| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/4993 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Pyrimethamine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CNTRL | centriolin | 1.61 |
| MYH7B | myosin, heavy chain 7B, cardiac muscle, beta | 1.33 |
| ACTN2 | actinin, alpha 2 | 1.33 |
| DHFR | dihydrofolate reductase | 1.26 |
| MYH2 | myosin, heavy chain 2, skeletal muscle, adult | 0.95 |
| MYH6 | myosin, heavy chain 6, cardiac muscle, alpha | 0.62 |
| DNAH2 | dynein, axonemal, heavy chain 2 | 0.51 |
| ZSCAN29 | zinc finger and SCAN domain containing 29 | 0.5 |
| SLC6A17 | solute carrier family 6 (neutral amino acid transporter), member 17 | 0.49 |
| CMTM4 | CKLF-like MARVEL transmembrane domain containing 4 | 0.48 |
| MYH1 | myosin, heavy chain 1, skeletal muscle, adult | 0.46 |
| ANKRD12 | ankyrin repeat domain 12 | 0.44 |
| POLE4 | polymerase (DNA-directed), epsilon 4, accessory subunit | 0.41 |
| ZNF184 | zinc finger protein 184 | 0.4 |
| ZDHHC9 | zinc finger, DHHC-type containing 9 | 0.4 |
| ZNF175 | zinc finger protein 175 | 0.39 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | 0.39 |
| TTN | titin | 0.38 |
| MCPH1 | microcephalin 1 | 0.38 |
| SUMO2 | small ubiquitin-like modifier 2 | 0.38 |
| CECR2 | cat eye syndrome chromosome region, candidate 2 | 0.38 |
| HPD | 4-hydroxyphenylpyruvate dioxygenase | 0.37 |
| MSL3P1 | male-specific lethal 3 homolog (Drosophila) pseudogene 1 | 0.36 |
| BMT2 | base methyltransferase of 25S rRNA 2 homolog | 0.36 |
| FGF2 | fibroblast growth factor 2 (basic) | 0.36 |
| ZNF711 | zinc finger protein 711 | 0.36 |
| GATA6 | GATA binding protein 6 | 0.36 |
| FAM53B | family with sequence similarity 53, member B | 0.34 |
| BAK1 | BCL2-antagonist/killer 1 | 0.34 |
| NCKAP1L | NCK-associated protein 1-like | 0.33 |
| C1D | C1D nuclear receptor corepressor | 0.32 |
| PDE2A | phosphodiesterase 2A, cGMP-stimulated | 0.32 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.31 |
| EGR1 | early growth response 1 | 0.3 |
| COMMD9 | COMM domain containing 9 | 0.3 |
| CCAR2 | cell cycle and apoptosis regulator 2 | 0.3 |
| MYH3 | myosin, heavy chain 3, skeletal muscle, embryonic | 0.29 |
| COQ4 | coenzyme Q4 | 0.29 |
| RMI2 | RecQ mediated genome instability 2 | 0.28 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | 0.28 |
| DNAH8 | dynein, axonemal, heavy chain 8 | 0.28 |
| MOCS2 | molybdenum cofactor synthesis 2 | 0.28 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | 0.28 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.27 |
| SPIDR | scaffolding protein involved in DNA repair | 0.27 |
| ODF2L | outer dense fiber of sperm tails 2-like | 0.27 |
| ZNF770 | zinc finger protein 770 | 0.26 |
| TDRD6 | tudor domain containing 6 | 0.26 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | 0.26 |
| B2M | beta-2-microglobulin | 0.26 |
| PLIN2 | perilipin 2 | 0.26 |
| DCLRE1B | DNA cross-link repair 1B | 0.25 |
| BNIP2 | BCL2/adenovirus E1B 19kDa interacting protein 2 | 0.25 |
| CBX6 | chromobox homolog 6 | 0.25 |
| SYTL2 | synaptotagmin-like 2 | 0.25 |
| CYBRD1 | cytochrome b reductase 1 | 0.24 |
| TMEM208 | transmembrane protein 208 | 0.24 |
| GUCD1 | guanylyl cyclase domain containing 1 | 0.24 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.23 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.23 |
| ZNF189 | zinc finger protein 189 | 0.23 |
| LIPT1 | lipoyltransferase 1 | 0.23 |
| CARD8 | caspase recruitment domain family, member 8 | 0.23 |
| IFFO2 | intermediate filament family orphan 2 | 0.23 |
| SLC38A7 | solute carrier family 38, member 7 | 0.23 |
| CYTH3 | cytohesin 3 | 0.23 |
| GDE1 | glycerophosphodiester phosphodiesterase 1 | 0.23 |
| ZNF611 | zinc finger protein 611 | 0.23 |
| RTN1 | reticulon 1 | 0.22 |
| NADK | NAD kinase | 0.22 |
| FAM13A | family with sequence similarity 13, member A | 0.22 |
| NR1D1 | nuclear receptor subfamily 1, group D, member 1 | 0.22 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.22 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.22 |
| PRKCB | protein kinase C, beta | 0.22 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 0.22 |
| C5ORF34 | chromosome 5 open reading frame 34 | 0.22 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.22 |
| NPHP3 | nephronophthisis 3 (adolescent) | 0.21 |
| NF1 | neurofibromin 1 | 0.21 |
| IKZF5 | IKAROS family zinc finger 5 (Pegasus) | 0.21 |
| RIBC2 | RIB43A domain with coiled-coils 2 | 0.21 |
| CRCP | CGRP receptor component | 0.21 |
| ZNF658 | zinc finger protein 658 | 0.21 |
| UVRAG | UV radiation resistance associated | 0.21 |
| WSB2 | WD repeat and SOCS box containing 2 | 0.21 |
| TPM1 | tropomyosin 1 (alpha) | 0.21 |
| IPMK | inositol polyphosphate multikinase | 0.21 |
| FAM110A | family with sequence similarity 110, member A | 0.21 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | 0.21 |
| SYT17 | synaptotagmin XVII | 0.21 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | 0.21 |
| HIST2H2AB | histone cluster 2, H2ab | 0.21 |
| ABCA13 | ATP-binding cassette, sub-family A (ABC1), member 13 | 0.2 |
| CBX7 | chromobox homolog 7 | 0.2 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.2 |
| AURKAIP1 | aurora kinase A interacting protein 1 | 0.2 |
| ALDOA | aldolase A, fructose-bisphosphate | 0.2 |
| AMN1 | antagonist of mitotic exit network 1 homolog (S. cerevisiae) | 0.2 |
| IER3IP1 | immediate early response 3 interacting protein 1 | 0.2 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PER2 | period circadian clock 2 | -2.05 |
| GJC1 | gap junction protein, gamma 1, 45kDa | -1.42 |
| SEMG1 | semenogelin I | -1.34 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.83 |
| GRK5 | G protein-coupled receptor kinase 5 | -0.83 |
| OSGIN1 | oxidative stress induced growth inhibitor 1 | -0.77 |
| FOXO1 | forkhead box O1 | -0.69 |
| TSPAN3 | tetraspanin 3 | -0.67 |
| TRAF3IP2 | TRAF3 interacting protein 2 | -0.65 |
| FGA | fibrinogen alpha chain | -0.57 |
| IL17RB | interleukin 17 receptor B | -0.53 |
| ECM1 | extracellular matrix protein 1 | -0.52 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.5 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | -0.49 |
| GVINP1 | GTPase, very large interferon inducible pseudogene 1 | -0.49 |
| KLHL22 | kelch-like family member 22 | -0.48 |
| SPRTN | SprT-like N-terminal domain | -0.47 |
| TUB | tubby bipartite transcription factor | -0.46 |
| H3-3A | H3.3 histone A | -0.45 |
| PIP | prolactin-induced protein | -0.44 |
| FOXRED2 | FAD-dependent oxidoreductase domain containing 2 | -0.44 |
| C9ORF72 | chromosome 9 open reading frame 72 | -0.43 |
| PRSS23 | protease, serine, 23 | -0.41 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.41 |
| BHLHA15 | basic helix-loop-helix family, member a15 | -0.4 |
| CBR1 | carbonyl reductase 1 | -0.4 |
| HMOX1 | heme oxygenase 1 | -0.4 |
| APOB | apolipoprotein B | -0.39 |
| RELL1 | RELT-like 1 | -0.39 |
| FOXM1 | forkhead box M1 | -0.38 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.38 |
| BHMT | betaine--homocysteine S-methyltransferase | -0.38 |
| HBA1 | hemoglobin, alpha 1 | -0.37 |
| CD63 | CD63 molecule | -0.37 |
| CCDC110 | coiled-coil domain containing 110 | -0.37 |
| ALDOB | aldolase B, fructose-bisphosphate | -0.37 |
| CDA | cytidine deaminase | -0.36 |
| FGB | fibrinogen beta chain | -0.36 |
| UNC5B | unc-5 homolog B (C. elegans) | -0.36 |
| ZNF219 | zinc finger protein 219 | -0.36 |
| STYK1 | serine/threonine/tyrosine kinase 1 | -0.36 |
| LIME1 | Lck interacting transmembrane adaptor 1 | -0.36 |
| GK5 | glycerol kinase 5 (putative) | -0.36 |
| SLC22A23 | solute carrier family 22, member 23 | -0.35 |
| EVL | Enah/Vasp-like | -0.34 |
| NRXN3 | neurexin 3 | -0.34 |
| TMPO | thymopoietin | -0.34 |
| RBX1 | ring-box 1, E3 ubiquitin protein ligase | -0.34 |
| BBS2 | Bardet-Biedl syndrome 2 | -0.34 |
| PPP2R2D | protein phosphatase 2, regulatory subunit B, delta | -0.34 |
| PHF13 | PHD finger protein 13 | -0.34 |
| CLTCL1 | clathrin, heavy chain-like 1 | -0.33 |
| B9D1 | B9 protein domain 1 | -0.33 |
| NECAB3 | N-terminal EF-hand calcium binding protein 3 | -0.33 |
| FAM241B | family with sequence similarity 241 member B | -0.33 |
| KIAA0513 | KIAA0513 | -0.33 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.32 |
| FAM171A1 | family with sequence similarity 171, member A1 | -0.32 |
| TMEM135 | transmembrane protein 135 | -0.31 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.31 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.31 |
| ZNF700 | zinc finger protein 700 | -0.3 |
| SOD1 | superoxide dismutase 1, soluble | -0.3 |
| ATP9B | ATPase, class II, type 9B | -0.3 |
| ICOSLG | inducible T-cell co-stimulator ligand | -0.29 |
| SHFL | shiftless antiviral inhibitor of ribosomal frameshifting | -0.29 |
| RAB30 | RAB30, member RAS oncogene family | -0.29 |
| TC2N | tandem C2 domains, nuclear | -0.29 |
| TESK1 | testis-specific kinase 1 | -0.29 |
| PDE7A | phosphodiesterase 7A | -0.29 |
| HOXA10 | homeobox A10 | -0.28 |
| PLGRKT | plasminogen receptor, C-terminal lysine transmembrane protein | -0.28 |
| SULF2 | sulfatase 2 | -0.28 |
| TPGS2 | tubulin polyglutamylase complex subunit 2 | -0.28 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.28 |
| CCNI | cyclin I | -0.28 |
| ABCA7 | ATP-binding cassette, sub-family A (ABC1), member 7 | -0.28 |
| TRAM2 | translocation associated membrane protein 2 | -0.27 |
| PRDM11 | PR domain containing 11 | -0.27 |
| TREX1 | three prime repair exonuclease 1 | -0.27 |
| SLC10A4 | solute carrier family 10, member 4 | -0.27 |
| TAB3 | TGF-beta activated kinase 1/MAP3K7 binding protein 3 | -0.27 |
| TMEM222 | transmembrane protein 222 | -0.27 |
| MCFD2 | multiple coagulation factor deficiency 2 | -0.27 |
| SF3B5 | splicing factor 3b, subunit 5, 10kDa | -0.26 |
| DXO | decapping exoribonuclease | -0.26 |
| KCTD21 | potassium channel tetramerization domain containing 21 | -0.26 |
| PIGX | phosphatidylinositol glycan anchor biosynthesis, class X | -0.26 |
| BBS7 | Bardet-Biedl syndrome 7 | -0.26 |
| RGS19 | regulator of G-protein signaling 19 | -0.26 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | -0.25 |
| C12ORF60 | chromosome 12 open reading frame 60 | -0.25 |
| PPME1 | protein phosphatase methylesterase 1 | -0.24 |
| IFFO1 | intermediate filament family orphan 1 | -0.24 |
| DNAAF3 | dynein, axonemal, assembly factor 3 | -0.24 |
| ACY1 | aminoacylase 1 | -0.24 |
| FAM114A1 | family with sequence similarity 114, member A1 | -0.24 |
| ABHD2 | abhydrolase domain containing 2 | -0.24 |
| PRSS8 | protease, serine, 8 | -0.24 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | -0.23 |
