| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/3925 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in QX 314 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 1.11 |
| THAP9 | THAP domain containing 9 | 0.96 |
| LYPD3 | LY6/PLAUR domain containing 3 | 0.94 |
| SH3RF2 | SH3 domain containing ring finger 2 | 0.92 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.8 |
| SNED1 | sushi, nidogen and EGF-like domains 1 | 0.77 |
| STON2 | stonin 2 | 0.55 |
| SLC41A3 | solute carrier family 41, member 3 | 0.5 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | 0.5 |
| PTGS1 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | 0.49 |
| SPPL3 | signal peptide peptidase like 3 | 0.47 |
| CA8 | carbonic anhydrase VIII | 0.46 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.44 |
| TP73 | tumor protein p73 | 0.44 |
| TFAP2E | transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) | 0.42 |
| ABITRAM | actin binding transcription modulator | 0.42 |
| ZFPM1 | zinc finger protein, FOG family member 1 | 0.41 |
| DMD | dystrophin | 0.39 |
| ZNF169 | zinc finger protein 169 | 0.39 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.38 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.37 |
| TSPAN4 | tetraspanin 4 | 0.36 |
| NFIB | nuclear factor I/B | 0.35 |
| GATD1 | glutamine amidotransferase class 1 domain containing 1 | 0.35 |
| ALKBH5 | AlkB family member 5, RNA demethylase | 0.33 |
| R3HDM2 | R3H domain containing 2 | 0.33 |
| FBXO33 | F-box protein 33 | 0.33 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.33 |
| ST5 | suppression of tumorigenicity 5 | 0.33 |
| ZNF692 | zinc finger protein 692 | 0.32 |
| PPP1R26 | protein phosphatase 1, regulatory subunit 26 | 0.32 |
| HIPK3 | homeodomain interacting protein kinase 3 | 0.32 |
| ZNF28 | zinc finger protein 28 | 0.31 |
| USP19 | ubiquitin specific peptidase 19 | 0.31 |
| CCSAP | centriole, cilia and spindle-associated protein | 0.31 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.3 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | 0.29 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | 0.29 |
| HSP90AA4P | heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene | 0.29 |
| MOCS2 | molybdenum cofactor synthesis 2 | 0.28 |
| TRAF3 | TNF receptor-associated factor 3 | 0.28 |
| TIPE1 | TNF alpha induced protein 8 like 1 | 0.28 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.28 |
| ZNF558 | zinc finger protein 558 | 0.28 |
| PUM2 | pumilio RNA-binding family member 2 | 0.28 |
| TESK1 | testis-specific kinase 1 | 0.28 |
| ST6GALNAC4 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 | 0.27 |
| FAM241B | family with sequence similarity 241 member B | 0.27 |
| TNK2 | tyrosine kinase, non-receptor, 2 | 0.27 |
| CENPK | centromere protein K | 0.27 |
| GDPGP1 | GDP-D-glucose phosphorylase 1 | 0.27 |
| LEPROTL1 | leptin receptor overlapping transcript-like 1 | 0.27 |
| RUFY2 | RUN and FYVE domain containing 2 | 0.27 |
| STK35 | serine/threonine kinase 35 | 0.27 |
| ESAM | endothelial cell adhesion molecule | 0.27 |
| LINGO1 | leucine rich repeat and Ig domain containing 1 | 0.26 |
| ZNF174 | zinc finger protein 174 | 0.26 |
| FMNL1 | formin-like 1 | 0.26 |
| TRIM29 | tripartite motif containing 29 | 0.26 |
| KIF3A | kinesin family member 3A | 0.26 |
| KCNAB2 | potassium channel, voltage gated subfamily A regulatory beta subunit 2 | 0.26 |
| CYHR1 | cysteine/histidine-rich 1 | 0.26 |
| ETV6 | ets variant 6 | 0.26 |
| ZNF276 | zinc finger protein 276 | 0.26 |
| ENTPD4 | ectonucleoside triphosphate diphosphohydrolase 4 | 0.25 |
| IFT52 | intraflagellar transport 52 | 0.25 |
| ZNF581 | zinc finger protein 581 | 0.25 |
| ZNF724 | zinc finger protein 724 | 0.25 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.25 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.25 |
| DCAF5 | DDB1 and CUL4 associated factor 5 | 0.24 |
| HSBP1 | heat shock factor binding protein 1 | 0.24 |
| MNX1 | motor neuron and pancreas homeobox 1 | 0.24 |
| ZNF608 | zinc finger protein 608 | 0.24 |
| TBC1D16 | TBC1 domain family, member 16 | 0.24 |
| MEST | mesoderm specific transcript | 0.24 |
| REX1BD | required for excision 1-B domain containing | 0.23 |
| SLC25A33 | solute carrier family 25 (pyrimidine nucleotide carrier), member 33 | 0.23 |
| POLR2K | polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa | 0.23 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.23 |
| ATXN7L3B | ataxin 7-like 3B | 0.23 |
| KLF3 | Kruppel-like factor 3 (basic) | 0.23 |
| CCDC112 | coiled-coil domain containing 112 | 0.23 |
| NUBP1 | nucleotide binding protein 1 | 0.22 |
| AP5B1 | adaptor-related protein complex 5, beta 1 subunit | 0.22 |
| CBARP | CACN subunit beta associated regulatory protein | 0.22 |
| MICOS10 | mitochondrial contact site and cristae organizing system subunit 10 | 0.22 |
| TMEM237 | transmembrane protein 237 | 0.22 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.22 |
| METTL9 | methyltransferase like 9 | 0.22 |
| SETD3 | SET domain containing 3 | 0.22 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.22 |
| EIF2B4 | eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa | 0.22 |
| VIM | vimentin | 0.22 |
| CEP152 | centrosomal protein 152kDa | 0.21 |
| IL17RD | interleukin 17 receptor D | 0.21 |
| MCUB | mitochondrial calcium uniporter dominant negative subunit beta | 0.21 |
| FBXO17 | F-box protein 17 | 0.21 |
| GPR161 | G protein-coupled receptor 161 | 0.21 |
| PIWIL2 | piwi-like RNA-mediated gene silencing 2 | 0.21 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ACTBL2 | actin, beta-like 2 | -1.31 |
| MEGF9 | multiple EGF-like-domains 9 | -0.77 |
| STK19 | serine/threonine kinase 19 | -0.69 |
| KLHL23 | kelch-like family member 23 | -0.61 |
| SS18L1 | synovial sarcoma translocation gene on chromosome 18-like 1 | -0.58 |
| DNAH6 | dynein, axonemal, heavy chain 6 | -0.58 |
| LINS1 | lines homolog 1 | -0.56 |
| ZBED8 | zinc finger, BED-type containing 8 | -0.54 |
| EGFL7 | EGF-like-domain, multiple 7 | -0.53 |
| SGSM1 | small G protein signaling modulator 1 | -0.5 |
| UTP14C | UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) | -0.49 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | -0.47 |
| SPHK2 | sphingosine kinase 2 | -0.47 |
| ATL1 | atlastin GTPase 1 | -0.46 |
| SLC25A20 | solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 | -0.46 |
| C11ORF49 | chromosome 11 open reading frame 49 | -0.45 |
| YAE1 | YAE1 maturation factor of ABCE1 | -0.44 |
| TBC1D13 | TBC1 domain family, member 13 | -0.43 |
| CCNF | cyclin F | -0.42 |
| NOS1 | nitric oxide synthase 1 (neuronal) | -0.42 |
| TULP4 | tubby like protein 4 | -0.42 |
| ADCK5 | aarF domain containing kinase 5 | -0.42 |
| MEX3A | mex-3 RNA binding family member A | -0.41 |
| AKNA | AT-hook transcription factor | -0.41 |
| PCNX1 | pecanex 1 | -0.41 |
| NPNT | nephronectin | -0.41 |
| ADAP2 | ArfGAP with dual PH domains 2 | -0.4 |
| FGB | fibrinogen beta chain | -0.4 |
| ALG12 | ALG12, alpha-1,6-mannosyltransferase | -0.39 |
| MSMO1 | methylsterol monooxygenase 1 | -0.39 |
| ANTXR2 | anthrax toxin receptor 2 | -0.38 |
| MT1F | metallothionein 1F | -0.38 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.37 |
| PPP4R4 | protein phosphatase 4, regulatory subunit 4 | -0.37 |
| TSR2 | TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) | -0.37 |
| ASB8 | ankyrin repeat and SOCS box containing 8 | -0.36 |
| KDM6B | lysine (K)-specific demethylase 6B | -0.35 |
| PTMS | parathymosin | -0.34 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.34 |
| SPPL2A | signal peptide peptidase like 2A | -0.34 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | -0.33 |
| B3GNTL1 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 | -0.33 |
| NLRC3 | NLR family, CARD domain containing 3 | -0.33 |
| LCMT2 | leucine carboxyl methyltransferase 2 | -0.33 |
| RBAK | RB-associated KRAB zinc finger | -0.32 |
| ZC3H14 | zinc finger CCCH-type containing 14 | -0.32 |
| FANCL | Fanconi anemia, complementation group L | -0.31 |
| TRAPPC6A | trafficking protein particle complex 6A | -0.31 |
| ACD | adrenocortical dysplasia homolog (mouse) | -0.31 |
| IFT22 | intraflagellar transport 22 | -0.31 |
| SLC44A2 | solute carrier family 44 (choline transporter), member 2 | -0.31 |
| DHTKD1 | dehydrogenase E1 and transketolase domain containing 1 | -0.31 |
| FN1 | fibronectin 1 | -0.31 |
| PMFBP1 | polyamine modulated factor 1 binding protein 1 | -0.3 |
| SLC45A1 | solute carrier family 45, member 1 | -0.3 |
| SYNE4 | spectrin repeat containing, nuclear envelope family member 4 | -0.3 |
| MYT1L | myelin transcription factor 1-like | -0.29 |
| CCDC150 | coiled-coil domain containing 150 | -0.29 |
| ANKRD13C | ankyrin repeat domain 13C | -0.28 |
| SP140L | SP140 nuclear body protein-like | -0.28 |
| ABHD17B | abhydrolase domain containing 17B | -0.28 |
| GEMIN7 | gem (nuclear organelle) associated protein 7 | -0.28 |
| FKBPL | FK506 binding protein like | -0.28 |
| EID2 | EP300 interacting inhibitor of differentiation 2 | -0.27 |
| SRD5A3 | steroid 5 alpha-reductase 3 | -0.27 |
| TMEM135 | transmembrane protein 135 | -0.27 |
| SKIL | SKI-like proto-oncogene | -0.27 |
| SRF | serum response factor (c-fos serum response element-binding transcription factor) | -0.27 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | -0.27 |
| NADSYN1 | NAD synthetase 1 | -0.27 |
| CASZ1 | castor zinc finger 1 | -0.26 |
| GON7 | GON7 subunit of KEOPS complex | -0.26 |
| ZNF780A | zinc finger protein 780A | -0.26 |
| TFCP2L1 | transcription factor CP2-like 1 | -0.26 |
| DENND5A | DENN/MADD domain containing 5A | -0.26 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.26 |
| ATP8B2 | ATPase, aminophospholipid transporter, class I, type 8B, member 2 | -0.26 |
| PCGF1 | polycomb group ring finger 1 | -0.26 |
| SELENOM | selenoprotein M | -0.25 |
| OTC | ornithine carbamoyltransferase | -0.25 |
| PLEKHH1 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 | -0.25 |
| USH2A | Usher syndrome 2A (autosomal recessive, mild) | -0.25 |
| BTN2A1 | butyrophilin, subfamily 2, member A1 | -0.25 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.25 |
| B3GALNT1 | beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) | -0.25 |
| AAMDC | adipogenesis associated, Mth938 domain containing | -0.24 |
| C2ORF42 | chromosome 2 open reading frame 42 | -0.24 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | -0.24 |
| HECA | headcase homolog (Drosophila) | -0.24 |
| ARMC7 | armadillo repeat containing 7 | -0.24 |
| SYNPO | synaptopodin | -0.24 |
| HSPA14 | heat shock 70kDa protein 14 | -0.24 |
| ATG4A | autophagy related 4A, cysteine peptidase | -0.24 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | -0.23 |
| ABLIM2 | actin binding LIM protein family, member 2 | -0.23 |
| CMC2 | C-x(9)-C motif containing 2 | -0.23 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.23 |
| FBXO34 | F-box protein 34 | -0.23 |
| ABHD2 | abhydrolase domain containing 2 | -0.23 |
| ELAC1 | elaC ribonuclease Z 1 | -0.23 |
