Quinestrol_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Quinestrol perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Quinestrol_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.270556
SMAD3 SMAD family member 3 0.111836
SPTBN1 spectrin, beta, non-erythrocytic 1 0.104857
TJP1 tight junction protein 1 0.0938438
MACC1 metastasis associated in colon cancer 1 0.0901254
DSCAM Down syndrome cell adhesion molecule 0.0896619
VCL vinculin 0.0895327
ANXA2 annexin A2 0.0889503
AKAP13 A kinase (PRKA) anchor protein 13 0.0886764
MYO1E myosin IE 0.0813615
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0771218
STK24 serine/threonine kinase 24 0.0644194
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0579909
EXT1 exostosin glycosyltransferase 1 0.0567684
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0564929
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0548322
EFNB2 ephrin-B2 0.0545997
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0519672
AREG amphiregulin 0.0515265
EZR ezrin 0.0504388
FNDC3B fibronectin type III domain containing 3B 0.0502921
SHB Src homology 2 domain containing adaptor protein B 0.0493392
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0491985
SQSTM1 sequestosome 1 0.0466943
BCLAF1 BCL2-associated transcription factor 1 0.0465356
SPAG9 sperm associated antigen 9 0.0459919
BCL2L1 BCL2-like 1 0.0451008
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0444422
EPS8 epidermal growth factor receptor pathway substrate 8 0.0431422
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0430368
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0419431
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0408444
SAMD4A sterile alpha motif domain containing 4A 0.0406655
ATP11A ATPase, class VI, type 11A 0.038199
INTS6 integrator complex subunit 6 0.0381571
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.038156
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0376311
BTBD9 BTB (POZ) domain containing 9 0.0375731
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0368408
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0366633
ANKRD10 ankyrin repeat domain 10 0.0365494
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0365458
LPP LIM domain containing preferred translocation partner in lipoma 0.0363228
MYO5B myosin VB 0.034689
VMP1 vacuole membrane protein 1 0.0327592
CTBP2 C-terminal binding protein 2 0.0321434
ZNF292 zinc finger protein 292 0.0314016
SLK STE20-like kinase 0.0312643
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0312032
ZSWIM6 zinc finger, SWIM-type containing 6 0.0309969
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.030852
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0308393
USP53 ubiquitin specific peptidase 53 0.0298541
NAMPT nicotinamide phosphoribosyltransferase 0.0296447
SEC31A SEC31 homolog A (S. cerevisiae) 0.0294857
EREG epiregulin 0.0294798
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0294746
RIGI RNA sensor RIG-I 0.0292604
OCLN occludin 0.0289439
ITGA6 integrin, alpha 6 0.0289297
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0284789
SOD2 superoxide dismutase 2, mitochondrial 0.0282361
GCLC glutamate-cysteine ligase, catalytic subunit 0.0280448
N4BP2L2 NEDD4 binding protein 2-like 2 0.0280329
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0279035
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0271568
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0268779
RAB7A RAB7A, member RAS oncogene family 0.0268154
ZHX2 zinc fingers and homeoboxes 2 0.0266297
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0260606
PMM2 phosphomannomutase 2 0.0255854
SDC4 syndecan 4 0.0255703
NABP1 nucleic acid binding protein 1 0.025374
TRIO trio Rho guanine nucleotide exchange factor 0.0252141
FAT1 FAT atypical cadherin 1 0.0250574
DIAPH1 diaphanous-related formin 1 0.0248714
RDH10 retinol dehydrogenase 10 (all-trans) 0.0247271
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0247209
MCL1 myeloid cell leukemia 1 0.0245
RUNX1 runt-related transcription factor 1 0.0244733
KYNU kynureninase 0.0244213
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0243534
TRIP12 thyroid hormone receptor interactor 12 0.0243291
DUSP10 dual specificity phosphatase 10 0.0239064
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0233667
ZCCHC7 zinc finger, CCHC domain containing 7 0.0233396
SUCO SUN domain containing ossification factor 0.0233135
ARHGAP5 Rho GTPase activating protein 5 0.0230543
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0229524
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0229185
FNIP1 folliculin interacting protein 1 0.0229142
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 0.0228466
MAP7 microtubule-associated protein 7 0.0228366
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.022378
EPHB2 EPH receptor B2 0.022309
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0222611
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0222299
PLSCR1 phospholipid scramblase 1 0.0221574
RND3 Rho family GTPase 3 0.0221547
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.021986

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.215127
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.148887
HLA-B major histocompatibility complex, class I, B -0.138011
PKM pyruvate kinase, muscle -0.108194
ZMYND8 zinc finger, MYND-type containing 8 -0.105354
LCN2 lipocalin 2 -0.0838641
NDRG1 N-myc downstream regulated 1 -0.0776804
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.076668
PTMA prothymosin, alpha -0.0765293
IFI6 interferon, alpha-inducible protein 6 -0.0734611
TMSB10 thymosin beta 10 -0.0716738
IFI27 interferon, alpha-inducible protein 27 -0.0688323
EGR1 early growth response 1 -0.0658561
RPLP1 ribosomal protein, large, P1 -0.0604476
TXNIP thioredoxin interacting protein -0.0598219
LOC112694756 uncharaterized LOC112694756 -0.0586897
FTL ferritin, light polypeptide -0.0559101
RPS6 ribosomal protein S6 -0.0543948
RPL35A ribosomal protein L35a -0.0482922
MT2A metallothionein 2A -0.0470907
HLA-C major histocompatibility complex, class I, C -0.0462491
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0462469
HLA-A major histocompatibility complex, class I, A -0.0461273
SLC38A1 solute carrier family 38, member 1 -0.046101
RPS19 ribosomal protein S19 -0.0444669
H1-0 H1.0 linker histone -0.0440417
CST3 cystatin C -0.0424075
RPL19 ribosomal protein L19 -0.042098
S100A6 S100 calcium binding protein A6 -0.0409117
RPL23 ribosomal protein L23 -0.0408176
ANXA4 annexin A4 -0.0403006
MUC13 mucin 13, cell surface associated -0.0383266
LYZ lysozyme -0.0380406
RPS24 ribosomal protein S24 -0.036877
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0368543
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0364856
VDAC1 voltage-dependent anion channel 1 -0.0361437
XAF1 XIAP associated factor 1 -0.0358992
RPL34 ribosomal protein L34 -0.0358295
APOL1 apolipoprotein L, 1 -0.035096
CSTB cystatin B (stefin B) -0.035081
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0346951
RPS27 ribosomal protein S27 -0.0346852
POTEF POTE ankyrin domain family, member F -0.0344106
ENO1 enolase 1, (alpha) -0.0343492
TFF3 trefoil factor 3 (intestinal) -0.0342792
RPL28 ribosomal protein L28 -0.0338452
KRT19 keratin 19, type I -0.0333254
DSTN destrin (actin depolymerizing factor) -0.0331122
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0330159
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0329241
PTBP3 polypyrimidine tract binding protein 3 -0.0326628
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0322712
GNAS GNAS complex locus -0.0322552
EPSTI1 epithelial stromal interaction 1 (breast) -0.0317252
NPSR1 neuropeptide S receptor 1 -0.0316234
S100A9 S100 calcium binding protein A9 -0.0315851
RHOBTB3 Rho-related BTB domain containing 3 -0.0315652
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0314594
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0313847
RPL31 ribosomal protein L31 -0.0312651
RPL12 ribosomal protein L12 -0.0310066
EIF1 eukaryotic translation initiation factor 1 -0.0306049
SSH2 slingshot protein phosphatase 2 -0.0305484
EPCAM epithelial cell adhesion molecule -0.0304913
CTSD cathepsin D -0.0304908
RPL11 ribosomal protein L11 -0.0300643
S100A10 S100 calcium binding protein A10 -0.0300315
LY6E lymphocyte antigen 6 complex, locus E -0.0295394
KIF16B kinesin family member 16B -0.0287679
HMGB1 high mobility group box 1 -0.0281199
IFITM3 interferon induced transmembrane protein 3 -0.0280047
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.027867
GCC2 GRIP and coiled-coil domain containing 2 -0.0278106
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0277699
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0277327
HLA-E major histocompatibility complex, class I, E -0.0275489
RPS8 ribosomal protein S8 -0.0274177
RNF149 ring finger protein 149 -0.0272131
RNF43 ring finger protein 43 -0.0270506
RPL37 ribosomal protein L37 -0.0269799
TPI1 triosephosphate isomerase 1 -0.0269784
PTGR1 prostaglandin reductase 1 -0.0263746
NCKAP5 NCK-associated protein 5 -0.0262797
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.026072
BMP4 bone morphogenetic protein 4 -0.0258754
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.0256927
TRIM56 tripartite motif containing 56 -0.0255063
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0254374
RPLP2 ribosomal protein, large, P2 -0.0250247
SERF2 small EDRK-rich factor 2 -0.0247999
SRRM2 serine/arginine repetitive matrix 2 -0.0247987
H3-3B H3.3 histone B -0.0245359
GPX2 glutathione peroxidase 2 -0.0244361
LIMA1 LIM domain and actin binding 1 -0.024319
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0242808
MT1X metallothionein 1X -0.0235768
UBC ubiquitin C -0.0235124
RPS14 ribosomal protein S14 -0.0232322
ISG15 ISG15 ubiquitin-like modifier -0.0231327