Quinestrol_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Quinestrol perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Quinestrol_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.159983
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.135755
DST dystonin 0.0799264
CDH13 cadherin 13 0.0790546
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0713845
COL5A1 collagen, type V, alpha 1 0.0691294
NAV1 neuron navigator 1 0.0639694
NAV2 neuron navigator 2 0.0623327
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0585411
PRELID2 PRELI domain containing 2 0.0568075
VEGFC vascular endothelial growth factor C 0.0548309
HDAC9 histone deacetylase 9 0.0545442
MAP1B microtubule-associated protein 1B 0.0525223
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0517026
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0506481
FN1 fibronectin 1 0.0498884
FNDC3B fibronectin type III domain containing 3B 0.0491801
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0490288
MACF1 microtubule-actin crosslinking factor 1 0.0484736
FBXL7 F-box and leucine-rich repeat protein 7 0.0482632
DCLK2 doublecortin-like kinase 2 0.0476093
SLC39A11 solute carrier family 39, member 11 0.0474392
TPM3 tropomyosin 3 0.0462823
COPA coatomer protein complex, subunit alpha 0.044536
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.044413
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0436646
ANKRD36 ankyrin repeat domain 36 0.0433542
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0420663
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0419497
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0416003
ASPH aspartate beta-hydroxylase 0.0403581
CD109 CD109 molecule 0.0400662
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0396013
FLNA filamin A, alpha 0.0387277
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0383814
PICALM phosphatidylinositol binding clathrin assembly protein 0.0383188
PTK2 protein tyrosine kinase 2 0.0376988
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0376768
EGFR epidermal growth factor receptor 0.0350326
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0347522
RNF213 ring finger protein 213 0.0337426
PBX3 pre-B-cell leukemia homeobox 3 0.0336685
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0334851
DIAPH3 diaphanous-related formin 3 0.0327723
MSN moesin 0.0324227
CANX calnexin 0.031954
ANKRD11 ankyrin repeat domain 11 0.0312083
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0311524
TLE4 transducin-like enhancer of split 4 0.0302132
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0300315
MSI2 musashi RNA-binding protein 2 0.0296733
DOCK5 dedicator of cytokinesis 5 0.0295574
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0294658
MYH9 myosin, heavy chain 9, non-muscle 0.0289497
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0282385
ADAM9 ADAM metallopeptidase domain 9 0.0281542
MBNL1 muscleblind-like splicing regulator 1 0.02794
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0279213
NEK7 NIMA-related kinase 7 0.0276822
SDK1 sidekick cell adhesion molecule 1 0.0272494
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0269832
SPAG9 sperm associated antigen 9 0.0266864
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0260229
WWTR1 WW domain containing transcription regulator 1 0.0260011
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0256681
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0254667
SRPK2 SRSF protein kinase 2 0.025385
MYOF myoferlin 0.0253717
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0249405
FLNB filamin B, beta 0.0248927
NCOR2 nuclear receptor corepressor 2 0.0247382
OGA O-GlcNAcase 0.0247218
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0246657
PDLIM5 PDZ and LIM domain 5 0.0244712
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0244372
RUNX1 runt-related transcription factor 1 0.0244255
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0243555
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0241459
E2F7 E2F transcription factor 7 0.0240397
USP34 ubiquitin specific peptidase 34 0.0238414
ZFAND3 zinc finger, AN1-type domain 3 0.0238288
PUM2 pumilio RNA-binding family member 2 0.0233946
FNIP1 folliculin interacting protein 1 0.0233363
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0227256
ATXN1 ataxin 1 0.0226605
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0225596
RABGAP1L RAB GTPase activating protein 1-like 0.0222913
BCL2L1 BCL2-like 1 0.022116
RND3 Rho family GTPase 3 0.0220047
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0219839
RB1 retinoblastoma 1 0.021577
CSNK1A1 casein kinase 1, alpha 1 0.0215312
DSPP dentin sialophosphoprotein 0.0213721
MPRIP myosin phosphatase Rho interacting protein 0.0213643
FMN2 formin 2 0.0213357
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0211433
GLS2 glutaminase 2 (liver, mitochondrial) 0.0210267
ZC3H11A zinc finger CCCH-type containing 11A 0.0208532
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0207875
CYTH3 cytohesin 3 0.0206605

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.285828
MT2A metallothionein 2A -0.194369
TMSB10 thymosin beta 10 -0.186373
AKAP12 A kinase (PRKA) anchor protein 12 -0.123982
VIM vimentin -0.117065
NDRG1 N-myc downstream regulated 1 -0.10453
LOX lysyl oxidase -0.102155
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0842038
HLA-B major histocompatibility complex, class I, B -0.0788354
IGFBP3 insulin-like growth factor binding protein 3 -0.0768643
S100A10 S100 calcium binding protein A10 -0.0673189
B2M beta-2-microglobulin -0.065391
COL3A1 collagen, type III, alpha 1 -0.0634453
ANXA2 annexin A2 -0.0633584
THBS2 thrombospondin 2 -0.0603996
CSTB cystatin B (stefin B) -0.0595517
S100A6 S100 calcium binding protein A6 -0.0588974
LOXL2 lysyl oxidase-like 2 -0.0551616
PTMA prothymosin, alpha -0.0528359
COL1A2 collagen, type I, alpha 2 -0.0516299
EIF1 eukaryotic translation initiation factor 1 -0.0514169
LOC112694756 uncharaterized LOC112694756 -0.0487396
STC1 stanniocalcin 1 -0.0472842
PLAT plasminogen activator, tissue -0.047129
CAVIN1 caveolae associated protein 1 -0.0440704
IFITM3 interferon induced transmembrane protein 3 -0.0436002
FTL ferritin, light polypeptide -0.0425286
UBC ubiquitin C -0.0425027
HLA-C major histocompatibility complex, class I, C -0.0407309
CCND1 cyclin D1 -0.0401808
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0397386
DLG1 discs, large homolog 1 (Drosophila) -0.039005
TPM4 tropomyosin 4 -0.0388952
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0377376
RPL23 ribosomal protein L23 -0.0370435
RPL35A ribosomal protein L35a -0.036686
RPL12 ribosomal protein L12 -0.0362143
FTH1 ferritin, heavy polypeptide 1 -0.0361702
RPS24 ribosomal protein S24 -0.0344955
IFITM1 interferon induced transmembrane protein 1 -0.0343934
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.034238
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0333339
RPLP1 ribosomal protein, large, P1 -0.0327078
CTSB cathepsin B -0.0325291
FBN1 fibrillin 1 -0.0323949
RPL32 ribosomal protein L32 -0.0320585
ELL2 elongation factor, RNA polymerase II, 2 -0.0319106
HSPB1 heat shock 27kDa protein 1 -0.0316162
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0314502
GNAS GNAS complex locus -0.0309652
SLC38A1 solute carrier family 38, member 1 -0.0305515
ABI3BP ABI family, member 3 (NESH) binding protein -0.0300547
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0297847
RPL34 ribosomal protein L34 -0.0297537
RPS3 ribosomal protein S3 -0.0293251
TMSB4X thymosin beta 4, X-linked -0.028329
HLA-E major histocompatibility complex, class I, E -0.0281809
PODXL podocalyxin-like -0.0281656
TM4SF1 transmembrane 4 L six family member 1 -0.0279104
RPS6 ribosomal protein S6 -0.0278663
RPL28 ribosomal protein L28 -0.0275818
TPT1 tumor protein, translationally-controlled 1 -0.027204
ARL4C ADP-ribosylation factor-like 4C -0.0267939
SOD2 superoxide dismutase 2, mitochondrial -0.0267821
MYADM myeloid-associated differentiation marker -0.0266241
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0265914
RPS8 ribosomal protein S8 -0.0265523
RPL36 ribosomal protein L36 -0.0264419
RPL26 ribosomal protein L26 -0.0260124
RPLP2 ribosomal protein, large, P2 -0.0255829
S100A4 S100 calcium binding protein A4 -0.025569
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0250652
RPS19 ribosomal protein S19 -0.0248812
VDAC1 voltage-dependent anion channel 1 -0.024745
RPL37A ribosomal protein L37a -0.0244855
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0244745
PLAUR plasminogen activator, urokinase receptor -0.0243307
RPS15 ribosomal protein S15 -0.0243271
BSG basigin (Ok blood group) -0.0240358
RPL31 ribosomal protein L31 -0.0239796
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0234965
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0232962
IFIH1 interferon induced with helicase C domain 1 -0.023159
RACK1 receptor for activated C kinase 1 -0.023112
RPL37 ribosomal protein L37 -0.0230925
RPL35 ribosomal protein L35 -0.0226061
RPL19 ribosomal protein L19 -0.0222327
S100A11 S100 calcium binding protein A11 -0.0220737
MT1X metallothionein 1X -0.0220543
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0219155
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0215645
RPS23 ribosomal protein S23 -0.0214671
RPLP0 ribosomal protein, large, P0 -0.0212634
RPS5 ribosomal protein S5 -0.0210572
CD99 CD99 molecule -0.0208089
RPS16 ribosomal protein S16 -0.0206557
CCL5 chemokine (C-C motif) ligand 5 -0.0203196
HLA-A major histocompatibility complex, class I, A -0.0202245
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0199581
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0199479