Quinestrol_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Quinestrol perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Quinestrol_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.12138
THSD4 thrombospondin, type I, domain containing 4 0.120301
LAMC2 laminin, gamma 2 0.118314
GRAMD1B GRAM domain containing 1B 0.106356
SLTM SAFB-like, transcription modulator 0.10277
CEMIP cell migration inducing protein, hyaluronan binding 0.0885654
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0858995
STC1 stanniocalcin 1 0.0842608
CXCL8 chemokine (C-X-C motif) ligand 8 0.0839458
FNDC3B fibronectin type III domain containing 3B 0.0800241
INTS6 integrator complex subunit 6 0.0692346
TPT1 tumor protein, translationally-controlled 1 0.0684274
EGFR epidermal growth factor receptor 0.0670373
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0663526
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0646239
SAMD4A sterile alpha motif domain containing 4A 0.0642386
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0617966
RNF213 ring finger protein 213 0.0617538
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0591509
LMO7 LIM domain 7 0.058344
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0579235
GRB10 growth factor receptor-bound protein 10 0.0570775
SMAD3 SMAD family member 3 0.0523636
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0518376
PTPRM protein tyrosine phosphatase, receptor type, M 0.051404
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.050188
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0488397
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0476945
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0476679
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0473618
NPAS2 neuronal PAS domain protein 2 0.0448455
ZSWIM6 zinc finger, SWIM-type containing 6 0.0439688
MYOF myoferlin 0.0423233
DSCAM Down syndrome cell adhesion molecule 0.0421473
RAD51B RAD51 paralog B 0.0418385
MYO1E myosin IE 0.0411964
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0402863
BCAR3 breast cancer anti-estrogen resistance 3 0.0396041
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0395288
LPP LIM domain containing preferred translocation partner in lipoma 0.0392647
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0390906
PDLIM5 PDZ and LIM domain 5 0.038726
DOCK1 dedicator of cytokinesis 1 0.0387121
SMYD3 SET and MYND domain containing 3 0.0383353
SOD2 superoxide dismutase 2, mitochondrial 0.037067
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0363658
CMIP c-Maf inducing protein 0.035488
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0347292
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0345947
NABP1 nucleic acid binding protein 1 0.0343908
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0333957
FAM107B family with sequence similarity 107, member B 0.0333024
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0330583
SVIL supervillin 0.0329977
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0324648
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0323861
FUS FUS RNA binding protein 0.0323204
ANKRD12 ankyrin repeat domain 12 0.0318682
DOCK4 dedicator of cytokinesis 4 0.0317068
PM20D1 peptidase M20 domain containing 1 0.0315197
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0314864
LAMB3 laminin, beta 3 0.0314699
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.031429
CTBP2 C-terminal binding protein 2 0.0311243
SUMF1 sulfatase modifying factor 1 0.0310727
DST dystonin 0.030389
EXT1 exostosin glycosyltransferase 1 0.0297677
MACF1 microtubule-actin crosslinking factor 1 0.0292777
VCL vinculin 0.0292206
HOMER1 homer scaffolding protein 1 0.0290591
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0287498
HSPA8 heat shock 70kDa protein 8 0.0287103
NAP1L1 nucleosome assembly protein 1-like 1 0.0284338
TBC1D22A TBC1 domain family, member 22A 0.0281996
SFPQ splicing factor proline/glutamine-rich 0.028164
IGFBP5 insulin-like growth factor binding protein 5 0.0281599
KRT18 keratin 18, type I 0.0279547
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0271724
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0270837
DOCK5 dedicator of cytokinesis 5 0.0266659
SLK STE20-like kinase 0.0266251
ACTG1 actin gamma 1 0.0261369
BACE2 beta-site APP-cleaving enzyme 2 0.0261316
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0261248
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0256871
RIMS2 regulating synaptic membrane exocytosis 2 0.0253644
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0252773
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0246908
PSD3 pleckstrin and Sec7 domain containing 3 0.0245933
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0245534
BZW1 basic leucine zipper and W2 domains 1 0.0243922
PRKCA protein kinase C, alpha 0.0242341
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.023858
MSN moesin 0.0235958
NTSR1 neurotensin receptor 1 (high affinity) 0.0234651
MX1 MX dynamin-like GTPase 1 0.0233199
LRP12 low density lipoprotein receptor-related protein 12 0.0230937
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.023069
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0227007
ATF6 activating transcription factor 6 0.0225963

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.264744
MT2A metallothionein 2A -0.165666
FTH1 ferritin, heavy polypeptide 1 -0.134158
CAV1 caveolin 1, caveolae protein, 22kDa -0.10538
TMSB10 thymosin beta 10 -0.0909631
GCLC glutamate-cysteine ligase, catalytic subunit -0.0842077
PDE4D phosphodiesterase 4D, cAMP-specific -0.0795216
NAMPT nicotinamide phosphoribosyltransferase -0.077768
FAM13A family with sequence similarity 13, member A -0.0757095
CES1 carboxylesterase 1 -0.070245
LOC112694756 uncharaterized LOC112694756 -0.0699776
TXNRD1 thioredoxin reductase 1 -0.0686247
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0634989
TMEM165 transmembrane protein 165 -0.0625728
PKM pyruvate kinase, muscle -0.0600055
NDRG1 N-myc downstream regulated 1 -0.0571097
EGR1 early growth response 1 -0.0552474
FTL ferritin, light polypeptide -0.0535736
RNF145 ring finger protein 145 -0.0532696
UBC ubiquitin C -0.0474488
TOP1 topoisomerase (DNA) I -0.0473277
AKR1C1 aldo-keto reductase family 1, member C1 -0.039781
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0396817
MKI67 marker of proliferation Ki-67 -0.0394181
CST3 cystatin C -0.0388309
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0384279
WDR45B WD repeat domain 45B -0.0381077
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0376989
MT1X metallothionein 1X -0.0364477
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0360012
BRWD1 bromodomain and WD repeat domain containing 1 -0.0348161
S100P S100 calcium binding protein P -0.0346126
WASF2 WAS protein family, member 2 -0.0338715
H1-0 H1.0 linker histone -0.0334928
RPLP1 ribosomal protein, large, P1 -0.0300789
CAMTA1 calmodulin binding transcription activator 1 -0.0294336
FKBP5 FK506 binding protein 5 -0.0290512
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0290421
RNF149 ring finger protein 149 -0.0288986
KCMF1 potassium channel modulatory factor 1 -0.0286184
DNER delta/notch-like EGF repeat containing -0.0271433
CCNL1 cyclin L1 -0.0269274
UVRAG UV radiation resistance associated -0.0268302
HDLBP high density lipoprotein binding protein -0.0267863
TES testin LIM domain protein -0.0262948
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0262724
SRRM2 serine/arginine repetitive matrix 2 -0.02605
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0258695
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0257952
SREBF2 sterol regulatory element binding transcription factor 2 -0.0255319
ARL5B ADP-ribosylation factor-like 5B -0.02497
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0249259
MGAT4C MGAT4 family, member C -0.0247655
KMT2A lysine (K)-specific methyltransferase 2A -0.0245402
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0242121
RAP1B RAP1B, member of RAS oncogene family -0.0241671
AGO2 argonaute RISC catalytic component 2 -0.0239444
PDIA3 protein disulfide isomerase family A, member 3 -0.0238956
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 -0.0238256
ANXA2 annexin A2 -0.0232394
FRY furry homolog (Drosophila) -0.0229805
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0227846
SEPTIN2 septin 2 -0.0225421
MORF4L2 mortality factor 4 like 2 -0.0223457
AKAP12 A kinase (PRKA) anchor protein 12 -0.0213176
TKT transketolase -0.0209073
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0206836
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0206641
PGK1 phosphoglycerate kinase 1 -0.0204907
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0204604
MAP2K1 mitogen-activated protein kinase kinase 1 -0.0203803
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.020241
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0201382
CCND3 cyclin D3 -0.0199358
RPS6 ribosomal protein S6 -0.0198862
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0197967
NCOA3 nuclear receptor coactivator 3 -0.019605
ZC3H15 zinc finger CCCH-type containing 15 -0.019491
ZMYND8 zinc finger, MYND-type containing 8 -0.0194132
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0192656
MATR3 matrin 3 -0.0191399
PHF21A PHD finger protein 21A -0.0188834
DYNC2I1 dynein 2 intermediate chain 1 -0.0188405
PNISR PNN-interacting serine/arginine-rich protein -0.0187747
BRWD3 bromodomain and WD repeat domain containing 3 -0.0185661
ADAM17 ADAM metallopeptidase domain 17 -0.0185544
NGLY1 N-glycanase 1 -0.0184592
NDE1 nudE neurodevelopment protein 1 -0.0184163
HELZ helicase with zinc finger -0.0183551
STRN3 striatin, calmodulin binding protein 3 -0.0178046
CSNK1E casein kinase 1, epsilon -0.017679
PTEN phosphatase and tensin homolog -0.0176603
OGA O-GlcNAcase -0.0176434
PER1 period circadian clock 1 -0.017522
SRP54 signal recognition particle 54kDa -0.0174506
MARF1 meiosis regulator and mRNA stability factor 1 -0.017334
UBE2B ubiquitin-conjugating enzyme E2B -0.0172929
SYAP1 synapse associated protein 1 -0.0172587
MXI1 MAX interactor 1, dimerization protein -0.0170449
BIRC3 baculoviral IAP repeat containing 3 -0.0170136