Quinestrol_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Quinestrol perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Quinestrol_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.1493
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.149181
FLNB filamin B, beta 0.0888984
TM4SF1 transmembrane 4 L six family member 1 0.0873578
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0865785
SAMD4A sterile alpha motif domain containing 4A 0.0861627
IGFBP3 insulin-like growth factor binding protein 3 0.0859703
FMNL2 formin-like 2 0.0819096
STC1 stanniocalcin 1 0.0770221
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0764904
THSD4 thrombospondin, type I, domain containing 4 0.0715139
DOCK4 dedicator of cytokinesis 4 0.0691064
BASP1 brain abundant, membrane attached signal protein 1 0.0676579
FNDC3B fibronectin type III domain containing 3B 0.0669116
SMOC1 SPARC related modular calcium binding 1 0.0664214
SFPQ splicing factor proline/glutamine-rich 0.0657795
FAM107B family with sequence similarity 107, member B 0.0638167
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0580156
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0559253
MACF1 microtubule-actin crosslinking factor 1 0.0542512
CMIP c-Maf inducing protein 0.0537498
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0535875
LAMC2 laminin, gamma 2 0.0530374
ELL2 elongation factor, RNA polymerase II, 2 0.051074
PYGL phosphorylase, glycogen, liver 0.0500754
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0496158
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0496131
WAC WW domain containing adaptor with coiled-coil 0.0485656
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0473149
SOD2 superoxide dismutase 2, mitochondrial 0.0461797
TPM3 tropomyosin 3 0.0460648
ITCH itchy E3 ubiquitin protein ligase 0.045713
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0456402
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0455912
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.044457
ATXN1 ataxin 1 0.0440222
SVIL supervillin 0.0439158
BIRC6 baculoviral IAP repeat containing 6 0.0439153
ARHGAP26 Rho GTPase activating protein 26 0.0421668
TRIO trio Rho guanine nucleotide exchange factor 0.0417688
TFPI2 tissue factor pathway inhibitor 2 0.0416005
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0405919
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0400923
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0399973
GOLGA4 golgin A4 0.0399179
DOCK5 dedicator of cytokinesis 5 0.0396772
PTPRM protein tyrosine phosphatase, receptor type, M 0.0390353
KTN1 kinectin 1 (kinesin receptor) 0.0389934
CYTH1 cytohesin 1 0.0386248
LPP LIM domain containing preferred translocation partner in lipoma 0.0383381
DST dystonin 0.0371284
SH3KBP1 SH3-domain kinase binding protein 1 0.0368375
BRD2 bromodomain containing 2 0.0364976
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0361396
YTHDC1 YTH domain containing 1 0.035852
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.035827
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0354536
ACTG1 actin gamma 1 0.0350483
ZSWIM6 zinc finger, SWIM-type containing 6 0.034936
EXT1 exostosin glycosyltransferase 1 0.034771
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.034307
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0335178
BCAR3 breast cancer anti-estrogen resistance 3 0.033102
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0327063
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0324662
RBM25 RNA binding motif protein 25 0.0321463
PRRC2C proline-rich coiled-coil 2C 0.0320726
CALR calreticulin 0.0317303
APLP2 amyloid beta (A4) precursor-like protein 2 0.0315918
AKAP13 A kinase (PRKA) anchor protein 13 0.0315876
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0311693
EGFR epidermal growth factor receptor 0.0310766
RICTOR RPTOR independent companion of MTOR, complex 2 0.030483
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0303599
EXOC6B exocyst complex component 6B 0.0301615
COPA coatomer protein complex, subunit alpha 0.0295749
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0295402
MYO1E myosin IE 0.0295097
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0294592
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0292841
PARD3 par-3 family cell polarity regulator 0.0292312
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0292294
PUM1 pumilio RNA-binding family member 1 0.0288873
NDRG1 N-myc downstream regulated 1 0.0285503
EEF2 eukaryotic translation elongation factor 2 0.0284475
GRB10 growth factor receptor-bound protein 10 0.0283929
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0282647
AHNAK AHNAK nucleoprotein 0.0281895
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0280403
KMT2C lysine (K)-specific methyltransferase 2C 0.0278609
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.027749
JUN jun proto-oncogene 0.0276116
GSK3B glycogen synthase kinase 3 beta 0.0276046
CSNK1A1 casein kinase 1, alpha 1 0.0275511
ALCAM activated leukocyte cell adhesion molecule 0.0273996
MCL1 myeloid cell leukemia 1 0.0270996
NUMB numb homolog (Drosophila) 0.0270159
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0268219
INHBA inhibin, beta A 0.0267823
ERBIN erbb2 interacting protein 0.0267198

decreased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B -0.193244
TMSB10 thymosin beta 10 -0.185674
MT2A metallothionein 2A -0.159954
PM20D1 peptidase M20 domain containing 1 -0.148417
FTL ferritin, light polypeptide -0.143293
PDE4D phosphodiesterase 4D, cAMP-specific -0.138772
TXNRD1 thioredoxin reductase 1 -0.118915
NNMT nicotinamide N-methyltransferase -0.0814826
RPLP1 ribosomal protein, large, P1 -0.0777012
IGF2 insulin-like growth factor 2 -0.0742318
FTH1 ferritin, heavy polypeptide 1 -0.071336
RPL31 ribosomal protein L31 -0.0600504
RPL19 ribosomal protein L19 -0.0599605
PKM pyruvate kinase, muscle -0.0597153
FGB fibrinogen beta chain -0.0596047
RPL4 ribosomal protein L4 -0.0534188
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0532193
PTMA prothymosin, alpha -0.0504555
WWOX WW domain containing oxidoreductase -0.0502099
BIRC3 baculoviral IAP repeat containing 3 -0.0492433
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0487079
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0477862
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0433912
VIM vimentin -0.0426502
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0419415
RPS25 ribosomal protein S25 -0.0416606
RPL23 ribosomal protein L23 -0.0415019
RPL35A ribosomal protein L35a -0.0413262
RPS24 ribosomal protein S24 -0.0400931
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0387387
HDAC9 histone deacetylase 9 -0.0377081
FGA fibrinogen alpha chain -0.0367196
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0362307
MKI67 marker of proliferation Ki-67 -0.0360898
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0357252
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0356867
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0349169
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0346843
NAMPT nicotinamide phosphoribosyltransferase -0.0334935
EFNA5 ephrin-A5 -0.0333112
RPS5 ribosomal protein S5 -0.0319868
FGG fibrinogen gamma chain -0.0317069
BICC1 BicC family RNA binding protein 1 -0.0316804
RPS20 ribosomal protein S20 -0.031212
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.030413
RPL11 ribosomal protein L11 -0.0303418
ADGRG6 adhesion G protein-coupled receptor G6 -0.0302393
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.030171
RPS29 ribosomal protein S29 -0.0300442
NCOA7 nuclear receptor coactivator 7 -0.029742
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0295781
RFWD3 ring finger and WD repeat domain 3 -0.0295778
RPL28 ribosomal protein L28 -0.0294993
RPS16 ribosomal protein S16 -0.0286766
RPS23 ribosomal protein S23 -0.0286262
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0283651
SLC38A1 solute carrier family 38, member 1 -0.0280336
WDR43 WD repeat domain 43 -0.0280089
RPL9 ribosomal protein L9 -0.0275518
CENPF centromere protein F, 350/400kDa -0.0270726
BIRC2 baculoviral IAP repeat containing 2 -0.0260011
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0259206
RPS21 ribosomal protein S21 -0.0258721
TMEM123 transmembrane protein 123 -0.025666
NTN4 netrin 4 -0.025556
LAMB1 laminin, beta 1 -0.0252258
TTC28 tetratricopeptide repeat domain 28 -0.0248728
ANKRD28 ankyrin repeat domain 28 -0.0248207
VDAC1 voltage-dependent anion channel 1 -0.0247535
S100A10 S100 calcium binding protein A10 -0.0247473
BHLHE40 basic helix-loop-helix family, member e40 -0.0245164
RPLP2 ribosomal protein, large, P2 -0.024155
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0239218
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0232495
SRGN serglycin -0.0230715
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0229675
ZNF804A zinc finger protein 804A -0.022746
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0222987
RPS19 ribosomal protein S19 -0.0221905
RPS27A ribosomal protein S27a -0.0216918
LDHB lactate dehydrogenase B -0.0215643
MIS18BP1 MIS18 binding protein 1 -0.0214097
RPS27 ribosomal protein S27 -0.0213181
NFIA nuclear factor I/A -0.0213126
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0212588
DENND4A DENN/MADD domain containing 4A -0.0209814
SRRM2 serine/arginine repetitive matrix 2 -0.0209149
FAM168A family with sequence similarity 168, member A -0.0207121
RPL5 ribosomal protein L5 -0.0205756
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.020007
AHR aryl hydrocarbon receptor -0.0199238
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0198644
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0196327
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0196038
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0194589
USP3 ubiquitin specific peptidase 3 -0.0194083
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0193888
PARK7 parkinson protein 7 -0.0193273
YBX3 Y box binding protein 3 -0.0193128
IGF1R insulin-like growth factor 1 receptor -0.0192463