Quinestrol_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Quinestrol perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Quinestrol_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.152399
NRG1 neuregulin 1 0.122954
EXT1 exostosin glycosyltransferase 1 0.121681
FMN1 formin 1 0.0956743
PTPRD protein tyrosine phosphatase, receptor type, D 0.080392
TLE4 transducin-like enhancer of split 4 0.0739036
ANTXR1 anthrax toxin receptor 1 0.0731234
LPP LIM domain containing preferred translocation partner in lipoma 0.0679868
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.062039
LSAMP limbic system-associated membrane protein 0.0608823
DST dystonin 0.0542781
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0517852
TPT1 tumor protein, translationally-controlled 1 0.0509331
MACF1 microtubule-actin crosslinking factor 1 0.0501014
THBS1 thrombospondin 1 0.0492579
SLIT2 slit homolog 2 (Drosophila) 0.0489593
VMP1 vacuole membrane protein 1 0.0488596
PLAT plasminogen activator, tissue 0.0475404
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0473518
ZSWIM6 zinc finger, SWIM-type containing 6 0.0450572
TPST1 tyrosylprotein sulfotransferase 1 0.0439836
GPC5 glypican 5 0.04142
FRMD4A FERM domain containing 4A 0.0403183
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0383133
NPAS2 neuronal PAS domain protein 2 0.0370365
MED13 mediator complex subunit 13 0.0361476
ADARB1 adenosine deaminase, RNA-specific, B1 0.0354022
THSD4 thrombospondin, type I, domain containing 4 0.0352646
MCL1 myeloid cell leukemia 1 0.0339875
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0337599
FAM107B family with sequence similarity 107, member B 0.0326217
FNDC3B fibronectin type III domain containing 3B 0.0318862
MYO6 myosin VI 0.0317585
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0316442
SEPTIN9 septin 9 0.031516
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0314036
ZNF804A zinc finger protein 804A 0.0311289
PSD3 pleckstrin and Sec7 domain containing 3 0.0311196
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.0301334
TAS2R14 taste receptor, type 2, member 14 0.0299117
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0298956
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0293099
ATXN1 ataxin 1 0.0290268
RABGAP1L RAB GTPase activating protein 1-like 0.0284009
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.027855
ZMIZ1 zinc finger, MIZ-type containing 1 0.0278407
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0278021
INTS6 integrator complex subunit 6 0.0276363
ASCC3 activating signal cointegrator 1 complex subunit 3 0.027547
BICD1 bicaudal D homolog 1 (Drosophila) 0.0274746
TRIO trio Rho guanine nucleotide exchange factor 0.0274667
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.027232
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0271148
TIMP3 TIMP metallopeptidase inhibitor 3 0.0270442
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0269154
DSCAM Down syndrome cell adhesion molecule 0.0268704
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0267308
ARHGAP9 Rho GTPase activating protein 9 0.0265712
NALF1 NALCN channel auxiliary factor 1 0.0265658
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0263851
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0262325
PTPRK protein tyrosine phosphatase, receptor type, K 0.0261912
RAD51B RAD51 paralog B 0.0261635
STK38L serine/threonine kinase 38 like 0.0261598
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0261207
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.025959
DGKH diacylglycerol kinase, eta 0.0256516
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0255172
RPTOR regulatory associated protein of MTOR, complex 1 0.024884
N4BP2L2 NEDD4 binding protein 2-like 2 0.0247288
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0246038
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0244543
SFPQ splicing factor proline/glutamine-rich 0.0242575
RAB7A RAB7A, member RAS oncogene family 0.0242126
AHR aryl hydrocarbon receptor 0.0240479
DNM3 dynamin 3 0.0238003
SPAG9 sperm associated antigen 9 0.0233175
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0230813
CTNND1 catenin (cadherin-associated protein), delta 1 0.0230719
BPTF bromodomain PHD finger transcription factor 0.023052
PLPP1 phospholipid phosphatase 1 0.022991
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0228442
EFNA5 ephrin-A5 0.0226795
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0225207
MYO1E myosin IE 0.0222226
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0221673
GMDS GDP-mannose 4,6-dehydratase 0.0220583
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0217462
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0216275
KLF7 Kruppel-like factor 7 (ubiquitous) 0.021551
NREP neuronal regeneration related protein 0.0215431
CEMIP2 cell migration inducing hyaluronidase 2 0.0214355
PCBP3 poly(rC) binding protein 3 0.0213688
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.02132
RNF213 ring finger protein 213 0.0213191
HIP1 huntingtin interacting protein 1 0.0212693
KLF6 Kruppel-like factor 6 0.0211462
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.020956
BABAM2 BRISC and BRCA1 A complex member 2 0.0208622
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.020747

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.414949
IGF2 insulin-like growth factor 2 -0.383102
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.120211
RPL23 ribosomal protein L23 -0.0646302
RPLP1 ribosomal protein, large, P1 -0.0630498
PTMA prothymosin, alpha -0.0560178
RPS6 ribosomal protein S6 -0.050136
VIM vimentin -0.0499858
TMSB10 thymosin beta 10 -0.0477179
RPL19 ribosomal protein L19 -0.0440856
PKM pyruvate kinase, muscle -0.0431179
SYT1 synaptotagmin I -0.034468
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0329415
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0322256
RPL35A ribosomal protein L35a -0.0320194
POTEF POTE ankyrin domain family, member F -0.0320178
RPS19 ribosomal protein S19 -0.0319137
RPS24 ribosomal protein S24 -0.0317331
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0310267
RPL34 ribosomal protein L34 -0.0309577
LPIN1 lipin 1 -0.027844
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0277171
ZNF292 zinc finger protein 292 -0.0275502
FTL ferritin, light polypeptide -0.0267636
RPS14 ribosomal protein S14 -0.0264225
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0257995
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0257868
RPS25 ribosomal protein S25 -0.0256273
RPL36 ribosomal protein L36 -0.0252368
RPS5 ribosomal protein S5 -0.0248983
PRRC2C proline-rich coiled-coil 2C -0.0246829
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0246372
NDRG1 N-myc downstream regulated 1 -0.0246003
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0241414
WDR45B WD repeat domain 45B -0.022865
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0225882
DCAF7 DDB1 and CUL4 associated factor 7 -0.0225361
B2M beta-2-microglobulin -0.0225193
RPL27 ribosomal protein L27 -0.0224001
RPS23 ribosomal protein S23 -0.0222369
S100A9 S100 calcium binding protein A9 -0.0217193
S100A6 S100 calcium binding protein A6 -0.0215615
RPL28 ribosomal protein L28 -0.0214904
FBXL20 F-box and leucine-rich repeat protein 20 -0.02147
FAM13A family with sequence similarity 13, member A -0.0213353
LARP1 La ribonucleoprotein domain family, member 1 -0.0213268
RPL32 ribosomal protein L32 -0.021137
NPEPPS aminopeptidase puromycin sensitive -0.0206329
RNF145 ring finger protein 145 -0.0205851
MAP1B microtubule-associated protein 1B -0.0204809
VDAC1 voltage-dependent anion channel 1 -0.0201887
FKBP1A FK506 binding protein 1A, 12kDa -0.0201656
RPS15 ribosomal protein S15 -0.0197792
RHOA ras homolog family member A -0.0195983
MEIS2 Meis homeobox 2 -0.0193466
COL1A1 collagen, type I, alpha 1 -0.019095
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0190159
RPLP2 ribosomal protein, large, P2 -0.0184027
IGFBP3 insulin-like growth factor binding protein 3 -0.0180172
NSD3 nuclear receptor binding SET domain protein 3 -0.0179965
EIF5B eukaryotic translation initiation factor 5B -0.0179533
PDIA3 protein disulfide isomerase family A, member 3 -0.0177437
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.017636
PFN1 profilin 1 -0.0176089
MMP2 matrix metallopeptidase 2 -0.017477
RACK1 receptor for activated C kinase 1 -0.0174435
TUBB tubulin, beta class I -0.0172632
RNMT RNA (guanine-7-) methyltransferase -0.0169385
LDHB lactate dehydrogenase B -0.0169248
BSG basigin (Ok blood group) -0.0168357
SETD5 SET domain containing 5 -0.0166714
NEMF nuclear export mediator factor -0.016614
IARS1 isoleucyl-tRNA synthetase 1 -0.0166041
CD46 CD46 molecule, complement regulatory protein -0.0164197
GNAS GNAS complex locus -0.0164043
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0163065
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0161299
SCAF11 SR-related CTD-associated factor 11 -0.0159442
GLG1 golgi glycoprotein 1 -0.0158831
IFI16 interferon, gamma-inducible protein 16 -0.0158645
LOC112694756 uncharaterized LOC112694756 -0.0157044
COPS2 COP9 signalosome subunit 2 -0.0156138
TKT transketolase -0.015472
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0154679
RPS20 ribosomal protein S20 -0.0154287
MORF4L2 mortality factor 4 like 2 -0.0153974
PHOX2B paired-like homeobox 2b -0.0153911
GATAD2B GATA zinc finger domain containing 2B -0.0153262
RPL4 ribosomal protein L4 -0.015295
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0152202
SEC63 SEC63 homolog (S. cerevisiae) -0.0152195
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0151881
RHOBTB3 Rho-related BTB domain containing 3 -0.0150574
RPL38 ribosomal protein L38 -0.0150158
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0149896
RPS21 ribosomal protein S21 -0.0149779
ZMYM2 zinc finger, MYM-type 2 -0.0149645
SET SET nuclear proto-oncogene -0.0148945
PRAME preferentially expressed antigen in melanoma -0.0148721
KTN1 kinectin 1 (kinesin receptor) -0.0148474