| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A dibenzothiazepine that has formula C21H25N3O2S. (Chemical Entities of Biological Interest Ontology, CHEBI_8707) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5002 |
| Similar Terms | |
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198 proteins with high or low expression in Quetiapine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| WDR60 | WD repeat domain 60 | 0.72 |
| KLHL8 | kelch-like family member 8 | 0.66 |
| FGD1 | FYVE, RhoGEF and PH domain containing 1 | 0.66 |
| HFE | hemochromatosis | 0.64 |
| PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 0.63 |
| TSPAN3 | tetraspanin 3 | 0.56 |
| FBXO44 | F-box protein 44 | 0.54 |
| MYO18B | myosin XVIIIB | 0.54 |
| NEMP2 | nuclear envelope integral membrane protein 2 | 0.54 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.53 |
| KIF21B | kinesin family member 21B | 0.53 |
| TIMM10B | translocase of inner mitochondrial membrane 10 homolog B (yeast) | 0.52 |
| BCO2 | beta-carotene oxygenase 2 | 0.51 |
| GRHL1 | grainyhead-like 1 (Drosophila) | 0.5 |
| HGH1 | HGH1 homolog (S. cerevisiae) | 0.46 |
| PALB2 | partner and localizer of BRCA2 | 0.45 |
| DMTN | dematin actin binding protein | 0.45 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.42 |
| LMO4 | LIM domain only 4 | 0.41 |
| PROS1 | protein S (alpha) | 0.39 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | 0.38 |
| MXRA7 | matrix-remodelling associated 7 | 0.38 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.37 |
| RPE | ribulose-5-phosphate-3-epimerase | 0.37 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | 0.37 |
| ANKRD22 | ankyrin repeat domain 22 | 0.37 |
| SLC66A2 | solute carrier family 66 member 2 | 0.36 |
| PAH | phenylalanine hydroxylase | 0.36 |
| TM2D3 | TM2 domain containing 3 | 0.35 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.35 |
| FBRS | fibrosin | 0.35 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | 0.35 |
| SLC25A23 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 | 0.34 |
| POLR2J | polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa | 0.34 |
| ZNF460 | zinc finger protein 460 | 0.34 |
| ZNF354B | zinc finger protein 354B | 0.32 |
| CEP68 | centrosomal protein 68kDa | 0.32 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.32 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.32 |
| TSTD1 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 | 0.32 |
| PNKD | paroxysmal nonkinesigenic dyskinesia | 0.32 |
| UQCR10 | ubiquinol-cytochrome c reductase, complex III subunit X | 0.31 |
| ZNF35 | zinc finger protein 35 | 0.31 |
| COL5A1 | collagen, type V, alpha 1 | 0.31 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | 0.31 |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 | 0.31 |
| DUSP6 | dual specificity phosphatase 6 | 0.31 |
| RNF220 | ring finger protein 220 | 0.3 |
| BBS10 | Bardet-Biedl syndrome 10 | 0.3 |
| PLEKHA7 | pleckstrin homology domain containing, family A member 7 | 0.3 |
| MDP1 | magnesium-dependent phosphatase 1 | 0.3 |
| HMCN1 | hemicentin 1 | 0.3 |
| TATDN2 | TatD DNase domain containing 2 | 0.29 |
| UBQLN2 | ubiquilin 2 | 0.29 |
| FAR2 | fatty acyl CoA reductase 2 | 0.29 |
| DOCK10 | dedicator of cytokinesis 10 | 0.29 |
| COPRS | coordinator of PRMT5, differentiation stimulator | 0.29 |
| TP53 | tumor protein p53 | 0.29 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.29 |
| ADAM21 | ADAM metallopeptidase domain 21 | 0.29 |
| RNF185 | ring finger protein 185 | 0.29 |
| KYAT1 | kynurenine aminotransferase 1 | 0.29 |
| AP4S1 | adaptor-related protein complex 4, sigma 1 subunit | 0.29 |
| ZNF827 | zinc finger protein 827 | 0.29 |
| KATNBL1 | katanin p80 subunit B-like 1 | 0.29 |
| COX6B1 | cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) | 0.28 |
| IFI30 | interferon, gamma-inducible protein 30 | 0.28 |
| WRB | tryptophan rich basic protein | 0.28 |
| ZNF706 | zinc finger protein 706 | 0.28 |
| DEDD | death effector domain containing | 0.28 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.28 |
| CALU | calumenin | 0.28 |
| ARL8A | ADP-ribosylation factor-like 8A | 0.27 |
| ZNF729 | zinc finger protein 729 | 0.27 |
| F2R | coagulation factor II (thrombin) receptor | 0.27 |
| ATE1 | arginyltransferase 1 | 0.27 |
| LAMC3 | laminin, gamma 3 | 0.27 |
| CSNK1G3 | casein kinase 1, gamma 3 | 0.26 |
| SON | SON DNA binding protein | 0.26 |
| INPP5J | inositol polyphosphate-5-phosphatase J | 0.26 |
| ERH | enhancer of rudimentary homolog (Drosophila) | 0.26 |
| PFDN5 | prefoldin subunit 5 | 0.26 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.26 |
| PLPP3 | phospholipid phosphatase 3 | 0.26 |
| M6PR | mannose-6-phosphate receptor (cation dependent) | 0.26 |
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | 0.26 |
| RHOQ | ras homolog family member Q | 0.26 |
| COX7A2 | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | 0.26 |
| HTT | huntingtin | 0.26 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.26 |
| SERINC5 | serine incorporator 5 | 0.26 |
| CYTH3 | cytohesin 3 | 0.25 |
| CETN2 | centrin, EF-hand protein, 2 | 0.25 |
| CRELD1 | cysteine-rich with EGF-like domains 1 | 0.25 |
| CYB5A | cytochrome b5 type A (microsomal) | 0.25 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.25 |
| CEBPZOS | CEBPZ opposite strand | 0.25 |
| MAGEA6 | melanoma antigen family A6 | 0.25 |
| IL10RB | interleukin 10 receptor, beta | 0.25 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SBSN | suprabasin | -1.87 |
| COL17A1 | collagen, type XVII, alpha 1 | -1.41 |
| PIP | prolactin-induced protein | -1.17 |
| PREX1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | -1.15 |
| BCOR | BCL6 corepressor | -0.95 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.8 |
| FGF19 | fibroblast growth factor 19 | -0.72 |
| PITX1 | paired-like homeodomain 1 | -0.64 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | -0.62 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | -0.62 |
| ZNF274 | zinc finger protein 274 | -0.6 |
| ZG16B | zymogen granule protein 16B | -0.57 |
| DOP1A | DOP1 leucine zipper like protein A | -0.54 |
| SET | SET nuclear proto-oncogene | -0.52 |
| TREX1 | three prime repair exonuclease 1 | -0.51 |
| ABHD17C | abhydrolase domain containing 17C | -0.5 |
| DUOX1 | dual oxidase 1 | -0.5 |
| PRX | periaxin | -0.5 |
| UBE2W | ubiquitin-conjugating enzyme E2W (putative) | -0.48 |
| HKDC1 | hexokinase domain containing 1 | -0.47 |
| TNNC2 | troponin C type 2 (fast) | -0.47 |
| ZBTB12 | zinc finger and BTB domain containing 12 | -0.47 |
| CFAP57 | cilia and flagella associated protein 57 | -0.47 |
| ATXN7L3B | ataxin 7-like 3B | -0.45 |
| SGSH | N-sulfoglucosamine sulfohydrolase | -0.44 |
| FAM199X | family with sequence similarity 199, X-linked | -0.43 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | -0.42 |
| TSPAN15 | tetraspanin 15 | -0.42 |
| PLAUR | plasminogen activator, urokinase receptor | -0.42 |
| MERTK | MER proto-oncogene, tyrosine kinase | -0.41 |
| L1RE1 | LINE1 retrotransposable element 1 | -0.4 |
| WNK2 | WNK lysine deficient protein kinase 2 | -0.4 |
| TTC9C | tetratricopeptide repeat domain 9C | -0.4 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | -0.4 |
| USP27X | ubiquitin specific peptidase 27, X-linked | -0.39 |
| SLC39A3 | solute carrier family 39 (zinc transporter), member 3 | -0.39 |
| SPTBN5 | spectrin, beta, non-erythrocytic 5 | -0.39 |
| MAGEA2 | melanoma antigen family A2 | -0.38 |
| ESAM | endothelial cell adhesion molecule | -0.38 |
| TMEM184C | transmembrane protein 184C | -0.38 |
| NEBL | nebulette | -0.38 |
| FBXL15 | F-box and leucine-rich repeat protein 15 | -0.37 |
| ST3GAL4 | ST3 beta-galactoside alpha-2,3-sialyltransferase 4 | -0.37 |
| MCRIP1 | MAPK regulated corepressor interacting protein 1 | -0.37 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.36 |
| NPNT | nephronectin | -0.36 |
| STARD3NL | STARD3 N-terminal like | -0.36 |
| CCDC102A | coiled-coil domain containing 102A | -0.35 |
| RPL26 | ribosomal protein L26 | -0.34 |
| TPM4 | tropomyosin 4 | -0.34 |
| NLGN2 | neuroligin 2 | -0.34 |
| HIPK1 | homeodomain interacting protein kinase 1 | -0.34 |
| FAM160A1 | family with sequence similarity 160, member A1 | -0.33 |
| PET100 | PET100 homolog (S. cerevisiae) | -0.33 |
| SLC2A4RG | SLC2A4 regulator | -0.33 |
| PCBD2 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 | -0.33 |
| AP3M2 | adaptor-related protein complex 3, mu 2 subunit | -0.33 |
| INHBA | inhibin, beta A | -0.32 |
| ELMO1 | engulfment and cell motility 1 | -0.32 |
| MED12L | mediator complex subunit 12-like | -0.32 |
| SLC43A3 | solute carrier family 43, member 3 | -0.32 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.32 |
| EIF5A2 | eukaryotic translation initiation factor 5A2 | -0.31 |
| SOX7 | SRY (sex determining region Y)-box 7 | -0.31 |
| ALKBH5 | AlkB family member 5, RNA demethylase | -0.3 |
| USH2A | Usher syndrome 2A (autosomal recessive, mild) | -0.3 |
| GAS2L1 | growth arrest-specific 2 like 1 | -0.3 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.3 |
| ZNF417 | zinc finger protein 417 | -0.29 |
| RPAIN | RPA interacting protein | -0.29 |
| ATP5IF1 | ATP synthase inhibitory factor subunit 1 | -0.29 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | -0.29 |
| POLR3K | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa | -0.29 |
| NMU | neuromedin U | -0.29 |
| FSIP2 | fibrous sheath interacting protein 2 | -0.28 |
| SH3RF2 | SH3 domain containing ring finger 2 | -0.28 |
| ATP6V1E2 | ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2 | -0.28 |
| GJC1 | gap junction protein, gamma 1, 45kDa | -0.28 |
| FAM241B | family with sequence similarity 241 member B | -0.28 |
| MED18 | mediator complex subunit 18 | -0.28 |
| ZNF721 | zinc finger protein 721 | -0.28 |
| TEAD2 | TEA domain family member 2 | -0.28 |
| NEB | nebulin | -0.27 |
| HTD2 | hydroxyacyl-thioester dehydratase type 2 | -0.27 |
| VAMP8 | vesicle-associated membrane protein 8 | -0.27 |
| CCS | copper chaperone for superoxide dismutase | -0.27 |
| LYST | lysosomal trafficking regulator | -0.27 |
| MRPS23 | mitochondrial ribosomal protein S23 | -0.27 |
| GEM | GTP binding protein overexpressed in skeletal muscle | -0.26 |
| BCL3 | B-cell CLL/lymphoma 3 | -0.26 |
| MED8 | mediator complex subunit 8 | -0.26 |
| NF1 | neurofibromin 1 | -0.26 |
| MRPS18C | mitochondrial ribosomal protein S18C | -0.26 |
| NADK | NAD kinase | -0.26 |
| PLEKHA8 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 | -0.26 |
| CTSV | cathepsin V | -0.26 |
| C16ORF70 | chromosome 16 open reading frame 70 | -0.26 |
| ASB7 | ankyrin repeat and SOCS box containing 7 | -0.26 |
| COMMD2 | COMM domain containing 2 | -0.26 |
