Pyridoxine_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pyridoxine perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pyridoxine_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.15594
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0800081
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0578317
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0541039
ELL2 elongation factor, RNA polymerase II, 2 0.0529372
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0500394
CD109 CD109 molecule 0.0499858
AHR aryl hydrocarbon receptor 0.0491698
TXNIP thioredoxin interacting protein 0.0490501
OGA O-GlcNAcase 0.0480668
CANX calnexin 0.0458259
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0454918
RICTOR RPTOR independent companion of MTOR, complex 2 0.0443612
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0413531
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0412969
ERRFI1 ERBB receptor feedback inhibitor 1 0.0398684
ANKRD28 ankyrin repeat domain 28 0.0395685
OSMR oncostatin M receptor 0.0393548
SMAD3 SMAD family member 3 0.0389645
WAC WW domain containing adaptor with coiled-coil 0.0388606
RNF145 ring finger protein 145 0.0379765
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0377167
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0371521
LIFR leukemia inhibitory factor receptor alpha 0.0367597
FAM13A family with sequence similarity 13, member A 0.0363234
IL6ST interleukin 6 signal transducer 0.035466
CAB39 calcium binding protein 39 0.0352369
FNDC3B fibronectin type III domain containing 3B 0.0340278
NEK7 NIMA-related kinase 7 0.0336473
NRIP1 nuclear receptor interacting protein 1 0.0334287
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0334004
RAB8B RAB8B, member RAS oncogene family 0.0317148
TENT2 terminal nucleotidyltransferase 2 0.030459
LCORL ligand dependent nuclear receptor corepressor-like 0.0303692
SUCO SUN domain containing ossification factor 0.0300612
MCTP2 multiple C2 domains, transmembrane 2 0.029646
KMT2C lysine (K)-specific methyltransferase 2C 0.0296073
GOLGA4 golgin A4 0.0288524
WWTR1 WW domain containing transcription regulator 1 0.0287184
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0287076
CDC73 cell division cycle 73 0.0286658
AHNAK AHNAK nucleoprotein 0.028257
RNF24 ring finger protein 24 0.0278902
NIPBL Nipped-B homolog (Drosophila) 0.0277572
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0277526
ZNF292 zinc finger protein 292 0.0277025
ARRDC3 arrestin domain containing 3 0.0276791
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0273825
RUNX2 runt-related transcription factor 2 0.0272828
DENND5B DENN/MADD domain containing 5B 0.0271284
HELZ helicase with zinc finger 0.0268494
KDM3A lysine (K)-specific demethylase 3A 0.0268406
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0267555
SEC23A Sec23 homolog A (S. cerevisiae) 0.0266594
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0256484
SOD2 superoxide dismutase 2, mitochondrial 0.0254137
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0254113
ZC3H11A zinc finger CCCH-type containing 11A 0.0251018
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0250404
RB1CC1 RB1-inducible coiled-coil 1 0.0249344
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0249153
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0247319
BHLHE40 basic helix-loop-helix family, member e40 0.0244317
PELI1 pellino E3 ubiquitin protein ligase 1 0.0243791
RAD21 RAD21 homolog (S. pombe) 0.0243619
PELO pelota homolog (Drosophila) 0.0242588
ZFR zinc finger RNA binding protein 0.0242534
USP12 ubiquitin specific peptidase 12 0.024135
FNBP1 formin binding protein 1 0.0241173
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0234633
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0234511
PRRC2C proline-rich coiled-coil 2C 0.0233433
PRELID2 PRELI domain containing 2 0.0233158
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0231254
RBM39 RNA binding motif protein 39 0.0230962
APP amyloid beta (A4) precursor protein 0.0229285
TM9SF3 transmembrane 9 superfamily member 3 0.0228864
CD44 CD44 molecule (Indian blood group) 0.0226042
EPS8 epidermal growth factor receptor pathway substrate 8 0.0223833
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0223291
WDR26 WD repeat domain 26 0.0220556
QKI QKI, KH domain containing, RNA binding 0.0219286
EREG epiregulin 0.0218472
SNX13 sorting nexin 13 0.0216853
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0213077
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.02126
NPEPPS aminopeptidase puromycin sensitive 0.0212553
FOXO3 forkhead box O3 0.0211791
FBXO32 F-box protein 32 0.0209463
FAT1 FAT atypical cadherin 1 0.0209401
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0208823
ADD3 adducin 3 (gamma) 0.020821
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.020733
ZNF638 zinc finger protein 638 0.0205188
FBXW11 F-box and WD repeat domain containing 11 0.0205104
UGCG UDP-glucose ceramide glucosyltransferase 0.0204977
NUP58 nucleoporin 58 0.0203137
ARHGAP5 Rho GTPase activating protein 5 0.0202447
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0200663
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0200431

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.292948
IFI27 interferon, alpha-inducible protein 27 -0.135263
TMSB10 thymosin beta 10 -0.128592
FN1 fibronectin 1 -0.118034
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0972216
VCL vinculin -0.0926674
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.088321
HLA-B major histocompatibility complex, class I, B -0.084135
P4HB prolyl 4-hydroxylase, beta polypeptide -0.082366
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0808877
PTMA prothymosin, alpha -0.0798648
S100A6 S100 calcium binding protein A6 -0.07292
HMGA2 high mobility group AT-hook 2 -0.0723076
SQSTM1 sequestosome 1 -0.0719324
LOC102724023 ES1 protein homolog, mitochondrial -0.071801
FTL ferritin, light polypeptide -0.0710154
POTEF POTE ankyrin domain family, member F -0.0683211
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0668293
MAP1B microtubule-associated protein 1B -0.0667031
EXT1 exostosin glycosyltransferase 1 -0.0588962
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0569019
HMGA1 high mobility group AT-hook 1 -0.0526901
ENO2 enolase 2 (gamma, neuronal) -0.051797
NTN4 netrin 4 -0.0517028
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0501348
VIM vimentin -0.0500797
SYT1 synaptotagmin I -0.0495546
STC2 stanniocalcin 2 -0.0488593
AEBP2 AE binding protein 2 -0.0459491
EGR1 early growth response 1 -0.044385
ACTG1 actin gamma 1 -0.0429571
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0423738
IFI6 interferon, alpha-inducible protein 6 -0.0411929
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0400401
SOX4 SRY (sex determining region Y)-box 4 -0.0378188
INTS6 integrator complex subunit 6 -0.0376195
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0357432
SOX5 SRY (sex determining region Y)-box 5 -0.0355858
GRB10 growth factor receptor-bound protein 10 -0.034929
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0346653
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0343834
MCL1 myeloid cell leukemia 1 -0.0338816
MRPS6 mitochondrial ribosomal protein S6 -0.033881
LY6E lymphocyte antigen 6 complex, locus E -0.0337971
HLA-A major histocompatibility complex, class I, A -0.0334637
GLIS3 GLIS family zinc finger 3 -0.0333852
TPI1 triosephosphate isomerase 1 -0.0321192
PDLIM5 PDZ and LIM domain 5 -0.0304517
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0301469
PLIN2 perilipin 2 -0.0299032
LMNA lamin A/C -0.0296806
GPATCH2L G patch domain containing 2-like -0.0295043
RPL31 ribosomal protein L31 -0.0289221
PKM pyruvate kinase, muscle -0.0288948
B2M beta-2-microglobulin -0.0284798
TPT1 tumor protein, translationally-controlled 1 -0.0284204
PRH1 proline-rich protein HaeIII subfamily 1 -0.0277122
RACK1 receptor for activated C kinase 1 -0.0274321
DSTN destrin (actin depolymerizing factor) -0.0272001
RPS21 ribosomal protein S21 -0.0270425
SLC35F3 solute carrier family 35, member F3 -0.026662
ZBTB20 zinc finger and BTB domain containing 20 -0.0264233
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0262653
TTC28 tetratricopeptide repeat domain 28 -0.0261295
TPM4 tropomyosin 4 -0.0260533
CTSD cathepsin D -0.0257372
KLHL5 kelch-like family member 5 -0.0257104
KRT81 keratin 81, type II -0.0252504
RNF213 ring finger protein 213 -0.0251662
SFTPA2 surfactant protein A2 -0.0247693
HM13 histocompatibility (minor) 13 -0.0247252
RAD51B RAD51 paralog B -0.0246287
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0240315
RAB7A RAB7A, member RAS oncogene family -0.0238806
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0237072
RASAL2 RAS protein activator like 2 -0.0236363
IGFBP5 insulin-like growth factor binding protein 5 -0.0235019
RPL9 ribosomal protein L9 -0.0232863
HSPB1 heat shock 27kDa protein 1 -0.0232106
TUBA1B tubulin, alpha 1b -0.0229368
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.022872
S100A9 S100 calcium binding protein A9 -0.0225985
IFI44L interferon-induced protein 44-like -0.0225388
BICD1 bicaudal D homolog 1 (Drosophila) -0.022509
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0224018
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0222365
SLC38A2 solute carrier family 38, member 2 -0.0221636
TTC19 tetratricopeptide repeat domain 19 -0.0221246
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0220048
NALF1 NALCN channel auxiliary factor 1 -0.0219827
TENM4 teneurin transmembrane protein 4 -0.0218979
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0217934
PFN1 profilin 1 -0.0214877
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0214214
LRMDA leucine rich melanocyte differentiation associated -0.0212563
CCND1 cyclin D1 -0.0212513
RPS24 ribosomal protein S24 -0.0211685
RABGAP1L RAB GTPase activating protein 1-like -0.0211035
TGFB1 transforming growth factor, beta 1 -0.0210674
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0208472