| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pyridoxine perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pyridoxine_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PHIP | pleckstrin homology domain interacting protein | 0.187534 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.135973 |
| LRRC4C | leucine rich repeat containing 4C | 0.102253 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.100123 |
| COL11A1 | collagen, type XI, alpha 1 | 0.0917938 |
| AHNAK | AHNAK nucleoprotein | 0.0734793 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.073393 |
| PGK1 | phosphoglycerate kinase 1 | 0.0622081 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0603385 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0564518 |
| PCDH9 | protocadherin 9 | 0.0537526 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0527239 |
| GPC3 | glypican 3 | 0.0510893 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0508254 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0504341 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0498403 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0492098 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0471439 |
| COL1A2 | collagen, type I, alpha 2 | 0.0466038 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0460661 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0450124 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0448854 |
| FN1 | fibronectin 1 | 0.044719 |
| RSF1 | remodeling and spacing factor 1 | 0.043638 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0435606 |
| HELZ | helicase with zinc finger | 0.0416468 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0405626 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.040451 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0403223 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 0.0402532 |
| PROS1 | protein S (alpha) | 0.0398034 |
| ANK2 | ankyrin 2, neuronal | 0.0397469 |
| H1-0 | H1.0 linker histone | 0.0397463 |
| PRTG | protogenin | 0.0393812 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.0393245 |
| NHSL1 | NHS-like 1 | 0.038899 |
| BBX | bobby sox homolog (Drosophila) | 0.0376991 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.036772 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0362533 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0360316 |
| RAD51B | RAD51 paralog B | 0.0359346 |
| MED13 | mediator complex subunit 13 | 0.0355572 |
| CEP350 | centrosomal protein 350kDa | 0.0355002 |
| CUX1 | cut-like homeobox 1 | 0.0341932 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0333947 |
| BMPR1A | bone morphogenetic protein receptor, type IA | 0.0333793 |
| BLTP1 | bridge-like lipid transfer protein family member 1 | 0.0332044 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.033091 |
| SETD2 | SET domain containing 2 | 0.0330196 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.032865 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0326525 |
| EPS15 | epidermal growth factor receptor pathway substrate 15 | 0.0322697 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0313813 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0311707 |
| USP34 | ubiquitin specific peptidase 34 | 0.0307046 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.030641 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0305982 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | 0.0303677 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0302762 |
| MTREX | Mtr4 exosome RNA helicase | 0.0300393 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0299699 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.0297051 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0296506 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0296372 |
| FTL | ferritin, light polypeptide | 0.0295792 |
| DYNC2H1 | dynein, cytoplasmic 2, heavy chain 1 | 0.0295646 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.029406 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0289716 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.028963 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0289521 |
| ENO1 | enolase 1, (alpha) | 0.0284459 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0281993 |
| WWC2 | WW and C2 domain containing 2 | 0.0279983 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0275659 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | 0.0275535 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 0.0272586 |
| SEC62 | SEC62 homolog (S. cerevisiae) | 0.0272142 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | 0.0268779 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0267261 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0265191 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0263687 |
| XPO1 | exportin 1 | 0.0258724 |
| FST | follistatin | 0.0257376 |
| TMEM41B | transmembrane protein 41B | 0.0256556 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0254959 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0254806 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0253456 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.0253167 |
| RBM39 | RNA binding motif protein 39 | 0.0252477 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0252428 |
| LMO7 | LIM domain 7 | 0.025138 |
| FOXN2 | forkhead box N2 | 0.0249057 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0248251 |
| CLASP2 | cytoplasmic linker associated protein 2 | 0.0247875 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0243618 |
| NDUFS1 | NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) | 0.0243463 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0243462 |
| TRIM2 | tripartite motif containing 2 | 0.0241276 |
| GRM1 | glutamate receptor, metabotropic 1 | 0.0240381 |
| RPL11 | ribosomal protein L11 | 0.0240187 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HDAC9 | histone deacetylase 9 | -0.112744 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0731839 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0681141 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0671559 |
| COL5A2 | collagen, type V, alpha 2 | -0.0671138 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0665323 |
| SPAG9 | sperm associated antigen 9 | -0.0657543 |
| DST | dystonin | -0.056532 |
| VIM | vimentin | -0.0559867 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0551226 |
| SFRP4 | secreted frizzled-related protein 4 | -0.0545672 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0533131 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0530556 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0493525 |
| TMSB4X | thymosin beta 4, X-linked | -0.0466591 |
| RASAL2 | RAS protein activator like 2 | -0.0449185 |
| MEF2C | myocyte enhancer factor 2C | -0.0448926 |
| USP25 | ubiquitin specific peptidase 25 | -0.0446373 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0431675 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.042664 |
| POTEF | POTE ankyrin domain family, member F | -0.0421231 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | -0.0417967 |
| PDGFC | platelet derived growth factor C | -0.0407201 |
| DPYD | dihydropyrimidine dehydrogenase | -0.039763 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0391625 |
| ANXA1 | annexin A1 | -0.0387207 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0382943 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0382757 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0380854 |
| RIGI | RNA sensor RIG-I | -0.037125 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0362608 |
| FUS | FUS RNA binding protein | -0.0360892 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0359754 |
| MB21D2 | Mab-21 domain containing 2 | -0.0357219 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0354618 |
| TSC22D2 | TSC22 domain family, member 2 | -0.034421 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0335621 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0329038 |
| CSRNP3 | cysteine-serine-rich nuclear protein 3 | -0.0328155 |
| RHEB | Ras homolog enriched in brain | -0.0323102 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0323004 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0315853 |
| SQSTM1 | sequestosome 1 | -0.0312888 |
| ZNF608 | zinc finger protein 608 | -0.0311334 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0308005 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0307349 |
| HMCN1 | hemicentin 1 | -0.0305693 |
| ENAH | enabled homolog (Drosophila) | -0.0302846 |
| NTM | neurotrimin | -0.0299421 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0298155 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | -0.0297872 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | -0.0296955 |
| CRY1 | cryptochrome circadian clock 1 | -0.0290544 |
| CADM2 | cell adhesion molecule 2 | -0.0288826 |
| INTS6 | integrator complex subunit 6 | -0.0287524 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0287195 |
| TMSB10 | thymosin beta 10 | -0.0286138 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0283749 |
| SRSF3 | serine/arginine-rich splicing factor 3 | -0.0281784 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0281763 |
| SFPQ | splicing factor proline/glutamine-rich | -0.02808 |
| NUP153 | nucleoporin 153kDa | -0.0280489 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0276336 |
| STAG2 | stromal antigen 2 | -0.0274114 |
| ACTG1 | actin gamma 1 | -0.0273767 |
| IVNS1ABP | influenza virus NS1A binding protein | -0.0265779 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0265572 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0263954 |
| RAB31 | RAB31, member RAS oncogene family | -0.0260775 |
| OPHN1 | oligophrenin 1 | -0.0254887 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0253159 |
| ATF6 | activating transcription factor 6 | -0.0252939 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0252011 |
| SIK2 | salt-inducible kinase 2 | -0.0250155 |
| CTPS1 | CTP synthase 1 | -0.0248878 |
| FOXO1 | forkhead box O1 | -0.0243313 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0240259 |
| PDCD5 | programmed cell death 5 | -0.0240048 |
| ITSN2 | intersectin 2 | -0.0239923 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0239652 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0237619 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0237069 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0236309 |
| YBX1 | Y box binding protein 1 | -0.0234723 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | -0.0232787 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.023013 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.022905 |
| RPL37 | ribosomal protein L37 | -0.0227993 |
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | -0.0223603 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0221914 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0219674 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0218192 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0217798 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0216605 |
| SYT1 | synaptotagmin I | -0.021633 |
| TPX2 | TPX2, microtubule-associated | -0.0215663 |
| TGFB2 | transforming growth factor, beta 2 | -0.0214343 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | -0.0214113 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | -0.0213414 |
| VCL | vinculin | -0.021196 |
