Quinestrol_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Quinestrol perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Quinestrol_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.129635
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0730907
CD44 CD44 molecule (Indian blood group) 0.0558145
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0531918
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.053166
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0524911
DPYD dihydropyrimidine dehydrogenase 0.0483718
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0479224
ARHGAP21 Rho GTPase activating protein 21 0.0454749
CEMIP cell migration inducing protein, hyaluronan binding 0.045284
TPM3 tropomyosin 3 0.0451905
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0448398
OSMR oncostatin M receptor 0.0444978
MACF1 microtubule-actin crosslinking factor 1 0.0426725
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0399423
TTC3 tetratricopeptide repeat domain 3 0.0376593
OPTN optineurin 0.0341418
FAM107B family with sequence similarity 107, member B 0.0340912
RIN2 Ras and Rab interactor 2 0.0338946
N4BP2L2 NEDD4 binding protein 2-like 2 0.0338892
TGM2 transglutaminase 2 0.033818
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0329571
CALU calumenin 0.0326926
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0323148
RAI14 retinoic acid induced 14 0.0316035
TXNRD1 thioredoxin reductase 1 0.0315371
CDCP1 CUB domain containing protein 1 0.0309085
LAMC2 laminin, gamma 2 0.0304634
DOCK5 dedicator of cytokinesis 5 0.0297609
NRIP1 nuclear receptor interacting protein 1 0.0295246
EXOC6B exocyst complex component 6B 0.0292096
THSD4 thrombospondin, type I, domain containing 4 0.0274997
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0273665
BLCAP bladder cancer associated protein 0.0270598
HLA-E major histocompatibility complex, class I, E 0.0268648
TBC1D5 TBC1 domain family, member 5 0.0266758
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0264722
SLK STE20-like kinase 0.0253437
EHD4 EH-domain containing 4 0.0248781
PICALM phosphatidylinositol binding clathrin assembly protein 0.0243213
EXT1 exostosin glycosyltransferase 1 0.0236427
CMIP c-Maf inducing protein 0.023419
TRIP11 thyroid hormone receptor interactor 11 0.0233181
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0227971
WARS1 tryptophanyl-tRNA synthetase 1 0.0226953
PTHLH parathyroid hormone-like hormone 0.0224576
RAD51B RAD51 paralog B 0.0221825
USP33 ubiquitin specific peptidase 33 0.0221041
ADAM19 ADAM metallopeptidase domain 19 0.0220919
DSCAM Down syndrome cell adhesion molecule 0.0219792
EFHD2 EF-hand domain family, member D2 0.0219443
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0218706
FER fer (fps/fes related) tyrosine kinase 0.0215204
PRSS23 protease, serine, 23 0.0214294
AMOTL1 angiomotin like 1 0.0212114
NKTR natural killer cell triggering receptor 0.0211487
EFNA5 ephrin-A5 0.0209278
PCCA propionyl CoA carboxylase, alpha polypeptide 0.020924
EHBP1 EH domain binding protein 1 0.0209042
WDR70 WD repeat domain 70 0.0208436
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.020753
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0206438
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0206225
ANTXR2 anthrax toxin receptor 2 0.0203263
TJP1 tight junction protein 1 0.0202662
ATL1 atlastin GTPase 1 0.0202515
LRRC8C leucine rich repeat containing 8 family, member C 0.020179
GANAB glucosidase, alpha; neutral AB 0.0201546
CPOX coproporphyrinogen oxidase 0.0199664
FOXO1 forkhead box O1 0.0197777
EIF4A2 eukaryotic translation initiation factor 4A2 0.0196937
RLIM ring finger protein, LIM domain interacting 0.0196792
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0196507
GOLGA2 golgin A2 0.0196419
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0195721
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.019528
CD47 CD47 molecule 0.0194708
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0194321
SPIRE1 spire-type actin nucleation factor 1 0.0193379
USP34 ubiquitin specific peptidase 34 0.0190699
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0190641
AFDN afadin, adherens junction formation factor 0.0189821
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0189712
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.0189094
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0187712
TRAPPC9 trafficking protein particle complex 9 0.0186185
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.0185596
BACE2 beta-site APP-cleaving enzyme 2 0.0185285
PYGL phosphorylase, glycogen, liver 0.0185024
ZMIZ1 zinc finger, MIZ-type containing 1 0.0184692
GBP2 guanylate binding protein 2, interferon-inducible 0.0183689
ERAP2 endoplasmic reticulum aminopeptidase 2 0.0183323
TRIM44 tripartite motif containing 44 0.0182957
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease 0.0182711
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0182632
SHB Src homology 2 domain containing adaptor protein B 0.0180752
THOC2 THO complex 2 0.0179092
NSD1 nuclear receptor binding SET domain protein 1 0.0179038
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0178813
TRRAP transformation/transcription domain-associated protein 0.0178475

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.226579
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.221843
TMSB10 thymosin beta 10 -0.146217
MTSS1 metastasis suppressor 1 -0.128321
NDRG1 N-myc downstream regulated 1 -0.110865
LDHA lactate dehydrogenase A -0.106245
MT2A metallothionein 2A -0.103961
S100A10 S100 calcium binding protein A10 -0.0998533
LOC112694756 uncharaterized LOC112694756 -0.0970634
AHNAK AHNAK nucleoprotein -0.0947289
GNAS GNAS complex locus -0.0876193
KRT17 keratin 17, type I -0.0871274
H1-0 H1.0 linker histone -0.0823094
MBNL1 muscleblind-like splicing regulator 1 -0.0788746
INTS6 integrator complex subunit 6 -0.0780554
LMNA lamin A/C -0.0768163
RPS21 ribosomal protein S21 -0.0765117
PDLIM5 PDZ and LIM domain 5 -0.0726337
CAV1 caveolin 1, caveolae protein, 22kDa -0.0697186
HSPG2 heparan sulfate proteoglycan 2 -0.0695356
TRIO trio Rho guanine nucleotide exchange factor -0.0689398
PALLD palladin, cytoskeletal associated protein -0.0679883
RPS24 ribosomal protein S24 -0.0651346
PLS3 plastin 3 -0.063023
KRT6A keratin 6A, type II -0.0612624
POTEF POTE ankyrin domain family, member F -0.0610221
STC1 stanniocalcin 1 -0.0608261
PTMA prothymosin, alpha -0.0589044
PKM pyruvate kinase, muscle -0.0585911
VCL vinculin -0.0563515
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0560019
IGF2 insulin-like growth factor 2 -0.0558313
ANXA2 annexin A2 -0.0542379
RPL11 ribosomal protein L11 -0.0525511
LAMA5 laminin, alpha 5 -0.0516496
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0511859
IFITM3 interferon induced transmembrane protein 3 -0.0505751
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0484998
RPS6 ribosomal protein S6 -0.0484683
WASF2 WAS protein family, member 2 -0.0477356
RPLP1 ribosomal protein, large, P1 -0.0469528
RPL34 ribosomal protein L34 -0.0467773
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0462096
S100A2 S100 calcium binding protein A2 -0.0460811
PLEC plectin -0.0453499
AKAP13 A kinase (PRKA) anchor protein 13 -0.0453228
RPS19 ribosomal protein S19 -0.0449165
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0449149
RACK1 receptor for activated C kinase 1 -0.0441509
RPL19 ribosomal protein L19 -0.0438654
MORF4L2 mortality factor 4 like 2 -0.0436221
PNISR PNN-interacting serine/arginine-rich protein -0.0429878
RPS25 ribosomal protein S25 -0.0429618
EGR1 early growth response 1 -0.0427767
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0427689
KLF6 Kruppel-like factor 6 -0.0426629
ANXA1 annexin A1 -0.0426276
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.042594
ARF1 ADP-ribosylation factor 1 -0.0417376
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.041092
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0406616
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0406605
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.04041
RPLP0 ribosomal protein, large, P0 -0.0402424
SERTAD2 SERTA domain containing 2 -0.040238
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0394832
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0391597
FKBP5 FK506 binding protein 5 -0.0389348
FSCN1 fascin actin-bundling protein 1 -0.0388273
KRT14 keratin 14, type I -0.0387385
RPS4X ribosomal protein S4, X-linked -0.0383667
SP100 SP100 nuclear antigen -0.0380122
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0378677
ANKRD33B ankyrin repeat domain 33B -0.0378056
CYB5R3 cytochrome b5 reductase 3 -0.0377847
RNF145 ring finger protein 145 -0.0377456
ACTN4 actinin, alpha 4 -0.0373257
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0372417
MT1X metallothionein 1X -0.0372208
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0371858
S100A6 S100 calcium binding protein A6 -0.0369897
ENO1 enolase 1, (alpha) -0.0367482
KDM3A lysine (K)-specific demethylase 3A -0.0366262
RPL35A ribosomal protein L35a -0.0365679
EPHA2 EPH receptor A2 -0.0358286
RPL23 ribosomal protein L23 -0.0355406
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0355314
DSTN destrin (actin depolymerizing factor) -0.0353513
TRA2A transformer 2 alpha homolog (Drosophila) -0.035286
DENND4C DENN/MADD domain containing 4C -0.0351896
CLIC4 chloride intracellular channel 4 -0.0350416
RPLP2 ribosomal protein, large, P2 -0.0348455
HMGA2 high mobility group AT-hook 2 -0.0344909
ANLN anillin, actin binding protein -0.03408
UBE2B ubiquitin-conjugating enzyme E2B -0.0339148
RPS8 ribosomal protein S8 -0.0338954
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0338844
TOP1 topoisomerase (DNA) I -0.0336672
CLEC1B C-type lectin domain family 1, member B -0.0336629
FTL ferritin, light polypeptide -0.0336498