0158087
ARHGAP29 Rho GTPase activating protein 29 0.0155066
ATXN1 ataxin 1 0.0153846
ARHGAP12 Rho GTPase activating protein 12 0.0153689
CSNK1A1 casein kinase 1, alpha 1 0.0150008
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.014983
RPL37A ribosomal protein L37a 0.0149285
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0147197
GOLGA4 golgin A4 0.0144311
TGFBR1 transforming growth factor, beta receptor 1 0.0143106
RPL5 ribosomal protein L5 0.0142294
RTN1 reticulon 1 0.0141568
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.014039
PTPRM protein tyrosine phosphatase, receptor type, M 0.0139837
TENM2 teneurin transmembrane protein 2 0.0139589
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0138872
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0138065
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0137602
RNF145 ring finger protein 145 0.0137195
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0136943
ATXN7 ataxin 7 0.0135378
RPL19 ribosomal protein L19 0.0134878
CAB39 calcium binding protein 39 0.0134595
MACROD2 MACRO domain containing 2 0.013215
TBC1D5 TBC1 domain family, member 5 0.0131463
EPHA4 EPH receptor A4 0.0128902
DNER delta/notch-like EGF repeat containing 0.0128657
GLCCI1 glucocorticoid induced 1 0.0128189
ALPK2 alpha-kinase 2 0.0127048
SON SON DNA binding protein 0.0125303
USP9X ubiquitin specific peptidase 9, X-linked 0.0124432
PRKCE protein kinase C, epsilon 0.0124209
KDM6A lysine (K)-specific demethylase 6A 0.0124135
RABGAP1L RAB GTPase activating protein 1-like 0.0123886
MFSD12 major facilitator superfamily domain containing 12 0.0123745
RPL18 ribosomal protein L18 0.0123217
RSPO3 R-spondin 3 0.0122486
FBXL17 F-box and leucine-rich repeat protein 17 0.0122171
SET SET nuclear proto-oncogene 0.0121397
ACTN4 actinin, alpha 4 0.0120893
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.011755
RPLP2 ribosomal protein, large, P2 0.0117505
ETV1 ets variant 1 0.0117349
BMPER BMP binding endothelial regulator 0.011583
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0115502
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0114905

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.371379
FN1 fibronectin 1 -0.202634
VIM vimentin -0.159586
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.142307
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.119695
PTMA prothymosin, alpha -0.110758
CDH13 cadherin 13 -0.0670519
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0620235
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0618182
TPT1 tumor protein, translationally-controlled 1 -0.0603065
SMYD3 SET and MYND domain containing 3 -0.0568778
CANX calnexin -0.0554353
TMSB10 thymosin beta 10 -0.0549623
IGFBP3 insulin-like growth factor binding protein 3 -0.0538698
RPS24 ribosomal protein S24 -0.0534921
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0530617
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.051297
TBXT T-box transcription factor T -0.0484272
BZW1 basic leucine zipper and W2 domains 1 -0.0480081
ANXA2 annexin A2 -0.0480031
SPAG9 sperm associated antigen 9 -0.0475637
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0452942
TFPI2 tissue factor pathway inhibitor 2 -0.0439651
COL5A2 collagen, type V, alpha 2 -0.0437447
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0434352
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0417751
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0408915
SOX4 SRY (sex determining region Y)-box 4 -0.0407833
KPNB1 karyopherin (importin) beta 1 -0.0405148
LMNA lamin A/C -0.0392099
RPL37 ribosomal protein L37 -0.0392019
NCOA7 nuclear receptor coactivator 7 -0.0389852
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.038584
RPLP0 ribosomal protein, large, P0 -0.0377066
WARS1 tryptophanyl-tRNA synthetase 1 -0.0372774
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0365055
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0360085
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0354936
CD109 CD109 molecule -0.0352524
ELL2 elongation factor, RNA polymerase II, 2 -0.0351471
LOC102724023 ES1 protein homolog, mitochondrial -0.0350441
RPLP1 ribosomal protein, large, P1 -0.034926
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0343876
TMX4 thioredoxin-related transmembrane protein 4 -0.0342722
IL6 interleukin 6 -0.0337165
GNAS GNAS complex locus -0.0331347
CENPF centromere protein F, 350/400kDa -0.032271
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0322096
TPM4 tropomyosin 4 -0.0314972
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0313375
P3H2 prolyl 3-hydroxylase 2 -0.0312892
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0312684
MATR3 matrin 3 -0.0312466
MKI67 marker of proliferation Ki-67 -0.0300425
RPL7A ribosomal protein L7a -0.0300342
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0298888
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0295503
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0295372
HLA-B major histocompatibility complex, class I, B -0.0289782
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0289132
S100A6 S100 calcium binding protein A6 -0.0287522
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0286837
CTSL cathepsin L -0.027932
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0278862
CUX1 cut-like homeobox 1 -0.0278525
FOXC1 forkhead box C1 -0.0278055
POTEF POTE ankyrin domain family, member F -0.0274659
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0273103
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0270948
PRRC2C proline-rich coiled-coil 2C -0.0268821
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0267047
SLC16A6 solute carrier family 16, member 6 -0.0262289
IFIH1 interferon induced with helicase C domain 1 -0.0261681
ATP5F1B ATP synthase F1 subunit beta -0.0257338
SRGN serglycin -0.0256792
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0254577
TMSB4X thymosin beta 4, X-linked -0.0253918
BTG1 B-cell translocation gene 1, anti-proliferative -0.0250541
PKM pyruvate kinase, muscle -0.0250054
KDM3A lysine (K)-specific demethylase 3A -0.0248594
RSL1D1 ribosomal L1 domain containing 1 -0.0248377
EIF1 eukaryotic translation initiation factor 1 -0.0247365
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0246075
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0245351
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0244956
ESM1 endothelial cell-specific molecule 1 -0.0244057
CD44 CD44 molecule (Indian blood group) -0.024393
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0240326
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0240092
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0239247
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0237659
INHBA inhibin, beta A -0.0233053
SH3KBP1 SH3-domain kinase binding protein 1 -0.0232845
NAMPT nicotinamide phosphoribosyltransferase -0.0231571
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.023077
FTH1 ferritin, heavy polypeptide 1 -0.023037
SQSTM1 sequestosome 1 -0.0230294
KMT2C lysine (K)-specific methyltransferase 2C -0.0228202
TM4SF1 transmembrane 4 L six family member 1 -0.0227818
VDAC1 voltage-dependent anion channel 1 -0.0225721